Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pan2 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Pan2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PAN2 mRNA | CTD | PMID:22206623 | Pan2 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Pan2 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of PAN2 mRNA | CTD | PMID:17555576 | Pan2 | Rat | 17alpha-ethynylestradiol | multiple interactions | ISO | Pan2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PAN2 mRNA | CTD | PMID:17942748 | Pan2 | Rat | 17alpha-ethynylestradiol | increases expression | ISO | Pan2 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of PAN2 mRNA | CTD | PMID:17942748 | Pan2 | Rat | 17beta-estradiol | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of PAN2 mRNA | CTD | PMID:31614463 | Pan2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pan2 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PAN2 mRNA | CTD | PMID:17942748 | Pan2 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pan2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PAN2 mRNA | CTD | PMID:21570461 | Pan2 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of PAN2 mRNA | CTD | PMID:21346803 | Pan2 | Rat | acrolein | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PAN2 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | Pan2 | Rat | aflatoxin B1 | affects expression | ISO | PAN2 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of PAN2 protein | CTD | PMID:20106945 | Pan2 | Rat | aflatoxin B1 | increases methylation | ISO | PAN2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of PAN2 gene | CTD | PMID:27153756 | Pan2 | Rat | alpha-pinene | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PAN2 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of PAN2 mRNA | CTD | PMID:32699268 | Pan2 | Rat | aristolochic acid A | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PAN2 mRNA | CTD | PMID:33212167 | Pan2 | Rat | Aroclor 1254 | decreases expression | ISO | Pan2 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PAN2 mRNA | CTD | PMID:23650126 | Pan2 | Rat | arsenous acid | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of PAN2 mRNA | CTD | PMID:27829220 | Pan2 | Rat | benzo[a]pyrene | increases expression | ISO | Pan2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PAN2 mRNA | CTD | PMID:22228805 | Pan2 | Rat | benzo[a]pyrene | decreases methylation | ISO | PAN2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PAN2 3' UTR | CTD | PMID:27901495 | Pan2 | Rat | benzo[a]pyrene | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of PAN2 mRNA | CTD | PMID:26238291 | Pan2 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of PAN2 mRNA | CTD | PMID:31163220 | Pan2 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PAN2 mRNA | CTD | PMID:25181051 and PMID:30816183 | Pan2 | Rat | bisphenol A | affects splicing | ISO | Pan2 (Mus musculus) | 6480464 | bisphenol A affects the splicing of PAN2 mRNA | CTD | PMID:37894381 | Pan2 | Rat | bisphenol A | increases expression | ISO | Pan2 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PAN2 mRNA | CTD | PMID:29165653 | Pan2 | Rat | butanal | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of PAN2 mRNA | CTD | PMID:26079696 | Pan2 | Rat | caffeine | decreases phosphorylation | ISO | PAN2 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of PAN2 protein | CTD | PMID:35688186 | Pan2 | Rat | carbamazepine | affects expression | ISO | PAN2 (Homo sapiens) | 6480464 | Carbamazepine affects the expression of PAN2 mRNA | CTD | PMID:25979313 | Pan2 | Rat | carbon nanotube | decreases expression | ISO | Pan2 (Mus musculus) | 6480464 | Nanotubes and Carbon analog results in decreased expression of PAN2 mRNA | CTD | PMID:25554681 | Pan2 | Rat | CGP 52608 | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PAN2 gene] | CTD | PMID:28238834 | Pan2 | Rat | chlorpyrifos | decreases expression | ISO | Pan2 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of PAN2 mRNA | CTD | PMID:37019170 | Pan2 | Rat | cobalt dichloride | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of PAN2 mRNA | CTD | PMID:19376846 | Pan2 | Rat | copper(II) sulfate | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of PAN2 mRNA | CTD | PMID:19549813 | Pan2 | Rat | coumestrol | increases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of PAN2 mRNA | CTD | PMID:19167446 | Pan2 | Rat | cyclosporin A | increases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of PAN2 mRNA | CTD | PMID:27989131 | Pan2 | Rat | diarsenic trioxide | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of PAN2 mRNA | CTD | PMID:27829220 | Pan2 | Rat | Dibutyl phosphate | affects expression | ISO | PAN2 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PAN2 mRNA | CTD | PMID:37042841 | Pan2 | Rat | dorsomorphin | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Pan2 | Rat | doxorubicin | increases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Doxorubicin results in increased expression of PAN2 mRNA | CTD | PMID:29803840 | Pan2 | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of PAN2 mRNA | CTD | PMID:29391264 | Pan2 | Rat | fenthion | decreases expression | ISO | Pan2 (Mus musculus) | 6480464 | Fenthion results in decreased expression of PAN2 mRNA | CTD | PMID:34813904 | Pan2 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of PAN2 mRNA | CTD | PMID:24793618 | Pan2 | Rat | folic acid | multiple interactions | ISO | Pan2 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PAN2 mRNA | CTD | PMID:22206623 | Pan2 | Rat | formaldehyde | increases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of PAN2 mRNA | CTD | PMID:23649840 | Pan2 | Rat | FR900359 | decreases phosphorylation | ISO | PAN2 (Homo sapiens) | 6480464 | FR900359 results in decreased phosphorylation of PAN2 protein | CTD | PMID:37730182 | Pan2 | Rat | fulvestrant | increases methylation | ISO | PAN2 (Homo sapiens) | 6480464 | Fulvestrant results in increased methylation of PAN2 gene | CTD | PMID:31601247 | Pan2 | Rat | furan | decreases methylation | EXP | | 6480464 | furan results in decreased methylation of PAN2 gene | CTD | PMID:22079235 | Pan2 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of PAN2 mRNA | CTD | PMID:33387578 | Pan2 | Rat | hydrogen peroxide | affects expression | ISO | PAN2 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of PAN2 mRNA | CTD | PMID:21179406 | Pan2 | Rat | methyl methanesulfonate | increases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PAN2 mRNA | CTD | PMID:23649840 | Pan2 | Rat | methylmercury chloride | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PAN2 mRNA | CTD | PMID:28001369 | Pan2 | Rat | oxaliplatin | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PAN2 mRNA | CTD | PMID:25729387 | Pan2 | Rat | ozone | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of PAN2 mRNA more ... | CTD | PMID:32699268 and PMID:32845096 | Pan2 | Rat | paracetamol | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PAN2 mRNA | CTD | PMID:21420995 | Pan2 | Rat | phenylmercury acetate | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of PAN2 mRNA | CTD | PMID:26272509 | Pan2 | Rat | phenylmercury acetate | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAN2 mRNA | CTD | PMID:27188386 | Pan2 | Rat | pirinixic acid | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PAN2 mRNA | CTD | PMID:19710929 | Pan2 | Rat | quercetin | increases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Quercetin results in increased expression of PAN2 mRNA | CTD | PMID:21632981 | Pan2 | Rat | quercetin | increases phosphorylation | ISO | PAN2 (Homo sapiens) | 6480464 | Quercetin results in increased phosphorylation of PAN2 protein | CTD | PMID:35688186 | Pan2 | Rat | resveratrol | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PAN2 mRNA | CTD | PMID:23557933 | Pan2 | Rat | SB 431542 | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Pan2 | Rat | tamoxifen | affects expression | ISO | Pan2 (Mus musculus) | 6480464 | Tamoxifen affects the expression of PAN2 mRNA | CTD | PMID:17555576 | Pan2 | Rat | temozolomide | increases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of PAN2 mRNA | CTD | PMID:31758290 | Pan2 | Rat | tert-butyl hydroperoxide | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of PAN2 mRNA | CTD | PMID:15336504 | Pan2 | Rat | tetraphene | affects expression | ISO | Pan2 (Mus musculus) | 6480464 | benz(a)anthracene affects the expression of PAN2 mRNA | CTD | PMID:26377693 | Pan2 | Rat | thapsigargin | increases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Thapsigargin results in increased expression of PAN2 mRNA | CTD | PMID:22378314 | Pan2 | Rat | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of PAN2 mRNA | CTD | PMID:34492290 | Pan2 | Rat | topotecan | multiple interactions | EXP | | 6480464 | [oxaliplatin co-treated with Topotecan] results in decreased expression of PAN2 mRNA | CTD | PMID:25729387 | Pan2 | Rat | triptonide | decreases expression | ISO | Pan2 (Mus musculus) | 6480464 | triptonide results in decreased expression of PAN2 mRNA | CTD | PMID:33045310 | Pan2 | Rat | troglitazone | decreases expression | ISO | Pan2 (Mus musculus) | 6480464 | troglitazone results in decreased expression of PAN2 mRNA | CTD | PMID:28973697 | Pan2 | Rat | tunicamycin | increases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of PAN2 mRNA | CTD | PMID:29453283 | Pan2 | Rat | valproic acid | affects expression | ISO | PAN2 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PAN2 mRNA | CTD | PMID:25979313 | Pan2 | Rat | valproic acid | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PAN2 mRNA | CTD | PMID:27188386 | Pan2 | Rat | valproic acid | decreases expression | ISO | PAN2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PAN2 mRNA | CTD | PMID:23179753 more ... | Pan2 | Rat | zinc atom | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of PAN2 mRNA | CTD | PMID:18593933 | Pan2 | Rat | zinc(0) | multiple interactions | ISO | PAN2 (Homo sapiens) | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of PAN2 mRNA | CTD | PMID:18593933 | |