Arhgef3 (Rho guanine nucleotide exchange factor 3) - Rat Genome Database

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Gene: Arhgef3 (Rho guanine nucleotide exchange factor 3) Rattus norvegicus
Analyze
Symbol: Arhgef3
Name: Rho guanine nucleotide exchange factor 3
RGD ID: 1310672
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Orthologous to human ARHGEF3 (Rho guanine nucleotide exchange factor 3); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC290541; Rho guanine nucleotide exchange factor (GEF) 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8162,308,311 - 2,588,634 (+)NCBIGRCr8
mRatBN7.2162,301,573 - 2,581,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl162,300,138 - 2,581,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx162,519,162 - 2,588,620 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0163,664,854 - 3,734,303 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,523,968 - 2,593,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,743,714 - 3,026,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,743,823 - 3,026,760 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,716,264 - 2,994,163 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4162,595,636 - 2,665,051 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1162,473,664 - 2,663,130 (+)NCBI
Celera162,477,340 - 2,546,773 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 119 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Arhgef3Rat(-)-epigallocatechin 3-gallate multiple interactionsISOARHGEF3 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ARHGEF3 mRNACTDPMID:22079256
Arhgef3Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of ARHGEF3 mRNACTDPMID:32145629
Arhgef3Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of ARHGEF3 mRNACTDPMID:35192832
Arhgef3Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOArhgef3 (Mus musculus)64804642 more ...CTDPMID:31388691
Arhgef3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOArhgef3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ARHGEF3 mRNACTDPMID:19933214
Arhgef3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ARHGEF3 mRNACTDPMID:33387578 and PMID:34747641
Arhgef3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOArhgef3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ARHGEF3 mRNACTDPMID:21570461
Arhgef3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ARHGEF3 mRNACTDPMID:21215274
Arhgef3Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of ARHGEF3 mRNACTDPMID:21346803
Arhgef3Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of ARHGEF3 mRNACTDPMID:21346803
Arhgef3Rat2-palmitoylglycerol increases expressionISOARHGEF3 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of ARHGEF3 mRNACTDPMID:37199045
Arhgef3Rat4,4'-sulfonyldiphenol increases expressionISOArhgef3 (Mus musculus)6480464bisphenol S results in increased expression of ARHGEF3 mRNACTDPMID:30951980
Arhgef3Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of ARHGEF3 mRNACTDPMID:36041667
Arhgef3Rat4,4'-sulfonyldiphenol decreases expressionISOArhgef3 (Mus musculus)6480464bisphenol S results in decreased expression of ARHGEF3 mRNACTDPMID:39298647
Arhgef3Rat4-hydroxynon-2-enal decreases expressionISOArhgef3 (Mus musculus)64804644-hydroxy-2-nonenal results in decreased expression of ARHGEF3 mRNACTDPMID:19191707
Arhgef3Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of ARHGEF3 mRNACTDPMID:24780913
Arhgef3Rataflatoxin B1 affects expressionISOARHGEF3 (Homo sapiens)6480464Aflatoxin B1 affects the expression of ARHGEF3 proteinCTDPMID:20106945
Arhgef3RatAflatoxin B2 alpha increases methylationISOARHGEF3 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of ARHGEF3 intronCTDPMID:30157460
Arhgef3Ratall-trans-retinoic acid increases expressionISOARHGEF3 (Homo sapiens)6480464Tretinoin results in increased expression of ARHGEF3 mRNACTDPMID:21934132 and PMID:33167477
Arhgef3Ratantirheumatic drug decreases expressionISOARHGEF3 (Homo sapiens)6480464Antirheumatic Agents results in decreased expression of ARHGEF3 mRNACTDPMID:24449571

1 to 20 of 119 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Arhgef3Ratintracellular signal transduction involved_inIEAInterPro:IPR0013311600115GO_REF:0000002InterProGO_REF:0000002
Arhgef3Ratpositive regulation of Rho protein signal transduction involved_inIBAFB:FBgn0035574 and PANTHER:PTN0005178111600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Arhgef3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Arhgef3Ratguanyl-nucleotide exchange factor activity enablesIEAUniProtKB-KW:KW-03441600115GO_REF:0000043UniProtGO_REF:0000043
Arhgef3Ratguanyl-nucleotide exchange factor activity enablesIEAInterPro:IPR000219 and InterPro:IPR0013311600115GO_REF:0000002InterProGO_REF:0000002
Arhgef3Ratprotein binding enablesISOARHGEF3 (Homo sapiens)1624291UniProtKB:O75031 more ...RGDPMID:25416956 more ...


