Ankk1 (ankyrin repeat and kinase domain containing 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Ankk1 (ankyrin repeat and kinase domain containing 1) Rattus norvegicus
Analyze
Symbol: Ankk1
Name: ankyrin repeat and kinase domain containing 1
RGD ID: 1305538
Description: Predicted to enable ATP binding activity and protein kinase activity. Involved in cellular response to retinoic acid. Predicted to be located in cell projection and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; alexithymia; drug dependence (multiple); and mild cognitive impairment. Orthologous to human ANKK1 (ankyrin repeat and kinase domain containing 1); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ankyrin repeat and protein kinase domain-containing protein 1; LOC367080; LOC690279; similar to ankyrin repeat and kinase domain containing 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,676,327 - 58,685,012 (-)NCBIGRCr8
mRatBN7.2849,779,862 - 49,788,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,779,862 - 49,788,024 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx855,283,981 - 55,292,160 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,562,857 - 53,571,036 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,427,117 - 51,435,296 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0853,750,631 - 53,758,925 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,751,091 - 53,758,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,370,801 - 52,378,944 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,714,745 - 52,722,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,734,164 - 52,741,935 (-)NCBI
Celera849,331,721 - 49,340,015 (-)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 23 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ankk1Ratalcohol dependence susceptibilityISOANKK1 (Homo sapiens)401959222DNA:polymorphism:exon:RGD 
Ankk1Ratalcohol dependence susceptibilityISOANKK1 (Homo sapiens)401959307DNA:SNP and haplotype:exon:rs1800497(human)RGD 
Ankk1Ratalcohol use disorder  ISOANKK1 (Homo sapiens)401940151DNA:polymorphism: :rs1800497(human)RGD 
Ankk1Ratalcohol use disorder severityISOANKK1 (Homo sapiens)401959296DNA:SNP more ...RGD 
Ankk1Ratalcohol-induced mental disorder  ISOANKK1 (Homo sapiens)401959336DNA:SNP:exon:rs1800497(human)RGD 
Ankk1Ratalexithymia  ISOANKK1 (Homo sapiens)401959322associated with Binge Drinking and DNA:SNP:exon:rs1800497(human)RGD 
Ankk1Ratcocaine dependence treatmentISOANKK1 (Homo sapiens)401959203DNA:SNP: :rs1800497(human)RGD 
Ankk1Ratdrug dependence  ISOANKK1 (Homo sapiens)401959320associated with alcohol dependence and DNA:haplotype:exons:RGD 
Ankk1Ratheroin dependence susceptibilityISOANKK1 (Homo sapiens)401959223DNA:SNP:exon:rs1800497(human)RGD 
Ankk1Ratheroin dependence onsetISOANKK1 (Homo sapiens)401959202DNA:SNPS:exon:rs17115439 more ...RGD 
Ankk1Ratheroin dependence  ISOANKK1 (Homo sapiens)401959205DNA:SNPs more ...RGD 
Ankk1Ratheroin dependence susceptibilityISOANKK1 (Homo sapiens)401959304DNA:SNPs:5'UTR more ...RGD 
Ankk1RatLanguage Development Disorders  ISOANKK1 (Homo sapiens)401959324DNA:SNPs more ...RGD 
Ankk1Ratmild cognitive impairment susceptibilityISOANKK1 (Homo sapiens)401959397associated with pathological gambling and DNA:SNP:exon:rs1800497(human)RGD 
Ankk1Ratnicotine dependence onsetISOANKK1 (Homo sapiens)401959296DNA:SNP more ...RGD 
Ankk1Ratnicotine dependence susceptibilityISOANKK1 (Homo sapiens)401959232DNA:SNP:exon:rs2734849(human)RGD 
Ankk1Ratnicotine dependence susceptibilityISOANKK1 (Homo sapiens)401959319DNA:SNPs more ...RGD 
Ankk1Ratnicotine dependence susceptibilityISOANKK1 (Homo sapiens)401959315DNA:SNP and haplotype:exon:rs1800497(human)RGD 
Ankk1Ratnicotine dependence  ISOANKK1 (Homo sapiens)401959295DNA:haplotype: :multipleRGD 
Ankk1Ratnicotine dependence treatmentISOANKK1 (Homo sapiens)401959399associated with depressive disorder and DNA:SNP:exon:rs1800497(human)RGD 
1 to 20 of 23 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ankk1Ratchromosome 11 partial duplication syndrome  ISOANKK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Distal trisomy 11qClinVarPMID:25741868
Ankk1Ratintellectual disability  ISOANKK1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Ankk1Ratschizophrenia  ISOANKK1 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:10395223 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ankk1Ratlanguage disorder  ISOANKK1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23691092

1 to 20 of 25 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ankk1Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ANKK1 mRNACTDPMID:32741896
Ankk1Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of ANKK1 mRNACTDPMID:32741896
Ankk1Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of ANKK1 mRNACTDPMID:24780913
Ankk1Ratacrylamide decreases expressionEXP 6480464Acrylamide results in decreased expression of ANKK1 mRNACTDPMID:28959563
Ankk1Rataflatoxin B1 increases methylationISOANKK1 (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of ANKK1 exonCTDPMID:30157460
Ankk1Ratarsane increases methylationISOANKK1 (Homo sapiens)6480464Arsenic results in increased methylation of ANKK1 geneCTDPMID:24525453
Ankk1Ratarsenic atom increases methylationISOANKK1 (Homo sapiens)6480464Arsenic results in increased methylation of ANKK1 geneCTDPMID:24525453
Ankk1Ratbenzo[a]pyrene increases expressionISOAnkk1 (Mus musculus)6480464Benzo(a)pyrene results in increased expression of ANKK1 mRNACTDPMID:23735875
Ankk1Ratbenzo[a]pyrene increases methylationISOANKK1 (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of ANKK1 exonCTDPMID:27901495
Ankk1Ratbenzo[a]pyrene affects methylationISOANKK1 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of ANKK1 promoterCTDPMID:27901495
Ankk1Ratbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of ANKK1 mRNACTDPMID:25181051
Ankk1Ratcadmium dichloride decreases expressionISOANKK1 (Homo sapiens)6480464Cadmium Chloride results in decreased expression of ANKK1 mRNACTDPMID:38382870
Ankk1Ratcopper atom increases expressionEXP 6480464Copper deficiency results in increased expression of ANKK1 mRNACTDPMID:26033743
Ankk1Ratcopper(0) increases expressionEXP 6480464Copper deficiency results in increased expression of ANKK1 mRNACTDPMID:26033743
Ankk1Ratcopper(II) sulfate increases expressionISOANKK1 (Homo sapiens)6480464Copper Sulfate results in increased expression of ANKK1 mRNACTDPMID:19549813
Ankk1RatDibutyl phosphate affects expressionISOANKK1 (Homo sapiens)6480464di-n-butylphosphoric acid affects the expression of ANKK1 mRNACTDPMID:37042841
Ankk1RatN-Nitrosopyrrolidine decreases expressionISOANKK1 (Homo sapiens)6480464N-Nitrosopyrrolidine results in decreased expression of ANKK1 mRNACTDPMID:32234424
Ankk1Ratozone multiple interactionsISOAnkk1 (Mus musculus)6480464[Air Pollutants results in increased abundance of Ozone] which results in decreased expression of ANKK1 mRNACTDPMID:27106289
Ankk1Ratparacetamol increases expressionISOANKK1 (Homo sapiens)6480464Acetaminophen results in increased expression of ANKK1 mRNACTDPMID:26690555
Ankk1Ratpotassium dichromate decreases expressionISOAnkk1 (Mus musculus)6480464Potassium Dichromate results in decreased expression of ANKK1 mRNACTDPMID:23608068

1 to 20 of 25 rows

Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ankk1Ratcellular response to retinoic acid  IEP 401959583 RGD 
Ankk1Ratregulation of cell cycle process acts_upstream_of_or_withinISOANKK1 (Homo sapiens)1624291 PMID:27166167RGDPMID:27166167
Ankk1Ratregulation of cell cycle process acts_upstream_of_or_withinIEAUniProtKB:Q8BZ25 and ensembl:ENSMUSP000000347921600115GO_REF:0000107EnsemblGO_REF:0000107
Ankk1Ratregulation of cell cycle process acts_upstream_of_or_withinIEAUniProtKB:Q8NFD2 and ensembl:ENSP000003066781600115GO_REF:0000107EnsemblGO_REF:0000107
Ankk1Ratregulation of cell cycle process acts_upstream_of_or_withinISOAnkk1 (Mus musculus)1624291 PMID:27166167RGDPMID:27166167
Ankk1Ratregulation of cell cycle process involved_inIBAMGI:3045301 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ankk1Ratcell projection located_inISOAnkk1 (Mus musculus)1624291 PMID:27166167RGDPMID:27166167
Ankk1Ratcell projection located_inIEAUniProtKB:Q8BZ25 and ensembl:ENSMUSP000000347921600115GO_REF:0000107EnsemblGO_REF:0000107
Ankk1Ratcytoplasm is_active_inIBAMGI:1919638 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ankk1Ratcytoplasm located_inIEAUniProtKB:Q8BZ25 and ensembl:ENSMUSP000000347921600115GO_REF:0000107EnsemblGO_REF:0000107
Ankk1Ratcytoplasm located_inISOAnkk1 (Mus musculus)1624291 PMID:27166167RGDPMID:27166167
Ankk1Ratnucleus located_inISOANKK1 (Homo sapiens)1624291 PMID:27166167RGDPMID:27166167
Ankk1Ratnucleus located_inIEAUniProtKB:Q8NFD2 and ensembl:ENSP000003066781600115GO_REF:0000107EnsemblGO_REF:0000107
Ankk1Ratnucleus located_inISOAnkk1 (Mus musculus)1624291 PMID:27166167RGDPMID:27166167
Ankk1Ratnucleus located_inIEAUniProtKB:Q8BZ25 and ensembl:ENSMUSP000000347921600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 9 of 9 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Ankk1RatATP binding enablesIEAInterPro:IPR0007191600115GO_REF:0000002InterProGO_REF:0000002
Ankk1Ratprotein binding enablesISOANKK1 (Homo sapiens)1624291UniProtKB:O95619 more ...RGDPMID:32296183 more ...
Ankk1Ratprotein kinase activity enablesIEAInterPro:IPR000719 more ...1600115GO_REF:0000002InterProGO_REF:0000002


1 to 20 of 26 rows
#
Reference Title
Reference Citation
1. NCAM1-TTC12-ANKK1-DRD2 variants and smoking motives as intermediate phenotypes for nicotine dependence. Bidwell LC, etal., Psychopharmacology (Berl). 2015 Apr;232(7):1177-86. doi: 10.1007/s00213-014-3748-2. Epub 2014 Oct 3.
2. Association between the traditional Chinese medicine pathological factors of opioid addiction and DRD2/ANKK1 TaqIA polymorphisms. Cai M, etal., BMC Complement Altern Med. 2015 Jul 3;15:209. doi: 10.1186/s12906-015-0727-z.
3. Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution. Doehring A, etal., Pharmacogenet Genomics. 2009 Jun;19(6):407-14. doi: 10.1097/FPC.0b013e328320a3fd.
4. Associations of prenatal nicotine exposure and the dopamine related genes ANKK1 and DRD2 to verbal language. Eicher JD, etal., PLoS One. 2013 May 15;8(5):e63762. doi: 10.1371/journal.pone.0063762. Print 2013.
5. Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers. Fagundo AB, etal., J Psychopharmacol. 2014 Dec;28(12):1170-7. doi: 10.1177/0269881114551079. Epub 2014 Sep 18.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Haplotype spanning TTC12 and ANKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations. Gelernter J, etal., Hum Mol Genet. 2006 Dec 15;15(24):3498-507. doi: 10.1093/hmg/ddl426. Epub 2006 Nov 3.
8. The ANKK1 gene associated with addictions is expressed in astroglial cells and upregulated by apomorphine. Hoenicka J, etal., Biol Psychiatry. 2010 Jan 1;67(1):3-11. doi: 10.1016/j.biopsych.2009.08.012.
9. Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. Huang W, etal., Neuropsychopharmacology. 2009 Jan;34(2):319-30. doi: 10.1038/npp.2008.37. Epub 2008 Mar 19.
10. Epistatic effect of Ankyrin repeat and kinase domain containing 1 - Dopamine receptor D2 and catechol-o-methyltransferase single nucleotide polymorphisms on the risk for hazardous use of alcohol in Lithuanian population. Kaminskaite M, etal., Gene. 2021 Jan 10;765:145107. doi: 10.1016/j.gene.2020.145107. Epub 2020 Sep 2.
11. The role of ANKK1 and TTC12 genes on drinking behaviour in tobacco dependent subjects. Lobo DS, etal., World J Biol Psychiatry. 2012 Mar;13(3):232-8. doi: 10.3109/15622975.2011.598560. Epub 2011 Sep 22.
12. ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure. Nelson EC, etal., JAMA Psychiatry. 2013 Mar;70(3):325-33. doi: 10.1001/jamapsychiatry.2013.282.
13. DRD2 and ANKK1 genotype in alcohol-dependent patients with psychopathic traits: association and interaction study. Ponce G, etal., Br J Psychiatry. 2008 Aug;193(2):121-5. doi: 10.1192/bjp.bp.107.041582.
14. Association of ankyrin repeats & kinase domain containing 1 (ANKK1) gene polymorphism with co-morbid alcohol & nicotine dependence: A pilot study from a tertiary care treatment centre in north India. Quraishi R, etal., Indian J Med Res. 2017 Jan;145(1):33-38. doi: 10.4103/ijmr.IJMR_458_14.
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. Spellicy CJ, etal., Pharmacogenet Genomics. 2013 Jul;23(7):333-40. doi: 10.1097/FPC.0b013e328361c39d.
19. Association between DRD2/ANKK1 Taq1A genotypes, depression and smoking cessation with nicotine replacement therapy. Stapleton JA, etal., Pharmacogenet Genomics. 2011 Aug;21(8):447-53. doi: 10.1097/FPC.0b013e328347473a.
20. DRD2 and ANKK1 gene polymorphisms and alcohol dependence: a case-control study among a Mendelian population of East Asian ancestry. Suraj Singh H, etal., Alcohol Alcohol. 2013 Jul-Aug;48(4):409-14. doi: 10.1093/alcalc/agt014. Epub 2013 Feb 26.
1 to 20 of 26 rows
PMID:8889548   PMID:27166167  



Ankk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8858,676,327 - 58,685,012 (-)NCBIGRCr8
mRatBN7.2849,779,862 - 49,788,024 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl849,779,862 - 49,788,024 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx855,283,981 - 55,292,160 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0853,562,857 - 53,571,036 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0851,427,117 - 51,435,296 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0853,750,631 - 53,758,925 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl853,751,091 - 53,758,774 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0852,370,801 - 52,378,944 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4852,714,745 - 52,722,913 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1852,734,164 - 52,741,935 (-)NCBI
Celera849,331,721 - 49,340,015 (-)NCBICelera
Cytogenetic Map8q23NCBI
ANKK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811113,387,779 - 113,400,416 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11113,387,779 - 113,400,416 (+)EnsemblGRCh38hg38GRCh38
GRCh3711113,258,501 - 113,271,138 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611112,763,723 - 112,776,350 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411112,763,722 - 112,776,350NCBI
Celera11110,411,445 - 110,424,071 (+)NCBICelera
Cytogenetic Map11q23.2NCBI
HuRef11109,186,137 - 109,198,762 (+)NCBIHuRef
CHM1_111113,141,499 - 113,154,124 (+)NCBICHM1_1
T2T-CHM13v2.011113,398,282 - 113,410,917 (+)NCBIT2T-CHM13v2.0
Ankk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39949,326,494 - 49,338,341 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl949,326,494 - 49,338,321 (-)EnsemblGRCm39 Ensembl
GRCm38949,415,194 - 49,427,041 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl949,415,194 - 49,427,021 (-)EnsemblGRCm38mm10GRCm38
MGSCv37949,223,327 - 49,235,126 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36949,167,452 - 49,179,251 (-)NCBIMGSCv36mm8
Celera946,712,988 - 46,724,868 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map926.83NCBI
Ankk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541215,035,388 - 15,046,139 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541215,036,071 - 15,046,118 (+)NCBIChiLan1.0ChiLan1.0
ANKK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29114,132,094 - 114,145,920 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111115,226,472 - 115,240,295 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011108,267,717 - 108,280,635 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111112,111,003 - 112,125,952 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11112,111,003 - 112,123,382 (+)Ensemblpanpan1.1panPan2
ANKK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1519,801,511 - 19,814,359 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl519,801,542 - 19,814,481 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha519,723,265 - 19,736,301 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0519,822,410 - 19,835,444 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl519,822,441 - 19,835,756 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1519,884,965 - 19,897,951 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0519,786,175 - 19,799,184 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0519,833,938 - 19,846,967 (-)NCBIUU_Cfam_GSD_1.0
Ankk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494795,531,923 - 95,543,648 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366121,161,961 - 1,173,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANKK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11104,752,023 - 104,765,071 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604321,245,489 - 21,261,506 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ankk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247848,810,559 - 8,820,444 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247848,810,409 - 8,821,732 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ankk1
20 total Variants

Predicted Target Of
Summary Value
Count of predictions:112
Count of miRNA genes:103
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000068040
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 58 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat

1 to 10 of 58 rows
BM384954  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2849,779,921 - 49,780,088 (+)MAPPERmRatBN7.2
Rnor_6.0853,750,691 - 53,750,857NCBIRnor6.0
Rnor_5.0852,370,861 - 52,371,027UniSTSRnor5.0
RGSC_v3.4852,714,798 - 52,714,964UniSTSRGSC3.4
Celera849,331,781 - 49,331,947UniSTS
RH 3.4 Map8534.9UniSTS
Cytogenetic Map8q23UniSTS




alimentary part of gastrointestinal system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 40 14 24 9 3 29 11 35 15 30 24



Ensembl Acc Id: ENSRNOT00000068040   ⟹   ENSRNOP00000062510
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl849,779,862 - 49,788,024 (-)Ensembl
Rnor_6.0 Ensembl853,751,091 - 53,758,774 (-)Ensembl
RefSeq Acc Id: NM_001108999   ⟹   NP_001102469
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,676,327 - 58,684,489 (-)NCBI
mRatBN7.2849,779,862 - 49,788,024 (-)NCBI
RefSeq Acc Id: XM_063265876   ⟹   XP_063121946
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8858,676,327 - 58,685,012 (-)NCBI
Protein RefSeqs NP_001102469 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121946 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL95442 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062510
  ENSRNOP00000062510.3
Ensembl Acc Id: ENSRNOP00000062510   ⟸   ENSRNOT00000068040
RefSeq Acc Id: NP_001102469   ⟸   NM_001108999
- UniProtKB: D3ZDY2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063121946   ⟸   XM_063265876
- Peptide Label: isoform X1
- UniProtKB: A6J4B9 (UniProtKB/TrEMBL)
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-D3ZDY2-F1-model_v2 AlphaFold D3ZDY2 1-746 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-30583 BioCyc
Ensembl Genes ENSRNOG00000025037 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000068040 ENTREZGENE
  ENSRNOT00000068040.3 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  Ser/Thr_Kinases-Pseudokinases UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
NCBI Gene 367080 ENTREZGENE
PANTHER ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN 1 UniProtKB/TrEMBL
  PROTEIN KINASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED UniProtKB/TrEMBL
Pfam Ank UniProtKB/TrEMBL
  Ank_2 UniProtKB/TrEMBL
  Ank_4 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PhenoGen Ankk1 PhenoGen
PRINTS ANKYRIN UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000025037 RatGTEx
SMART ANK UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A6J4B9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDY2 ENTREZGENE, UniProtKB/TrEMBL
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Ankk1  ankyrin repeat and kinase domain containing 1  LOC690279  similar to ankyrin repeat and kinase domain containing 1  Data merged from RGD:1582835 737654 PROVISIONAL
2008-04-30 Ankk1  ankyrin repeat and kinase domain containing 1   Ankk1_predicted  ankyrin repeat and kinase domain containing 1 (predicted)  'predicted' is removed 2292626 APPROVED
2008-01-09 LOC690279  similar to ankyrin repeat and kinase domain containing 1  LOC684394  similar to ankyrin repeat and kinase domain containing 1  Data merged from RGD:1591418 1643240 APPROVED
2006-11-20 LOC684394  similar to ankyrin repeat and kinase domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC690279  similar to ankyrin repeat and kinase domain containing 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Ankk1_predicted  ankyrin repeat and kinase domain containing 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED