Elavl1 (ELAV like RNA binding protein 1) - Rat Genome Database

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Gene: Elavl1 (ELAV like RNA binding protein 1) Rattus norvegicus
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Symbol: Elavl1
Name: ELAV like RNA binding protein 1
RGD ID: 1308649
Description: Enables mRNA 3'-UTR binding activity and protein kinase binding activity. Involved in several processes, including positive regulation of autophagosome size; positive regulation of metabolic process; and response to glucose. Located in cytoplasm and nucleus. Biomarker of degenerative disc disease. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1); PARTICIPATES IN CRM1 export pathway; INTERACTS WITH 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV like 1; ELAV-like protein 1; hu-antigen R; Hua; HuR; LOC363854; mRNA-stabilizing factor HuR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,441,699 - 7,482,625 (-)NCBIGRCr8
mRatBN7.2122,640,936 - 2,684,787 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,645,061 - 2,684,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx123,291,952 - 3,332,869 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,915,541 - 3,956,458 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,678,578 - 2,719,442 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,461,502 - 2,502,432 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,461,502 - 2,502,432 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,614,839 - 4,655,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,459,046 - 1,500,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,458,769 - 1,500,043 (+)NCBI
Celera124,459,379 - 4,500,318 (-)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Elavl1Ratdegenerative disc disease  IEP 407571673associated with diabetes mellitus and protein:decreased expression:nucleus pulposusRGD 
Elavl1Ratdegenerative disc disease  ISOELAVL1 (Homo sapiens)407571673associated with diabetes mellitus and protein:decreased expression:nucleus pulposusRGD 
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Elavl1Ratautistic disorder  ISOELAVL1 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Elavl1Ratfamilial hemophagocytic lymphohistiocytosis 5  ISOELAVL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial hemophagocytic lymphohistiocytosis 5ClinVarPMID:28492532
Elavl1Ratmucolipidosis type IV  ISOELAVL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Mucolipidosis type IVClinVarPMID:11030752 more ...
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Original Reference(s)
Elavl1Ratendometriosis  ISOELAVL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20889954

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Original Reference(s)
Elavl1Rat(-)-epigallocatechin 3-gallate increases expressionISOELAVL1 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of ELAVL1 proteinCTDPMID:31195006
Elavl1Rat(Z)-3-butylidenephthalide decreases expressionISOELAVL1 (Homo sapiens)6480464butylidenephthalide results in decreased expression of ELAVL1 proteinCTDPMID:23770345
Elavl1Rat1,2-dimethylhydrazine multiple interactionsISOElavl1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ELAVL1 mRNACTDPMID:22206623
Elavl1Rat1,2-dimethylhydrazine affects expressionISOElavl1 (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of ELAVL1 mRNACTDPMID:22206623
Elavl1Rat1,4-benzoquinone decreases expressionISOELAVL1 (Homo sapiens)6480464quinone results in decreased expression of ELAVL1 mRNACTDPMID:38367942
Elavl1Rat1-chloro-2,4-dinitrobenzene increases expressionISOELAVL1 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of ELAVL1 proteinCTDPMID:21969073
Elavl1Rat17alpha-ethynylestradiol affects expressionISOElavl1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of ELAVL1 mRNACTDPMID:17555576
Elavl1Rat17alpha-ethynylestradiol increases expressionISOElavl1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ELAVL1 mRNACTDPMID:17942748
Elavl1Rat17alpha-ethynylestradiol multiple interactionsISOElavl1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ELAVL1 mRNACTDPMID:17942748
Elavl1Rat17beta-estradiol affects expressionISOElavl1 (Mus musculus)6480464Estradiol affects the expression of ELAVL1 mRNACTDPMID:15598610
Elavl1Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOElavl1 (Mus musculus)64804642 more ...CTDPMID:30294300
Elavl1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOELAVL1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Elavl1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOELAVL1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of ELAVL1 proteinCTDPMID:19962423
Elavl1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOElavl1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ELAVL1 mRNACTDPMID:21570461
Elavl1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOElavl1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ELAVL1 mRNACTDPMID:17942748
Elavl1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOELAVL1 (Homo sapiens)6480464U 0126 inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ELAVL1 protein]CTDPMID:19962423
Elavl1Rat2,4,6-tribromophenol increases expressionISOELAVL1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Elavl1Rat2,6-di-tert-butyl-4-methylphenol affects localizationISOElavl1 (Mus musculus)6480464Butylated Hydroxytoluene affects the localization of ELAVL1 proteinCTDPMID:10900464
Elavl1Rat3',5'-cyclic UMP affects bindingISOELAVL1 (Homo sapiens)6480464ELAVL1 protein binds to cyclic 3' and 5'-uridine monophosphateCTDPMID:30528433
Elavl1Rat3,3',5,5'-tetrabromobisphenol A increases expressionISOELAVL1 (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of ELAVL1 proteinCTDPMID:31675489