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


Arhgef3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8162,308,311 - 2,588,634 (+)NCBIGRCr8
mRatBN7.2162,301,573 - 2,581,951 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl162,300,138 - 2,581,945 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx162,519,162 - 2,588,620 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0163,664,854 - 3,734,303 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0162,523,968 - 2,593,442 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0162,743,714 - 3,026,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl162,743,823 - 3,026,760 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0162,716,264 - 2,994,163 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4162,595,636 - 2,665,051 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1162,473,664 - 2,663,130 (+)NCBI
Celera162,477,340 - 2,546,773 (+)NCBICelera
Cytogenetic Map16p16NCBI
ARHGEF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38356,727,420 - 57,079,268 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl356,727,418 - 57,079,329 (-)EnsemblGRCh38hg38GRCh38
GRCh37356,761,448 - 57,113,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36356,736,486 - 56,810,993 (-)NCBINCBI36Build 36hg18NCBI36
Build 34356,736,485 - 56,810,993NCBI
Celera356,727,164 - 57,078,931 (-)NCBICelera
Cytogenetic Map3p14.3NCBI
HuRef356,809,905 - 57,161,427 (-)NCBIHuRef
CHM1_1356,712,114 - 57,063,671 (-)NCBICHM1_1
T2T-CHM13v2.0356,767,765 - 57,119,568 (-)NCBIT2T-CHM13v2.0
Arhgef3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391426,836,418 - 27,125,873 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1426,836,856 - 27,125,868 (+)EnsemblGRCm39 Ensembl
GRCm381427,114,461 - 27,403,916 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1427,114,899 - 27,403,911 (+)EnsemblGRCm38mm10GRCm38
MGSCv371428,051,225 - 28,217,090 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361426,064,923 - 26,230,788 (+)NCBIMGSCv36mm8
Celera1423,496,924 - 23,635,464 (+)NCBICelera
Cytogenetic Map14A3NCBI
cM Map1416.09NCBI
Arhgef3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554306,513,765 - 6,834,892 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554306,515,949 - 6,837,997 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2256,714,391 - 57,058,722 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1356,719,160 - 57,063,481 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0356,663,382 - 57,012,955 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1357,878,054 - 58,223,189 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl357,878,054 - 58,179,339 (-)Ensemblpanpan1.1panPan2
ARHGEF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12033,318,255 - 33,625,364 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2033,311,630 - 33,623,704 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2033,245,620 - 33,552,246 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02033,590,514 - 33,894,766 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2033,590,505 - 33,895,184 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12033,039,576 - 33,340,539 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02033,398,192 - 33,701,068 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02033,569,536 - 33,873,906 (+)NCBIUU_Cfam_GSD_1.0
Arhgef3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118173,981,524 - 174,282,332 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364737,119,501 - 7,291,495 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364737,120,097 - 7,387,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1338,581,574 - 38,657,128 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11338,582,618 - 38,925,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21342,429,458 - 42,455,396 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12218,059,377 - 18,398,742 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2218,058,302 - 18,398,213 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041148,467,024 - 148,812,742 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624822347,001 - 539,196 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624822226,276 - 536,381 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Arhgef3
1691 total Variants

Predicted Target Of
Summary Value
Count of predictions:434
Count of miRNA genes:238
Interacting mature miRNAs:288
Transcripts:ENSRNOT00000019511
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 29 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)163802452995463Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
12903952Cm117Cardiac mass QTL 1170.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)168323802995225Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat

1 to 10 of 29 rows
D16Chm16  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2162,552,512 - 2,552,695 (+)MAPPERmRatBN7.2
Rnor_6.0162,997,172 - 2,997,352NCBIRnor6.0
Rnor_5.0162,964,567 - 2,964,747UniSTSRnor5.0
RGSC_v3.4162,635,636 - 2,635,816UniSTSRGSC3.4
Celera162,517,339 - 2,517,519UniSTS
Cytogenetic Map16p16UniSTS
D16Chm43  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2162,526,783 - 2,526,987 (+)MAPPERmRatBN7.2
Rnor_6.0162,971,447 - 2,971,646NCBIRnor6.0
Rnor_5.0162,938,842 - 2,939,041UniSTSRnor5.0
RGSC_v3.4162,609,911 - 2,610,110UniSTSRGSC3.4
Celera162,491,614 - 2,491,813UniSTS
Cytogenetic Map16p16UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000019511   ⟹   ENSRNOP00000019511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,512,511 - 2,581,937 (+)Ensembl
Rnor_6.0 Ensembl162,958,283 - 3,026,760 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087873   ⟹   ENSRNOP00000070700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,301,668 - 2,581,939 (+)Ensembl
Rnor_6.0 Ensembl162,743,823 - 3,025,019 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096646   ⟹   ENSRNOP00000086642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,418,116 - 2,581,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101017   ⟹   ENSRNOP00000095441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,302,207 - 2,581,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106161   ⟹   ENSRNOP00000085357
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,306,807 - 2,581,939 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108807   ⟹   ENSRNOP00000092034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,360,574 - 2,581,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118865   ⟹   ENSRNOP00000086947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,360,837 - 2,581,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119297   ⟹   ENSRNOP00000097424
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,538,241 - 2,581,945 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119548   ⟹   ENSRNOP00000097457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl162,300,138 - 2,581,945 (+)Ensembl
RefSeq Acc Id: NM_001106061   ⟹   NP_001099531
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,519,211 - 2,588,626 (+)NCBI
mRatBN7.2162,512,511 - 2,581,937 (+)NCBI
Rnor_6.0162,958,283 - 3,026,760 (+)NCBI
Rnor_5.0162,716,264 - 2,994,163 (+)NCBI
RGSC_v3.4162,595,636 - 2,665,051 (+)RGD
Celera162,477,340 - 2,546,773 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252574   ⟹   XP_006252636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,308,700 - 2,588,634 (+)NCBI
mRatBN7.2162,301,979 - 2,581,951 (+)NCBI
Rnor_6.0162,744,176 - 3,026,768 (+)NCBI
Rnor_5.0162,716,264 - 2,994,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252575   ⟹   XP_006252637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,308,568 - 2,588,634 (+)NCBI
mRatBN7.2162,301,844 - 2,581,951 (+)NCBI
Rnor_6.0162,744,049 - 3,026,768 (+)NCBI
Rnor_5.0162,716,264 - 2,994,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006252576   ⟹   XP_006252638
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,424,688 - 2,588,634 (+)NCBI
mRatBN7.2162,418,176 - 2,581,951 (+)NCBI
Rnor_6.0162,860,525 - 3,026,768 (+)NCBI
Rnor_5.0162,716,264 - 2,994,163 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600022   ⟹   XP_017455511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,544,634 - 2,588,634 (+)NCBI
mRatBN7.2162,538,106 - 2,581,951 (+)NCBI
Rnor_6.0162,980,878 - 3,026,768 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017600023   ⟹   XP_017455512
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8162,308,311 - 2,588,634 (+)NCBI
mRatBN7.2162,301,573 - 2,581,951 (+)NCBI
Rnor_6.0162,743,714 - 3,026,768 (+)NCBI
Sequence:
1 to 5 of 15 rows
1 to 5 of 15 rows
RefSeq Acc Id: NP_001099531   ⟸   NM_001106061
- UniProtKB: D4A1J1 (UniProtKB/TrEMBL),   A6KMK9 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252637   ⟸   XM_006252575
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYL3 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252636   ⟸   XM_006252574
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYL3 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252638   ⟸   XM_006252576
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A424 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017455512   ⟸   XM_017600023
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JYL3 (UniProtKB/TrEMBL),   A0A8I6GK05 (UniProtKB/TrEMBL)
- Sequence:
DH   PH

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JYL3-F1-model_v2 AlphaFold A0A0G2JYL3 1-551 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699901
Promoter ID:EPDNEW_R10422
Type:initiation region
Name:Arhgef3_2
Description:Rho guanine nucleotide exchange factor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10423  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0162,743,823 - 2,743,883EPDNEW
RGD ID:13699899
Promoter ID:EPDNEW_R10423
Type:multiple initiation site
Name:Arhgef3_1
Description:Rho guanine nucleotide exchange factor 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R10422  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0162,958,284 - 2,958,344EPDNEW


1 to 40 of 50 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-12239 BioCyc
Ensembl Genes ENSRNOG00000014363 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019511 ENTREZGENE
  ENSRNOT00000019511.6 UniProtKB/TrEMBL
  ENSRNOT00000087873.2 UniProtKB/TrEMBL
  ENSRNOT00000096646 ENTREZGENE
  ENSRNOT00000096646.1 UniProtKB/TrEMBL
  ENSRNOT00000101017 ENTREZGENE
  ENSRNOT00000101017.1 UniProtKB/TrEMBL
  ENSRNOT00000106161.1 UniProtKB/TrEMBL
  ENSRNOT00000108807.1 UniProtKB/TrEMBL
  ENSRNOT00000118865.1 UniProtKB/TrEMBL
  ENSRNOT00000119297 ENTREZGENE
  ENSRNOT00000119297.1 UniProtKB/TrEMBL
  ENSRNOT00000119548.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  Endocytic_GEF_Adapter UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH_RhoGEF3_XPLN UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
KEGG Report rno:290541 UniProtKB/TrEMBL
NCBI Gene 290541 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A UniProtKB/TrEMBL
Pfam RhoGEF UniProtKB/TrEMBL
  SOS1_NGEF_PH UniProtKB/TrEMBL
PhenoGen Arhgef3 PhenoGen
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014363 RatGTEx
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
1 to 40 of 50 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef3  Rho guanine nucleotide exchange factor 3  Arhgef3  Rho guanine nucleotide exchange factor (GEF) 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Arhgef3  Rho guanine nucleotide exchange factor (GEF) 3   Arhgef3_predicted  Rho guanine nucleotide exchange factor (GEF) 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arhgef3_predicted  Rho guanine nucleotide exchange factor (GEF) 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED