RGD Reference Report - Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers. - Rat Genome Database

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Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers.

Authors: Fagundo, Ana B  Fernández-Aranda, Fernando  de la Torre, Rafael  Verdejo-García, Antonio  Granero, Roser  Penelo, Eva  Gené, Manel  Barrot, Carme  Sánchez, Cristina  Alvarez-Moya, Eva  Ochoa, Cristian  Aymamí, Maria Neus  Gómez-Peña, Mónica  Menchón, Jose M  Jiménez-Murcia, Susana 
Citation: Fagundo AB, etal., J Psychopharmacol. 2014 Dec;28(12):1170-7. doi: 10.1177/0269881114551079. Epub 2014 Sep 18.
RGD ID: 401959397
Pubmed: PMID:25237117   (View Abstract at PubMed)
DOI: DOI:10.1177/0269881114551079   (Journal Full-text)

Like drug addiction, pathological gambling (PG) has been associated with impairments in executive functions and alterations in dopaminergic functioning; however, the role of dopamine (DA) in the executive profile of PG remains unclear. The aim of this study was to identify whether the DRD2/ANKK1 Taq1A-rs1800497 and the DAT1-40 bp VNTR polymorphisms are associated with cognitive flexibility (measured by Wisconsin Card Sorting Test (WCST) and Trail Making Test (TMT)) and inhibition response (measured by Stroop Color and Word Test (SCWT)), in a clinical sample of 69 PG patients. Our results showed an association between DA functioning and cognitive flexibility performance. The Taq1A A1+ (A1A2/A1A1) genotype was associated with poorer TMT performance (p<0.05), while DAT1 9-repeat homozygotes displayed better WCST performance (p<0.05) than either 10-repeat homozygotes or heterozygotes. We did not find any association between the DRD2 or DAT1 polymorphisms and the inhibition response. These results suggested that pathological gamblers with genetic predispositions toward lower availability of DA and D2 receptor density are at a higher risk of cognitive flexibility difficulties. Future studies should aim to shed more light on the genetic mechanisms underlying the executive profile in PG.




  
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Original Reference(s)
ANKK1Humanmild cognitive impairment susceptibilityIAGP associated with pathological gambling and DNA:SNP:exon:rs1800497(human)RGD 
Ankk1Ratmild cognitive impairment susceptibilityISOANKK1 (Homo sapiens)associated with pathological gambling and DNA:SNP:exon:rs1800497(human)RGD 
Ankk1Mousemild cognitive impairment susceptibilityISOANKK1 (Homo sapiens)associated with pathological gambling and DNA:SNP:exon:rs1800497(human)RGD 
SLC6A3Humanmild cognitive impairment susceptibilityIAGP associated with pathological gambling and DNA:repeats::RGD 
Slc6a3Ratmild cognitive impairment susceptibilityISOSLC6A3 (Homo sapiens)associated with pathological gambling and DNA:repeats::RGD 
Slc6a3Mousemild cognitive impairment susceptibilityISOSLC6A3 (Homo sapiens)associated with pathological gambling and DNA:repeats::RGD 


Genes (Rattus norvegicus)
Ankk1  (ankyrin repeat and kinase domain containing 1) Slc6a3  (solute carrier family 6 member 3)

Genes (Mus musculus)
Ankk1  (ankyrin repeat and kinase domain containing 1) Slc6a3  (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3)

Genes (Homo sapiens)
ANKK1  (ankyrin repeat and kinase domain containing 1) SLC6A3  (solute carrier family 6 member 3)