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Biological Process
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Original Reference(s)
Elavl1Rat3'-UTR-mediated mRNA stabilization involved_inISSUniProtKB:P703721600115GO_REF:0000024UniProtGO_REF:0000024
Elavl1Rat3'-UTR-mediated mRNA stabilization involved_inIEAUniProtKB:Q15717 and ensembl:ENSP000003852691600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1Rat3'-UTR-mediated mRNA stabilization involved_inIEAUniProtKB:P70372 and ensembl:ENSMUSP000000965491600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1Rat3'-UTR-mediated mRNA stabilization involved_inISOElavl1 (Mus musculus)1624291 PMID:27616329RGDPMID:27616329
Elavl1Rat3'-UTR-mediated mRNA stabilization involved_inISOELAVL1 (Homo sapiens)1624291 PMID:14517288 more ...RGDPMID:14517288 more ...
Elavl1Rat3'-UTR-mediated mRNA stabilization involved_inISSUniProtKB:Q157171600115GO_REF:0000024UniProtGO_REF:0000024
Elavl1Ratcell population proliferation  IMP 407571673 RGD 
Elavl1RatlncRNA-mediated post-transcriptional gene silencing involved_inISOElavl1 (Mus musculus)1624291 PMID:22841487RGDPMID:22841487
Elavl1RatlncRNA-mediated post-transcriptional gene silencing involved_inIEAUniProtKB:P70372 and ensembl:ENSMUSP000000965491600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1RatmRNA destabilization  IMP 329961560 RGD 
Elavl1RatmRNA stabilization involved_inISOELAVL1 (Homo sapiens)1624291 PMID:19029303 and PMID:31358969RGDPMID:19029303 and PMID:31358969
Elavl1RatmRNA stabilization involved_inISOElavl1 (Mus musculus)1624291 PMID:24394384 and PMID:27609837RGDPMID:24394384 and PMID:27609837
Elavl1RatmRNA stabilization acts_upstream_of_or_withinIEAUniProtKB:Q15717 and ensembl:ENSP000003852691600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1RatmRNA stabilization acts_upstream_of_or_withinISOElavl1 (Mus musculus)1624291 PMID:14976220 and PMID:21613615RGDPMID:14976220 and PMID:21613615
Elavl1RatmRNA stabilization involved_inIEAUniProtKB:P70372 and ensembl:ENSMUSP000000965491600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1RatmRNA stabilization involved_inISSUniProtKB:Q157171600115GO_REF:0000024UniProtGO_REF:0000024
Elavl1RatmRNA stabilization acts_upstream_of_or_withinISOELAVL1 (Homo sapiens)1624291 PMID:21613615RGDPMID:21613615
Elavl1Ratnegative regulation of miRNA-mediated gene silencing involved_inISSUniProtKB:Q157171600115GO_REF:0000024UniProtGO_REF:0000024
Elavl1Ratnegative regulation of miRNA-mediated gene silencing involved_inIEAUniProtKB:Q15717 and ensembl:ENSP000003852691600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1Ratnegative regulation of miRNA-mediated gene silencing involved_inISOELAVL1 (Homo sapiens)1624291 PMID:26595526RGDPMID:26595526
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Cellular Component
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Original Reference(s)
Elavl1Ratcytoplasm located_inIDA 40902962PMID:28350193ARUK-UCL 
Elavl1Ratcytoplasm located_inIEAUniProtKB:P70372 and ensembl:ENSMUSP000000965491600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Elavl1Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Elavl1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Elavl1Ratcytoplasm located_inISOELAVL1 (Homo sapiens)1624291 PMID:14517288 and PMID:19029303RGDPMID:14517288 and PMID:19029303
Elavl1Ratcytoplasm located_inISSUniProtKB:P703721600115GO_REF:0000024UniProtGO_REF:0000024
Elavl1Ratcytoplasm located_inISOElavl1 (Mus musculus)1624291 PMID:17288565RGDPMID:17288565
Elavl1Ratcytoplasm located_inIEAUniProtKB:Q15717 and ensembl:ENSP000003852691600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1Ratcytoplasmic stress granule located_inISSUniProtKB:P703721600115GO_REF:0000024UniProtGO_REF:0000024
Elavl1Ratcytoplasmic stress granule located_inIEAUniProtKB:P70372 and ensembl:ENSMUSP000000965491600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1Ratcytoplasmic stress granule located_inIEAUniProtKB-SubCell:SL-04961600115GO_REF:0000044UniProtGO_REF:0000044
Elavl1Ratcytoplasmic stress granule located_inISOElavl1 (Mus musculus)1624291 PMID:27430620 and PMID:27616329RGDPMID:27430620 and PMID:27616329
Elavl1Ratcytoplasmic vesicle is_active_inISOElavl1 (Mus musculus)1624291UniProtKB:Q8N7N6 and PMID:29563620RGDPMID:29563620
Elavl1Ratcytoplasmic vesicle is_active_inIEAUniProtKB:P70372 and ensembl:ENSMUSP000000965491600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1Ratcytosol located_inISSUniProtKB:Q157171600115GO_REF:0000024UniProtGO_REF:0000024
Elavl1Ratcytosol located_inIEAUniProtKB:Q15717 and ensembl:ENSP000003852691600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1Ratcytosol located_inISOELAVL1 (Homo sapiens)1624291 PMID:17632515RGDPMID:17632515
Elavl1Ratendoplasmic reticulum located_inISOElavl1 (Mus musculus)1624291 PMID:27609837RGDPMID:27609837
Elavl1Ratendoplasmic reticulum part_ofIEAUniProtKB:P70372 and ensembl:ENSMUSP000000965491600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
Elavl1Ratdouble-stranded RNA binding enablesISOELAVL1 (Homo sapiens)1624291 PMID:21266579RGDPMID:21266579
Elavl1Ratdouble-stranded RNA binding enablesIEAUniProtKB:Q15717 and ensembl:ENSP000003852691600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1RatlncRNA binding enablesISOElavl1 (Mus musculus)1624291MGI:3045386 PMID:28763438 and PMID:33262333RGDPMID:28763438 and PMID:33262333
Elavl1RatlncRNA binding enablesIEAUniProtKB:P70372 and ensembl:ENSMUSP000000965491600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1RatmiRNA binding enablesISOELAVL1 (Homo sapiens)1624291 PMID:26595526RGDPMID:26595526
Elavl1RatmiRNA binding enablesIEAUniProtKB:Q15717 and ensembl:ENSP000003852691600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1RatmiRNA binding enablesISSUniProtKB:Q157171600115GO_REF:0000024UniProtGO_REF:0000024
Elavl1RatmRNA 3'-UTR AU-rich region binding enablesISOELAVL1 (Homo sapiens)1624291 PMID:14517288 more ...RGDPMID:14517288 more ...
Elavl1RatmRNA 3'-UTR AU-rich region binding enablesIEAUniProtKB:Q15717 and ensembl:ENSP000003852691600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1RatmRNA 3'-UTR AU-rich region binding enablesIEAUniProtKB:P70372 and ensembl:ENSMUSP000000965491600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1RatmRNA 3'-UTR AU-rich region binding enablesISOElavl1 (Mus musculus)1624291 PMID:17288565 and PMID:17971298RGDPMID:17288565 and PMID:17971298
Elavl1RatmRNA 3'-UTR AU-rich region binding enablesISSUniProtKB:P703721600115GO_REF:0000024UniProtGO_REF:0000024
Elavl1RatmRNA 3'-UTR AU-rich region binding enablesISSUniProtKB:Q157171600115GO_REF:0000024UniProtGO_REF:0000024
Elavl1RatmRNA 3'-UTR binding  IDA 625662 RGD 
Elavl1RatmRNA 3'-UTR binding enablesIEAUniProtKB:P70372 and ensembl:ENSMUSP000000965491600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1RatmRNA 3'-UTR binding enablesIEAUniProtKB:Q15717 and ensembl:ENSP000003852691600115GO_REF:0000107EnsemblGO_REF:0000107
Elavl1RatmRNA 3'-UTR binding enablesIEAARBA:ARBA000284221600115GO_REF:0000117UniProtGO_REF:0000117
Elavl1RatmRNA 3'-UTR binding enablesISOELAVL1 (Homo sapiens)1624291 PMID:26595526RGDPMID:26595526
Elavl1RatmRNA 3'-UTR binding enablesIDA 11344948PMID:27193233UniProt 
Elavl1RatmRNA 3'-UTR binding enablesISOElavl1 (Mus musculus)1624291 PMID:24394384 and PMID:28350193RGDPMID:24394384 and PMID:28350193
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RGD Manual Annotations


  
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Original Reference(s)
Elavl1RatCRM1 export pathway  ISOELAVL1 (Homo sapiens)9743967 RGD 

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Reference Title
Reference Citation
1. Hu antigen R is required for NOX-1 but not NOX-4 regulation by inflammatory stimuli in vascular smooth muscle cells. Aguado A, etal., J Hypertens. 2016 Feb;34(2):253-65. doi: 10.1097/HJH.0000000000000801.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Reconstitution of HuR-Inhibited CUGBP1 Expression Protects Cardiomyocytes from Acute Myocardial Infarction-Induced Injury. Gu L, etal., Antioxid Redox Signal. 2017 Nov 10;27(14):1013-1026. doi: 10.1089/ars.2016.6880. Epub 2017 Mar 28.
4. Polyamines regulate c-Myc translation through Chk2-dependent HuR phosphorylation. Liu L, etal., Mol Biol Cell. 2009 Dec;20(23):4885-98. doi: 10.1091/mbc.E09-07-0550. Epub 2009 Oct 7.
5. Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes. Matsui K, etal., Hepatology. 2008 Feb;47(2):686-97.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
8. Destabilization of the ornithine decarboxylase mRNA transcript by the RNA-binding protein tristetraprolin. Nowotarski SL, etal., Amino Acids. 2016 May 19.
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. RNA-binding protein HuR suppresses senescence through Atg7 mediated autophagy activation in diabetic intervertebral disc degeneration. Shao Z, etal., Cell Prolif. 2021 Feb;54(2):e12975. doi: 10.1111/cpr.12975. Epub 2020 Dec 28.
13. Hu protein R-mediated posttranscriptional regulation of VEGF expression in rat gastrocnemius muscle. Tang K, etal., Am J Physiol Heart Circ Physiol 2002 Oct;283(4):H1497-504.
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PMID:8626503   PMID:12477932   PMID:12832476   PMID:12876290   PMID:14517288   PMID:14523003   PMID:14731398   PMID:14976220   PMID:15883232   PMID:16126846   PMID:16168373   PMID:16690610  
PMID:16831604   PMID:17288565   PMID:17475777   PMID:17632515   PMID:17804813   PMID:17971298   PMID:19029303   PMID:19106619   PMID:19246637   PMID:19420108   PMID:19561594   PMID:19676129  
PMID:19946888   PMID:20001965   PMID:20102719   PMID:20599775   PMID:21164076   PMID:21266579   PMID:21613615   PMID:21700703   PMID:22215678   PMID:22492050   PMID:22658674   PMID:22681889  
PMID:23056314   PMID:23519412   PMID:24394384   PMID:24625528   PMID:25528059   PMID:25805336   PMID:26489465   PMID:26554012   PMID:26595526   PMID:26850084   PMID:26866372   PMID:27035432  
PMID:27089893   PMID:27401462   PMID:27430620   PMID:27475885   PMID:27521603   PMID:27609837   PMID:27616329   PMID:28031329   PMID:28763438   PMID:29107807   PMID:29180010   PMID:30092282  
PMID:31172341   PMID:31358969   PMID:32478392   PMID:32779957   PMID:33450132   PMID:33607255   PMID:33753727   PMID:34788763   PMID:35352799   PMID:36173508   PMID:37164303   PMID:37713069  
PMID:38342180  



