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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1311192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map3k4
Name: mitogen activated protein kinase kinase kinase 4
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map3k4decreases expressionISOMAP3K4 (Homo sapiens)6480464CTDQuercetin results in decreased expression of MAP3K4 mRNAPMID:21632981
Map3k4multiple interactionsISOMAP3K4 (Homo sapiens)6480464CTD[Cisplatin co-treated with Quercetin] results in increased expression of MAP3K4 mRNAPMID:27514524
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