Gabbr2 (gamma-aminobutyric acid type B receptor subunit 2) - Rat Genome Database

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Gene: Gabbr2 (gamma-aminobutyric acid type B receptor subunit 2) Chinchilla lanigera
Analyze
Symbol: Gabbr2
Name: gamma-aminobutyric acid type B receptor subunit 2
RGD ID: 8838365
Description: ENCODES a protein that exhibits G protein-coupled GABA receptor activity (ortholog); protein heterodimerization activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); gamma-aminobutyric acid signaling pathway (ortholog); neuron-glial cell signaling (ortholog); ASSOCIATED WITH alcohol dependence (ortholog); alcohol use disorder (ortholog); autism spectrum disorder (ortholog); FOUND IN cytoplasm (ortholog); G protein-coupled GABA receptor complex (ortholog); G protein-coupled receptor heterodimeric complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: gamma-aminobutyric acid (GABA) B receptor, 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541926,872,728 - 27,239,464 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541926,872,734 - 27,241,917 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gabbr2Chinchillaalcohol dependence  ISOGabbr2 (Rattus norvegicus)9068941mRNA:decreased expression:hippocampus (rat)RGDPMID:22253714 and REF_RGD_ID:401900163
Gabbr2Chinchillaalcohol use disorder susceptibilityISOGABBR2 (Homo sapiens)9068941DNA:SNP:intron: (rs2900512) (human)RGDPMID:28118741 and REF_RGD_ID:401940105
Gabbr2Chinchillanicotine dependence susceptibilityISOGABBR2 (Homo sapiens)9068941DNA:SNPs and haplotypes:multipleRGDPMID:19763258 and REF_RGD_ID:401940104
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gabbr2Chinchillaautism spectrum disorder  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Autism spectrum disorderClinVarPMID:25741868
Gabbr2Chinchillacongenital disorder of glycosylation Ii  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital disorder of glycosylation type 1IClinVarPMID:20813212 and PMID:28492532
Gabbr2Chinchillacongenital disorder of glycosylation type II  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: CDG IiClinVarPMID:20813212 and PMID:28492532
Gabbr2Chinchillacongenital myasthenic syndrome 14  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Myasthenic syndrome more ...ClinVarPMID:20813212 and PMID:28492532
Gabbr2Chinchilladevelopmental and epileptic encephalopathy 59  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 59ClinVarPMID:25262651 more ...
Gabbr2Chinchillageneralized epilepsy  ISOGABBR2 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16199547 more ...
Gabbr2Chinchillagenetic disease  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Gabbr2Chinchillaintellectual disability  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868
Gabbr2Chinchillanephronophthisis  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: NephronophthisisClinVarPMID:12872123 and PMID:28492532
Gabbr2ChinchillaNeurodevelopmental Disorder with Poor Language and Loss of Hand Skills  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorder with poor language and loss of hand skillsClinVarPMID:16199547 more ...
Gabbr2Chinchillanicotine dependence  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Tobacco addiction and susceptibility toClinVarPMID:25741868 and PMID:28492532
Gabbr2ChinchillaRett syndrome  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Rett syndromeClinVarPMID:25741868 more ...
Gabbr2Chinchillathoracic aortic aneurysm  ISOGABBR2 (Homo sapiens)8554872ClinVar Annotator: match by term: Thoracic aortic aneurysm and aortic dissectionClinVarPMID:20813212 and PMID:28492532
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gabbr2Chinchillaautistic disorder  ISOGABBR2 (Homo sapiens)9068941CTD Direct Evidence: marker/mechanismCTDPMID:19002745


Cellular Component
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gabbr2Chinchillacytoplasm located_inISOGabbr2 (Mus musculus)9068941 PMID:15013631MGIPMID:15013631
Gabbr2ChinchillaG protein-coupled GABA receptor complex part_ofISOGABBR2 (Homo sapiens)9068941 PMID:24305054ComplexPortalPMID:24305054
Gabbr2ChinchillaG protein-coupled GABA receptor complex part_ofISOGabbr2 (Rattus norvegicus)9068941PMID:21063387ComplexPortalPMID:21063387 and REF_RGD_ID:8553604
Gabbr2ChinchillaG protein-coupled receptor heterodimeric complex part_ofISOUniProtKB:Q9UBS59068941 PMID:9872316UniProtPMID:9872316
Gabbr2ChinchillaGABA receptor complex part_ofISOGABBR2 (Homo sapiens)9068941 PMID:15304491CAFAPMID:15304491
Gabbr2ChinchillaGABA-ergic synapse is_active_inISOGabbr2 (Rattus norvegicus)9068941PMID:14657159SynGOPMID:14657159 and REF_RGD_ID:13702400
Gabbr2Chinchillaglutamatergic synapse is_active_inISOGabbr2 (Rattus norvegicus)9068941PMID:14657159SynGOPMID:14657159 and REF_RGD_ID:13702400
Gabbr2Chinchillaneuron projection located_inISOGabbr2 (Mus musculus)9068941 PMID:15013631MGIPMID:15013631
Gabbr2Chinchillaplasma membrane located_inISOGABBR2 (Homo sapiens)9068941 PMID:15304491 and PMID:9872316CAFAPMID:15304491 and PMID:9872316
Gabbr2Chinchillapostsynaptic membrane is_active_inISOGabbr2 (Rattus norvegicus)9068941PMID:14657159SynGOPMID:14657159 and REF_RGD_ID:13702400
Gabbr2Chinchillapresynaptic membrane is_active_inISOGabbr2 (Rattus norvegicus)9068941PMID:14657159SynGOPMID:14657159 and REF_RGD_ID:13702400
1 to 11 of 11 rows

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gabbr2ChinchillaG protein-coupled GABA receptor activity  ISOGabbr2 (Rattus norvegicus)9068941 RGDPMID:11389174 and REF_RGD_ID:632824
Gabbr2ChinchillaG protein-coupled GABA receptor activity contributes_toISOGABBR2 (Homo sapiens)9068941 PMID:9872316UniProtKBPMID:9872316
Gabbr2Chinchillaprotein binding enablesISOPR:Q065079068941 PMID:15013631MGIPMID:15013631
Gabbr2Chinchillaprotein binding enablesISOUniProtKB:P46459 and UniProtKB:Q9UBS59068941 PMID:16724110IntActPMID:16724110
Gabbr2Chinchillaprotein binding enablesISOUniProtKB:Q9UBS59068941 PMID:24658140 and PMID:32555460IntActPMID:24658140 and PMID:32555460
Gabbr2Chinchillaprotein binding enablesISOUniProtKB:Q86UR59068941 PMID:37207277IntActPMID:37207277
Gabbr2Chinchillaprotein binding enablesISOUniProtKB:Q9UBS5-29068941 PMID:24305054 more ...IntActPMID:24305054 more ...
Gabbr2Chinchillaprotein binding enablesISOUniProtKB:Q9Z0U49068941PMID:21552208IntActPMID:21552208 and REF_RGD_ID:8554334
Gabbr2Chinchillaprotein binding enablesISOUniProtKB:P277329068941PMID:20627102IntActPMID:20627102 and REF_RGD_ID:8554172
Gabbr2Chinchillaprotein binding enablesISOUniProtKB:Q9Z0U49068941PMID:21063387IntActPMID:21063387 and REF_RGD_ID:8553604
Gabbr2Chinchillaprotein binding enablesISOUniProtKB:Q9Z0U49068941PMID:19590495IntActPMID:19590495 and REF_RGD_ID:8553550
Gabbr2Chinchillaprotein heterodimerization activity enablesISOUniProtKB:Q9Z0U49068941 PMID:15304491CAFAPMID:15304491
1 to 12 of 12 rows


#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
PMID:22301074   PMID:30032202  



