Klf1 (Kruppel-like factor 1 (erythroid)) - Rat Genome Database
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Gene: Klf1 (Kruppel-like factor 1 (erythroid)) Mus musculus
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Symbol: Klf1
Name: Kruppel-like factor 1 (erythroid)
RGD ID: 1319724
MGI Page MGI
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and activating transcription factor binding activity. Involved in several processes, including hemopoiesis; liver development; and positive regulation of transcription by RNA polymerase II. Predicted to localize to nuclear chromatin and nucleoplasm. Is expressed in several structures, including extraembryonic component; hemolymphoid system; olfactory placode; testis; and urethra. Used to study beta thalassemia and hereditary spherocytosis. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia type IV. Orthologous to human KLF1 (Kruppel like factor 1); INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ekl; Eklf; erythroid krueppel-like transcription factor; erythroid transcription factor; Krueppel-like factor 1; Nan; neonatal anemia
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,628,611 - 85,631,920 (+)NCBIGRCm39mm39
GRCm38884,901,982 - 84,905,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,901,928 - 84,905,295 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl884,901,928 - 84,905,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,425,827 - 87,429,194 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,792,033 - 87,795,396 (+)NCBImm8
Celera889,201,315 - 89,204,684 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

References

Additional References at PubMed
PMID:7565748   PMID:7682653   PMID:7753194   PMID:7753195   PMID:8195185   PMID:8566749   PMID:8799165   PMID:8896981   PMID:8924208   PMID:9119377   PMID:9457687   PMID:9545245  
PMID:9603943   PMID:10349636   PMID:10366853   PMID:10430179   PMID:10688844   PMID:10773455   PMID:10903447   PMID:11042159   PMID:11069894   PMID:11076861   PMID:11217851   PMID:11566887  
PMID:11934854   PMID:12466851   PMID:12477932   PMID:14610273   PMID:14764531   PMID:15107403   PMID:15344908   PMID:15489291   PMID:15516974   PMID:15542849   PMID:15618518   PMID:15694345  
PMID:15820306   PMID:15847847   PMID:15923635   PMID:16141072   PMID:16141073   PMID:16380451   PMID:16606611   PMID:16617330   PMID:16705186   PMID:16728274   PMID:17242208   PMID:17283065  
PMID:17374603   PMID:17442339   PMID:17476283   PMID:17675555   PMID:17715392   PMID:17938210   PMID:18287559   PMID:18329016   PMID:18369441   PMID:18448565   PMID:18523154   PMID:18687676  
PMID:18710946   PMID:18800919   PMID:18852285   PMID:19251649   PMID:19409822   PMID:19457859   PMID:19704006   PMID:20010836   PMID:20059953   PMID:20368355   PMID:20508144   PMID:20676097  
PMID:20696915   PMID:20711979   PMID:20720183   PMID:21051695   PMID:21190291   PMID:21267068   PMID:21610079   PMID:21731673   PMID:21807894   PMID:21873635   PMID:21900194   PMID:22157820  
PMID:22260730   PMID:22357756   PMID:22566683   PMID:22711990   PMID:22835905   PMID:22933519   PMID:23056320   PMID:23190530   PMID:23285212   PMID:23361909   PMID:23530053   PMID:24576425  
PMID:24866116   PMID:24916507   PMID:25075100   PMID:25150253   PMID:25197097   PMID:25283745   PMID:25451176   PMID:25713074   PMID:25870109   PMID:25952549   PMID:25970251   PMID:26166573  
PMID:26303528   PMID:26527618   PMID:27480112   PMID:28143845   PMID:28180284   PMID:28432216   PMID:28541545   PMID:28600522   PMID:29230002   PMID:29898395   PMID:30143664   PMID:30921348  
PMID:31126231   PMID:31729420   PMID:31813828  


Genomics

Comparative Map Data
Klf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,628,611 - 85,631,920 (+)NCBIGRCm39mm39
GRCm38884,901,982 - 84,905,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,901,928 - 84,905,295 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl884,901,928 - 84,905,291 (+)EnsemblGRCm38mm10GRCm38
MGSCv37887,425,827 - 87,429,194 (+)NCBIGRCm37mm9NCBIm37
MGSCv36887,792,033 - 87,795,396 (+)NCBImm8
Celera889,201,315 - 89,204,684 (+)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.3NCBI
KLF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1912,884,422 - 12,887,201 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1912,884,422 - 12,887,199 (-)EnsemblGRCh38hg38GRCh38
GRCh381912,884,422 - 12,887,201 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371912,995,236 - 12,998,017 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361912,856,236 - 12,859,017 (-)NCBINCBI36hg18NCBI36
Build 341912,856,238 - 12,859,017NCBI
Celera1912,884,944 - 12,887,725 (-)NCBI
Cytogenetic Map19p13.13NCBI
HuRef1912,567,102 - 12,569,883 (-)NCBIHuRef
CHM1_11912,995,734 - 12,998,515 (-)NCBICHM1_1
Klf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01926,016,289 - 26,019,557 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1926,016,382 - 26,019,553 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01936,991,935 - 36,995,180 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41924,906,887 - 24,910,058 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11924,912,048 - 24,914,837 (-)NCBI
Celera1922,807,529 - 22,810,700 (-)NCBICelera
Cytogenetic Map19q11NCBI
Klf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541531,939,873 - 31,943,545 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541531,939,994 - 31,943,539 (-)NCBIChiLan1.0ChiLan1.0
KLF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11913,188,652 - 13,191,425 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1913,188,652 - 13,191,425 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01912,446,130 - 12,449,238 (-)NCBIMhudiblu_PPA_v0panPan3
KLF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2049,295,195 - 49,298,602 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12049,295,097 - 49,298,668 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Klf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366591,946,614 - 1,950,003 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl266,144,777 - 66,148,517 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1266,144,767 - 66,148,500 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2266,451,872 - 66,455,605 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLF1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl611,564,235 - 11,566,495 (-)Ensembl
ChlSab1.1611,563,773 - 11,566,615 (-)NCBI
Klf1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624901467,937 - 471,917 (-)NCBI

Position Markers
Klf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,902,651 - 84,902,782UniSTSGRCm38
MGSCv37887,427,248 - 87,428,894UniSTSGRCm37
MGSCv37887,427,240 - 87,428,860UniSTSGRCm37
Celera889,202,038 - 89,202,169UniSTS
Cytogenetic Map8C3UniSTS
cM Map838.6UniSTS
cM Map841.3UniSTS
UniSTS:224711  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,905,058 - 84,905,209UniSTSGRCm38
MGSCv37887,428,957 - 87,429,108UniSTSGRCm37
Celera889,204,447 - 89,204,598UniSTS
Cytogenetic Map8C3UniSTS
cM Map841.3UniSTS
Klf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,903,349 - 84,904,995UniSTSGRCm38
MGSCv37887,427,248 - 87,428,894UniSTSGRCm37
Celera889,202,736 - 89,204,384UniSTS
Cytogenetic Map8C3UniSTS
Klf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS
cM Map838.6UniSTS
Klf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38884,903,341 - 84,904,961UniSTSGRCm38
MGSCv37887,427,240 - 87,428,860UniSTSGRCm37
Celera889,202,728 - 89,204,350UniSTS
Cytogenetic Map8C3UniSTS
Klf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map8C3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse
1300920Pitm3_mprion incubation time 3 (mouse)Not determined873202495107202598Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
1558890Lith18_mlithogenic gene 18 (mouse)Not determined875675517109675623Mouse
1357470Obq16_mobesity QTL 16 (mouse)Not determined875685348109685497Mouse
1301808Nhdlq1_mnon-HDL QTL 1 (mouse)Not determined875685348109685497Mouse
1301874Hdlq16_mHDL QTL 16 (mouse)Not determined875685348109685497Mouse
10412234Nhdlq14_mnon-HDL QTL 14 (mouse)Not determined875685348109685497Mouse
1301099Cbm2_mcerebellum weight 2 (mouse)Not determined878518613112518703Mouse
1301581Char2_mP. chabaudi malaria resistance QTL 2 (mouse)Not determined879082178113082403Mouse
12904012Cfq10_mconditioned fear QTL 10 (mouse)88006677589014359Mouse
10755530Wbc2_mwhite blood cell count 2 (mouse)881092664115092664Mouse
10755519Wbc1_mwhite blood cell count 1 (mouse)881619151115619151Mouse
1301766Desp1_mdespair 1 (mouse)Not determined884759576118759741Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:121
Count of miRNA genes:108
Interacting mature miRNAs:116
Transcripts:ENSMUST00000067060
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000067060   ⟹   ENSMUSP00000064366
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,901,928 - 84,905,291 (+)Ensembl
RefSeq Acc Id: ENSMUST00000239392   ⟹   ENSMUSP00000159324
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl884,901,928 - 84,905,295 (+)Ensembl
RefSeq Acc Id: NM_010635   ⟹   NP_034765
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39885,628,611 - 85,631,920 (+)NCBI
GRCm38884,901,982 - 84,905,291 (+)NCBI
MGSCv37887,425,827 - 87,429,194 (+)RGD
Celera889,201,315 - 89,204,684 (+)RGD
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034765   ⟸   NM_010635
- Sequence:
RefSeq Acc Id: ENSMUSP00000159324   ⟸   ENSMUST00000239392
RefSeq Acc Id: ENSMUSP00000064366   ⟸   ENSMUST00000067060
Protein Domains
C2H2-type

Promoters
RGD ID:8667729
Promoter ID:EPDNEW_M11885
Type:multiple initiation site
Name:Klf1_1
Description:Mus musculus Kruppel-like factor 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38884,901,982 - 84,902,042EPDNEW
RGD ID:6843366
Promoter ID:MM_KWN:55105
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:NM_010635
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36887,425,586 - 87,426,086 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1342771 AgrOrtholog
Ensembl Genes ENSMUSG00000054191 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000064366 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000159324 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000067060 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000239392 UniProtKB/TrEMBL
InterPro EKLF_TAD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EKLF_TAD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16596 UniProtKB/TrEMBL
MGD MGI:1342771 ENTREZGENE
NCBI Gene 16596 ENTREZGENE
Pfam EKLF_TAD1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EKLF_TAD2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Klf1 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.4847 ENTREZGENE
UniProt A0A6I8MWY6_MOUSE UniProtKB/TrEMBL
  E9QNP6_MOUSE UniProtKB/TrEMBL
  KLF1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q1RME5_MOUSE UniProtKB/TrEMBL
  Q3TZ82_MOUSE UniProtKB/TrEMBL
UniProt Secondary O70261 UniProtKB/Swiss-Prot