Gne (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) - Rat Genome Database

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Gene: Gne (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) Chinchilla lanigera
Analyze
Symbol: Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
RGD ID: 8847849
Description: ENCODES a protein that exhibits N-acylmannosamine kinase activity (ortholog); UDP-N-acetylglucosamine 2-epimerase activity (ortholog); INVOLVED IN CMP-N-acetylneuraminate biosynthetic process (ortholog); glycosylation (ortholog); N-acetylneuraminate biosynthetic process (ortholog); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547245,926 - 97,082 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547256,623 - 92,553 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 26 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GneChinchillaacromesomelic dysplasia, Maroteaux type  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Acromesomelic dysplasia 1 and Maroteaux typeClinVarPMID:28492532
GneChinchillaanauxetic dysplasia  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Anauxetic dysplasiaClinVarPMID:28492532
GneChinchillaautosomal recessive distal hereditary motor neuronopathy 2  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal recessive distal spinal muscular atrophy 2ClinVarPMID:28492532
GneChinchilladistal arthrogryposis type 1A  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Arthrogryposis more ...ClinVarPMID:28492532
GneChinchilladistal myopathy with rimmed vacuoles  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: MYOPATHY more ...ClinVarPMID:11528398 more ...
GneChinchillaFrench Type Sialuria  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Sialuria and French typeClinVarPMID:11528398 more ...
GneChinchillafrontotemporal dementia and/or amyotrophic lateral sclerosis 6  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Frontotemporal dementia and/or amyotrophic lateral sclerosis 6ClinVarPMID:28492532
GneChinchillagalactosemia  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Deficiency of UDPglucose-hexose-1-phosphate uridylyltransferaseClinVarPMID:28492532
GneChinchillagenetic disease  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10330343 more ...
GneChinchillaGNE myopathy  ISOGNE (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10330343 more ...
GneChinchillahyperphosphatasia with impaired intellectual development syndrome 2  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 6ClinVarPMID:22683086 more ...
GneChinchillainclusion body myositis  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Inclusion body myositisClinVarPMID:25741868
GneChinchillaLynch syndrome  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary nonpolyposis colon cancerClinVarPMID:11528398 more ...
GneChinchillaparaplegia  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegiaClinVarPMID:23332916 more ...
GneChinchillaprimary ciliary dyskinesia  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesiaClinVarPMID:28492532
GneChinchillasialuria  ISOGNE (Homo sapiens)8554872ClinVar Annotator: match by term: SialuriaClinVarPMID:10330343 more ...
GneChinchillasialuria  ISOGNE (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10330343 more ...
GneChinchillasialuria  ISOGNE (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10330343 more ...
GneChinchillasialuria  ISOGNE (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10330343 more ...
GneChinchillasialuria  ISOGNE (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10330343 more ...
1 to 20 of 26 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GneChinchillaGNE myopathy  ISOGNE (Homo sapiens)7240710 OMIM 
GneChinchillasialuria  ISOGNE (Homo sapiens)7240710 OMIM 
GneChinchillaThrombocytopenia 12  ISOGNE (Homo sapiens)7240710 OMIM 


Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GneChinchillacytosol is_active_inISOGne (Rattus norvegicus)9068941PMID:9305888UniProtPMID:9305888 and REF_RGD_ID:68786
GneChinchillacytosol is_active_inISOGne (Mus musculus)9068941 PMID:10745088MGIPMID:10745088
GneChinchillacytosol is_active_inISOGne (Rattus norvegicus)9068941PMID:9305887UniProtPMID:9305887 and REF_RGD_ID:401901241

Molecular Function
1 to 20 of 20 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GneChinchillaN-acylmannosamine kinase activity  ISOGne (Rattus norvegicus)9068941 RGDPMID:9305888 and REF_RGD_ID:68786
GneChinchillaN-acylmannosamine kinase activity enablesISOMGI:76118369068941 PMID:38237079MGIPMID:38237079
GneChinchillaN-acylmannosamine kinase activity enablesISOGNE (Homo sapiens)9068941 PMID:14707127UniProtPMID:14707127
GneChinchillaN-acylmannosamine kinase activity enablesISOGne (Rattus norvegicus)9068941PMID:9305887UniProtPMID:9305887 and REF_RGD_ID:401901241
GneChinchillaN-acylmannosamine kinase activity enablesISOGne (Rattus norvegicus)9068941PMID:10497249UniProtPMID:10497249 and REF_RGD_ID:401901233
GneChinchillaprotein binding enablesISOUniProtKB:A8MQ03 more ...9068941 PMID:32296183IntActPMID:32296183
GneChinchillaprotein binding enablesISOUniProtKB:O43597 more ...9068941 PMID:25416956IntActPMID:25416956
GneChinchillaprotein binding enablesISOUniProtKB:Q7Z3S99068941 PMID:31515488IntActPMID:31515488
GneChinchillaprotein binding enablesISOUniProtKB:O76024 and UniProtKB:P287999068941 PMID:32814053IntActPMID:32814053
GneChinchillaprotein binding enablesISOUniProtKB:Q055169068941PMID:17118363IntActPMID:17118363 and REF_RGD_ID:8554691
GneChinchillaprotein binding enablesISOUniProtKB:P128149068941 PMID:18560563IntActPMID:18560563
GneChinchillaUDP-N-acetylglucosamine 2-epimerase activity  ISOGne (Rattus norvegicus)9068941 RGDPMID:9305888 and REF_RGD_ID:68786
GneChinchillaUDP-N-acetylglucosamine 2-epimerase activity enablesISOGne (Mus musculus)9068941 PMID:11929971UniProtPMID:11929971
GneChinchillaUDP-N-acetylglucosamine 2-epimerase activity enablesISOMGI:37137999068941 PMID:17549255MGIPMID:17549255
GneChinchillaUDP-N-acetylglucosamine 2-epimerase activity enablesISOGne (Rattus norvegicus)9068941PMID:10497249UniProtPMID:10497249 and REF_RGD_ID:401901233
GneChinchillaUDP-N-acetylglucosamine 2-epimerase activity enablesISOGNE (Homo sapiens)9068941 PMID:26980148 and PMID:2808337UniProtPMID:26980148 and PMID:2808337
GneChinchillaUDP-N-acetylglucosamine 2-epimerase activity enablesISOGNE (Homo sapiens)9068941 PMID:14707127UniProtPMID:14707127
GneChinchillaUDP-N-acetylglucosamine 2-epimerase activity enablesISOGne (Mus musculus)9068941 PMID:10745088UniProtPMID:10745088
GneChinchillaUDP-N-acetylglucosamine 2-epimerase activity enablesISOGne (Rattus norvegicus)9068941PMID:10334995UniProtPMID:10334995 and REF_RGD_ID:401901215
GneChinchillaUDP-N-acetylglucosamine 2-epimerase activity enablesISOGne (Rattus norvegicus)9068941PMID:9305887UniProtPMID:9305887 and REF_RGD_ID:401901241
1 to 20 of 20 rows

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GneChinchillaamino sugar metabolic pathway  ISOGNE (Homo sapiens)9068941 SMPDBSMP:00045
GneChinchillafrench type sialuria pathway  ISOGNE (Homo sapiens)9068941 SMPDBSMP:00216 and SMP:00217
GneChinchillasialic acid storage disease pathway  ISOGNE (Homo sapiens)9068941 SMPDBSMP:00240
GneChinchillaTay-Sachs disease pathway  ISOGNE (Homo sapiens)9068941 SMPDBSMP:00390

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Gne
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547245,926 - 97,082 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547256,623 - 92,553 (+)NCBIChiLan1.0ChiLan1.0
GNE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38936,214,441 - 36,276,978 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl936,214,441 - 36,277,042 (-)EnsemblGRCh38hg38GRCh38
GRCh37936,214,438 - 36,276,975 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36936,204,438 - 36,248,401 (-)NCBINCBI36Build 36hg18NCBI36
Build 34936,204,440 - 36,248,401NCBI
Celera936,148,023 - 36,210,614 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef936,168,432 - 36,230,185 (-)NCBIHuRef
CHM1_1936,214,844 - 36,277,494 (-)NCBICHM1_1
T2T-CHM13v2.0936,236,447 - 36,298,980 (-)NCBIT2T-CHM13v2.0
Gne
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39444,034,075 - 44,084,177 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl444,034,075 - 44,084,177 (-)EnsemblGRCm39 Ensembl
GRCm38444,034,075 - 44,084,177 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl444,034,075 - 44,084,177 (-)EnsemblGRCm38mm10GRCm38
MGSCv37444,046,947 - 44,097,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36444,057,926 - 44,105,266 (-)NCBIMGSCv36mm8
Celera444,055,271 - 44,105,902 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map423.1NCBI
Gne
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8563,062,953 - 63,103,320 (-)NCBIGRCr8
mRatBN7.2558,267,189 - 58,307,396 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl558,267,210 - 58,307,499 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx560,248,992 - 60,279,247 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0562,067,800 - 62,098,053 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0562,037,233 - 62,067,502 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,511,738 - 59,553,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,512,872 - 59,553,416 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0564,034,863 - 64,075,144 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,506,171 - 60,536,403 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,506,350 - 60,536,582 (-)NCBI
Celera556,845,530 - 56,875,714 (-)NCBICelera
Cytogenetic Map5q22NCBI
GNE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,331,427 - 88,375,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,337,369 - 88,381,103 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0936,064,128 - 36,107,822 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,867,094 - 36,908,212 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,867,096 - 36,926,588 (-)Ensemblpanpan1.1panPan2
GNE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,688,295 - 52,731,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,689,343 - 52,731,231 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1151,278,943 - 51,322,087 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,794,650 - 53,837,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,794,653 - 53,837,619 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11152,297,479 - 52,340,394 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01152,319,509 - 52,362,669 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01153,021,057 - 53,064,247 (-)NCBIUU_Cfam_GSD_1.0
Gne
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,637,251 - 167,686,478 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365244,196,830 - 4,252,163 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365244,184,831 - 4,234,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,998,757 - 237,065,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,998,754 - 237,065,819 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GNE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,300,321 - 44,340,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,282,809 - 44,344,311 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,390,535 - 41,432,094 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gne
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,361,752 - 4,417,604 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248684,362,144 - 4,417,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000002073   ⟹   ENSCLAP00000002028
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495547245,926 - 97,082 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000002074   ⟹   ENSCLAP00000002029
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495547260,286 - 92,473 (+)Ensembl
RefSeq Acc Id: XM_005400982   ⟹   XP_005401039
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495547256,623 - 92,553 (+)NCBI
Sequence:
Protein RefSeqs XP_005401039 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000002028
  ENSCLAP00000002028.1
  ENSCLAP00000002029.1
RefSeq Acc Id: XP_005401039   ⟸   XM_005400982
- UniProtKB: A0A8C2URA7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000002029   ⟸   ENSCLAT00000002074
Ensembl Acc Id: ENSCLAP00000002028   ⟸   ENSCLAT00000002073


1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000001475 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002073 ENTREZGENE
  ENSCLAT00000002073.1 UniProtKB/TrEMBL
  ENSCLAT00000002074.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
  Glycogen Phosphorylase B UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  ROK UniProtKB/TrEMBL
  ROK_cs UniProtKB/TrEMBL
  UDP-GlcNAc_Epase UniProtKB/TrEMBL
  UDP_GlcNAc_Epimerase_2_dom UniProtKB/TrEMBL
NCBI Gene Gne ENTREZGENE
PANTHER BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE UniProtKB/TrEMBL
  PTHR18964 UniProtKB/TrEMBL
Pfam Epimerase_2 UniProtKB/TrEMBL
  ROK UniProtKB/TrEMBL
PRINTS HEXOKINASE UniProtKB/TrEMBL
PROSITE ROK UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
  UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/TrEMBL
UniProt A0A8C2UKR7_CHILA UniProtKB/TrEMBL
  A0A8C2URA7 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows