RGD Reference Report - [Expression of CCL20 and CXCR4 in epidermal condyloma acuminatum lesions]. - Rat Genome Database

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[Expression of CCL20 and CXCR4 in epidermal condyloma acuminatum lesions].

Authors: Feng, Jin-yun  Peng, Zhen-hui  Tang, Xiao-ping  Wang, Mei-ju  Liu, Yu-ping 
Citation: Feng JY, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2007 Apr;27(4):418-20.
RGD ID: 7483603
Pubmed: (View Article at PubMed) PMID:17545018


OBJECTIVE: To detect CCL20 and CXCR4 expressions in epidermis infected with condyloma acuminatum (CA) and normal epidermis and investigate the effect of their expressions on Langerhans cells in CA epidermis.
METHODS: Gene expression of CCL20 and CXCR4 in 3 epidermal CA lesions and in 3 normal epidermis specimens were detected using Affymetrix oligonucleotide microarrays HG-U 133A 2.0, and the protein levels of CCL20 and CXCR4 in these specimens were measured by Western blotting.
RESULTS: Microarray analysis revealed markedly down-regulated mRNA expressions of CCL20 and CXCR4 in the 3 epidermal CA lesions as compared with those in the normal specimens. Western blot analysis showed that the protein expressions of CCL20 and CXCR4 in the CA lesions were significantly lower than those in normal epidermis.
CONCLUSION: The protein and mRNA expressions of CCL20 and CXCR4 are markedly down-regulated in epidermal CA lesions, which may contribute to decreased number and backflow disturbance of Langerhans cells in these lesions.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Ccl20  (C-C motif chemokine ligand 20)

Genes (Mus musculus)
Ccl20  (chemokine (C-C motif) ligand 20)

Genes (Homo sapiens)
CCL20  (C-C motif chemokine ligand 20)


Additional Information