Klf1 (KLF transcription factor 1) - Rat Genome Database

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Gene: Klf1 (KLF transcription factor 1) Chinchilla lanigera
Analyze
Symbol: Klf1
Name: KLF transcription factor 1
RGD ID: 8971238
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN cellular response to endothelin (ortholog); chromatin remodeling (ortholog); embryonic hemopoiesis (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Aicardi-Goutieres Syndrome 4 (ortholog); alpha-mannosidosis (ortholog); FOUND IN chromatin (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Krueppel-like factor 1; Kruppel like factor 1; Kruppel-like factor 1 (erythroid)
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,939,873 - 31,943,545 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,939,994 - 31,943,539 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klf1Chinchillaacute myeloid leukemia disease_progressionISOKLF1 (Homo sapiens)9068941 RGDPMID:19097174 and REF_RGD_ID:10769344
Klf1Chinchillachromosome 5q deletion syndrome  ISOKLF1 (Homo sapiens)9068941mRNA:decreased expression:bone marrow and bloodRGDPMID:22965552 and REF_RGD_ID:10769343
Klf1ChinchillaDiamond-Blackfan anemia  ISOKLF1 (Homo sapiens)9068941mRNA:decreased expression:bone marrow and bloodRGDPMID:22965552 and REF_RGD_ID:10769343
Klf1Chinchillahereditary spherocytosis  ISOKlf1 (Mus musculus)9068941DNA:missense mutation:exon:p.E339D (1065A>T) (human)RGDPMID:20691777 and REF_RGD_ID:10769342
Klf1ChinchillaTherapy-related Acute Myeloid Leukemia  ISOKLF1 (Homo sapiens)9068941 RGDPMID:12417757 and REF_RGD_ID:10769345
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klf1ChinchillaAicardi-Goutieres Syndrome 4  ISOKLF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Aicardi-Goutieres syndrome 4ClinVarPMID:10371528 more ...
Klf1Chinchillaalpha-mannosidosis  ISOKLF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of alpha-mannosidaseClinVarPMID:28492532
Klf1ChinchillaCharcot-Marie-Tooth disease dominant intermediate B  ISOKLF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate BClinVarPMID:28492532
Klf1Chinchillacongenital dyserythropoietic anemia type IVa  ISOKLF1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11825066 more ...
Klf1Chinchillacongenital dyserythropoietic anemia type IVb  ISOKLF1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18487511 more ...
Klf1Chinchillaepisodic ataxia type 2  ISOKLF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Episodic ataxia type 2ClinVarPMID:10371528 more ...
Klf1Chinchillagenetic disease  ISOKLF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Klf1Chinchillaglutaric acidemia I  ISOKLF1 (Homo sapiens)8554872ClinVar Annotator: match by term: Glutaric aciduria and type 1ClinVarPMID:10371528 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klf1Chinchillacongenital dyserythropoietic anemia  ISOKLF1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTD 
Klf1Chinchillahematopoietic system disease  ISOKLF1 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:20676099
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klf1Chinchillabeta thalassemia  ISOKlf1 (Mus musculus)9068941OMIM:187550 more ...MouseDO 
Klf1Chinchillahereditary spherocytosis  ISOKlf1 (Mus musculus)9068941 MouseDO 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klf1Chinchillacongenital dyserythropoietic anemia type IVa  ISOKLF1 (Homo sapiens)7240710 OMIM 
Klf1Chinchillacongenital dyserythropoietic anemia type IVb  ISOKLF1 (Homo sapiens)7240710 OMIM 


Biological Process
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klf1Chinchillacellular response to endothelin  ISOKlf1 (Rattus norvegicus)9068941 RGDPMID:18406357 and REF_RGD_ID:2316543
Klf1Chinchillachromatin remodeling acts_upstream_of_or_withinISOKlf1 (Mus musculus)9068941 PMID:15489291MGIPMID:15489291
Klf1Chinchillaembryonic hemopoiesis acts_upstream_of_or_withinISOMGI:18611079068941 PMID:19409822MGIPMID:19409822
Klf1Chinchillaembryonic hemopoiesis acts_upstream_of_or_withinISOMGI:18575579068941 PMID:7753194MGIPMID:7753194
Klf1Chinchillaerythrocyte development acts_upstream_of_or_withinISOMGI:18571629068941 PMID:15923635MGIPMID:15923635
Klf1Chinchillaerythrocyte development acts_upstream_of_or_withinISOMGI:18575579068941 PMID:7753194MGIPMID:7753194
Klf1Chinchillaerythrocyte differentiation involved_inISOKLF1 (Homo sapiens)9068941 PMID:21055716UniProtPMID:21055716
Klf1Chinchillaerythrocyte differentiation involved_inISOKlf1 (Mus musculus)9068941 PMID:22835905MGIPMID:22835905
Klf1Chinchillaerythrocyte maturation acts_upstream_of_or_withinISOKlf1 (Mus musculus)9068941 PMID:7753195MGIPMID:7753195
Klf1Chinchillain utero embryonic development acts_upstream_of_or_withinISOMGI:18575579068941 PMID:7753194MGIPMID:7753194
Klf1Chinchillaliver development acts_upstream_of_or_withinISOMGI:18575579068941 PMID:7753194MGIPMID:7753194
Klf1Chinchillamaternal process involved in female pregnancy  ISOKlf1 (Rattus norvegicus)9068941 RGDPMID:18255020 and REF_RGD_ID:4144779
Klf1Chinchillapositive regulation of DNA-templated transcription involved_inISOKLF1 (Homo sapiens)9068941 PMID:15084587 more ...UniProtPMID:15084587 more ...
Klf1Chinchillapositive regulation of DNA-templated transcription involved_inISOKlf1 (Mus musculus)9068941 PMID:19251649BHF-UCLPMID:19251649
Klf1Chinchillapositive regulation of gene expression involved_inISOKlf1 (Mus musculus)9068941 PMID:22835905MGIPMID:22835905
Klf1Chinchillapositive regulation of transcription by RNA polymerase II involved_inISOKlf1 (Mus musculus)9068941 PMID:19251649BHF-UCLPMID:19251649
Klf1Chinchillapositive regulation of transcription by RNA polymerase II involved_inISOKlf1 (Mus musculus)9068941 PMID:17442339NTNU_SBPMID:17442339
Klf1Chinchillaprotein destabilization involved_inISOKLF1 (Homo sapiens)9068941 PMID:24139988DisProtPMID:24139988
Klf1Chinchillaregulation of DNA-templated transcription involved_inISOKLF1 (Homo sapiens)9068941 PMID:25585695UniProtPMID:25585695
Klf1Chinchillaubiquitin-dependent protein catabolic process involved_inISOKLF1 (Homo sapiens)9068941 PMID:24139988DisProtPMID:24139988
1 to 20 of 20 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klf1Chinchillachromatin located_inISOKLF1 (Homo sapiens)9068941 PMID:21539536BHF-UCLPMID:21539536
Klf1Chinchillanucleoplasm located_inISOKLF1 (Homo sapiens)9068941 HPAGO_REF:0000052
Klf1Chinchillanucleus located_inISOKLF1 (Homo sapiens)9068941 PMID:21055716 and PMID:25585695UniProtPMID:21055716 and PMID:25585695

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Klf1ChinchillaDNA binding enablesISOKlf1 (Mus musculus)9068941 PMID:22835905MGIPMID:22835905
Klf1ChinchillaDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOKlf1 (Mus musculus)9068941 PMID:17442339NTNU_SBPMID:17442339
Klf1ChinchillaDNA-binding transcription factor activity enablesISOKlf1 (Mus musculus)9068941 PMID:22835905MGIPMID:22835905
Klf1ChinchillaDNA-binding transcription factor binding enablesISOUniProtKB:Q165949068941 PMID:19251649BHF-UCLPMID:19251649
Klf1Chinchillaprotein binding enablesISOUniProtKB:P32776 more ...9068941 PMID:21670263IntActPMID:21670263
Klf1Chinchillaprotein binding enablesISOUniProtKB:Q165949068941 PMID:19251649IntActPMID:19251649
Klf1Chinchillaprotein binding enablesISOUniProtKB:A5D8V6 more ...9068941 PMID:32296183IntActPMID:32296183
Klf1Chinchillaprotein domain specific binding enablesISOUniProtKB:Q165949068941 PMID:19251649BHF-UCLPMID:19251649
Klf1ChinchillaRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOKLF1 (Homo sapiens)9068941 PMID:21539536BHF-UCLPMID:21539536
Klf1ChinchillaRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOKlf1 (Mus musculus)9068941 PMID:17442339NTNU_SBPMID:17442339
Klf1Chinchillatranscription cis-regulatory region binding enablesISOKLF1 (Homo sapiens)9068941 PMID:20676099UniProtPMID:20676099
Klf1Chinchillaubiquitin binding enablesISOKLF1 (Homo sapiens)9068941 PMID:24139988DisProtPMID:24139988
1 to 12 of 12 rows


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:30032202  



Klf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,939,873 - 31,943,545 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,939,994 - 31,943,539 (-)NCBIChiLan1.0ChiLan1.0
KLF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381912,884,422 - 12,887,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1912,884,422 - 12,887,201 (-)EnsemblGRCh38hg38GRCh38
GRCh371912,995,236 - 12,998,015 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,856,236 - 12,859,017 (-)NCBINCBI36Build 36hg18NCBI36
Build 341912,856,238 - 12,859,017NCBI
Celera1912,884,944 - 12,887,725 (-)NCBICelera
Cytogenetic Map19p13.13NCBI
HuRef1912,567,102 - 12,569,883 (-)NCBIHuRef
CHM1_11912,995,734 - 12,998,515 (-)NCBICHM1_1
T2T-CHM13v2.01913,008,871 - 13,011,650 (-)NCBIT2T-CHM13v2.0
Klf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,628,611 - 85,631,920 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,628,557 - 85,631,924 (+)EnsemblGRCm39 Ensembl
GRCm38884,901,982 - 84,905,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,901,928 - 84,905,295 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl884,901,928 - 84,905,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,425,827 - 87,429,194 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36887,792,033 - 87,795,396 (+)NCBIMGSCv36mm8
Celera889,201,315 - 89,204,684 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.3NCBI
Klf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81940,155,476 - 40,158,651 (-)NCBIGRCr8
mRatBN7.21923,250,627 - 23,253,802 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1923,250,631 - 23,253,758 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1930,073,549 - 30,076,720 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01930,727,909 - 30,731,080 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01932,950,597 - 32,953,768 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01926,016,289 - 26,019,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,016,382 - 26,019,553 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,991,935 - 36,995,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,906,887 - 24,910,058 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11924,912,048 - 24,914,837 (-)NCBI
Celera1922,807,529 - 22,810,700 (-)NCBICelera
Cytogenetic Map19q11NCBI
KLF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22017,813,004 - 17,816,281 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11916,813,599 - 16,816,877 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01912,446,130 - 12,449,238 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11913,188,652 - 13,191,425 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,188,652 - 13,191,425 (-)Ensemblpanpan1.1panPan2
KLF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12049,295,097 - 49,298,668 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2049,295,195 - 49,298,602 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2049,167,333 - 49,170,856 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02049,812,012 - 49,815,534 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2049,812,065 - 49,815,535 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12049,023,330 - 49,026,851 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02049,449,814 - 49,453,336 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02049,692,152 - 49,695,675 (+)NCBIUU_Cfam_GSD_1.0
Klf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118208,405,121 - 208,408,019 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366591,947,075 - 1,950,003 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366591,946,614 - 1,950,003 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,144,777 - 66,148,517 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,144,767 - 66,148,500 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,451,872 - 66,455,605 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1611,563,773 - 11,566,615 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl611,564,235 - 11,566,495 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660748,215,420 - 8,223,612 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624901468,662 - 471,500 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624901467,937 - 471,917 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000019481   ⟹   ENSCLAP00000019293
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541531,939,873 - 31,943,545 (-)Ensembl
RefSeq Acc Id: XM_005381037   ⟹   XP_005381094
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541531,939,994 - 31,943,539 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013512240   ⟹   XP_013367694
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541531,940,693 - 31,943,539 (-)NCBI
Sequence:
Protein RefSeqs XP_005381094 (Get FASTA)   NCBI Sequence Viewer  
  XP_013367694 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000019293
  ENSCLAP00000019293.1
RefSeq Acc Id: XP_005381094   ⟸   XM_005381037
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VT79 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013367694   ⟸   XM_013512240
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSCLAP00000019293   ⟸   ENSCLAT00000019481
C2H2-type



1 to 19 of 19 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000013218 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019481 ENTREZGENE
  ENSCLAT00000019481.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro EKLF_TAD1 UniProtKB/TrEMBL
  EKLF_TAD2 UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene Klf1 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 1 UniProtKB/TrEMBL
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/TrEMBL
Pfam EKLF_TAD1 UniProtKB/TrEMBL
  EKLF_TAD2 UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/TrEMBL
UniProt A0A8C2VT79 ENTREZGENE, UniProtKB/TrEMBL
1 to 19 of 19 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-12 Klf1  KLF transcription factor 1  Klf1  Kruppel like factor 1  Symbol and/or name change 5135510 APPROVED
2016-08-03 Klf1  Kruppel like factor 1    Kruppel-like factor 1 (erythroid)  Symbol and/or name change 5135510 APPROVED