Elavl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,441,699 - 7,482,625 (-)NCBIGRCr8
mRatBN7.2122,640,936 - 2,684,787 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,645,061 - 2,684,784 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx123,291,952 - 3,332,869 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,915,541 - 3,956,458 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,678,578 - 2,719,442 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,461,502 - 2,502,432 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,461,502 - 2,502,432 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,614,839 - 4,655,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,459,046 - 1,500,042 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,458,769 - 1,500,043 (+)NCBI
Celera124,459,379 - 4,500,318 (-)NCBICelera
Cytogenetic Map12p12NCBI
ELAVL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,958,573 - 8,005,641 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,958,573 - 8,005,659 (-)EnsemblGRCh38hg38GRCh38
GRCh37198,023,457 - 8,070,525 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,929,457 - 7,976,529 (-)NCBINCBI36Build 36hg18NCBI36
Build 34197,929,457 - 7,976,529NCBI
Celera197,894,704 - 7,941,773 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,693,669 - 7,740,685 (-)NCBIHuRef
CHM1_1198,022,943 - 8,069,993 (-)NCBICHM1_1
T2T-CHM13v2.0197,959,562 - 8,006,636 (-)NCBIT2T-CHM13v2.0
Elavl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,334,781 - 4,375,104 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,335,382 - 4,375,413 (-)EnsemblGRCm39 Ensembl
GRCm3884,284,781 - 4,325,140 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,285,382 - 4,325,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv3784,284,782 - 4,325,100 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3684,288,343 - 4,324,906 (-)NCBIMGSCv36mm8
Celera84,485,398 - 4,525,701 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map82.0NCBI
Elavl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,283,421 - 1,315,283 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,283,424 - 1,315,283 (+)NCBIChiLan1.0ChiLan1.0
ELAVL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,645,019 - 12,688,426 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,758,555 - 11,805,677 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,259,829 - 7,306,808 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,114,849 - 8,147,142 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,114,849 - 8,147,137 (-)Ensemblpanpan1.1panPan2
ELAVL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,648,878 - 52,677,578 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,454,132 - 52,491,784 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02053,179,951 - 53,217,640 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,180,820 - 53,217,660 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,383,218 - 52,420,649 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,827,713 - 52,865,411 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,059,378 - 53,097,043 (-)NCBIUU_Cfam_GSD_1.0
Elavl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,875,753 - 212,906,793 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,927,950 - 4,959,064 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,931,665 - 4,959,032 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ELAVL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,207,096 - 71,248,906 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,207,141 - 71,245,863 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,607,515 - 71,646,238 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ELAVL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,419,489 - 7,448,917 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,414,757 - 7,448,445 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081353,624 - 400,190 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Elavl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828914,141 - 948,831 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828913,001 - 948,826 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Elavl1
150 total Variants

Predicted Target Of
Summary Value
Count of predictions:117
Count of miRNA genes:98
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000001415
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 20 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat

1 to 10 of 20 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000001415   ⟹   ENSRNOP00000001415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl122,645,061 - 2,684,784 (-)Ensembl
Rnor_6.0 Ensembl122,461,502 - 2,502,432 (+)Ensembl
RefSeq Acc Id: NM_001108848   ⟹   NP_001102318
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8127,441,699 - 7,482,625 (-)NCBI
mRatBN7.2122,643,861 - 2,684,787 (-)NCBI
Rnor_6.0122,461,502 - 2,502,432 (+)NCBI
Rnor_5.0124,614,839 - 4,655,379 (+)NCBI
RGSC_v3.4121,459,046 - 1,500,042 (+)RGD
Celera124,459,379 - 4,500,318 (-)RGD
Sequence:
Protein RefSeqs NP_001102318 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68972 (Get FASTA)   NCBI Sequence Viewer  
  B5DF91 (Get FASTA)   NCBI Sequence Viewer  
  BAG72208 (Get FASTA)   NCBI Sequence Viewer  
  EDL75000 (Get FASTA)   NCBI Sequence Viewer  
  EDL75001 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001415
  ENSRNOP00000001415.5
RefSeq Acc Id: NP_001102318   ⟸   NM_001108848
- UniProtKB: B5DF91 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001415   ⟸   ENSRNOT00000001415
RRM

Name Modeler Protein Id AA Range Protein Structure
AF-B5DF91-F1-model_v2 AlphaFold B5DF91 1-326 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698380
Promoter ID:EPDNEW_R8904
Type:initiation region
Name:Elavl1_1
Description:ELAV like RNA binding protein 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0122,461,496 - 2,461,556EPDNEW


1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20346 BioCyc
Ensembl Genes ENSRNOG00000001069 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001415 ENTREZGENE
  ENSRNOT00000001415.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.70.330 UniProtKB/Swiss-Prot
InterPro ELAD_HUD_SF UniProtKB/Swiss-Prot
  Hud_Sxl_RNA UniProtKB/Swiss-Prot
  HuR_RRM2 UniProtKB/Swiss-Prot
  Nucleotide-bd_a/b_plait_sf UniProtKB/Swiss-Prot
  RBD_domain_sf UniProtKB/Swiss-Prot
  RRM_dom UniProtKB/Swiss-Prot
KEGG Report rno:363854 UniProtKB/Swiss-Prot
NCBI Gene 363854 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G UniProtKB/Swiss-Prot
Pfam RRM_1 UniProtKB/Swiss-Prot
PhenoGen Elavl1 PhenoGen
PRINTS HUDSXLRNA UniProtKB/Swiss-Prot
PROSITE RRM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001069 RatGTEx
SMART RRM UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54928 UniProtKB/Swiss-Prot
UniProt B5DF91 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Elavl1  ELAV like RNA binding protein 1  Elavl1  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Elavl1  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)   Elavl1_predicted  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (predicted)  'predicted' is removed 2292626 APPROVED
2007-04-23 Elavl1_predicted  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (predicted)  Elavl1  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)  Data merged from RGD:731215 737654 APPROVED
2005-01-12 Elavl1_predicted  ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) (predicted)      Symbol and Name status set to approved 70820 APPROVED

Note Type Note Reference
gene_function binds with high affinity and specificity to adenylate/uridylate-rich elements (AREs) located in the 3-untranslated region (3-UTR) of several mRNAs 625662
gene_product member of a family of RNA binding proteins 625662