Scaf4 (SR-related CTD associated factor 4) - Rat Genome Database

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Gene: Scaf4 (SR-related CTD associated factor 4) Chinchilla lanigera
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Symbol: Scaf4
Name: SR-related CTD associated factor 4
RGD ID: 8954454
Description: ENCODES a protein that exhibits RNA binding (ortholog); RNA polymerase II C-terminal domain phosphoserine binding (ortholog); INVOLVED IN mRNA processing (ortholog); negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); autosomal dominant intellectual developmental disorder 7 (ortholog); developmental and epileptic encephalopathy 11 (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: splicing factor, arginine/serine-rich 15; SR-related CTD-associated factor 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540731,270,035 - 31,303,823 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540731,269,673 - 31,303,823 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Scaf4Chinchillaamyotrophic lateral sclerosis type 1  ISOSCAF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Amyotrophic lateral sclerosis type 1ClinVarPMID:16435343 more ...
Scaf4Chinchillaautosomal dominant intellectual developmental disorder 7  ISOSCAF4 (Homo sapiens)8554872ClinVar Annotator: match by term: DYRK1A-related intellectual disability syndromeClinVarPMID:17237124 more ...
Scaf4Chinchilladevelopmental and epileptic encephalopathy 11  ISOSCAF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Complex neurodevelopmental disorderClinVarPMID:25741868 and PMID:32730804
Scaf4ChinchillaFamilial Platelet Disorder with Associated Myeloid Malignancy  ISOSCAF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1ClinVarPMID:17237124 more ...
Scaf4ChinchillaFLIEDNER-ZWEIER SYNDROME  ISOSCAF4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Scaf4Chinchillagenetic disease  ISOSCAF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Scaf4Chinchillaimmunodeficiency 28  ISOSCAF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 28ClinVarPMID:17237124 more ...
Scaf4Chinchillaintellectual disability  ISOSCAF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868
Scaf4ChinchillaMulticystic Dysplastic Kidney  ISOSCAF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Multicystic dysplastic kidneyClinVar 
Scaf4Chinchillaneurodevelopmental disorder with dysmorphic facies and distal limb anomalies  ISOSCAF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesClinVarPMID:25741868
Scaf4ChinchillaNeurodevelopmental Disorders  ISOSCAF4 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:32730804
Scaf4ChinchillaParkinson's disease 20  ISOSCAF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Early-onset Parkinson disease 20ClinVarPMID:28492532
1 to 12 of 12 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Scaf4ChinchillaFLIEDNER-ZWEIER SYNDROME  ISOSCAF4 (Homo sapiens)7240710 OMIM 


Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Scaf4Chinchillanucleoplasm located_inISOSCAF4 (Homo sapiens)9068941 HPAGO_REF:0000052
Scaf4Chinchillanucleus located_inISOSCAF4 (Homo sapiens)9068941 PMID:31104839UniProtPMID:31104839

Molecular Function

  


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:22301074   PMID:30032202  



Scaf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540731,270,035 - 31,303,823 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540731,269,673 - 31,303,823 (-)NCBIChiLan1.0ChiLan1.0
SCAF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382131,671,000 - 31,732,118 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2131,671,000 - 31,732,118 (-)EnsemblGRCh38hg38GRCh38
GRCh372133,043,313 - 33,104,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,965,416 - 32,026,133 (-)NCBINCBI36Build 36hg18NCBI36
Celera2118,226,630 - 18,287,746 (-)NCBICelera
Cytogenetic Map21q22.11NCBI
HuRef2118,453,341 - 18,514,530 (-)NCBIHuRef
CHM1_12132,605,296 - 32,666,386 (-)NCBICHM1_1
T2T-CHM13v2.02130,038,984 - 30,100,110 (-)NCBIT2T-CHM13v2.0
Scaf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,021,504 - 90,082,074 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1690,022,568 - 90,081,391 (-)EnsemblGRCm39 Ensembl
GRCm381690,228,950 - 90,286,140 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1690,225,680 - 90,284,503 (-)EnsemblGRCm38mm10GRCm38
MGSCv371690,229,384 - 90,284,670 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361690,229,384 - 90,284,670 (-)NCBIMGSCv36mm8
Celera1690,424,774 - 90,479,985 (-)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.57NCBI
Scaf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,951,254 - 43,007,293 (-)NCBIGRCr8
mRatBN7.21129,460,479 - 29,521,153 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,465,106 - 29,521,153 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1138,153,091 - 38,209,037 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01130,824,482 - 30,880,426 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,013,841 - 30,069,810 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01130,371,713 - 30,428,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,371,713 - 30,428,073 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,987,199 - 34,047,580 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41129,751,872 - 29,807,911 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11129,751,869 - 29,807,911 (+)NCBI
Celera1129,152,167 - 29,208,170 (-)NCBICelera
Cytogenetic Map11q11NCBI
SCAF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22227,790,329 - 27,852,175 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12122,649,978 - 22,711,795 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02118,039,507 - 18,101,700 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12131,421,160 - 31,482,543 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2131,421,160 - 31,482,543 (-)Ensemblpanpan1.1panPan2
SCAF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13126,546,801 - 26,583,040 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3126,547,108 - 26,636,811 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3126,538,227 - 26,597,009 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03126,665,041 - 26,723,881 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3126,665,575 - 26,756,253 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13126,610,942 - 26,669,751 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03126,622,773 - 26,681,555 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03127,129,000 - 27,187,809 (-)NCBIUU_Cfam_GSD_1.0
Scaf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497127,123,792 - 27,168,322 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650010,307,835 - 10,342,588 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650010,307,868 - 10,342,952 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCAF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13195,333,260 - 195,396,204 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113195,335,178 - 195,396,246 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213205,632,094 - 205,690,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCAF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1260,397,173 - 60,459,295 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl260,397,233 - 60,458,553 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660712,938,854 - 3,002,480 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scaf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474520,040,770 - 20,097,835 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474520,040,416 - 20,097,764 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000009144   ⟹   ENSCLAP00000009016
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540731,270,035 - 31,303,823 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000009145   ⟹   ENSCLAP00000009017
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540731,270,035 - 31,303,811 (-)Ensembl
RefSeq Acc Id: XM_013504099   ⟹   XP_013359553
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540731,269,673 - 31,303,823 (-)NCBI
Sequence:
Protein RefSeqs XP_013359553 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000009016
  ENSCLAP00000009016.1
  ENSCLAP00000009017.1
RefSeq Acc Id: XP_013359553   ⟸   XM_013504099
- UniProtKB: A0A8C2V2V8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000009016   ⟸   ENSCLAT00000009144
Ensembl Acc Id: ENSCLAP00000009017   ⟸   ENSCLAT00000009145
CID   RRM



1 to 26 of 26 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000006298 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000009144 ENTREZGENE
  ENSCLAT00000009144.1 UniProtKB/TrEMBL
  ENSCLAT00000009145.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.90 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
InterPro CID_dom UniProtKB/TrEMBL
  ENTH_VHS UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  RRM_dom UniProtKB/TrEMBL
  SCAF4_RRM UniProtKB/TrEMBL
  SR-CTD_assoc_factor UniProtKB/TrEMBL
NCBI Gene Scaf4 ENTREZGENE
PANTHER RNA PROCESSING PROTEIN LD23810P UniProtKB/TrEMBL
  SR-RELATED AND CTD-ASSOCIATED FACTOR 4 UniProtKB/TrEMBL
Pfam CID UniProtKB/TrEMBL
  RRM_1 UniProtKB/TrEMBL
PROSITE CID UniProtKB/TrEMBL
  RRM UniProtKB/TrEMBL
SMART RPR UniProtKB/TrEMBL
  RRM UniProtKB/TrEMBL
Superfamily-SCOP SSF48464 UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
UniProt A0A8C2V2V8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2V5A4_CHILA UniProtKB/TrEMBL
1 to 26 of 26 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Scaf4  SR-related CTD associated factor 4    SR-related CTD-associated factor 4  Symbol and/or name change 5135510 APPROVED