GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) - Rat Genome Database

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Pathways
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Gene: GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase) Sus scrofa
Analyze
Symbol: GNE
Name: glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
RGD ID: 14055091
Description: ENCODES a protein that exhibits N-acylmannosamine kinase activity (ortholog); UDP-N-acetylglucosamine 2-epimerase activity (ortholog); INVOLVED IN carbohydrate phosphorylation (inferred); N-acetylneuraminate biosynthetic process (inferred); UDP-N-acetylglucosamine metabolic process (inferred); PARTICIPATES IN amino sugar metabolic pathway; french type sialuria pathway; sialic acid storage disease pathway; ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase; DMRV; GLCNE; IBM2; UAE1; UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,998,757 - 237,065,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,998,754 - 237,065,819 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
GNE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,998,757 - 237,065,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11236,998,754 - 237,065,819 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
GNE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38936,214,441 - 36,276,978 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl936,214,441 - 36,277,042 (-)EnsemblGRCh38hg38GRCh38
GRCh37936,214,438 - 36,276,975 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36936,204,438 - 36,248,401 (-)NCBINCBI36Build 36hg18NCBI36
Build 34936,204,440 - 36,248,401NCBI
Celera936,148,023 - 36,210,614 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef936,168,432 - 36,230,185 (-)NCBIHuRef
CHM1_1936,214,844 - 36,277,494 (-)NCBICHM1_1
T2T-CHM13v2.0936,236,447 - 36,298,980 (-)NCBIT2T-CHM13v2.0
Gne
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39444,034,075 - 44,084,177 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl444,034,075 - 44,084,177 (-)EnsemblGRCm39 Ensembl
GRCm38444,034,075 - 44,084,177 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl444,034,075 - 44,084,177 (-)EnsemblGRCm38mm10GRCm38
MGSCv37444,046,947 - 44,097,049 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36444,057,926 - 44,105,266 (-)NCBIMGSCv36mm8
Celera444,055,271 - 44,105,902 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map423.1NCBI
Gne
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8563,062,953 - 63,103,320 (-)NCBIGRCr8
mRatBN7.2558,267,189 - 58,307,396 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl558,267,210 - 58,307,499 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx560,248,992 - 60,279,247 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0562,067,800 - 62,098,053 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0562,037,233 - 62,067,502 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0559,511,738 - 59,553,421 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl559,512,872 - 59,553,416 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0564,034,863 - 64,075,144 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4560,506,171 - 60,536,403 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1560,506,350 - 60,536,582 (-)NCBI
Celera556,845,530 - 56,875,714 (-)NCBICelera
Cytogenetic Map5q22NCBI
Gne
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547245,926 - 97,082 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547256,623 - 92,553 (+)NCBIChiLan1.0ChiLan1.0
GNE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21188,331,427 - 88,375,166 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1988,337,369 - 88,381,103 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0936,064,128 - 36,107,822 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1936,867,094 - 36,908,212 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl936,867,096 - 36,926,588 (-)Ensemblpanpan1.1panPan2
GNE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11152,688,295 - 52,731,160 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1152,689,343 - 52,731,231 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1151,278,943 - 51,322,087 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01153,794,650 - 53,837,589 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1153,794,653 - 53,837,619 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11152,297,479 - 52,340,394 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01152,319,509 - 52,362,669 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01153,021,057 - 53,064,247 (-)NCBIUU_Cfam_GSD_1.0
Gne
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947167,637,251 - 167,686,478 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365244,196,830 - 4,252,163 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365244,184,831 - 4,234,257 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GNE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11244,300,321 - 44,340,917 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1244,282,809 - 44,344,311 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603841,390,535 - 41,432,094 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gne
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248684,361,752 - 4,417,604 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248684,362,144 - 4,417,604 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in GNE
1896 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 7 3 2 5 2 1
Low 3 4 3 2 18 2 1 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000055202   ⟹   ENSSSCP00000034566
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1236,998,757 - 237,029,308 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000058473   ⟹   ENSSSCP00000057689
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1236,999,996 - 237,052,107 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000063939   ⟹   ENSSSCP00000055990
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1237,000,000 - 237,065,767 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000074688   ⟹   ENSSSCP00000065881
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1236,999,996 - 237,052,107 (-)Ensembl
RefSeq Acc Id: NM_001167630   ⟹   NP_001161102
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11237,000,931 - 237,028,975 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083984   ⟹   XP_020939643
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11236,998,754 - 237,065,818 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083986   ⟹   XP_020939645
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11236,998,754 - 237,051,711 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083990   ⟹   XP_020939649
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11236,998,754 - 237,053,201 (-)NCBI
Sequence:
RefSeq Acc Id: XM_021083996   ⟹   XP_020939655
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11236,998,754 - 237,065,819 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_020939655   ⟸   XM_021083996
- Peptide Label: isoform X3
- UniProtKB: A0A8D1P7N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020939643   ⟸   XM_021083984
- Peptide Label: isoform X1
- UniProtKB: A0A4X1VK02 (UniProtKB/TrEMBL),   A0A480PS03 (UniProtKB/TrEMBL),   A0A8D0LLF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020939649   ⟸   XM_021083990
- Peptide Label: isoform X2
- UniProtKB: A0A4X1VP99 (UniProtKB/TrEMBL),   Q30E20 (UniProtKB/TrEMBL),   A0A480TMZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_020939645   ⟸   XM_021083986
- Peptide Label: isoform X2
- UniProtKB: A0A4X1VP99 (UniProtKB/TrEMBL),   Q30E20 (UniProtKB/TrEMBL),   A0A480TMZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001161102   ⟸   NM_001167630
- UniProtKB: D0G6X6 (UniProtKB/TrEMBL),   A0A8D0Y257 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000065881   ⟸   ENSSSCT00000074688
RefSeq Acc Id: ENSSSCP00000057689   ⟸   ENSSSCT00000058473
RefSeq Acc Id: ENSSSCP00000034566   ⟸   ENSSSCT00000055202
RefSeq Acc Id: ENSSSCP00000055990   ⟸   ENSSSCT00000063939
Protein Domains
UDP-N-acetylglucosamine 2-epimerase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000037468 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005019376 UniProtKB/TrEMBL
  ENSSSCG00015049998 UniProtKB/TrEMBL
  ENSSSCG00030071361 UniProtKB/TrEMBL
  ENSSSCG00035014595 UniProtKB/TrEMBL
  ENSSSCG00040059539 UniProtKB/TrEMBL
  ENSSSCG00045019702 UniProtKB/TrEMBL
  ENSSSCG00050078573 UniProtKB/TrEMBL
  ENSSSCG00060048237 UniProtKB/TrEMBL
  ENSSSCG00065025822 UniProtKB/TrEMBL
  ENSSSCG00070025857 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000055202.2 UniProtKB/TrEMBL
  ENSSSCT00000058473 ENTREZGENE
  ENSSSCT00000058473.3 UniProtKB/TrEMBL
  ENSSSCT00000063939 ENTREZGENE
  ENSSSCT00000063939.2 UniProtKB/TrEMBL
  ENSSSCT00000074688.2 UniProtKB/TrEMBL
  ENSSSCT00005030988.1 UniProtKB/TrEMBL
  ENSSSCT00005031001.1 UniProtKB/TrEMBL
  ENSSSCT00005031027.1 UniProtKB/TrEMBL
  ENSSSCT00015066823.1 UniProtKB/TrEMBL
  ENSSSCT00015066969.1 UniProtKB/TrEMBL
  ENSSSCT00030099923.1 UniProtKB/TrEMBL
  ENSSSCT00030099967.1 UniProtKB/TrEMBL
  ENSSSCT00030100016.1 UniProtKB/TrEMBL
  ENSSSCT00035018513.1 UniProtKB/TrEMBL
  ENSSSCT00035018525.1 UniProtKB/TrEMBL
  ENSSSCT00040080950.1 UniProtKB/TrEMBL
  ENSSSCT00040080980.1 UniProtKB/TrEMBL
  ENSSSCT00045033626.1 UniProtKB/TrEMBL
  ENSSSCT00045033727.1 UniProtKB/TrEMBL
  ENSSSCT00050108276.1 UniProtKB/TrEMBL
  ENSSSCT00050108288.1 UniProtKB/TrEMBL
  ENSSSCT00050108299.1 UniProtKB/TrEMBL
  ENSSSCT00060065499.1 UniProtKB/TrEMBL
  ENSSSCT00060065504.1 UniProtKB/TrEMBL
  ENSSSCT00065034609.1 UniProtKB/TrEMBL
  ENSSSCT00065034616.1 UniProtKB/TrEMBL
  ENSSSCT00070051795.1 UniProtKB/TrEMBL
  ENSSSCT00070051864.1 UniProtKB/TrEMBL
  ENSSSCT00070051908.1 UniProtKB/TrEMBL
  ENSSSCT00070051946.1 UniProtKB/TrEMBL
  ENSSSCT00070051950.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.40 UniProtKB/TrEMBL
  Glycogen Phosphorylase B UniProtKB/TrEMBL
InterPro ATPase_NBD UniProtKB/TrEMBL
  ROK UniProtKB/TrEMBL
  UDP-GlcNAc_Epase UniProtKB/TrEMBL
  UDP_GlcNAc_Epimerase_2_dom UniProtKB/TrEMBL
KEGG Report ssc:641344 UniProtKB/TrEMBL
NCBI Gene GNE ENTREZGENE
PANTHER BIFUNCTIONAL UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE/N-ACETYLMANNOSAMINE KINASE UniProtKB/TrEMBL
  PTHR18964 UniProtKB/TrEMBL
Pfam Epimerase_2 UniProtKB/TrEMBL
  ROK UniProtKB/TrEMBL
PRINTS HEXOKINASE UniProtKB/TrEMBL
PROSITE ROK UniProtKB/TrEMBL
Superfamily-SCOP SSF53067 UniProtKB/TrEMBL
  UDP-Glycosyltransferase/glycogen phosphorylase UniProtKB/TrEMBL
UniProt A0A286ZSG0_PIG UniProtKB/TrEMBL
  A0A287BHC3_PIG UniProtKB/TrEMBL
  A0A287BMG4_PIG UniProtKB/TrEMBL
  A0A480PS03 ENTREZGENE, UniProtKB/TrEMBL
  A0A480TMZ9 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VK02 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VP99 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X1VQ60_PIG UniProtKB/TrEMBL
  A0A4X1VQY8_PIG UniProtKB/TrEMBL
  A0A5G2QP86_PIG UniProtKB/TrEMBL
  A0A8D0J014_PIG UniProtKB/TrEMBL
  A0A8D0J5V7_PIG UniProtKB/TrEMBL
  A0A8D0LLF6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D0Y257 ENTREZGENE, UniProtKB/TrEMBL
  A0A8D1P7N1 ENTREZGENE, UniProtKB/TrEMBL
  D0G6X6 ENTREZGENE, UniProtKB/TrEMBL
  Q30E20 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:103101 ENTREZGENE