Gne (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) - Rat Genome Database

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Gene: Gne (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) Ictidomys tridecemlineatus
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Symbol: Gne
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
RGD ID: 12557416
Description: ENCODES a protein that exhibits N-acylmannosamine kinase activity (ortholog); UDP-N-acetylglucosamine 2-epimerase activity (ortholog); INVOLVED IN N-acetylneuraminate metabolic process (ortholog); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, transcript variant X1; glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase, transcript variant X2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,637,251 - 167,686,478 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365244,196,830 - 4,252,163 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365244,184,831 - 4,234,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gne
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,637,251 - 167,686,478 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365244,196,830 - 4,252,163 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365244,184,831 - 4,234,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38936,214,441 - 36,276,978 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl936,214,441 - 36,277,042 (-)EnsemblGRCh38hg38GRCh38
GRCh37936,214,438 - 36,276,975 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36936,204,438 - 36,248,401 (-)NCBINCBI36Build 36hg18NCBI36
Build 34936,204,440 - 36,248,401NCBI
Celera936,148,023 - 36,210,614 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef936,168,432 - 36,230,185 (-)NCBIHuRef
CHM1_1936,214,844 - 36,277,494 (-)NCBICHM1_1
T2T-CHM13v2.0936,236,447 - 36,298,980 (-)NCBIT2T-CHM13v2.0
Gne
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39444,034,075 - 44,084,177 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl444,034,075 - 44,084,177 (-)EnsemblGRCm39 Ensembl
GRCm38444,034,075 - 44,084,177 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl444,034,075 - 44,084,177 (-)EnsemblGRCm38mm10GRCm38
MGSCv37444,046,947 - 44,097,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36444,057,926 - 44,105,266 (-)NCBIMGSCv36mm8
Celera444,055,271 - 44,105,902 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map423.1NCBI
Gne
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8563,062,953 - 63,103,320 (-)NCBIGRCr8
mRatBN7.2558,267,189 - 58,307,396 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl558,267,210 - 58,307,499 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx560,248,992 - 60,279,247 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0562,067,800 - 62,098,053 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0562,037,233 - 62,067,502 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,511,738 - 59,553,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,512,872 - 59,553,416 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0564,034,863 - 64,075,144 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,506,171 - 60,536,403 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,506,350 - 60,536,582 (-)NCBI
Celera556,845,530 - 56,875,714 (-)NCBICelera
Cytogenetic Map5q22NCBI
Gne
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547245,926 - 97,082 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547256,623 - 92,553 (+)NCBIChiLan1.0ChiLan1.0
GNE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,331,427 - 88,375,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,337,369 - 88,381,103 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0936,064,128 - 36,107,822 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,867,094 - 36,908,212 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,867,096 - 36,926,588 (-)Ensemblpanpan1.1panPan2
GNE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,688,295 - 52,731,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,689,343 - 52,731,231 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1151,278,943 - 51,322,087 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,794,650 - 53,837,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,794,653 - 53,837,619 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11152,297,479 - 52,340,394 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01152,319,509 - 52,362,669 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01153,021,057 - 53,064,247 (-)NCBIUU_Cfam_GSD_1.0
GNE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,998,757 - 237,065,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,998,754 - 237,065,819 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GNE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,300,321 - 44,340,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,282,809 - 44,344,311 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,390,535 - 41,432,094 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gne
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,361,752 - 4,417,604 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248684,362,144 - 4,417,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000005056   ⟹   ENSSTOP00000004536
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365244,197,444 - 4,229,325 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000034624   ⟹   ENSSTOP00000027956
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365244,197,444 - 4,252,163 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000037700   ⟹   ENSSTOP00000026467
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365244,196,830 - 4,234,618 (-)Ensembl
RefSeq Acc Id: XM_013359058   ⟹   XP_013214512
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947167,647,221 - 167,686,474 (-)NCBI
SpeTri2.0NW_0049365244,196,820 - 4,234,248 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021726985   ⟹   XP_021582660
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947167,637,251 - 167,686,478 (-)NCBI
SpeTri2.0NW_0049365244,184,831 - 4,234,257 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040286044   ⟹   XP_040141978
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947167,647,221 - 167,686,047 (-)NCBI
RefSeq Acc Id: XM_040286045   ⟹   XP_040141979
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947167,647,221 - 167,686,477 (-)NCBI
RefSeq Acc Id: XM_040286046   ⟹   XP_040141980
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024404947167,645,593 - 167,686,476 (-)NCBI
RefSeq Acc Id: XP_013214512   ⟸   XM_013359058
- Peptide Label: isoform X1
- UniProtKB: A0A287CYS8 (UniProtKB/TrEMBL),   A0A287D304 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_021582660   ⟸   XM_021726985
- Peptide Label: isoform X2
- UniProtKB: A0A287D304 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040141980   ⟸   XM_040286046
- Peptide Label: isoform X4
- UniProtKB: A0A287D304 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040141979   ⟸   XM_040286045
- Peptide Label: isoform X3
- UniProtKB: A0A287D304 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040141978   ⟸   XM_040286044
- Peptide Label: isoform X1
- UniProtKB: A0A287CYS8 (UniProtKB/TrEMBL),   A0A287D304 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000004536   ⟸   ENSSTOT00000005056
Ensembl Acc Id: ENSSTOP00000026467   ⟸   ENSSTOT00000037700
Ensembl Acc Id: ENSSTOP00000027956   ⟸   ENSSTOT00000034624
Protein Domains
UDP-N-acetylglucosamine 2-epimerase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000005049 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000005056.3 UniProtKB/TrEMBL
  ENSSTOT00000034624.1 UniProtKB/TrEMBL
  ENSSTOT00000037700.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
  Glycogen Phosphorylase B UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  ROK UniProtKB/TrEMBL
  ROK_cs UniProtKB/TrEMBL
  UDP-GlcNAc_Epase UniProtKB/TrEMBL
  UDP_GlcNAc_Epimerase_2_dom UniProtKB/TrEMBL
NCBI Gene Gne ENTREZGENE
PANTHER BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE UniProtKB/TrEMBL
  PTHR18964 UniProtKB/TrEMBL
Pfam Epimerase_2 UniProtKB/TrEMBL
  ROK UniProtKB/TrEMBL
PRINTS HEXOKINASE UniProtKB/TrEMBL
PROSITE ROK UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
  UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/TrEMBL
UniProt A0A287CYS8 ENTREZGENE, UniProtKB/TrEMBL
  A0A287D304 ENTREZGENE, UniProtKB/TrEMBL
  I3M5E0_ICTTR UniProtKB/TrEMBL