Dnase1l1 (deoxyribonuclease 1 like 1)

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Gene: Dnase1l1 (deoxyribonuclease 1 like 1) Chinchilla lanigera

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Symbol:

Dnase1l1

Name:

deoxyribonuclease 1 like 1

RGD ID:

8808737

Description:

ASSOCIATED WITH adrenoleukodystrophy (ortholog); autistic disorder (ortholog); autosomal hemophilia A (ortholog); FOUND IN endoplasmic reticulum (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

deoxyribonuclease I-like 1; deoxyribonuclease-1-like 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	907,582 - 914,243 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	907,056 - 913,604 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

Barth syndrome (ISO)

cardiomyopathy (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

dilated cardiomyopathy (ISO)

Dilated Cardiomyopathy with Left Ventricular Noncompaction (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

endocardial fibroelastosis (ISO)

factor VIII deficiency (ISO)

favism (ISO)

immunodeficiency 33 (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

severe congenital encephalopathy due to MECP2 mutation (ISO)

Splenomegaly (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked dilated cardiomyopathy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

endoplasmic reticulum (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Dnase1l1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	907,582 - 914,243 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	907,056 - 913,604 (-)	NCBI	ChiLan1.0	ChiLan1.0

DNASE1L1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	154,401,236 - 154,412,101 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	154,401,236 - 154,412,112 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	153,629,577 - 153,640,438 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	153,282,773 - 153,293,621 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	153,150,425 - 153,158,422	NCBI
Celera	X	153,790,635 - 153,801,484 (-)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	142,206,968 - 142,217,816 (-)	NCBI		HuRef
CHM1_1	X	153,541,222 - 153,552,074 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	152,637,756 - 152,648,607 (-)	NCBI		T2T-CHM13v2.0

Dnase1l1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	73,316,823 - 73,325,939 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	73,316,823 - 73,325,943 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	74,273,217 - 74,282,333 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	74,273,217 - 74,282,337 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	71,518,556 - 71,527,672 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	70,525,938 - 70,534,454 (-)	NCBI		MGSCv36	mm8
Celera	X	65,526,994 - 65,536,124 (-)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.94	NCBI

Dnase1l1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	157,208,230 - 157,216,812 (-)	NCBI		GRCr8
mRatBN7.2	X	152,056,942 - 152,065,518 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	152,056,942 - 152,065,518 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	154,198,071 - 154,206,552 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,761,304 - 157,769,785 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	155,433,103 - 155,441,584 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	156,429,521 - 156,438,066 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	156,429,585 - 156,438,066 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,169,678 - 152,178,213 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	160,327,966 - 160,336,447 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	160,404,391 - 160,412,828 (+)	NCBI
Celera	1	135,831,332 - 135,839,813 (+)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

DNASE1L1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	154,376,064 - 154,385,167 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	154,379,690 - 154,388,048 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	143,842,920 - 143,851,795 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	153,712,050 - 153,725,868 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	153,712,054 - 153,725,868 (-)	Ensembl	panpan1.1		panPan2

DNASE1L1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	122,101,992 - 122,109,240 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	122,101,992 - 122,109,165 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	125,243,686 - 125,250,933 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	125,243,302 - 125,250,882 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	121,012,760 - 121,020,007 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	123,527,626 - 123,534,873 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	123,289,507 - 123,296,773 (-)	NCBI		UU_Cfam_GSD_1.0

Dnase1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	119,413,626 - 119,420,791 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	1,151,202 - 1,159,029 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	1,151,312 - 1,159,017 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DNASE1L1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	124,931,410 - 124,939,965 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	124,931,410 - 124,937,569 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DNASE1L1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666065	66,628,194 - 66,636,944 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dnase1l1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624946	864,657 - 870,396 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624946	858,638 - 869,859 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005414193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01075629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDK01190187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000005013 ⟹ ENSCLAP00000004921

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955580	907,582 - 914,243 (-)	Ensembl

Ensembl Acc Id:

ENSCLAT00000005014 ⟹ ENSCLAP00000004922

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955580	907,582 - 914,243 (-)	Ensembl

RefSeq Acc Id:

XM_005414193 ⟹ XP_005414250

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955580	907,056 - 913,604 (-)	NCBI

Sequence:

show sequence

ACCCAGGCTGGCGCAGCGACCCTGTCCCCTATCAGGTGTTGCGATCTGTTTAAGGCTAAGGCAG
TCGTGGTGGCGGACGGGTGTGACAGGGCCCCGGTGCGTGCGCGGCCATGCATGGCCTCGCCCCT
CTGCTGCTCATCTTCCTGGCCATTCAGGCTGAGGCCTTTCGCATCTGCGCCTTCAATGCCCACC
GGCTGACGCTGGCCAAGGTGACCAGGGAGCAAGTGAAGGATACCTTAGTACAGATCCTGGCTCG
CTGTGACATCATGGTGCTGCAGGAGGTGGTAGATGCCTCCAACAGGACCATCTCCTTCCTGCTG
CAAGAACTCAGACGCAAATTCGACAACTCTCGGTGCTACAGCTTCCTAAACAGCTCGCAGCTGG
GGCGCAGCACGTACAAGGAGAAATATGTGTACATCTACCGGTCCGACAAGACCCAAGTCCTGAA
TTTCTACCAGTATGAAGACAAGGATGACCTGTTTGCCCGGGAGCCTTTTGTGGCCCAGTTCACT
CTACCTAGCAAAATCCTTCCCAGTGTTGCGCTGGTCCCACTGCACACCACCCCTAAGGACGTGG
AGAACGAGCTGAACGCCCTCCATGCTGTATTCCTGGATGTCGCCCGGCGCTGGCAGAGCAAGGA
TGTCATCCTGCTGGGGGACTTCAATGCCGACTGTGCCTCGCTGGCCAAGAAGCGCCTGAGCACG
CTGCTGCTGCGCACCGAGGTGGGCTTCCGCTGGGCCATCGCCGACGGCGAGGACACCACAGTGC
GGGCCAGCACCAACTGCAGCTATGACCGCATCGTGCTGCATGGCGAGGCCTGCCAAGGGCTTGT
GCGCACCGCCGCGGCCTTCAACTTTCCCCAGAGCTTCCGGCTCTCTGAGGAGGAGGCCCTCAGT
ATCAGCGACCACTACCCTGTGGAGGTGGAGCTGGACCAAGCACCGTATGGCGTGCAGCACCCCA
GCCTGGCCACCTTGCTGCTGCTGTCACTGCTGCTGCCACTCTTGGCCCCTCAGTCAAGCCCTGT
GGCCTGACTCAGACCCTAGCCTCCCTCCGTTCCACCTGGGGCCTAAGCAACTCCCTGGGGGCTT
TTGTCTGACCGCCCTCCTCCATCCGCCAGTTTAGGTTCTGCTGTTGTGGCTGTTTGGGTTTGAG
CCAGCAGCTGAGGCTGGATCTTAGCCACCCCATCAGGTAGCGTGAGGGGCCGCGACAAGCCAAT
AGGAGGGCTAAGGTACTTGCCCGGGAACCAAACTCGGGACCTTGCGCTTGCCAGGCAGGCACTG
TGCCGCTGAGCTGTATCCTTGGCCTGAGCTGCCCTTACCGCACAGGGTTCACGTAGGTCAAGCG
GACAGGACAAGACAAGGCAGCCCTGAAAACCACACAGCCCAGGTCCTGTGGCAAGCATAACCTG
TGACGAGGGCACAGGATGCTGGGTGTAGGGAGAGGCAACCAGGCTGGCTACCAAGGCGGCACAC
CAGCAAAACTTCACTGACAGAATCGGAGACACTTCAATGAGCCTCCTCCCGAAGGTCAAAAATA
AAAGTTAATCTGAAACAGAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005414250	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000004921
	ENSCLAP00000004921.1
	ENSCLAP00000004922.1

RefSeq Acc Id:

XP_005414250 ⟸ XM_005414193

- UniProtKB:

A0A8C2UYA9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MHGLAPLLLIFLAIQAEAFRICAFNAHRLTLAKVTREQVKDTLVQILARCDIMVLQEVVDASNR
TISFLLQELRRKFDNSRCYSFLNSSQLGRSTYKEKYVYIYRSDKTQVLNFYQYEDKDDLFAREP
FVAQFTLPSKILPSVALVPLHTTPKDVENELNALHAVFLDVARRWQSKDVILLGDFNADCASLA
KKRLSTLLLRTEVGFRWAIADGEDTTVRASTNCSYDRIVLHGEACQGLVRTAAAFNFPQSFRLS
EEEALSISDHYPVEVELDQAPYGVQHPSLATLLLLSLLLPLLAPQSSPVA

hide sequence

Ensembl Acc Id:

ENSCLAP00000004921 ⟸ ENSCLAT00000005013

Ensembl Acc Id:

ENSCLAP00000004922 ⟸ ENSCLAT00000005014

Protein Domains

Endonuclease/exonuclease/phosphatase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000003494	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000005013	ENTREZGENE
	ENSCLAT00000005013.1	UniProtKB/TrEMBL
	ENSCLAT00000005014.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.10.10	UniProtKB/TrEMBL
InterPro	DNase_I	UniProtKB/TrEMBL
	DNASE_I_2	UniProtKB/TrEMBL
	Endo/exonu/phosph_ase_sf	UniProtKB/TrEMBL
	Endo/exonuclease/phosphatase	UniProtKB/TrEMBL
NCBI Gene	Dnase1l1	ENTREZGENE
PANTHER	DEOXYRIBONUCLEASE	UniProtKB/TrEMBL
	DEOXYRIBONUCLEASE-1-LIKE 1	UniProtKB/TrEMBL
Pfam	Exo_endo_phos	UniProtKB/TrEMBL
PIRSF	DNase_I_euk	UniProtKB/TrEMBL
PRINTS	DNASEI	UniProtKB/TrEMBL
PROSITE	DNASE_I_2	UniProtKB/TrEMBL
SMART	DNaseIc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56219	UniProtKB/TrEMBL
UniProt	A0A8C2UYA9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Dnase1l1	deoxyribonuclease 1 like 1		deoxyribonuclease I-like 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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