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Gene: Slc9a6 (solute carrier family 9 member A6) Chinchilla lanigera

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Symbol:

Slc9a6

Name:

solute carrier family 9 member A6

RGD ID:

8855587

Description:

ENCODES a protein that exhibits identical protein binding (ortholog); potassium:proton antiporter activity (ortholog); sodium:proton antiporter activity (ortholog); INVOLVED IN axon extension (ortholog); brain-derived neurotrophic factor receptor signaling pathway (ortholog); dendrite extension (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; ASSOCIATED WITH astigmatism (ortholog); autistic disorder (ortholog); autosomal hemophilia A (ortholog); FOUND IN axon terminus (ortholog); axonal spine (ortholog); cytoplasmic vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

sodium/hydrogen exchanger 6; solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955489	9,019,425 - 9,078,705 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955489	9,020,719 - 9,078,375 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

astigmatism (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

Christianson syndrome (ISO)

Congenital Heart Defects, Multiple Types, 1, X-Linked (ISO)

Developmental Disabilities (ISO)

factor VIII deficiency (ISO)

genetic disease (ISO)

intellectual disability (ISO)

Neurodevelopmental Disorders (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked hyper IgM syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon extension (ISO)

brain-derived neurotrophic factor receptor signaling pathway (ISO)

dendrite extension (ISO)

dendritic spine development (ISO)

establishment of cell polarity (ISO)

glial cell activation (ISO)

neuron projection morphogenesis (ISO)

proton transmembrane transport (ISO)

regulation of intracellular pH (ISO)

regulation of neurotrophin TRK receptor signaling pathway (ISO)

regulation of postsynaptic membrane neurotransmitter receptor levels (ISO)

regulation of synaptic vesicle lumen acidification (ISO)

synapse organization (ISO)

Cellular Component

axon terminus (ISO)

axonal spine (ISO)

cytoplasmic vesicle (ISO)

dendrite (ISO)

early endosome (ISO)

early endosome membrane (ISO)

endoplasmic reticulum membrane (ISO)

endosome (ISO)

glutamatergic synapse (ISO)

intracellular membrane-bounded organelle (ISO)

late endosome (ISO)

mitochondrion (ISO)

plasma membrane (ISO)

presynapse (ISO)

recycling endosome (ISO)

recycling endosome membrane (ISO)

Schaffer collateral - CA1 synapse (ISO)

synapse (ISO)

Molecular Function

identical protein binding (ISO)

potassium:proton antiporter activity (ISO)

protein binding (ISO)

sodium:proton antiporter activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

angiotensin II signaling pathway via AT2 receptor (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Slc9a6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955489	9,019,425 - 9,078,705 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955489	9,020,719 - 9,078,375 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC9A6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	135,973,837 - 136,047,269 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	135,973,841 - 136,047,269 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	135,055,996 - 135,129,428 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	134,895,252 - 134,957,094 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	134,793,146 - 134,854,812	NCBI
Celera	X	135,428,360 - 135,490,286 (+)	NCBI		Celera
Cytogenetic Map	X	q26.3	NCBI
HuRef	X	124,341,164 - 124,403,216 (+)	NCBI		HuRef
CHM1_1	X	134,978,471 - 135,040,349 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	134,282,570 - 134,355,980 (+)	NCBI		T2T-CHM13v2.0

Slc9a6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	55,654,921 - 55,709,590 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	55,655,117 - 55,709,590 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	56,609,556 - 56,664,230 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	56,609,757 - 56,664,230 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	53,863,012 - 53,917,407 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	52,956,638 - 53,008,677 (+)	NCBI		MGSCv36	mm8
Celera	X	43,091,843 - 43,146,238 (+)	NCBI		Celera
Cytogenetic Map	X	A5- A6	NCBI
cM Map	X	30.06	NCBI

Slc9a6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	139,468,045 - 139,524,111 (+)	NCBI		GRCr8
mRatBN7.2	X	134,430,677 - 134,486,747 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	134,420,756 - 134,485,375 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	X	158,979,081 - 159,045,019 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	158,978,755 - 159,045,044 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	153,620,082 - 153,675,717 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	141,146,237 - 141,201,234 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	142,471,399 - 142,536,119 (+)	NCBI		Celera
Cytogenetic Map	X	q36	NCBI

SLC9A6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	135,398,673 - 135,460,202 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	135,402,314 - 135,463,798 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	125,099,378 - 125,171,161 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	135,378,091 - 135,439,781 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	135,378,094 - 135,439,781 (+)	Ensembl	panpan1.1		panPan2

SLC9A6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	106,408,789 - 106,465,504 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	106,398,850 - 106,463,252 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	92,228,868 - 92,285,695 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	108,385,561 - 108,442,397 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	108,375,657 - 108,440,140 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	105,522,975 - 105,586,115 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	107,706,620 - 107,763,439 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	107,355,362 - 107,412,198 (+)	NCBI		UU_Cfam_GSD_1.0

Slc9a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	104,399,038 - 104,455,882 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936513	11,158,730 - 11,215,568 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936513	11,158,609 - 11,215,477 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC9A6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	111,176,495 - 111,233,099 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	111,176,461 - 111,233,108 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	127,098,575 - 127,154,902 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC9A6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	110,997,985 - 111,060,164 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	110,998,281 - 111,060,252 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	48,664,039 - 48,725,734 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc9a6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624808	11,107,125 - 11,157,913 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005404600	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005404602	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01060025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBBH01035448	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000004577 ⟹ ENSCLAP00000004492

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955489	9,019,425 - 9,078,705 (-)	Ensembl

RefSeq Acc Id:

XM_005404600 ⟹ XP_005404657

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955489	9,020,719 - 9,078,301 (-)	NCBI

Sequence:

show sequence

GGAGGGGCAGGGGGTGGGGGGAGACATGGCTCGGCGCGGCTGGCGGCAAGCGCCCTTCCATCGC
GGTGTCGGTGTCGGCGTCGGCGTCGGCTTCGGCGTCGGGCCCCGAGCCCGGCCGCTCATGCGGC
CGCTCTGGTTGCTCCTCGCAGTGGGCGTCTTTGGCTGGGCCGGGGCTTCGGACGGCGCCGGCGG
AGCGGCGAGAGCCATGGACGAGGAGATCGTGTCCGAGAAGCAAGCGGAGGAGAGTCACCGGCAG
GACAGCGCCAATCTGCTCATCTTCATCCTGCTGCTCACCCTCACCATTCTCACGATCTGGCTCT
TCAAGCACCGGCGGGCCCGCTTCCTGCATGAGACCGGCCTGGCTATGATTTATGGTCTGTTGGT
GGGCCTTGTGCTTCGGTATGGCATTCATGTTCCAAGTGATGTAAATAATGTGACCCTGAGCTGC
GAAGTGCAGTCAAGTCCAACTACCCTGTTGGTAAATGTTAGTGGAAAATTTTATGAGTATACGC
TGAAAGGAGAGATTAGCTCACATGAACTCAATAATGTCCAAGATAATGAAATGCTTAGGAAGGT
TACTTTTGACCCAGAAGTATTTTTCAACATATTACTTCCTCCTATCATATTTTATGCAGGATAT
AGTCTGAAAAGGAGACATTTCTTCCGGAACCTTGGTTCTATCCTCGCATATGCTTTTCTTGGAA
CAGCTATTTCTTGTTTTGTTATTGGGTCGATAATGTACGGCTGTGTAACGCTGATGAAAGTAAC
TGGGCAACTCGCAGGAGATTTTTACTTTACAGATTGCCTGCTATTTGGTGCCATCGTATCAGCA
ACAGACCCAGTGACTGTTCTTGCCATATTCCACGAGCTGCAAGTTGATGTGGAGCTCTATGCAC
TTCTTTTTGGGGAAAGTGTCCTCAATGATGCTGTTGCCATAGTGCTGTCCTCCTCAATAGTAGC
ATATCAGCCTGCTGGAGACAACAGTCATACTTTCGATGTCACAGCCATGTTCAAGTCTATCGGA
ATCTTCCTTGGGATCTTCAGTGGATCTTTTGCAATGGGTGCTGCTACTGGGGTGGTGACAGCTT
TGGTGACAAAGTTCACCAAATTGCGAGAGTTCCAGTTGCTGGAGACGGGCTTATTTTTCCTGAT
GTCCTGGAGCACCTTCCTTTTGGCTGAAGCATGGGGCTTCACAGGTGTGGTTGCAGTACTGTTC
TGTGGCATCACGCAAGCACATTACACATACAATAATTTATCCACAGAGTCTCAGCATCGAACTA
AACAGTTGTTTGAGCTTCTCAATTTCTTGGCAGAGAATTTCATCTTCTCCTACATGGGCCTCAC
ACTCTTCACCTTCCAGAGCCATGTCTTTAACCTAACATTTATAATAGGCGCATTTATGGCTATT
TTCTTGGGAAGAGCTGCCAATATTTACCCCTTGTCTCTCTTGCTTAATTTGGGTAGAAGAAGTA
AGATTGGATCAAATTTTCAACATATGATGATGTTTGCTGGTCTTCGCGGTGCGATGGCATTTGC
CTTGGCCATTAGAGATACTGCCACCTATGCACGGCAAATGATGTTCAGTACCACACTGCTGATC
GTGTTTTTTACCGTGTGGGTATTTGGCGGGGGCACCACAGCCATGCTGTCGTGCTTGCATATAA
GGGTTGGTGTTGATTCAGACCAAGAACATTTGGGTGTTCCTGAAAATGAAAGGAGAACTACTAA
AGCAGAGAGTGCTTGGCTCTTCCGAATATGGTACAACTTCGATCATAACTACCTGAAGCCTCTG
CTGACGCACAGCGGGCCTCCCCTCACCACCACGCTCCCAGCCTGCTGCGGGCCCATTGCCAGGT
GCCTGACCAGCCCTCAGGCTTACGAAAACCAAGAGCAACTGAAAGATGATGACTCCGATCTGAT
TCTGAATGATGGAGATATCAGTTTGACGTACGGGGATTCTACTGTGAACACAGAGTCGGGACCG
TCCAGTGCCCCCAGGAGATTTATGGGCAACAGCTCTGAAGATGCCTTGGATCGGGAGCTTGCAT
TTGGAGACCATGAACTGGTCATTCGAGGGACGCGCCTGGTTCTTCCTATGGATGATTCTGAACC
CGCGTTAAATTCTTTAGATGATACGAGACACAGCCCAGCCTAAGCTTATTAATACTTAGTGATT
TGTATAATTTGCACATGTGATTGTGAAGAAATTTGTACTACCTAAAAAGTCCTAGTGCATGTCT
CTGAATGTGTAAGCTATATAAATGCTATTTATATGGCATCGAAAGAATAGAAATATCCTGTACA
AGGCAGATTGTGAGCAAACTCTTCTTTTAAGTTTTGATGGCCGCACTATGTAGGCTGGATCTGT
CTTAGAAAGTTACTTTCACAGTGATGTTGTGTGTTCTGTTAGCTTTATGTCTCAGTTGACGTAT
AAAAAGTGACAGAGTTACTCTTTCTTATATTTACCTGACACTTATCCAGAGTACCAAGTTCTTG
TGATGAGAATTAATTTGTGTGTGCGTATGTGCGTGTATATGTGTGCGCGCGTGTGTATGTGTGT
GTGCGCGGTGAGGGAGGGAGAGGGATGAGGGGATGTTATTTCCTAGGGAACCCAGGGAGGAGAG
GTTCCTTTGTCGGAAACGTCTGTTGATTGCTGCTGCCTTTGTCGTGACCTTTTTCTTTCCTTTT
CTCTTGTGGCCCACTGTGGTGCAAGGAACTGACAGCATTTTGATCTTCCCCATTCGGGTTGGAG
AGCAACATGCGGGGGCCTTTTCCCTCCTTGCTATGAAAGAACAGATTCACTGACCACCATATAT
TGCAGATCACCTCCAAGACCTTAGGGCTTTGCTTCCAGGCCAAGACTGTAGGAGTCGCATCCAG
CTGGCTTTGCCAAAGTACAGGTGTACAGAGTTCAGGGCACTTGATTTGCATTTGGAGGGCACTG
GGCAGGTGGAGAGGGGGCAGAGGGCAAGGAAGGAGTAAAGAGGATGGAGGAGTCGGCGGTCTCT
CTTCCCAAATATGTAAATATACCAGATAAGTTTAAATAAGAATCTAATTGCTGCTTAATTTTTG
ATCATGTACTTTATCTGTATAGCAAGCTTTGTTGTCAGAAGTTTTTATAATGATTTAAATTGCT
GCTCTTGAGCAGCCAGGCAGGAGCAAAATGTAAAATTTTTAAACTTCCTGTGTCATATTGTTAT
TTGTTAGCCTGTAGTAGATGTGAAAAGTTAATTTATGAATCCATGGTCATCCCATACTACACCA
AAGGCAGTCATAAGAGTAATATGCTCTGGAGCATTTATGGTGAGGTGGCTCCTTTGTGTGCACT
GGGGATAGTTGTCTTCATTGTCATGTTATTTTTAATATTAAATACCTGAGCTGCCATGTGAGTT
TTTATTTTTACAGTTTTCAAGGAAGAGCACAGAAAAAATTCCCATTTCATATTCATAGTATGCA
AGTGGAGTCTATTTTGTAATGCTGAAAATACCTAACGATGCGTTCAACACTTAGAAGAGAAATA
CTTTTTTTTTTTTGCCCTTTAGAGACAGCGTCTCGCTATGCAGTTCAGGCTGGCCCTGAGCTCA
CTTTG

hide sequence

RefSeq Acc Id:

XM_005404602 ⟹ XP_005404659

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955489	9,020,719 - 9,078,375 (-)	NCBI

Sequence:

show sequence

CGGCTTTCCTCTAGCCCCGCCTCTTCCCGTGAGCCCTTGGGGAGTGGTCTGACCGCGGGCGGCT
GCCGTGGGCGTCTTTGGCTGGGCCGGGGCTTCGGACGGCGCCGGCGGAGCGGCGAGAGCCATGG
ACGAGGAGATCGTGTCCGAGAAGCAAGCGGAGGAGAGTCACCGGCAGGACAGCGCCAATCTGCT
CATCTTCATCCTGCTGCTCACCCTCACCATTCTCACGATCTGGCTCTTCAAGCACCGGCGGGCC
CGCTTCCTGCATGAGACCGGCCTGGCTATGATTTATGGTCTGTTGGTGGGCCTTGTGCTTCGGT
ATGGCATTCATGTTCCAAGTGATGTAAATAATGTGACCCTGAGCTGCGAAGTGCAGTCAAGTCC
AACTACCCTGTTGGTAAATGTTAGTGGAAAATTTTATGAGTATACGCTGAAAGGAGAGATTAGC
TCACATGAACTCAATAATGTCCAAGATAATGAAATGCTTAGGAAGGTTACTTTTGACCCAGAAG
TATTTTTCAACATATTACTTCCTCCTATCATATTTTATGCAGGATATAGTCTGAAAAGGAGACA
TTTCTTCCGGAACCTTGGTTCTATCCTCGCATATGCTTTTCTTGGAACAGCTATTTCTTGTTTT
GTTATTGGGTCGATAATGTACGGCTGTGTAACGCTGATGAAAGTAACTGGGCAACTCGCAGGAG
ATTTTTACTTTACAGATTGCCTGCTATTTGGTGCCATCGTATCAGCAACAGACCCAGTGACTGT
TCTTGCCATATTCCACGAGCTGCAAGTTGATGTGGAGCTCTATGCACTTCTTTTTGGGGAAAGT
GTCCTCAATGATGCTGTTGCCATAGTGCTGTCCTCCTCAATAGTAGCATATCAGCCTGCTGGAG
ACAACAGTCATACTTTCGATGTCACAGCCATGTTCAAGTCTATCGGAATCTTCCTTGGGATCTT
CAGTGGATCTTTTGCAATGGGTGCTGCTACTGGGGTGGTGACAGCTTTGGTGACAAAGTTCACC
AAATTGCGAGAGTTCCAGTTGCTGGAGACGGGCTTATTTTTCCTGATGTCCTGGAGCACCTTCC
TTTTGGCTGAAGCATGGGGCTTCACAGGTGTGGTTGCAGTACTGTTCTGTGGCATCACGCAAGC
ACATTACACATACAATAATTTATCCACAGAGTCTCAGCATCGAACTAAACAGTTGTTTGAGCTT
CTCAATTTCTTGGCAGAGAATTTCATCTTCTCCTACATGGGCCTCACACTCTTCACCTTCCAGA
GCCATGTCTTTAACCTAACATTTATAATAGGCGCATTTATGGCTATTTTCTTGGGAAGAGCTGC
CAATATTTACCCCTTGTCTCTCTTGCTTAATTTGGGTAGAAGAAGTAAGATTGGATCAAATTTT
CAACATATGATGATGTTTGCTGGTCTTCGCGGTGCGATGGCATTTGCCTTGGCCATTAGAGATA
CTGCCACCTATGCACGGCAAATGATGTTCAGTACCACACTGCTGATCGTGTTTTTTACCGTGTG
GGTATTTGGCGGGGGCACCACAGCCATGCTGTCGTGCTTGCATATAAGGGTTGGTGTTGATTCA
GACCAAGAACATTTGGGTGTTCCTGAAAATGAAAGGAGAACTACTAAAGCAGAGAGTGCTTGGC
TCTTCCGAATATGGTACAACTTCGATCATAACTACCTGAAGCCTCTGCTGACGCACAGCGGGCC
TCCCCTCACCACCACGCTCCCAGCCTGCTGCGGGCCCATTGCCAGGTGCCTGACCAGCCCTCAG
GCTTACGAAAACCAAGAGCAACTGAAAGATGATGACTCCGATCTGATTCTGAATGATGGAGATA
TCAGTTTGACGTACGGGGATTCTACTGTGAACACAGAGTCGGGACCGTCCAGTGCCCCCAGGAG
ATTTATGGGCAACAGCTCTGAAGATGCCTTGGATCGGGAGCTTGCATTTGGAGACCATGAACTG
GTCATTCGAGGGACGCGCCTGGTTCTTCCTATGGATGATTCTGAACCCGCGTTAAATTCTTTAG
ATGATACGAGACACAGCCCAGCCTAAGCTTATTAATACTTAGTGATTTGTATAATTTGCACATG
TGATTGTGAAGAAATTTGTACTACCTAAAAAGTCCTAGTGCATGTCTCTGAATGTGTAAGCTAT
ATAAATGCTATTTATATGGCATCGAAAGAATAGAAATATCCTGTACAAGGCAGATTGTGAGCAA
ACTCTTCTTTTAAGTTTTGATGGCCGCACTATGTAGGCTGGATCTGTCTTAGAAAGTTACTTTC
ACAGTGATGTTGTGTGTTCTGTTAGCTTTATGTCTCAGTTGACGTATAAAAAGTGACAGAGTTA
CTCTTTCTTATATTTACCTGACACTTATCCAGAGTACCAAGTTCTTGTGATGAGAATTAATTTG
TGTGTGCGTATGTGCGTGTATATGTGTGCGCGCGTGTGTATGTGTGTGTGCGCGGTGAGGGAGG
GAGAGGGATGAGGGGATGTTATTTCCTAGGGAACCCAGGGAGGAGAGGTTCCTTTGTCGGAAAC
GTCTGTTGATTGCTGCTGCCTTTGTCGTGACCTTTTTCTTTCCTTTTCTCTTGTGGCCCACTGT
GGTGCAAGGAACTGACAGCATTTTGATCTTCCCCATTCGGGTTGGAGAGCAACATGCGGGGGCC
TTTTCCCTCCTTGCTATGAAAGAACAGATTCACTGACCACCATATATTGCAGATCACCTCCAAG
ACCTTAGGGCTTTGCTTCCAGGCCAAGACTGTAGGAGTCGCATCCAGCTGGCTTTGCCAAAGTA
CAGGTGTACAGAGTTCAGGGCACTTGATTTGCATTTGGAGGGCACTGGGCAGGTGGAGAGGGGG
CAGAGGGCAAGGAAGGAGTAAAGAGGATGGAGGAGTCGGCGGTCTCTCTTCCCAAATATGTAAA
TATACCAGATAAGTTTAAATAAGAATCTAATTGCTGCTTAATTTTTGATCATGTACTTTATCTG
TATAGCAAGCTTTGTTGTCAGAAGTTTTTATAATGATTTAAATTGCTGCTCTTGAGCAGCCAGG
CAGGAGCAAAATGTAAAATTTTTAAACTTCCTGTGTCATATTGTTATTTGTTAGCCTGTAGTAG
ATGTGAAAAGTTAATTTATGAATCCATGGTCATCCCATACTACACCAAAGGCAGTCATAAGAGT
AATATGCTCTGGAGCATTTATGGTGAGGTGGCTCCTTTGTGTGCACTGGGGATAGTTGTCTTCA
TTGTCATGTTATTTTTAATATTAAATACCTGAGCTGCCATGTGAGTTTTTATTTTTACAGTTTT
CAAGGAAGAGCACAGAAAAAATTCCCATTTCATATTCATAGTATGCAAGTGGAGTCTATTTTGT
AATGCTGAAAATACCTAACGATGCGTTCAACACTTAGAAGAGAAATACTTTTTTTTTTTTGCCC
TTTAGAGACAGCGTCTCGCTATGCAGTTCAGGCTGGCCCTGAGCTCACTTTG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005404657	(Get FASTA)	NCBI Sequence Viewer
	XP_005404659	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000004492
	ENSCLAP00000004492.1

RefSeq Acc Id:

XP_005404659 ⟸ XM_005404602

- Peptide Label:

isoform X2

- Sequence:

show sequence

MDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVL
RYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYTLKGEISSHELNNVQDNEMLRKVTFDP
EVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLA
GDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPA
GDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWST
FLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTF
QSHVFNLTFIIGAFMAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIR
DTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESA
WLFRIWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDG
DISLTYGDSTVNTESGPSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPALNS
LDDTRHSPA

hide sequence

RefSeq Acc Id:	XP_005404657 ⟸ XM_005404600
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C2UWX9 (UniProtKB/TrEMBL)
- Sequence:	show sequence MARRGWRQAPFHRGVGVGVGVGFGVGPRARPLMRPLWLLLAVGVFGWAGASDGAGGAARAMDEE IVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGI HVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYTLKGEISSHELNNVQDNEMLRKVTFDPEVFF NILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFY FTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNS HTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLA EAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQSHV FNLTFIIGAFMAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTAT YARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPENERRTTKAESAWLFR IWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISL TYGDSTVNTESGPSSAPRRFMGNSSEDALDRELAFGDHELVIRGTRLVLPMDDSEPALNSLDDT RHSPA hide sequence

Ensembl Acc Id:

ENSCLAP00000004492 ⟸ ENSCLAT00000004577

Protein Domains

Cation/H+ exchanger

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003196	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000004577	ENTREZGENE
	ENSCLAT00000004577.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.140.1330	UniProtKB/TrEMBL
InterPro	Cation/H_exchanger	UniProtKB/TrEMBL
	Cation/H_exchanger_CPA1	UniProtKB/TrEMBL
	NaH_exchanger	UniProtKB/TrEMBL
	NHE6_7_9	UniProtKB/TrEMBL
NCBI Gene	Slc9a6	ENTREZGENE
PANTHER	PTHR10110	UniProtKB/TrEMBL
	SODIUM/HYDROGEN EXCHANGER 6	UniProtKB/TrEMBL
Pfam	Na_H_Exchanger	UniProtKB/TrEMBL
PRINTS	NAHEXCHNGR	UniProtKB/TrEMBL
	NAHEXCHNGR6	UniProtKB/TrEMBL
UniProt	A0A8C2UWX9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Slc9a6	solute carrier family 9 member A6		solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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