Gabbr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541926,872,728 - 27,239,464 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541926,872,734 - 27,241,917 (+)NCBIChiLan1.0ChiLan1.0
GABBR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38998,288,109 - 98,708,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl998,288,109 - 98,708,935 (-)EnsemblGRCh38hg38GRCh38
GRCh379101,050,391 - 101,471,217 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369100,090,187 - 100,511,300 (-)NCBINCBI36Build 36hg18NCBI36
Build 34998,129,920 - 98,551,034NCBI
Celera971,564,671 - 71,985,374 (-)NCBICelera
Cytogenetic Map9q22.33NCBI
HuRef970,650,446 - 70,940,183 (-)NCBIHuRef
CHM1_19101,196,866 - 101,617,897 (-)NCBICHM1_1
T2T-CHM13v2.09110,460,053 - 110,880,595 (-)NCBIT2T-CHM13v2.0
Gabbr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39446,662,318 - 46,991,714 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl446,662,305 - 46,991,873 (-)EnsemblGRCm39 Ensembl
GRCm38446,662,318 - 46,991,714 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl446,662,305 - 46,991,873 (-)EnsemblGRCm38mm10GRCm38
MGSCv37446,676,770 - 47,004,586 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36446,684,998 - 47,012,814 (-)NCBIMGSCv36mm8
Celera446,675,526 - 47,003,236 (-)NCBICelera
Cytogenetic Map4B1NCBI
cM Map425.18NCBI
Gabbr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8565,743,073 - 66,083,695 (-)NCBIGRCr8
mRatBN7.2560,947,517 - 61,288,104 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl560,947,526 - 61,288,104 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx562,918,639 - 63,259,788 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0564,738,005 - 65,079,085 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0564,707,402 - 65,048,578 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0562,276,100 - 62,621,737 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl562,276,100 - 62,621,737 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0566,802,348 - 67,142,203 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4563,241,397 - 63,611,907 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1563,241,575 - 63,612,086 (-)NCBI
Celera559,508,888 - 59,731,378 (-)NCBICelera
Cytogenetic Map5q22NCBI
GABBR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21140,747,751 - 41,170,503 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1940,750,129 - 41,172,879 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0969,377,091 - 69,799,867 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1997,500,606 - 97,919,053 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl997,500,904 - 97,790,605 (-)Ensemblpanpan1.1panPan2
GABBR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11155,469,327 - 55,817,930 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1155,470,197 - 55,817,945 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1153,902,316 - 54,251,118 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01156,578,376 - 56,927,274 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1156,580,523 - 56,927,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11155,076,468 - 55,431,616 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01155,107,840 - 55,455,961 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01155,804,321 - 56,153,068 (-)NCBIUU_Cfam_GSD_1.0
Gabbr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947170,397,327 - 170,750,253 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365246,943,147 - 7,297,835 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365246,944,923 - 7,297,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GABBR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1240,107,466 - 240,496,101 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11240,107,469 - 240,495,917 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21268,546,934 - 268,740,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GABBR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11240,719,126 - 41,135,602 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1240,719,577 - 41,135,770 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603837,753,365 - 38,173,474 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gabbr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248252,233,759 - 2,610,255 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248252,233,759 - 2,608,159 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000015582   ⟹   ENSCLAP00000015421
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541926,872,728 - 27,239,464 (+)Ensembl
RefSeq Acc Id: XM_005382826   ⟹   XP_005382883
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541926,872,734 - 27,241,917 (+)NCBI
Sequence:
Protein RefSeqs XP_005382883 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000015421
  ENSCLAP00000015421.1
RefSeq Acc Id: XP_005382883   ⟸   XM_005382826
- UniProtKB: A0A8C2YQA9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000015421   ⟸   ENSCLAT00000015582


1 to 25 of 25 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000010613 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015582 ENTREZGENE
  ENSCLAT00000015582.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.2300 UniProtKB/TrEMBL
InterPro ANF_lig-bd_rcpt UniProtKB/TrEMBL
  GBR2_CC UniProtKB/TrEMBL
  GPCR3_GABA-B UniProtKB/TrEMBL
  GPCR_3 UniProtKB/TrEMBL
  GPCR_3_C UniProtKB/TrEMBL
  GPCR_3_CS UniProtKB/TrEMBL
  GPCR_3_GABA_rcpt_B2 UniProtKB/TrEMBL
  Peripla_BP_I UniProtKB/TrEMBL
NCBI Gene Gabbr2 ENTREZGENE
PANTHER GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2 UniProtKB/TrEMBL
  PTHR10519 UniProtKB/TrEMBL
Pfam 7tm_3 UniProtKB/TrEMBL
  ANF_receptor UniProtKB/TrEMBL
  GBR2_CC UniProtKB/TrEMBL
PRINTS GABAB2RECPTR UniProtKB/TrEMBL
  GABABRECEPTR UniProtKB/TrEMBL
  GPCRMGR UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F3_3 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F3_4 UniProtKB/TrEMBL
Superfamily-SCOP SSF53822 UniProtKB/TrEMBL
UniProt A0A8C2YQA9 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Gabbr2  gamma-aminobutyric acid type B receptor subunit 2    gamma-aminobutyric acid (GABA) B receptor, 2  Symbol and/or name change 5135510 APPROVED