RGD Reference Report - UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation. - Rat Genome Database

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UDP-GlcNAc 2-epimerase: a regulator of cell surface sialylation.

Authors: Keppler, O T  Hinderlich, S  Langner, J  Schwartz-Albiez, R  Reutter, W  Pawlita, M 
Citation: Keppler OT, etal., Science. 1999 May 21;284(5418):1372-6. doi: 10.1126/science.284.5418.1372.
RGD ID: 401901215
Pubmed: PMID:10334995   (View Abstract at PubMed)
DOI: DOI:10.1126/science.284.5418.1372   (Journal Full-text)

Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate-N-acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.



Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GneRatUDP-N-acetylglucosamine 2-epimerase activity enablesIDA PMID:10334995UniProt 

Objects Annotated

Genes (Rattus norvegicus)
Gne  (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase)


Additional Information