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Gene: Klf1 (KLF transcription factor 1) Ictidomys tridecemlineatus

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Symbol:

Klf1

Name:

KLF transcription factor 1

RGD ID:

12464851

Description:

ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN cellular response to endothelin (ortholog); chromatin remodeling (ortholog); embryonic hemopoiesis (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); Aicardi-Goutieres Syndrome 4 (ortholog); alpha-mannosidosis (ortholog); FOUND IN chromatin (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

Krueppel-like factor 1; Kruppel like factor 1; Kruppel like factor 1, transcript variant X1; Kruppel like factor 1, transcript variant X2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	208,405,121 - 208,408,019 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	1,947,075 - 1,950,003 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936659	1,946,614 - 1,950,003 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Klf1	Squirrel	acute myeloid leukemia	disease_progression	ISO	KLF1 (Homo sapiens)	9068941		RGD	PMID:19097174 and REF_RGD_ID:10769344
Klf1	Squirrel	chromosome 5q deletion syndrome		ISO	KLF1 (Homo sapiens)	9068941	mRNA:decreased expression:bone marrow and blood	RGD	PMID:22965552 and REF_RGD_ID:10769343
Klf1	Squirrel	Diamond-Blackfan anemia		ISO	KLF1 (Homo sapiens)	9068941	mRNA:decreased expression:bone marrow and blood	RGD	PMID:22965552 and REF_RGD_ID:10769343
Klf1	Squirrel	hereditary spherocytosis		ISO	Klf1 (Mus musculus)	9068941	DNA:missense mutation:exon:p.E339D (1065A>T) (human)	RGD	PMID:20691777 and REF_RGD_ID:10769342
Klf1	Squirrel	Therapy-related Acute Myeloid Leukemia		ISO	KLF1 (Homo sapiens)	9068941		RGD	PMID:12417757 and REF_RGD_ID:10769345

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Klf1	Squirrel	Aicardi-Goutieres Syndrome 4		ISO	KLF1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Aicardi-Goutieres syndrome 4	ClinVar	PMID:10371528 more ...
Klf1	Squirrel	alpha-mannosidosis		ISO	KLF1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Deficiency of alpha-mannosidase	ClinVar	PMID:28492532
Klf1	Squirrel	Charcot-Marie-Tooth disease dominant intermediate B		ISO	KLF1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate B	ClinVar	PMID:28492532
Klf1	Squirrel	congenital dyserythropoietic anemia type IVa		ISO	KLF1 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:11825066 more ...
Klf1	Squirrel	congenital dyserythropoietic anemia type IVb		ISO	KLF1 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:18487511 more ...
Klf1	Squirrel	episodic ataxia type 2		ISO	KLF1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Episodic ataxia type 2	ClinVar	PMID:10371528 more ...
Klf1	Squirrel	genetic disease		ISO	KLF1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868 and PMID:28492532
Klf1	Squirrel	glutaric acidemia I		ISO	KLF1 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Glutaric aciduria and type 1	ClinVar	PMID:10371528 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Klf1	Squirrel	congenital dyserythropoietic anemia		ISO	KLF1 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD
Klf1	Squirrel	hematopoietic system disease		ISO	KLF1 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:20676099

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Klf1	Squirrel	beta thalassemia		ISO	Klf1 (Mus musculus)	9068941	OMIM:187550 more ...	MouseDO
Klf1	Squirrel	hereditary spherocytosis		ISO	Klf1 (Mus musculus)	9068941		MouseDO

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Klf1	Squirrel	congenital dyserythropoietic anemia type IVa		ISO	KLF1 (Homo sapiens)	7240710		OMIM
Klf1	Squirrel	congenital dyserythropoietic anemia type IVb		ISO	KLF1 (Homo sapiens)	7240710		OMIM

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Klf1	Squirrel	cellular response to endothelin		ISO	Klf1 (Rattus norvegicus)	9068941		RGD	PMID:18406357 and REF_RGD_ID:2316543
Klf1	Squirrel	chromatin remodeling	acts_upstream_of_or_within	ISO	Klf1 (Mus musculus)	9068941	PMID:15489291	MGI	PMID:15489291
Klf1	Squirrel	embryonic hemopoiesis	acts_upstream_of_or_within	ISO	MGI:1861107	9068941	PMID:19409822	MGI	PMID:19409822
Klf1	Squirrel	embryonic hemopoiesis	acts_upstream_of_or_within	ISO	MGI:1857557	9068941	PMID:7753194	MGI	PMID:7753194
Klf1	Squirrel	erythrocyte development	acts_upstream_of_or_within	ISO	MGI:1857557	9068941	PMID:7753194	MGI	PMID:7753194
Klf1	Squirrel	erythrocyte development	acts_upstream_of_or_within	ISO	MGI:1857162	9068941	PMID:15923635	MGI	PMID:15923635
Klf1	Squirrel	erythrocyte differentiation	involved_in	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107
Klf1	Squirrel	erythrocyte maturation	acts_upstream_of_or_within	ISO	Klf1 (Mus musculus)	9068941	PMID:7753195	MGI	PMID:7753195
Klf1	Squirrel	in utero embryonic development	acts_upstream_of_or_within	ISO	MGI:1857557	9068941	PMID:7753194	MGI	PMID:7753194
Klf1	Squirrel	liver development	acts_upstream_of_or_within	ISO	MGI:1857557	9068941	PMID:7753194	MGI	PMID:7753194
Klf1	Squirrel	maternal process involved in female pregnancy		ISO	Klf1 (Rattus norvegicus)	9068941		RGD	PMID:18255020 and REF_RGD_ID:4144779
Klf1	Squirrel	positive regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107
Klf1	Squirrel	positive regulation of gene expression	involved_in	ISO	Klf1 (Mus musculus)	9068941	PMID:22835905	MGI	PMID:22835905
Klf1	Squirrel	positive regulation of transcription by RNA polymerase II	involved_in	ISO	Klf1 (Mus musculus)	9068941	PMID:17442339	NTNU_SB	PMID:17442339
Klf1	Squirrel	positive regulation of transcription by RNA polymerase II	involved_in	ISO	Klf1 (Mus musculus)	9068941	PMID:19251649	BHF-UCL	PMID:19251649
Klf1	Squirrel	protein destabilization	involved_in	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107
Klf1	Squirrel	regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107
Klf1	Squirrel	regulation of transcription by RNA polymerase II	involved_in	IEA	PANTHER:PTN009066376	150520179		TreeGrafter	GO_REF:0000118
Klf1	Squirrel	ubiquitin-dependent protein catabolic process	involved_in	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Klf1	Squirrel	chromatin	located_in	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107
Klf1	Squirrel	nucleoplasm	located_in	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107
Klf1	Squirrel	nucleus	located_in	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107
Klf1	Squirrel	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	150520179		UniProt	GO_REF:0000044

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Klf1	Squirrel	DNA binding	enables	ISO	Klf1 (Mus musculus)	9068941	PMID:22835905	MGI	PMID:22835905
Klf1	Squirrel	DNA-binding transcription activator activity, RNA polymerase II-specific	enables	ISO	Klf1 (Mus musculus)	9068941	PMID:17442339	NTNU_SB	PMID:17442339
Klf1	Squirrel	DNA-binding transcription factor activity	enables	ISO	Klf1 (Mus musculus)	9068941	PMID:22835905	MGI	PMID:22835905
Klf1	Squirrel	DNA-binding transcription factor activity, RNA polymerase II-specific	enables	IEA	PANTHER:PTN009066376	150520179		TreeGrafter	GO_REF:0000118
Klf1	Squirrel	DNA-binding transcription factor binding	enables	ISO	UniProtKB:Q16594	9068941	PMID:19251649	BHF-UCL	PMID:19251649
Klf1	Squirrel	protein binding	enables	ISO	UniProtKB:P32776 more ...	9068941	PMID:21670263	IntAct	PMID:21670263
Klf1	Squirrel	protein binding	enables	ISO	UniProtKB:Q16594	9068941	PMID:19251649	IntAct	PMID:19251649
Klf1	Squirrel	protein binding	enables	ISO	UniProtKB:A5D8V6 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
Klf1	Squirrel	protein domain specific binding	enables	ISO	UniProtKB:Q16594	9068941	PMID:19251649	BHF-UCL	PMID:19251649
Klf1	Squirrel	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107
Klf1	Squirrel	RNA polymerase II cis-regulatory region sequence-specific DNA binding	enables	IEA	PANTHER:PTN009066376	150520179		TreeGrafter	GO_REF:0000118
Klf1	Squirrel	transcription cis-regulatory region binding	enables	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107
Klf1	Squirrel	ubiquitin binding	enables	IEA	UniProtKB:Q13351 and ensembl:ENSP00000264834	150520179		Ensembl	GO_REF:0000107
Klf1	Squirrel	zinc ion binding	enables	IEA	UniProtKB-KW:KW-0863	150520179		UniProt	GO_REF:0000043

PMID:30032202

Klf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	208,405,121 - 208,408,019 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936659	1,947,075 - 1,950,003 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936659	1,946,614 - 1,950,003 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KLF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	12,884,422 - 12,887,201 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	12,884,422 - 12,887,201 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	12,995,236 - 12,998,015 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	12,856,236 - 12,859,017 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	12,856,238 - 12,859,017	NCBI
Celera	19	12,884,944 - 12,887,725 (-)	NCBI		Celera
Cytogenetic Map	19	p13.13	NCBI
HuRef	19	12,567,102 - 12,569,883 (-)	NCBI		HuRef
CHM1_1	19	12,995,734 - 12,998,515 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	13,008,871 - 13,011,650 (-)	NCBI		T2T-CHM13v2.0

Klf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	85,628,611 - 85,631,920 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	85,628,557 - 85,631,924 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	84,901,982 - 84,905,291 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	84,901,928 - 84,905,295 (+)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	8	84,901,928 - 84,905,291 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	87,425,827 - 87,429,194 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	87,792,033 - 87,795,396 (+)	NCBI		MGSCv36	mm8
Celera	8	89,201,315 - 89,204,684 (+)	NCBI		Celera
Cytogenetic Map	8	C3	NCBI
cM Map	8	41.3	NCBI

Klf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	40,155,476 - 40,158,651 (-)	NCBI		GRCr8
mRatBN7.2	19	23,250,627 - 23,253,802 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	23,250,631 - 23,253,758 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	30,073,549 - 30,076,720 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	30,727,909 - 30,731,080 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	32,950,597 - 32,953,768 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	26,016,289 - 26,019,557 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	26,016,382 - 26,019,553 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	36,991,935 - 36,995,180 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	24,906,887 - 24,910,058 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	24,912,048 - 24,914,837 (-)	NCBI
Celera	19	22,807,529 - 22,810,700 (-)	NCBI		Celera
Cytogenetic Map	19	q11	NCBI

Klf1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955415	31,939,873 - 31,943,545 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955415	31,939,994 - 31,943,539 (-)	NCBI	ChiLan1.0	ChiLan1.0

KLF1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	17,813,004 - 17,816,281 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	16,813,599 - 16,816,877 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	12,446,130 - 12,449,238 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	13,188,652 - 13,191,425 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	13,188,652 - 13,191,425 (-)	Ensembl	panpan1.1		panPan2

KLF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	49,295,097 - 49,298,668 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	49,295,195 - 49,298,602 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	49,167,333 - 49,170,856 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	49,812,012 - 49,815,534 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	49,812,065 - 49,815,535 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	49,023,330 - 49,026,851 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	49,449,814 - 49,453,336 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	49,692,152 - 49,695,675 (+)	NCBI		UU_Cfam_GSD_1.0

KLF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	66,144,777 - 66,148,517 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	66,144,767 - 66,148,500 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	66,451,872 - 66,455,605 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KLF1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	11,563,773 - 11,566,615 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	11,564,235 - 11,566,495 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	8,215,420 - 8,223,612 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Klf1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624901	468,662 - 471,500 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624901	467,937 - 471,917 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_005336211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021733802	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000177	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000027334 ⟹ ENSSTOP00000017619

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936659	1,947,075 - 1,950,003 (-)	Ensembl

RefSeq Acc Id:

XM_021733802 ⟹ XP_021589477

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405118	208,405,121 - 208,408,019 (+)	NCBI
SpeTri2.0	NW_004936659	1,946,614 - 1,949,504 (-)	NCBI

Sequence:

show sequence

GATAAAGGAAGTCTTATCTTCTCTCTCCAGACAGACCTATGGACCTCTGTCTTTGGAGCTGAAGGAGAGTTAGGGGGGTAGTTTGGGGTATGACAGTCAGACAAGTCCCCTTTCAGAAGCCTCTGGCC
AGCCACTGTCCCTGGGTAAAGTACCCCTCGGTGTCTGCTCAAGTCTCAAGCTGTGCGCTCCCTCTCCAGTGGTGGCGTTCCGAGGAGGCACAGGACATGGGTCCAGGTCCCCCCGACCACACGGGGCC
ACCCCTTTACGTGGGCATGGAGTCGGAAGACCAGCCTAGGGAGAACGAGGACAATGAGAAGGACGCGGCCGCCGACTGGGACCTGAGTCTTTTGCTCACCAACTTTCCGGGCCCGGAGCCGGGCGGTG
AGCCCCGGACCTGTGCTCTGACGTCCAGTGAGGGCCCCGGGGCGCAGTTCCCACCGCCGCCTGAGACTCTGGGCCCGTATGCCGGCGGCTCGGAGTTTTCAGCTGGGCTCTTGGGCTCCGAGGAGCAG
GCAGGCTGGGTTCGCCCTGCCCAGGGGGCGACAGCTCCCAACCCCTTAGTGTCACCAGCCCTGGCCCCAGCCCCCGAGCCCAAGGCACTGCAGCTGCAGCCAGTGTACCCAGGGTCTGGTGCGGGCTC
CTCGGGTAGCTACTTCCCGCGGACCGGGTTTTCAGTGCCCGCGGCTCCGGGCGCCCCCTACGGGCTGCTATCGGGGTATCCCGCGCTGTACCCAGCGCCGCAGTATCAAGGGCACTTCCAGTTCTTCC
CCGGTCTCCCGGCGCCTTCGCCTGCCCCCGTCGCGACCCCATCCTATCTGAATTGCCTGGGACCCGGGACGGTGGGCACGGGACTCGGGGGCTCCGCAGGAGACTCAGGAGTAACTACAGACGTCGCT
CCATCTAAGCGCGGTCGGCGACCGTGGACGCACAAGAGGCAGGCTGCGCACACGTGCGCGCACCCGGGGTGCGGCAAGAGCTACACCAAGAGCTCCCACCTGAAGGCGCATCTGCGCACGCACACGGG
AGAGAAGCCATATGCCTGCTCGTGGGATGGCTGCGGCTGGAAGTTTGCACGCTCTGATGAGCTGACCCGTCACTTCCGGAAACACACAGGACTTCGTCCCTTCAGCTGCCAGTTCTGCCCGCGTGCTT
TTTCACGCTCCGACCACCTAGCCTTGCACATGAAGCGCCATCTTTAGGCCCTGCCCTGGTACTTGGATCTTGCCAGGAACTGGGGAATATAAAAAGTGGATCCATGCAGGGTTGTTTTCCCAAGGACA
GAGGACCCTTGTTTGGACTCCACAAATCCACGGAAAGATCAAGAACTGACACAGACAAACCTAGGGGAGTCTCCAACCAAAGGGAGCCACACAGAAATATCTAACAGTCACACAGACCCAGCGCAACA
GACCATCAAATAAATGGGACTCAGACCAGCTTGCAGGAAGCCCTGGACAGTGGGAGGTGGGTGGTGTGAGGTTTCCCAGAGACCCGGGGCCTGCAAAGGGGCTTCATGCCAATGCTCATGAACCTCCA
CATCAGTTGGGAATGGTTATGGGTCCTATAAAAATGCCCTTCCTATATAAAGCTTCCTCATTGACCTGACTGGATTATGAGTGTTGGAAGCTGGAAGGAAGTTGTACCACCAGAGGTGATATGA

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Protein RefSeqs	XP_021589477	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000017619.1
GenBank Protein	KAG3280198	(Get FASTA)	NCBI Sequence Viewer
	KAG3280199	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_021589477 ⟸ XM_021733802

- UniProtKB:

I3MZS3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTVRQVPFQKPLASHCPWVKYPSVSAQVSSCALPLQWWRSEEAQDMGPGPPDHTGPPLYVGMESEDQPRENEDNEKDAAADWDLSLLLTNFPGPEPGGEPRTCALTSSEGPGAQFPPPPETLGPYAGG
SEFSAGLLGSEEQAGWVRPAQGATAPNPLVSPALAPAPEPKALQLQPVYPGSGAGSSGSYFPRTGFSVPAAPGAPYGLLSGYPALYPAPQYQGHFQFFPGLPAPSPAPVATPSYLNCLGPGTVGTGLG
GSAGDSGVTTDVAPSKRGRRPWTHKRQAAHTCAHPGCGKSYTKSSHLKAHLRTHTGEKPYACSWDGCGWKFARSDELTRHFRKHTGLRPFSCQFCPRAFSRSDHLALHMKRHL

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Ensembl Acc Id:

ENSSTOP00000017619 ⟸ ENSSTOT00000027334

Protein Domains

C2H2-type

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000021956	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000027334.2	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	EKLF_TAD1	UniProtKB/TrEMBL
	EKLF_TAD2	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
NCBI Gene	Klf1	ENTREZGENE
PANTHER	KRUEPPEL-LIKE FACTOR 1	UniProtKB/TrEMBL
	KRUEPPEL-LIKE TRANSCRIPTION FACTOR	UniProtKB/TrEMBL
Pfam	EKLF_TAD1	UniProtKB/TrEMBL
	EKLF_TAD2	UniProtKB/TrEMBL
	zf-C2H2	UniProtKB/TrEMBL
PROSITE	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/TrEMBL
UniProt	I3MZS3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-07-12	Klf1	KLF transcription factor 1	Klf1	Kruppel like factor 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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