Egfem1 (EGF-like and EMI domain containing 1) - Rat Genome Database

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Gene: Egfem1 (EGF-like and EMI domain containing 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Egfem1
Name: EGF-like and EMI domain containing 1
RGD ID: 1307225
Description: Predicted to enable calcium ion binding activity; INTERACTS WITH 1,2-dimethylhydrazine; 6-propyl-2-thiouracil; atrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: EGF-like and EMI domain-containing protein 1; hypothetical protein LOC310269; LOC310269; RGD1307225; similar to MEGF6
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82115,601,768 - 116,253,029 (-)NCBIGRCr8
mRatBN7.22113,721,236 - 114,324,547 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2113,723,531 - 114,323,389 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2120,387,617 - 120,970,204 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02118,500,229 - 119,082,831 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02113,219,681 - 113,799,958 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02116,524,965 - 117,153,933 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2116,970,344 - 117,119,144 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02136,659,205 - 136,807,811 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02136,216,681 - 136,281,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42113,748,239 - 114,345,992 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12113,693,476 - 114,377,010 (+)NCBI
Celera2108,909,298 - 109,484,794 (-)NCBICelera
Cytogenetic Map2q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Egfem1Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in decreased expression of EGFEM1 mRNACTDPMID:27840820
Egfem1Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of EGFEM1 mRNACTDPMID:24780913
Egfem1Ratatrazine affects methylationEXP 6480464Atrazine affects the methylation of EGFEM1 geneCTDPMID:35440735
Egfem1Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of EGFEM1 mRNACTDPMID:25181051 more ...
Egfem1Ratmethoxychlor affects methylationEXP 6480464Methoxychlor affects the methylation of EGFEM1 geneCTDPMID:35440735
Egfem1Ratvalproic acid increases expressionEXP 6480464Valproic Acid results in increased expression of EGFEM1 mRNACTDPMID:29427782


Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Egfem1Ratcalcium ion binding enablesIEAInterPro:IPR001881 and InterPro:IPR0180971600115GO_REF:0000002InterProGO_REF:0000002


#
Reference Title
Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions


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Variants in Egfem1
3391 total Variants

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:63
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000039603
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 54 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
631566Bp90Blood pressure QTL 900.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2102803808147803808Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)238573329122609194Rat
1598862Glom9Glomerulus QTL 93.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)292337601137337601Rat

1 to 10 of 54 rows
D2Rat337  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82116,070,118 - 116,070,260 (+)Marker Load Pipeline
mRatBN7.22114,141,640 - 114,141,782 (-)MAPPERmRatBN7.2
Rnor_6.02116,712,650 - 116,712,791NCBIRnor6.0
Rnor_5.02136,401,585 - 136,401,726UniSTSRnor5.0
RGSC_v3.42113,936,723 - 113,936,864UniSTSRGSC3.4
RGSC_v3.42113,936,723 - 113,936,864RGDRGSC3.4
RGSC_v3.12113,881,685 - 113,881,826RGD
Celera2109,310,358 - 109,310,487UniSTS
RH 3.4 Map2694.6UniSTS
RH 3.4 Map2694.6RGD
SHRSP x BN Map242.2598RGD
SHRSP x BN Map242.2598UniSTS
Cytogenetic Map2q24UniSTS
BF387016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22114,246,684 - 114,246,871 (-)MAPPERmRatBN7.2
Rnor_6.02116,603,575 - 116,603,761NCBIRnor6.0
Rnor_5.02136,293,130 - 136,293,316UniSTSRnor5.0
RGSC_v3.42113,827,248 - 113,827,434UniSTSRGSC3.4
Celera2109,408,241 - 109,408,427UniSTS
RH 3.4 Map2688.9UniSTS
Cytogenetic Map2q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
7 1 6 105 38 45 18 20 18 6 69 36 93 7 31 27


1 to 19 of 19 rows
RefSeq Transcripts NM_001415037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039102234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281764 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001836456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005500283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010063603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010063604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000039603   ⟹   ENSRNOP00000034595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2113,737,839 - 114,323,389 (-)Ensembl
Rnor_6.0 Ensembl2116,970,344 - 117,119,144 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093839   ⟹   ENSRNOP00000078154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2113,723,531 - 114,323,389 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097570   ⟹   ENSRNOP00000081164
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2113,723,531 - 114,323,389 (-)Ensembl
RefSeq Acc Id: NM_001415037   ⟹   NP_001401966
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,649,676 - 116,252,124 (-)NCBI
mRatBN7.22113,721,236 - 114,323,677 (-)NCBI
RefSeq Acc Id: XM_017590848   ⟹   XP_017446337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,622,462 - 116,253,027 (-)NCBI
mRatBN7.22113,721,236 - 114,324,546 (-)NCBI
Rnor_6.02116,524,967 - 117,135,749 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017590851   ⟹   XP_017446340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,652,194 - 116,253,027 (-)NCBI
mRatBN7.22113,723,752 - 114,324,546 (-)NCBI
Rnor_6.02116,524,968 - 117,133,167 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102234   ⟹   XP_038958162
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,651,249 - 116,253,026 (-)NCBI
mRatBN7.22113,722,811 - 114,324,546 (-)NCBI
RefSeq Acc Id: XM_063281764   ⟹   XP_063137834
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,622,462 - 116,253,029 (-)NCBI
RefSeq Acc Id: XM_063281765   ⟹   XP_063137835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,622,462 - 116,253,028 (-)NCBI
RefSeq Acc Id: XM_063281767   ⟹   XP_063137837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,622,462 - 116,253,029 (-)NCBI
RefSeq Acc Id: XM_063281768   ⟹   XP_063137838
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,622,462 - 116,252,156 (-)NCBI
RefSeq Acc Id: XR_005500283
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,669,374 - 116,253,028 (-)NCBI
mRatBN7.22113,740,930 - 114,324,547 (-)NCBI
RefSeq Acc Id: XR_010063603
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,601,768 - 116,253,027 (-)NCBI
RefSeq Acc Id: XR_010063604
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82115,669,374 - 116,252,156 (-)NCBI
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: XP_017446337   ⟸   XM_017590848
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y2H5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446340   ⟸   XM_017590851
- Peptide Label: isoform X7
- UniProtKB: A6IHM9 (UniProtKB/TrEMBL),   F1LWU8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000034595   ⟸   ENSRNOT00000039603
RefSeq Acc Id: XP_038958162   ⟸   XM_039102234
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000081164   ⟸   ENSRNOT00000097570
EGF-like   EMI

Name Modeler Protein Id AA Range Protein Structure
AF-F1LWU8-F1-model_v2 AlphaFold F1LWU8 1-384 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 50 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-53440 BioCyc
Ensembl Genes ENSRNOG00000023908 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039603 ENTREZGENE
  ENSRNOT00000039603.6 UniProtKB/TrEMBL
  ENSRNOT00000093839.1 UniProtKB/TrEMBL
  ENSRNOT00000097570 ENTREZGENE
  ENSRNOT00000097570.1 UniProtKB/TrEMBL
  ENSRNOT00000132495 ENTREZGENE
  ENSRNOT00000142244 ENTREZGENE
  ENSRNOT00000142746 ENTREZGENE
  ENSRNOT00000160311 ENTREZGENE
Gene3D-CATH Laminin UniProtKB/TrEMBL
  Tie2 ligand-binding domain superfamily UniProtKB/TrEMBL
InterPro ECM_structural_protein UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  EMI_domain UniProtKB/TrEMBL
  GAS-SHBG-PROS UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/TrEMBL
  MEGF/SIB UniProtKB/TrEMBL
  NOTCH1_EGF-like UniProtKB/TrEMBL
NCBI Gene 310269 ENTREZGENE
PANTHER COMPLEMENT COMPONENT C1Q RECEPTOR UniProtKB/TrEMBL
  EGF-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  FIBROPELLIN-1 UniProtKB/TrEMBL
  LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN UniProtKB/TrEMBL
  MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 6 UniProtKB/TrEMBL
Pfam EGF_CA UniProtKB/TrEMBL
  EMI UniProtKB/TrEMBL
  FXa_inhibition UniProtKB/TrEMBL
PhenoGen Egfem1 PhenoGen
PRINTS EGFLAMININ UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
1 to 40 of 50 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-25 Egfem1  EGF-like and EMI domain containing 1   RGD1307225  similar to MEGF6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1307225  similar to MEGF6   RGD1307225_predicted  similar to MEGF6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1307225_predicted  similar to MEGF6 (predicted)  LOC310269_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310269_predicted  similar to MEGF6 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL