Slfn2 (schlafen family member 2) - Rat Genome Database

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Gene: Slfn2 (schlafen family member 2) Rattus norvegicus
Analyze
Symbol: Slfn2
Name: schlafen family member 2
RGD ID: 1308645
Description: Predicted to enable tRNA binding activity. Predicted to be involved in T cell mediated immunity; T cell proliferation involved in immune response; and tRNA stabilization. Predicted to act upstream of or within negative regulation of cell population proliferation and response to bacterium. Predicted to be active in cytoplasm. Orthologous to human SLFN12L (schlafen family member 12 like); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC303380; schlafen 2; schlafen family member 12-like
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp312
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,450,861 - 68,457,198 (+)NCBIGRCr8
mRatBN7.21067,953,322 - 67,959,659 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,953,171 - 67,959,458 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,573,354 - 72,579,691 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,078,736 - 72,085,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,542,782 - 67,549,119 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,370,381 - 70,376,718 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,370,300 - 70,376,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,001,084 - 70,007,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,236,408 - 71,242,745 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,248,325 - 71,279,012 (+)NCBI
Celera1066,897,016 - 66,903,353 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slfn2Ratperoxisome biogenesis disorder 3A  ISOSLFN12L (Homo sapiens)8554872ClinVar Annotator: match by term: Peroxisome biogenesis disorder 3A (Zellweger)ClinVarPMID:21031596 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slfn2RatExperimental Liver Cirrhosis  ISOSlfn2 (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136

1 to 20 of 74 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slfn2Rat(+)-catechin multiple interactionsISOSLFN12L (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of SLFN12L mRNACTDPMID:24763279
Slfn2Rat(1->4)-beta-D-glucan multiple interactionsISOSlfn2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of SLFN2 mRNACTDPMID:36331819
Slfn2Rat1,2-dichloroethane decreases expressionISOSlfn2 (Mus musculus)6480464ethylene dichloride results in decreased expression of SLFN2 mRNACTDPMID:28960355
Slfn2Rat1,2-dimethylhydrazine increases expressionISOSlfn2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of SLFN2 mRNACTDPMID:22206623
Slfn2Rat1-chloro-2,4-dinitrobenzene affects bindingISOSLFN12L (Homo sapiens)6480464Dinitrochlorobenzene binds to SLFN12L proteinCTDPMID:32991956
Slfn2Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of SLFN2 mRNACTDPMID:25380136
Slfn2Rat17beta-estradiol decreases expressionISOSlfn2 (Mus musculus)6480464Estradiol results in decreased expression of SLFN2 mRNACTDPMID:39298647
Slfn2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of SLFN2 mRNACTDPMID:34747641
Slfn2Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOSlfn2 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of SLFN2 mRNACTDPMID:21570461 and PMID:28922406
Slfn2Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of SLFN2 mRNACTDPMID:33387578
Slfn2Rat2,4-diaminotoluene increases expressionISOSlfn2 (Mus musculus)64804642 and 4-diaminotoluene results in increased expression of SLFN2 mRNACTDPMID:20713471
Slfn2Rat3-methylcholanthrene decreases expressionISOSlfn2 (Mus musculus)6480464Methylcholanthrene results in decreased expression of SLFN2 mRNACTDPMID:20713471
Slfn2Rat4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of SLFN2 mRNACTDPMID:25380136
Slfn2Rat4,4'-sulfonyldiphenol decreases expressionISOSlfn2 (Mus musculus)6480464bisphenol S results in decreased expression of SLFN2 mRNACTDPMID:39298647
Slfn2Rat4,4'-sulfonyldiphenol increases methylationISOSlfn2 (Mus musculus)6480464bisphenol S results in increased methylation of SLFN2 promoterCTDPMID:33297965
Slfn2Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of SLFN2 mRNACTDPMID:36041667
Slfn2Rat4,4'-sulfonyldiphenol increases expressionISOSlfn2 (Mus musculus)6480464bisphenol S results in increased expression of SLFN2 mRNACTDPMID:30951980
Slfn2Rat4-hydroxyphenyl retinamide increases expressionISOSlfn2 (Mus musculus)6480464Fenretinide results in increased expression of SLFN2 mRNACTDPMID:28973697
Slfn2Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of SLFN2 mRNACTDPMID:31881176
Slfn2Rataflatoxin B1 increases methylationISOSLFN12L (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of SLFN12L geneCTDPMID:27153756

1 to 20 of 74 rows

Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slfn2Ratcytoplasm is_active_inISOSlfn2 (Mus musculus)1624291 PMID:19592487RGDPMID:19592487

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slfn2RattRNA binding enablesISOSlfn2 (Mus musculus)1624291 PMID:33986151RGDPMID:33986151


#
Reference Title
Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:12477932  



Slfn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81068,450,861 - 68,457,198 (+)NCBIGRCr8
mRatBN7.21067,953,322 - 67,959,659 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1067,953,171 - 67,959,458 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,573,354 - 72,579,691 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01072,078,736 - 72,085,073 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01067,542,782 - 67,549,119 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01070,370,381 - 70,376,718 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,370,300 - 70,376,331 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,001,084 - 70,007,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,236,408 - 71,242,745 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,248,325 - 71,279,012 (+)NCBI
Celera1066,897,016 - 66,903,353 (+)NCBICelera
Cytogenetic Map10q26NCBI
SLFN12L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381735,464,254 - 35,537,678 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1735,464,249 - 35,537,683 (-)EnsemblGRCh38hg38GRCh38
GRCh371733,791,273 - 33,864,697 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361730,822,269 - 30,888,993 (-)NCBINCBI36Build 36hg18NCBI36
Celera1730,708,342 - 30,775,018 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1729,986,904 - 29,999,709 (-)NCBIHuRef
CHM1_11733,866,214 - 33,879,034 (-)NCBICHM1_1
T2T-CHM13v2.01736,412,245 - 36,485,638 (-)NCBIT2T-CHM13v2.0
Slfn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,955,938 - 82,961,504 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,955,938 - 82,961,504 (+)EnsemblGRCm39 Ensembl
GRCm381183,065,112 - 83,070,678 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,065,112 - 83,070,678 (+)EnsemblGRCm38mm10GRCm38
MGSCv371182,878,614 - 82,884,180 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361182,881,307 - 82,886,873 (+)NCBIMGSCv36mm8
Celera1192,688,834 - 92,694,433 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.3NCBI
SLFN12L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21928,936,467 - 29,009,032 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11730,817,469 - 30,890,008 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01721,256,494 - 21,318,659 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,550,104 - 21,611,943 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,599,330 - 21,611,851 (+)Ensemblpanpan1.1panPan2
SLFN12L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11628,947,024 - 28,969,178 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666075962,054 - 1,034,267 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Slfn2
13 total Variants

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:64
Interacting mature miRNAs:66
Transcripts:ENSRNOT00000055957
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 84 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat

1 to 10 of 84 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000055957   ⟹   ENSRNOP00000052810
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,953,171 - 67,959,458 (+)Ensembl
Rnor_6.0 Ensembl1070,370,300 - 70,376,331 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076536   ⟹   ENSRNOP00000068166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,953,260 - 67,959,266 (+)Ensembl
Rnor_6.0 Ensembl1070,370,447 - 70,376,331 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094055   ⟹   ENSRNOP00000090704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1067,953,227 - 67,959,456 (+)Ensembl
RefSeq Acc Id: NM_001107031   ⟹   NP_001100501
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,450,861 - 68,457,198 (+)NCBI
mRatBN7.21067,953,322 - 67,959,659 (+)NCBI
Rnor_6.01070,370,381 - 70,376,718 (+)NCBI
Rnor_5.01070,001,084 - 70,007,628 (+)NCBI
RGSC_v3.41071,236,408 - 71,242,745 (+)RGD
Celera1066,897,016 - 66,903,353 (+)RGD
Sequence:
RefSeq Acc Id: XM_039086039   ⟹   XP_038941967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81068,450,963 - 68,456,809 (+)NCBI
mRatBN7.21067,953,453 - 67,959,272 (+)NCBI
Protein RefSeqs NP_001100501 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941967 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05464 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000052810
  ENSRNOP00000052810.3
  ENSRNOP00000068166.2
  ENSRNOP00000090704.1
RefSeq Acc Id: NP_001100501   ⟸   NM_001107031
- UniProtKB: A6HHF9 (UniProtKB/TrEMBL),   A0A096MJK8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052810   ⟸   ENSRNOT00000055957
Ensembl Acc Id: ENSRNOP00000068166   ⟸   ENSRNOT00000076536
RefSeq Acc Id: XP_038941967   ⟸   XM_039086039
- Peptide Label: isoform X1
- UniProtKB: D4A2D6 (UniProtKB/TrEMBL),   A0A096MJK8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090704   ⟸   ENSRNOT00000094055
Name Modeler Protein Id AA Range Protein Structure
AF-D4A2D6-F1-model_v2 AlphaFold D4A2D6 1-381 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697524
Promoter ID:EPDNEW_R8049
Type:initiation region
Name:Slfn2_1
Description:schlafen 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,370,340 - 70,370,400EPDNEW


1 to 22 of 22 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23907 BioCyc
Ensembl Genes ENSRNOG00000037113 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055957 ENTREZGENE
  ENSRNOT00000055957.4 UniProtKB/TrEMBL
  ENSRNOT00000076536.2 UniProtKB/TrEMBL
  ENSRNOT00000094055.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.950.30 UniProtKB/TrEMBL
InterPro ATPase_AAA-4 UniProtKB/TrEMBL
  Poxin-SLFN/SLFN_N UniProtKB/TrEMBL
  Schlafen UniProtKB/TrEMBL
  Schlafen_AAA_dom_sf UniProtKB/TrEMBL
KEGG Report rno:303380 UniProtKB/TrEMBL
NCBI Gene 303380 ENTREZGENE
PANTHER PTHR12155 UniProtKB/TrEMBL
  SCHLAFEN FAMILY MEMBER 12 UniProtKB/TrEMBL
Pfam AAA_4 UniProtKB/TrEMBL
  B3R UniProtKB/TrEMBL
PhenoGen Slfn2 PhenoGen
RatGTEx ENSRNOG00000037113 RatGTEx
UniProt A0A096MJK8 ENTREZGENE, UniProtKB/TrEMBL
  A6HHF9 ENTREZGENE, UniProtKB/TrEMBL
  D4A2D6 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-10-04 Slfn2  schlafen family member 2  Slfn2  schlafen 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Slfn2  schlafen 2   Slfn2_predicted  schlafen 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Slfn2_predicted  schlafen 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED