Krt4 (keratin 4) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Krt4 (keratin 4) Rattus norvegicus
Analyze
Symbol: Krt4
Name: keratin 4
RGD ID: 1359272
Description: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization; keratinization; and negative regulation of epithelial cell proliferation. Predicted to be located in cell surface and intermediate filament cytoskeleton. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in white sponge nevus 1. Orthologous to human KRT4 (keratin 4); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CK-4; cytokeratin-4; K4; Kb4; keratin 4, type II; keratin, type II cytoskeletal 4; keratin-4; type II keratin Kb4; type-II keratin Kb4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,924,753 - 134,931,050 (-)NCBIGRCr8
mRatBN7.27133,046,067 - 133,052,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,046,515 - 133,052,019 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,807,258 - 134,813,217 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,036,779 - 137,042,738 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,015,435 - 137,021,394 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,517,562 - 143,523,522 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,518,010 - 143,523,503 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,315,271 - 141,321,166 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,622,632 - 140,628,079 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,699,068 - 140,704,516 (-)NCBI
Celera7129,484,207 - 129,489,655 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt4RatGenetic Skin Diseases susceptibilityISOKRT4 (Homo sapiens)1600193DNA:deletion: more ...RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt4Ratgenetic disease  ISOKRT4 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Krt4Ratwhite sponge nevus  ISOKRT4 (Homo sapiens)8554872ClinVar Annotator: match by term: White sponge nevus of cannonClinVarPMID:25741868 and PMID:28492532
Krt4Ratwhite sponge nevus 1  ISOKRT4 (Homo sapiens)8554872ClinVar Annotator: match by term: White sponge nevus 1ClinVarPMID:10652003 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt4Ratcontact dermatitis  ISOKRT4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Krt4Ratwhite sponge nevus  ISOKRT4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt4Ratwhite sponge nevus  ISSKrt4 (Mus musculus)13592920 MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt4Ratwhite sponge nevus 1  ISOKRT4 (Homo sapiens)7240710 OMIM 

1 to 20 of 97 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt4Rat1-chloro-2,4-dinitrobenzene affects bindingISOKRT4 (Homo sapiens)6480464Dinitrochlorobenzene binds to KRT4 proteinCTDPMID:32991956
Krt4Rat17alpha-ethynylestradiol affects expressionISOKrt4 (Mus musculus)6480464Ethinyl Estradiol affects the expression of KRT4 mRNACTDPMID:14976129
Krt4Rat17alpha-ethynylestradiol multiple interactionsISOKrt4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KRT4 mRNACTDPMID:17942748
Krt4Rat17alpha-ethynylestradiol increases expressionISOKrt4 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of KRT4 mRNACTDPMID:12072388 and PMID:17942748
Krt4Rat17beta-estradiol increases expressionISOKrt4 (Mus musculus)6480464Estradiol results in increased expression of KRT4 mRNACTDPMID:19484750 and PMID:37657410
Krt4Rat17beta-estradiol multiple interactionsISOKrt4 (Mus musculus)6480464Fulvestrant inhibits the reaction [Estradiol results in increased expression of KRT4 mRNA]CTDPMID:37657410
Krt4Rat17beta-estradiol decreases expressionISOKRT4 (Homo sapiens)6480464Estradiol results in decreased expression of KRT4 mRNACTDPMID:31614463 and PMID:36828454
Krt4Rat17beta-estradiol decreases expressionISOKrt4 (Mus musculus)6480464Estradiol results in decreased expression of KRT4 mRNACTDPMID:39298647
Krt4Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOKrt4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KRT4 mRNACTDPMID:17942748
Krt4Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOKrt4 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of KRT4 mRNACTDPMID:21570461
Krt4Rat2,3,7,8-Tetrachlorodibenzofuran increases expressionEXP 64804642 more ...CTDPMID:32109520
Krt4Rat2,6-dimethoxyphenol multiple interactionsISOKRT4 (Homo sapiens)6480464[pyrogallol 1 more ...CTDPMID:38598786
Krt4Rat2-acetamidofluorene increases expressionISOKrt4 (Mus musculus)64804642-Acetylaminofluorene results in increased expression of KRT4 mRNACTDPMID:17317680
Krt4Rat2-acetamidofluorene multiple interactionsISOKrt4 (Mus musculus)6480464TRP53 protein modified form affects the reaction [2-Acetylaminofluorene results in increased expression of KRT4 mRNA]CTDPMID:17317680
Krt4Rat3-chloropropane-1,2-diol decreases expressionEXP 6480464alpha-Chlorohydrin results in decreased expression of KRT4 proteinCTDPMID:26597043
Krt4Rat4,4'-sulfonyldiphenol increases expressionISOKrt4 (Mus musculus)6480464bisphenol S results in increased expression of KRT4 mRNACTDPMID:30951980
Krt4Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of KRT4 mRNACTDPMID:24780913 and PMID:30047161
Krt4Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of KRT4 mRNACTDPMID:28959563
Krt4Rataflatoxin B1 decreases expressionISOKRT4 (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of KRT4 mRNACTDPMID:32234424
Krt4Ratall-trans-retinoic acid increases expressionISOKRT4 (Homo sapiens)6480464Tretinoin results in increased expression of KRT4 mRNACTDPMID:16249480 and PMID:23830798

1 to 20 of 97 rows

Biological Process
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt4Ratbiological_process  ND 159840702/2007: no relevant rat dataRGD 
Krt4Ratcytoskeleton organization involved_inIEAUniProtKB:P19013 and ensembl:ENSP000004482201600115GO_REF:0000107EnsemblGO_REF:0000107
Krt4Ratcytoskeleton organization involved_inISOKRT4 (Homo sapiens)1624291 PMID:21371075RGDPMID:21371075
Krt4Ratepithelial cell differentiation involved_inIEAUniProtKB:P07744 and ensembl:ENSMUSP000000237971600115GO_REF:0000107EnsemblGO_REF:0000107
Krt4Ratepithelial cell differentiation involved_inISOKrt4 (Mus musculus)1624291 PMID:9727004RGDPMID:9727004
Krt4Ratepithelial cell differentiation involved_inISSUniProtKB:P077441600115GO_REF:0000024UniProtGO_REF:0000024
Krt4Ratintermediate filament organization involved_inIBAMGI:1100845 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Krt4Ratkeratinization involved_inIBAMGI:1100845 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Krt4Ratnegative regulation of epithelial cell proliferation involved_inISSUniProtKB:P077441600115GO_REF:0000024UniProtGO_REF:0000024
Krt4Ratnegative regulation of epithelial cell proliferation involved_inISOKrt4 (Mus musculus)1624291 PMID:9727004RGDPMID:9727004
Krt4Ratnegative regulation of epithelial cell proliferation involved_inIEAUniProtKB:P07744 and ensembl:ENSMUSP000000237971600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 11 of 11 rows

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt4Ratcell surface located_inISOKRT4 (Homo sapiens)1624291 PMID:17709412RGDPMID:17709412
Krt4Ratcell surface located_inIEAUniProtKB:P19013 and ensembl:ENSP000004482201600115GO_REF:0000107EnsemblGO_REF:0000107
Krt4Ratintermediate filament located_inIEAUniProtKB-KW:KW-0403 and UniProtKB-KW:KW-04161600115GO_REF:0000043UniProtGO_REF:0000043
Krt4Ratintermediate filament cytoskeleton located_inISOKRT4 (Homo sapiens)1624291 PMID:21371075RGDPMID:21371075
Krt4Ratintermediate filament cytoskeleton located_inIEAUniProtKB:P19013 and ensembl:ENSP000004482201600115GO_REF:0000107EnsemblGO_REF:0000107
Krt4Ratkeratin filament located_inISOKRT4 (Homo sapiens)1624291 PMID:21371075RGDPMID:21371075
Krt4Ratkeratin filament is_active_inIBAMGI:1861586 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Krt4Ratkeratin filament located_inIEAInterPro:IPR0030541600115GO_REF:0000002InterProGO_REF:0000002
Krt4Ratkeratin filament located_inIEAUniProtKB:P19013 and ensembl:ENSP000004482201600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 9 of 9 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Krt4Ratprotein binding enablesISOKRT4 (Homo sapiens)1624291UniProtKB:A1A4E9 more ...RGDPMID:17709412 more ...
Krt4Ratstructural constituent of skin epidermis enablesIBAMGI:96699 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Comprehensive analysis of keratin gene clusters in humans and rodents. Hesse M, etal., Eur J Cell Biol 2004 Feb;83(1):19-26.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
8. A mutation in the mucosal keratin K4 is associated with oral white sponge nevus. Rugg EL, etal., Nat Genet. 1995 Dec;11(4):450-2.
PMID:8950218   PMID:9727004   PMID:15057822   PMID:17709412   PMID:21371075   PMID:21630459   PMID:24625528  



Krt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,924,753 - 134,931,050 (-)NCBIGRCr8
mRatBN7.27133,046,067 - 133,052,027 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7133,046,515 - 133,052,019 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,807,258 - 134,813,217 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07137,036,779 - 137,042,738 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07137,015,435 - 137,021,394 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,517,562 - 143,523,522 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,518,010 - 143,523,503 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07141,315,271 - 141,321,166 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47140,622,632 - 140,628,079 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17140,699,068 - 140,704,516 (-)NCBI
Celera7129,484,207 - 129,489,655 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,806,549 - 52,814,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,806,549 - 52,814,116 (-)EnsemblGRCh38hg38GRCh38
GRCh371253,200,333 - 53,207,900 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,486,600 - 51,494,602 (-)NCBINCBI36Build 36hg18NCBI36
Build 341251,486,600 - 51,494,602NCBI
Celera1252,846,566 - 52,854,610 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1250,244,297 - 50,251,912 (-)NCBIHuRef
CHM1_11253,167,133 - 53,174,706 (-)NCBICHM1_1
T2T-CHM13v2.01252,771,007 - 52,778,574 (-)NCBIT2T-CHM13v2.0
Krt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,826,970 - 101,833,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,826,970 - 101,833,170 (-)EnsemblGRCm39 Ensembl
GRCm3815101,918,535 - 101,924,735 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,918,535 - 101,924,735 (-)EnsemblGRCm38mm10GRCm38
MGSCv3715101,748,966 - 101,755,166 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3615101,746,570 - 101,752,745 (-)NCBIMGSCv36mm8
Celera15104,070,333 - 104,076,533 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1557.13NCBI
Krt4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955458108,738 - 115,807 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955458108,803 - 115,755 (-)NCBIChiLan1.0ChiLan1.0
KRT4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,378,610 - 41,385,724 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,375,373 - 41,382,487 (+)NCBINHGRI_mPanPan1
KRT73
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,477,859 - 2,488,437 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,765,584 - 43,776,130 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0272,476,138 - 2,486,934 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,476,277 - 2,486,820 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,493,978 - 2,504,515 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,479,145 - 2,489,683 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02744,163,942 - 44,174,486 (-)NCBIUU_Cfam_GSD_1.0
Krt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494562,983,065 - 62,989,584 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651210,175,747 - 10,181,747 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651210,175,240 - 10,181,765 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl518,091,743 - 18,099,178 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1518,091,742 - 18,099,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,585,174 - 18,592,517 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KRT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,938,368 - 48,946,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037197,125,776 - 197,133,479 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624904901,368 - 907,710 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624904900,862 - 907,787 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Krt4
73 total Variants

Predicted Target Of
Summary Value
Count of predictions:171
Count of miRNA genes:126
Interacting mature miRNAs:137
Transcripts:ENSRNOT00000012943
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat

1 to 10 of 15 rows
AA818868  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27133,046,199 - 133,046,303 (+)MAPPERmRatBN7.2
Rnor_6.07143,517,695 - 143,517,798NCBIRnor6.0
Rnor_5.07141,315,404 - 141,315,507UniSTSRnor5.0
RGSC_v3.47140,622,317 - 140,622,420UniSTSRGSC3.4
Celera7129,483,892 - 129,483,995UniSTS
RH 3.4 Map71065.3UniSTS
Cytogenetic Map7q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 8 46 57 91 90 59 19 59 6 197 81 37 41 44 31



Ensembl Acc Id: ENSRNOT00000012943   ⟹   ENSRNOP00000012943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7143,518,010 - 143,523,457 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000082264   ⟹   ENSRNOP00000073894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7133,046,515 - 133,052,019 (-)Ensembl
Rnor_6.0 Ensembl7143,518,010 - 143,523,503 (-)Ensembl
RefSeq Acc Id: NM_001008806   ⟹   NP_001008806
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,924,753 - 134,930,713 (-)NCBI
mRatBN7.27133,046,067 - 133,052,027 (-)NCBI
Rnor_6.07143,518,010 - 143,523,457 (-)NCBI
Rnor_5.07141,315,271 - 141,321,166 (-)NCBI
RGSC_v3.47140,622,632 - 140,628,079 (-)RGD
Celera7129,484,207 - 129,489,655 (-)RGD
Sequence:
RefSeq Acc Id: XM_006242395   ⟹   XP_006242457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,924,753 - 134,931,050 (-)NCBI
mRatBN7.27133,046,067 - 133,052,021 (-)NCBI
Rnor_6.07143,517,562 - 143,523,522 (-)NCBI
Rnor_5.07141,315,271 - 141,321,166 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079345   ⟹   XP_038935273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,924,753 - 134,927,631 (-)NCBI
mRatBN7.27133,046,067 - 133,048,946 (-)NCBI
Protein RefSeqs NP_001008806 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242457 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935273 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein DAA02230 (Get FASTA)   NCBI Sequence Viewer  
  EDL86874 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073894
GenBank Protein Q6IG00 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008806   ⟸   NM_001008806
- UniProtKB: Q6IG00 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006242457   ⟸   XM_006242395
- Peptide Label: isoform X1
- UniProtKB: Q6IG00 (UniProtKB/Swiss-Prot),   A0A0G2K6P7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073894   ⟸   ENSRNOT00000082264
Ensembl Acc Id: ENSRNOP00000012943   ⟸   ENSRNOT00000012943
RefSeq Acc Id: XP_038935273   ⟸   XM_039079345
- Peptide Label: isoform X2
- UniProtKB: A6KCR8 (UniProtKB/TrEMBL)
IF rod

Name Modeler Protein Id AA Range Protein Structure
AF-Q6IG00-F1-model_v2 AlphaFold Q6IG00 1-536 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695684
Promoter ID:EPDNEW_R6208
Type:single initiation site
Name:Krt4_1
Description:keratin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,523,528 - 143,523,588EPDNEW


1 to 26 of 26 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31958 BioCyc
Ensembl Genes ENSRNOG00000032332 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000082264 ENTREZGENE
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
  Keratin_II UniProtKB/Swiss-Prot
KEGG Report rno:315323 UniProtKB/Swiss-Prot
NCBI Gene 315323 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  KERATIN, TYPE II CYTOSKELETAL 4 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
PhenoGen Krt4 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000032332 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
UniProt A0A0G2K6P7 ENTREZGENE, UniProtKB/TrEMBL
  A6KCR8 ENTREZGENE, UniProtKB/TrEMBL
  K2C4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Krt4  keratin 4  Krt4  keratin 4, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt4  keratin 4, type II  Krt4  keratin 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Krt4  keratin 4  Kb4  type II keratin Kb4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Kb4  type II keratin Kb4      Symbol and Name status set to approved 1299863 APPROVED
2005-07-29 Kb4  type II keratin Kb4      Symbol and Name status set to provisional 70820 PROVISIONAL