Map3k4 (mitogen activated protein kinase kinase kinase 4) - Rat Genome Database

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Gene: Map3k4 (mitogen activated protein kinase kinase kinase 4) Rattus norvegicus
Analyze
Symbol: Map3k4
Name: mitogen activated protein kinase kinase kinase 4
RGD ID: 1311192
Description: Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in several processes, including positive regulation of p38MAPK cascade; positive regulation of telomere maintenance; and response to UV-C. Predicted to act upstream of or within several processes, including chorionic trophoblast cell differentiation; male germ-line sex determination; and placenta development. Predicted to be located in cytoplasm. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4); PARTICIPATES IN adenosine signaling pathway; c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC308106; mitogen-activated protein kinase kinase kinase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,977,870 - 51,067,117 (+)NCBIGRCr8
mRatBN7.2148,431,801 - 48,519,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,431,830 - 48,519,358 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,123,422 - 49,210,946 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,108,862 - 55,196,008 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,198,915 - 49,286,447 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,625,714 - 48,711,642 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,625,743 - 48,711,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,043,920 - 51,129,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,891,172 - 42,978,862 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,894,086 - 42,981,804 (+)NCBI
Celera144,222,636 - 44,308,690 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
6-propyl-2-thiouracil  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
dibutyl phthalate  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glyphosate  (EXP)
ivermectin  (ISO)
josamycin  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
paracetamol  (EXP,ISO)
phenytoin  (EXP)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
sodium arsenate  (ISO)
tetrachloromethane  (EXP,ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Mechanisms and functions of p38 MAPK signalling. Cuadrado A and Nebreda AR, Biochem J. 2010 Aug 1;429(3):403-17. doi: 10.1042/BJ20100323.
2. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. The c-jun kinase/stress-activated pathway: regulation, function and role in human disease. Johnson GL and Nakamura K, Biochim Biophys Acta. 2007 Aug;1773(8):1341-8. Epub 2007 Jan 4.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:6855886   PMID:9305639   PMID:9827804   PMID:12878610   PMID:16157600   PMID:17015265   PMID:19289495   PMID:21531765   PMID:31602666  


Genomics

Comparative Map Data
Map3k4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8150,977,870 - 51,067,117 (+)NCBIGRCr8
mRatBN7.2148,431,801 - 48,519,358 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl148,431,830 - 48,519,358 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx149,123,422 - 49,210,946 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0155,108,862 - 55,196,008 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0149,198,915 - 49,286,447 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,625,714 - 48,711,642 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,625,743 - 48,711,642 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,043,920 - 51,129,819 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,891,172 - 42,978,862 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,894,086 - 42,981,804 (+)NCBI
Celera144,222,636 - 44,308,690 (+)NCBICelera
Cytogenetic Map1q11NCBI
MAP3K4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386160,991,769 - 161,117,380 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6160,991,727 - 161,117,385 (+)EnsemblGRCh38hg38GRCh38
GRCh376161,412,801 - 161,538,412 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366161,332,812 - 161,458,407 (+)NCBINCBI36Build 36hg18NCBI36
Build 346161,383,232 - 161,508,827NCBI
Celera6162,142,470 - 162,267,820 (+)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6158,868,162 - 158,993,547 (+)NCBIHuRef
CHM1_16161,675,694 - 161,801,069 (+)NCBICHM1_1
T2T-CHM13v2.06162,350,255 - 162,475,786 (+)NCBIT2T-CHM13v2.0
Map3k4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391712,446,508 - 12,537,683 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,446,508 - 12,537,683 (-)EnsemblGRCm39 Ensembl
GRCm381712,227,621 - 12,318,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,227,621 - 12,318,796 (-)EnsemblGRCm38mm10GRCm38
MGSCv371712,420,487 - 12,511,526 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,070,979 - 12,162,106 (-)NCBIMGSCv36mm8
Celera1712,261,355 - 12,347,211 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.42NCBI
Map3k4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543920,144,059 - 20,263,879 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,144,059 - 20,263,885 (-)NCBIChiLan1.0ChiLan1.0
MAP3K4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25181,166,613 - 181,292,313 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16179,070,978 - 179,197,841 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06158,937,424 - 159,062,550 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16163,948,643 - 164,073,264 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6163,948,122 - 164,073,264 (+)Ensemblpanpan1.1panPan2
MAP3K4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1149,590,615 - 49,702,289 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,548,274 - 49,702,289 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,433,855 - 50,545,486 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,776,134 - 49,887,469 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,776,184 - 49,887,472 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,658,474 - 49,769,746 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,530,210 - 49,640,896 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0150,145,324 - 50,257,061 (+)NCBIUU_Cfam_GSD_1.0
Map3k4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946144,657,957 - 144,720,199 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,909,922 - 11,975,715 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,908,083 - 11,972,186 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP3K4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl16,891,265 - 7,049,775 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.116,891,255 - 7,049,784 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.218,304,293 - 8,322,833 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP3K4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11388,489,835 - 88,621,504 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1388,490,200 - 88,620,992 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604060,826,355 - 60,952,511 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map3k4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248552,174,097 - 2,298,259 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248552,174,141 - 2,298,219 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Map3k4
134 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:301
Count of miRNA genes:179
Interacting mature miRNAs:206
Transcripts:ENSRNOT00000064018
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat

Markers in Region
BF418077  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,430,853 - 48,430,953 (+)MAPPERmRatBN7.2
Rnor_6.0148,624,724 - 48,624,823NCBIRnor6.0
Rnor_5.0151,130,739 - 51,130,838UniSTSRnor5.0
RGSC_v3.4142,890,153 - 42,890,252UniSTSRGSC3.4
Celera144,221,617 - 44,221,716UniSTS
RH 3.4 Map1570.8UniSTS
Cytogenetic Map1q11UniSTS
PMC148819P7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,475,974 - 48,476,206 (+)MAPPERmRatBN7.2
Rnor_6.0148,668,810 - 48,669,041NCBIRnor6.0
Rnor_5.0151,086,521 - 51,086,752UniSTSRnor5.0
RGSC_v3.4142,935,040 - 42,935,271UniSTSRGSC3.4
Celera144,265,309 - 44,265,540UniSTS
Cytogenetic Map1q11UniSTS
SHGC-59862  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0151,106,241 - 51,107,504UniSTSRnor5.0
Cytogenetic Map1q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 26 22 6 18 6 3 5 74 35 33 11 3
Low 1 17 35 35 1 35 5 6 8 5
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000064018   ⟹   ENSRNOP00000062453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,431,873 - 48,519,358 (+)Ensembl
Rnor_6.0 Ensembl148,625,743 - 48,711,642 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000084317   ⟹   ENSRNOP00000072741
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,431,841 - 48,519,353 (+)Ensembl
Rnor_6.0 Ensembl148,625,754 - 48,711,634 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094132   ⟹   ENSRNOP00000081978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,442,339 - 48,519,353 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112094   ⟹   ENSRNOP00000083079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,431,830 - 48,517,878 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000116657   ⟹   ENSRNOP00000096435
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,431,841 - 48,519,353 (+)Ensembl
RefSeq Acc Id: NM_001107456   ⟹   NP_001100926
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,979,600 - 51,067,117 (+)NCBI
mRatBN7.2148,431,840 - 48,519,358 (+)NCBI
Rnor_6.0148,625,743 - 48,711,642 (+)NCBI
Rnor_5.0151,043,920 - 51,129,819 (-)NCBI
RGSC_v3.4142,891,172 - 42,978,862 (+)RGD
Celera144,222,636 - 44,308,690 (+)RGD
Sequence:
RefSeq Acc Id: NM_001401453   ⟹   NP_001388382
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,979,600 - 51,067,117 (+)NCBI
mRatBN7.2148,431,840 - 48,519,358 (+)NCBI
RefSeq Acc Id: NM_001415845   ⟹   NP_001402774
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,979,600 - 51,067,117 (+)NCBI
mRatBN7.2148,431,840 - 48,519,358 (+)NCBI
RefSeq Acc Id: XM_039110561   ⟹   XP_038966489
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,981,552 - 51,067,117 (+)NCBI
mRatBN7.2148,437,537 - 48,519,358 (+)NCBI
RefSeq Acc Id: XM_039110574   ⟹   XP_038966502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,979,556 - 51,067,117 (+)NCBI
mRatBN7.2148,431,801 - 48,519,358 (+)NCBI
RefSeq Acc Id: XM_063288432   ⟹   XP_063144502
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8150,977,870 - 51,055,128 (+)NCBI
RefSeq Acc Id: XM_063288437   ⟹   XP_063144507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8151,035,999 - 51,067,117 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001100926   ⟸   NM_001107456
- Peptide Label: isoform 2
- UniProtKB: D3ZGU6 (UniProtKB/TrEMBL),   A6KJY7 (UniProtKB/TrEMBL),   A0A8I5ZTM8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072741   ⟸   ENSRNOT00000084317
RefSeq Acc Id: ENSRNOP00000062453   ⟸   ENSRNOT00000064018
RefSeq Acc Id: XP_038966502   ⟸   XM_039110574
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZUS1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966489   ⟸   XM_039110561
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTM8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000083079   ⟸   ENSRNOT00000112094
RefSeq Acc Id: ENSRNOP00000096435   ⟸   ENSRNOT00000116657
RefSeq Acc Id: ENSRNOP00000081978   ⟸   ENSRNOT00000094132
RefSeq Acc Id: NP_001388382   ⟸   NM_001401453
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K3R1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402774   ⟸   NM_001415845
- Peptide Label: isoform 3
- UniProtKB: A0A8I6GLL3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063144502   ⟸   XM_063288432
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063144507   ⟸   XM_063288437
- Peptide Label: isoform X4
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3R1-F1-model_v2 AlphaFold A0A0G2K3R1 1-1599 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689622
Promoter ID:EPDNEW_R147
Type:multiple initiation site
Name:Map3k4_1
Description:mitogen activated protein kinase kinase kinase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,625,710 - 48,625,770EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311192 AgrOrtholog
BioCyc Gene G2FUF-61560 BioCyc
Ensembl Genes ENSRNOG00000017419 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064018 ENTREZGENE
  ENSRNOT00000064018.4 UniProtKB/TrEMBL
  ENSRNOT00000084317 ENTREZGENE
  ENSRNOT00000084317.2 UniProtKB/TrEMBL
  ENSRNOT00000094132.1 UniProtKB/TrEMBL
  ENSRNOT00000112094.1 UniProtKB/TrEMBL
  ENSRNOT00000116657 ENTREZGENE
  ENSRNOT00000116657.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  MEKK4_N UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:308106 UniProtKB/TrEMBL
NCBI Gene 308106 ENTREZGENE
PANTHER MAP KINASE KINASE KINASE SSK2-RELATED-RELATED UniProtKB/TrEMBL
  MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4 UniProtKB/TrEMBL
Pfam MEKK4_N UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PhenoGen Map3k4 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017419 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2K3R1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUS1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLL3 ENTREZGENE, UniProtKB/TrEMBL
  A6KJY7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZGU6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Map3k4  mitogen activated protein kinase kinase kinase 4   Map3k4_predicted  mitogen activated protein kinase kinase kinase 4 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Map3k4_predicted  mitogen activated protein kinase kinase kinase 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED