Arl6 (ADP-ribosylation factor like GTPase 6) - Rat Genome Database

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Gene: Arl6 (ADP-ribosylation factor like GTPase 6) Rattus norvegicus
Analyze
Symbol: Arl6
Name: ADP-ribosylation factor like GTPase 6
RGD ID: 1305535
Description: Predicted to enable GTP binding activity. Predicted to be involved in several processes, including cilium assembly; fat cell differentiation; and protein localization to non-motile cilium. Predicted to act upstream of or within several processes, including protein transport from ciliary membrane to plasma membrane; regulation of smoothened signaling pathway; and retina layer formation. Predicted to be located in several cellular components, including cilium; cytosol; and microtubule cytoskeleton. Predicted to be active in axoneme. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Orthologous to human ARL6 (ADP ribosylation factor like GTPase 6); PARTICIPATES IN Arf family mediated signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ADP-ribosylation factor-like 6; ADP-ribosylation factor-like protein 6; LOC363760
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81154,180,271 - 54,207,136 (+)NCBIGRCr8
mRatBN7.21140,711,878 - 40,738,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,712,022 - 40,737,937 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,443,864 - 49,464,528 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,115,134 - 42,135,798 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,243,787 - 41,264,451 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,858,476 - 42,884,324 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,858,478 - 42,884,603 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01146,048,981 - 46,074,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41141,473,928 - 41,494,632 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11141,531,301 - 41,557,582 (+)NCBI
Celera1140,554,175 - 40,574,879 (+)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axoneme  (IBA)
cilium  (ISO)
cytoplasm  (ISO)
cytosol  (ISO)
membrane  (ISO)
microtubule cytoskeleton  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mutations in a member of the Ras superfamily of small GTP-binding proteins causes Bardet-Biedl syndrome. Fan Y, etal., Nat Genet. 2004 Sep;36(9):989-93. Epub 2004 Aug 15.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. Ingley E, etal., FEBS Lett. 1999 Oct 1;459(1):69-74.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:17379567   PMID:17646400   PMID:19056867   PMID:20207729   PMID:20333246   PMID:22139371   PMID:23376485   PMID:24939912  


Genomics

Comparative Map Data
Arl6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81154,180,271 - 54,207,136 (+)NCBIGRCr8
mRatBN7.21140,711,878 - 40,738,254 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1140,712,022 - 40,737,937 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,443,864 - 49,464,528 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01142,115,134 - 42,135,798 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01141,243,787 - 41,264,451 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,858,476 - 42,884,324 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,858,478 - 42,884,603 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01146,048,981 - 46,074,815 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41141,473,928 - 41,494,632 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11141,531,301 - 41,557,582 (+)NCBI
Celera1140,554,175 - 40,574,879 (+)NCBICelera
Cytogenetic Map11q12NCBI
ARL6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38397,764,521 - 97,801,242 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl397,764,521 - 97,801,229 (+)EnsemblGRCh38hg38GRCh38
GRCh37397,483,365 - 97,520,086 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36398,966,285 - 99,000,063 (+)NCBINCBI36Build 36hg18NCBI36
Build 34398,966,284 - 99,000,061NCBI
Celera395,873,167 - 95,906,953 (+)NCBICelera
Cytogenetic Map3q11.2NCBI
HuRef394,853,270 - 94,889,996 (+)NCBIHuRef
CHM1_1397,446,398 - 97,483,119 (+)NCBICHM1_1
T2T-CHM13v2.03100,468,299 - 100,505,006 (+)NCBIT2T-CHM13v2.0
Arl6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391659,433,312 - 59,459,772 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1659,433,312 - 59,459,754 (-)EnsemblGRCm39 Ensembl
GRCm381659,612,949 - 59,639,409 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1659,612,949 - 59,639,391 (-)EnsemblGRCm38mm10GRCm38
MGSCv371659,613,147 - 59,639,165 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361659,555,581 - 59,581,416 (-)NCBIMGSCv36mm8
Celera1659,964,613 - 59,990,692 (-)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1634.83NCBI
Arl6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955407360,600 - 380,900 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955407360,898 - 387,563 (-)NCBIChiLan1.0ChiLan1.0
ARL6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2295,662,263 - 95,717,482 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1395,666,445 - 95,715,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0394,832,577 - 94,870,531 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13101,519,718 - 101,556,419 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3101,519,718 - 101,556,419 (+)Ensemblpanpan1.1panPan2
ARL6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1334,797,944 - 4,857,566 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl334,800,917 - 4,839,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha334,978,946 - 5,038,532 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0334,907,747 - 4,967,366 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl334,907,537 - 4,955,060 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1334,784,258 - 4,843,859 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0334,844,615 - 4,904,175 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0335,118,965 - 5,178,560 (+)NCBIUU_Cfam_GSD_1.0
Arl6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602152,408,598 - 152,438,647 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366663,076,778 - 3,103,649 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366663,077,006 - 3,102,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARL6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13162,504,109 - 162,556,280 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113162,509,451 - 162,556,675 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213172,774,280 - 172,821,154 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARL6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12282,909,453 - 82,946,253 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2282,905,910 - 82,946,149 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604183,638,973 - 83,678,694 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arl6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478910,229,793 - 10,254,364 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478910,223,339 - 10,252,889 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arl6
126 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:103
Count of miRNA genes:85
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000002293
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat

Markers in Region
RH133556  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21140,737,649 - 40,737,840 (+)MAPPERmRatBN7.2
Rnor_6.01142,884,051 - 42,884,241NCBIRnor6.0
Rnor_5.01146,074,542 - 46,074,732UniSTSRnor5.0
RGSC_v3.41141,499,441 - 41,499,631UniSTSRGSC3.4
Celera1140,579,688 - 40,579,878UniSTS
RH 3.4 Map11300.9UniSTS
Cytogenetic Map11q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 10 4 6 4 74 35 41 10
Low 3 35 47 37 13 37 8 11 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002293   ⟹   ENSRNOP00000002293
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,712,022 - 40,737,937 (+)Ensembl
Rnor_6.0 Ensembl1142,858,478 - 42,884,603 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102337   ⟹   ENSRNOP00000080618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,712,022 - 40,732,159 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110067   ⟹   ENSRNOP00000091133
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,712,022 - 40,737,901 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110959   ⟹   ENSRNOP00000087563
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1140,712,159 - 40,737,919 (+)Ensembl
RefSeq Acc Id: NM_001108842   ⟹   NP_001102312
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81154,181,358 - 54,202,062 (+)NCBI
mRatBN7.21140,712,139 - 40,732,845 (+)NCBI
Rnor_6.01142,858,742 - 42,879,242 (+)NCBI
Rnor_5.01146,048,981 - 46,074,815 (+)NCBI
RGSC_v3.41141,473,928 - 41,494,632 (+)RGD
Celera1140,554,175 - 40,574,879 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248193   ⟹   XP_006248255
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81154,180,271 - 54,207,136 (+)NCBI
mRatBN7.21140,711,882 - 40,738,250 (+)NCBI
Rnor_6.01142,858,476 - 42,884,324 (+)NCBI
Rnor_5.01146,048,981 - 46,074,815 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001102312   ⟸   NM_001108842
- UniProtKB: A6IQI5 (UniProtKB/TrEMBL),   A0A8J8YB99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248255   ⟸   XM_006248193
- Peptide Label: isoform X1
- UniProtKB: B1WC73 (UniProtKB/TrEMBL),   F7F983 (UniProtKB/TrEMBL),   A0A8I6ACB6 (UniProtKB/TrEMBL),   A0A8J8YB99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002293   ⟸   ENSRNOT00000002293
RefSeq Acc Id: ENSRNOP00000087563   ⟸   ENSRNOT00000110959
RefSeq Acc Id: ENSRNOP00000091133   ⟸   ENSRNOT00000110067
RefSeq Acc Id: ENSRNOP00000080618   ⟸   ENSRNOT00000102337

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WC73-F1-model_v2 AlphaFold B1WC73 1-186 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698103
Promoter ID:EPDNEW_R8628
Type:initiation region
Name:Arl6_1
Description:ADP-ribosylation factor like GTPase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01142,858,735 - 42,858,795EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305535 AgrOrtholog
BioCyc Gene G2FUF-21620 BioCyc
Ensembl Genes ENSRNOG00000001689 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002293.8 UniProtKB/TrEMBL
  ENSRNOT00000102337.1 UniProtKB/TrEMBL
  ENSRNOT00000110067.1 UniProtKB/TrEMBL
  ENSRNOT00000110959.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9100375 IMAGE-MGC_LOAD
InterPro Arl6 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase_ARF/SAR UniProtKB/TrEMBL
KEGG Report rno:363760 UniProtKB/TrEMBL
MGC_CLONE MGC:187918 IMAGE-MGC_LOAD
NCBI Gene 363760 ENTREZGENE
PANTHER ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 6 UniProtKB/TrEMBL
  PTHR11711 UniProtKB/TrEMBL
Pfam Arf UniProtKB/TrEMBL
PhenoGen Arl6 PhenoGen
PRINTS SAR1GTPBP UniProtKB/TrEMBL
PROSITE ARF UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001689 RatGTEx
SMART ARF UniProtKB/TrEMBL
  SAR UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8I6ACB6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G6V6_RAT UniProtKB/TrEMBL
  A0A8I6GF94_RAT UniProtKB/TrEMBL
  A0A8J8YB99 ENTREZGENE, UniProtKB/TrEMBL
  A6IQI5 ENTREZGENE, UniProtKB/TrEMBL
  B1WC73 ENTREZGENE, UniProtKB/TrEMBL
  F7F983 ENTREZGENE
UniProt Secondary F7F983 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arl6  ADP-ribosylation factor like GTPase 6  Arl6  ADP-ribosylation factor-like 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Arl6  ADP-ribosylation factor-like 6   Arl6_predicted  ADP-ribosylation factor-like 6 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arl6_predicted  ADP-ribosylation factor-like 6 (predicted)      Symbol and Name status set to approved 70820 APPROVED