Ccl20 (C-C motif chemokine ligand 20)

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Gene: Ccl20 (C-C motif chemokine ligand 20) Chinchilla lanigera

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Symbol:

Ccl20

Name:

C-C motif chemokine ligand 20

RGD ID:

9062891

Description:

ENCODES a protein that exhibits CCR6 chemokine receptor binding (ortholog); chemokine activity (ortholog); cytokine activity (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); calcium-mediated signaling (ortholog); cell chemotaxis (ortholog); ASSOCIATED WITH acrodermatitis (ortholog); Acute Liver Failure (ortholog); Acute-On-Chronic Liver Failure (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C-C motif chemokine 20; chemokine (C-C motif) ligand 20

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	6,846,549 - 6,850,031 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	6,846,625 - 6,850,007 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acrodermatitis (ISO)

Acute Liver Failure (ISO)

Acute-On-Chronic Liver Failure (ISO)

allergic disease (ISO)

anogenital venereal wart (ISO)

Arsenic Poisoning (ISO)

asthma (ISO)

atopic dermatitis (ISO)

Brain Injuries (ISO)

brain ischemia (ISO)

Breast Neoplasms (ISO)

Colonic Neoplasms (ISO)

Colorectal Neoplasms (ISO)

COVID-19 (ISO)

dacryocystitis (ISO)

Diabetic Nephropathies (ISO)

dry eye syndrome (ISO)

exanthem (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Neoplasms (ISO)

Experimental Melanoma (ISO)

fungal infectious disease (ISO)

herpes simplex virus keratitis (ISO)

Hypothermia (ISO)

IgA glomerulonephritis (ISO)

invasive aspergillosis (ISO)

keratoconjunctivitis sicca (ISO)

Lyme disease (ISO)

multiple sclerosis (ISO)

Nasal Polyps (ISO)

Neoplasm Metastasis (ISO)

Oral Lichen Planus (ISO)

pancreatic cancer (ISO)

pneumonia (ISO)

primary cutaneous T-cell non-Hodgkin lymphoma (ISO)

psoriasis (ISO)

Rhinosinusitis (ISO)

skin disease (ISO)

skin papilloma (ISO)

Subarachnoid Hemorrhage (ISO)

systemic scleroderma (ISO)

transient cerebral ischemia (ISO)

type 1 diabetes mellitus (ISO)

ulcerative colitis (ISO)

ureteral obstruction (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antimicrobial humoral immune response mediated by antimicrobial peptide (ISO)

calcium-mediated signaling (ISO)

cell chemotaxis (ISO)

cellular response to lipopolysaccharide (ISO)

cellular response to lipoteichoic acid (ISO)

chemotaxis (ISO)

positive regulation of interleukin-1 alpha production (ISO)

positive regulation of T cell migration (ISO)

regulation of T cell cytokine production (ISO)

regulation of T-helper 17 cell differentiation (ISO)

T cell migration (ISO)

thymocyte migration (ISO)

Cellular Component

extracellular space (ISO)

Molecular Function

CCR6 chemokine receptor binding (ISO)

chemokine activity (ISO)

cytokine activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Ccl20
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955453	6,846,549 - 6,850,031 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955453	6,846,625 - 6,850,007 (-)	NCBI	ChiLan1.0	ChiLan1.0

CCL20
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	227,813,842 - 227,817,556 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	227,805,739 - 227,817,564 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	228,678,558 - 228,682,272 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	228,386,814 - 228,390,494 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	228,504,074 - 228,507,755	NCBI
Celera	2	222,448,001 - 222,451,723 (+)	NCBI		Celera
Cytogenetic Map	2	q36.3	NCBI
HuRef	2	220,520,976 - 220,524,697 (+)	NCBI		HuRef
CHM1_1	2	228,684,755 - 228,688,476 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	228,296,236 - 228,299,949 (+)	NCBI		T2T-CHM13v2.0

Ccl20
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	83,094,487 - 83,096,888 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	83,094,487 - 83,096,888 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	83,116,766 - 83,119,167 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	83,116,766 - 83,119,167 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	83,113,341 - 83,115,742 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	82,995,806 - 82,998,190 (+)	NCBI		MGSCv36	mm8
Celera	1	83,181,441 - 83,183,842 (+)	NCBI		Celera
Cytogenetic Map	1	C5	NCBI
cM Map	1	42.69	NCBI

Ccl20
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	91,837,139 - 91,839,736 (+)	NCBI		GRCr8
mRatBN7.2	9	84,389,031 - 84,391,629 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	84,388,904 - 84,391,629 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	92,819,272 - 92,821,849 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	97,947,738 - 97,950,315 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	96,330,459 - 96,333,051 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	88,918,359 - 88,921,017 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	88,918,433 - 88,921,001 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	88,662,765 - 88,665,379 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	9	82,440,965 - 82,443,542 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	9	82,624,383 - 82,626,960 (+)	NCBI
Celera	9	81,830,990 - 81,833,567 (+)	NCBI		Celera
Cytogenetic Map	9	q35	NCBI

CCL20
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	130,426,843 - 130,430,630 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	130,441,887 - 130,445,600 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	115,052,768 - 115,056,479 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	233,862,505 - 233,866,225 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	233,862,505 - 233,866,225 (+)	Ensembl	panpan1.1		panPan2

CCL20
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	40,506,385 - 40,509,903 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	40,506,753 - 40,509,709 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	41,124,207 - 41,127,161 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	40,753,667 - 40,756,954 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	40,753,401 - 40,756,953 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	40,689,847 - 40,692,573 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	40,531,942 - 40,534,671 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	40,704,782 - 40,707,510 (+)	NCBI		UU_Cfam_GSD_1.0

Ccl20
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	182,698,770 - 182,701,593 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936525	8,237,831 - 8,240,974 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936525	8,238,128 - 8,240,974 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CCL20
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	15	129,172,743 - 129,176,069 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	143,050,303 - 143,053,630 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CCL20
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	113,815,099 - 113,836,562 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	113,832,573 - 113,835,736 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	85,618,590 - 85,622,439 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ccl20
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624843	2,017,738 - 2,021,153 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005395441	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013519756	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01044732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01358667	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000012290 ⟹ ENSCLAP00000012149

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955453	6,846,549 - 6,850,031 (-)	Ensembl

RefSeq Acc Id:

XM_005395441 ⟹ XP_005395498

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955453	6,846,625 - 6,850,007 (-)	NCBI

Sequence:

show sequence

TCCTGCGCTGCTGTGAGAGCAGAACAGCTCTCGCAGGGCACCGAGTACTCAGAACTGAGCAGAC
CTGTTCTTTGAGCTGAAAATGATGTGCGATAGCAAGCGTTTGTTCCTGGTTGCTTTGGTGTCGG
TGCTTCTACTCTACTTCTGCAGCCAGTCACAAGCAGCAAGCAGCTTCGACTGTTGCCTCGGATA
TACACGACATGTGCTTAGCATCAAATATATTCGGAACTTCACAGAGCAGCTGGCCAGTGAAATC
TGCGACATCAACGCTATCATCTTTCACACACACAAGCGACTGTCTGTGTGCGCAGACCCCAAGA
AGCCGTGGGTGAAAAAAATTATGCGCTTTCTCAGCCAAAAAGACAAGAAGTAAAAACACCTGCG
CTCTCAGAATGAAATTGGACACAGCCCAAGAACAAAAGGACCTGATGGTGGTAGAAGTTTCACT
AGCACATCATTTAGCACTGACTGATCTGATTCATGTCTCATTGGACTTGTCCAGTTGATGAAGT
TGATTCATATTGCATCATAGTTTGCTTTGTTTAAGCATCATATTAAAGTCAAGCTCTATTTTAT
GTTAAGTTATTTACAGCTGTAGGTTTTTTTGTGTTTAGCTATTTATACTCATTTCTCATAAGCT
ATGGTTTAGTGGAAAGTATAACATTGTATTTGGAGAAATAGAATTATATGGGTCTTCTTGCAAG
TAGTAAGCTATTTTTAAAAAATCTATTTGACTTTCCTTTGTGTATATAATTTTGTTTCCTAAGT
TGTTGTGATTGCCTTATAAGAGAGAAGAATGATTATAGAAGGGTAATTACTAAAAATAAAAGAA
CCAAAAAGTTACTTGTCAA

hide sequence

RefSeq Acc Id:

XM_013519756 ⟹ XP_013375210

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955453	6,846,625 - 6,850,007 (-)	NCBI

Sequence:

show sequence

TCCTGCGCTGCTGTGAGAGCAGAACAGCTCTCGCAGGGCACCGAGTACTCAGAACTGAGCAGAC
CTGTTCTTTGAGCTGAAAATGATGTGCGATAGCAAGCGTTTGTTCCTGGTTGCTTTGGTGTCGG
TGCTTCTACTCTACTTCTGCAGCCAGTCACAAGCAAGCAGCTTCGACTGTTGCCTCGGATATAC
ACGACATGTGCTTAGCATCAAATATATTCGGAACTTCACAGAGCAGCTGGCCAGTGAAATCTGC
GACATCAACGCTATCATCTTTCACACACACAAGCGACTGTCTGTGTGCGCAGACCCCAAGAAGC
CGTGGGTGAAAAAAATTATGCGCTTTCTCAGCCAAAAAGACAAGAAGTAAAAACACCTGCGCTC
TCAGAATGAAATTGGACACAGCCCAAGAACAAAAGGACCTGATGGTGGTAGAAGTTTCACTAGC
ACATCATTTAGCACTGACTGATCTGATTCATGTCTCATTGGACTTGTCCAGTTGATGAAGTTGA
TTCATATTGCATCATAGTTTGCTTTGTTTAAGCATCATATTAAAGTCAAGCTCTATTTTATGTT
AAGTTATTTACAGCTGTAGGTTTTTTTGTGTTTAGCTATTTATACTCATTTCTCATAAGCTATG
GTTTAGTGGAAAGTATAACATTGTATTTGGAGAAATAGAATTATATGGGTCTTCTTGCAAGTAG
TAAGCTATTTTTAAAAAATCTATTTGACTTTCCTTTGTGTATATAATTTTGTTTCCTAAGTTGT
TGTGATTGCCTTATAAGAGAGAAGAATGATTATAGAAGGGTAATTACTAAAAATAAAAGAACCA
AAAAGTTACTTGTCAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005395498	(Get FASTA)	NCBI Sequence Viewer
	XP_013375210	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000012149
	ENSCLAP00000012149.1

RefSeq Acc Id:	XP_005395498 ⟸ XM_005395441
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2VCX9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMCDSKRLFLVALVSVLLLYFCSQSQAASSFDCCLGYTRHVLSIKYIRNFTEQLASEICDINAI IFHTHKRLSVCADPKKPWVKKIMRFLSQKDKK hide sequence

RefSeq Acc Id:	XP_013375210 ⟸ XM_013519756
- Peptide Label:	isoform X2
- Sequence:	show sequence MMCDSKRLFLVALVSVLLLYFCSQSQASSFDCCLGYTRHVLSIKYIRNFTEQLASEICDINAII FHTHKRLSVCADPKKPWVKKIMRFLSQKDKK hide sequence

Ensembl Acc Id:

ENSCLAP00000012149 ⟸ ENSCLAT00000012290

Protein Domains

Chemokine interleukin-8-like

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000008377	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000012290	ENTREZGENE
	ENSCLAT00000012290.1	UniProtKB/TrEMBL
Gene3D-CATH	2.40.50.40	UniProtKB/TrEMBL
InterPro	Chemokine_b/g/d	UniProtKB/TrEMBL
	Chemokine_CC_CS	UniProtKB/TrEMBL
	Chemokine_IL8-like_dom	UniProtKB/TrEMBL
	Interleukin_8-like_sf	UniProtKB/TrEMBL
NCBI Gene	Ccl20	ENTREZGENE
PANTHER	C-C MOTIF CHEMOKINE 20	UniProtKB/TrEMBL
	PTHR12015	UniProtKB/TrEMBL
Pfam	IL8	UniProtKB/TrEMBL
PRINTS	INTERLEUKIN8	UniProtKB/TrEMBL
PROSITE	SMALL_CYTOKINES_CC	UniProtKB/TrEMBL
SMART	SCY	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54117	UniProtKB/TrEMBL
UniProt	A0A8C2VCX9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Ccl20	C-C motif chemokine ligand 20		chemokine (C-C motif) ligand 20	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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