Nrp2 (neuropilin 2) - Rat Genome Database

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Gene: Nrp2 (neuropilin 2) Chinchilla lanigera
Analyze
Symbol: Nrp2
Name: neuropilin 2
RGD ID: 8734411
Description: ENCODES a protein that exhibits identical protein binding (ortholog); semaphorin receptor activity (ortholog); INVOLVED IN axon extension involved in axon guidance (ortholog); axon guidance (ortholog); cellular response to leukemia inhibitory factor (ortholog); PARTICIPATES IN vascular endothelial growth factor signaling pathway; ASSOCIATED WITH autism spectrum disorder (ortholog); autistic disorder (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); glutamatergic synapse (ortholog); postsynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: neuropilin-2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554579,197,405 - 9,316,787 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554579,197,621 - 9,316,789 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nrp2Chinchillagenetic disease  ISORGD:7321918554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
Nrp2ChinchillaHirschsprung Disease 1  ISORGD:7321918554872ClinVar Annotator: match by term: Hirschsprung disease 1ClinVarPMID:25741868
Nrp2ChinchillaHirschsprung's disease  ISORGD:7321918554872ClinVar Annotator: match by term: Hirschsprung disease, susceptibility to, 1ClinVarPMID:25741868
Nrp2ChinchillaNeurodevelopmental Disorders  ISORGD:7321918554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Nrp2Chinchillaprimary pulmonary hypertension  ISORGD:7321918554872ClinVar Annotator: match by term: Primary pulmonary hypertensionClinVarPMID:28492532|PMID:31727138
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nrp2Chinchillaautistic disorder  ISORGD:7321919068941CTD Direct Evidence: marker/mechanismCTDPMID:17427189
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nrp2Chinchillaautism spectrum disorder  ISORGD:15512579068941 MouseDO 


Biological Process
1 to 20 of 25 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nrp2Chinchillaaxon extension involved in axon guidance involved_inISORGD:15512579068941 PMID:22790009BHF-UCLPMID:22790009
Nrp2Chinchillaaxon guidance  ISORGD:6214429068941 RGDPMID:9288754|REF_RGD_ID:633436
Nrp2Chinchillaaxon guidance acts_upstream_of_or_withinISORGD:15512579068941 PMID:15814794MGIPMID:15814794
Nrp2Chinchillacellular response to leukemia inhibitory factor acts_upstream_of_or_withinISORGD:15512579068941 PMID:20439489MGIPMID:20439489
Nrp2Chinchilladorsal root ganglion morphogenesis involved_inISORGD:15512579068941 PMID:19386662ParkinsonsUK-UCLPMID:19386662
Nrp2Chinchillafacial nerve structural organization involved_inISORGD:15512579068941 PMID:18356247ParkinsonsUK-UCLPMID:18356247
Nrp2Chinchillafacioacoustic ganglion development involved_inISORGD:15512579068941 PMID:18356247ParkinsonsUK-UCLPMID:18356247
Nrp2Chinchillagonadotrophin-releasing hormone neuronal migration to the hypothalamus involved_inISORGD:15512579068941 PMID:21059704BHF-UCLPMID:21059704
Nrp2Chinchillaheart development acts_upstream_of_or_withinISOMGI:1062069068941 PMID:12852851MGIPMID:12852851
Nrp2Chinchillanegative chemotaxis acts_upstream_of_or_withinISORGD:15512579068941 PMID:15814794MGIPMID:15814794
Nrp2Chinchillanegative chemotaxis acts_upstream_of_or_withinISOMGI:10963479068941 PMID:16319111MGIPMID:16319111
Nrp2Chinchillanerve development involved_inISORGD:15512579068941 PMID:22790009BHF-UCLPMID:22790009
Nrp2Chinchillaneural crest cell migration involved in autonomic nervous system development involved_inISORGD:15512579068941 PMID:18356247, PMID:19386662ParkinsonsUK-UCLPMID:18356247|PMID:19386662
Nrp2Chinchillaneuron migration involved_inISORGD:15512579068941 PMID:21059704BHF-UCLPMID:21059704
Nrp2Chinchillaoutflow tract septum morphogenesis involved_inISOUniProtKB:Q621819068941 PMID:26053665BHF-UCLPMID:26053665
Nrp2Chinchillaregulation of postsynapse organization involved_inISORGD:15512579068941 PMID:20010807SynGOPMID:20010807
Nrp2Chinchillasemaphorin-plexin signaling pathway involved_inISORGD:15512579068941 PMID:22790009BHF-UCLPMID:22790009
Nrp2Chinchillasensory neuron axon guidance involved_inISORGD:15512579068941 PMID:18356247ParkinsonsUK-UCLPMID:18356247
Nrp2Chinchillasympathetic ganglion development involved_inISORGD:15512579068941 PMID:22790009BHF-UCLPMID:22790009
Nrp2Chinchillasympathetic neuron projection extension involved_inISORGD:15512579068941 PMID:22790009BHF-UCLPMID:22790009
1 to 20 of 25 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nrp2Chinchillaaxon located_inISORGD:15512579068941 PMID:15677725MGIPMID:15677725
Nrp2Chinchillaglutamatergic synapse is_active_inISORGD:15512579068941 PMID:20010807, PMID:25143608SynGOPMID:20010807|PMID:25143608
Nrp2Chinchillaglutamatergic synapse is_active_inISORGD:15512579068941 PMID:20010807SynGOPMID:20010807
Nrp2Chinchillapostsynaptic membrane is_active_inISORGD:15512579068941 PMID:25143608SynGOPMID:25143608

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nrp2Chinchillaidentical protein binding enablesISOUniProtKB:O60462-69068941 PMID:25752543IntActPMID:25752543
Nrp2Chinchillaprotein binding enablesISOUniProtKB:Q4LFA99068941 PMID:16098142UniProtPMID:16098142
Nrp2Chinchillaprotein binding enablesISOPR:P702069068941 PMID:10520994MGIPMID:10520994
Nrp2Chinchillaprotein binding enablesISOPR:Q621819068941 PMID:15239958MGIPMID:15239958
Nrp2Chinchillaprotein binding enablesISOUniProtKB:P97953-19068941 PMID:25752543IntActPMID:25752543
Nrp2Chinchillasemaphorin receptor activity enablesISORGD:15512579068941 PMID:15239958MGIPMID:15239958

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Nrp2Chinchillavascular endothelial growth factor signaling pathway   ISORGD:7321919068941 PIDPID:200109

#
Reference Title
Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
PMID:22301074  



Nrp2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554579,197,405 - 9,316,787 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554579,197,621 - 9,316,789 (-)NCBIChiLan1.0ChiLan1.0
NRP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382205,682,501 - 205,798,131 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2205,681,990 - 205,798,133 (+)EnsemblGRCh38hg38GRCh38
GRCh372206,547,225 - 206,662,855 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362206,255,469 - 206,371,102 (+)NCBINCBI36Build 36hg18NCBI36
Build 342206,372,729 - 206,488,362NCBI
Celera2200,305,001 - 200,420,624 (+)NCBICelera
Cytogenetic Map2q33.3NCBI
HuRef2198,395,758 - 198,511,368 (+)NCBIHuRef
CHM1_12206,553,933 - 206,669,559 (+)NCBICHM1_1
T2T-CHM13v2.02206,164,595 - 206,280,478 (+)NCBIT2T-CHM13v2.0
Nrp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39162,742,476 - 62,857,851 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl162,742,444 - 62,857,854 (+)EnsemblGRCm39 Ensembl
GRCm38162,703,317 - 62,818,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl162,703,285 - 62,818,695 (+)EnsemblGRCm38mm10GRCm38
MGSCv37162,749,891 - 62,865,266 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36162,637,986 - 62,750,163 (+)NCBIMGSCv36mm8
Celera163,214,234 - 63,328,949 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map131.35NCBI
Nrp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8971,616,602 - 71,731,869 (+)NCBIGRCr8
mRatBN7.2964,122,815 - 64,238,007 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl964,123,132 - 64,237,958 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx972,622,149 - 72,733,999 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0977,743,432 - 77,855,324 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0976,053,061 - 76,165,010 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0969,496,875 - 69,609,802 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl969,497,121 - 69,612,087 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0969,307,221 - 69,420,379 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4961,348,529 - 61,460,457 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1961,495,510 - 61,607,439 (+)NCBI
Celera961,541,966 - 61,654,219 (+)NCBICelera
Cytogenetic Map9q32NCBI
NRP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213108,283,734 - 108,399,945 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B108,299,569 - 108,414,927 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B92,911,721 - 93,027,032 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B211,042,324 - 211,157,547 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B211,042,324 - 211,157,547 (+)Ensemblpanpan1.1panPan2
NRP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13714,293,545 - 14,408,984 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3714,293,614 - 14,406,949 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3715,172,096 - 15,287,617 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03714,230,443 - 14,345,834 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3714,230,535 - 14,345,832 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13714,184,082 - 14,299,459 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03714,156,464 - 14,271,604 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03714,150,952 - 14,266,106 (+)NCBIUU_Cfam_GSD_1.0
Nrp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303162,471,295 - 162,587,007 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366312,106,453 - 2,222,088 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366312,106,378 - 2,222,082 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NRP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15108,974,816 - 109,092,305 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115108,974,246 - 109,092,316 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Pig Cytomap15q21-q26NCBI
NRP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11091,460,179 - 91,575,408 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1091,460,373 - 91,557,430 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040107,804,373 - 107,919,654 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nrp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476510,372,099 - 10,484,963 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476510,372,172 - 10,484,766 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSCLAT00000013358   ⟹   ENSCLAP00000013207
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554579,197,405 - 9,316,786 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000013359   ⟹   ENSCLAP00000013208
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554579,200,650 - 9,315,985 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000013360   ⟹   ENSCLAP00000013209
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554579,214,831 - 9,316,787 (-)Ensembl
RefSeq Acc Id: XM_005397004   ⟹   XP_005397061
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554579,197,621 - 9,316,787 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005397005   ⟹   XP_005397062
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554579,197,621 - 9,316,786 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005397007   ⟹   XP_005397064
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554579,215,385 - 9,316,788 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005397008   ⟹   XP_005397065
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554579,215,385 - 9,316,787 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013520730   ⟹   XP_013376184
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554579,197,621 - 9,316,789 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013520731   ⟹   XP_013376185
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554579,197,621 - 9,316,788 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013520732   ⟹   XP_013376186
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554579,215,385 - 9,316,789 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013520733   ⟹   XP_013376187
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554579,215,385 - 9,316,788 (-)NCBI
Sequence:
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: XP_005397062   ⟸   XM_005397005
- Peptide Label: isoform X4
- UniProtKB: A0A8C2VI52 (UniProtKB/TrEMBL),   A0A8C2VDY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005397061   ⟸   XM_005397004
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VDY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005397065   ⟸   XM_005397008
- Peptide Label: isoform X8
- UniProtKB: A0A8C2VH24 (UniProtKB/TrEMBL),   A0A8C2VDY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005397064   ⟸   XM_005397007
- Peptide Label: isoform X6
- UniProtKB: A0A8C2VDY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013376184   ⟸   XM_013520730
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VDY8 (UniProtKB/TrEMBL)
- Sequence:
CUB   F5/8 type C   MAM



1 to 40 of 42 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCLAG00000009120 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000013358 ENTREZGENE
  ENSCLAT00000013358.1 UniProtKB/TrEMBL
  ENSCLAT00000013359 ENTREZGENE
  ENSCLAT00000013359.1 UniProtKB/TrEMBL
  ENSCLAT00000013360 ENTREZGENE
  ENSCLAT00000013360.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  CUB_dom UniProtKB/TrEMBL
  FA58C UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  MAM_dom UniProtKB/TrEMBL
  Neuropilin UniProtKB/TrEMBL
  Neuropilin_C UniProtKB/TrEMBL
  Neuropilin_MCO_CoagFactor UniProtKB/TrEMBL
  Sperma_CUB_dom_sf UniProtKB/TrEMBL
NCBI Gene Nrp2 ENTREZGENE
PANTHER F5/8 TYPE C DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR46806:SF2 UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  DUF3481 UniProtKB/TrEMBL
  F5_F8_type_C UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
PIRSF Neuropilin UniProtKB/TrEMBL
PRINTS MAMDOMAIN UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  FA58C_1 UniProtKB/TrEMBL
  FA58C_2 UniProtKB/TrEMBL
  FA58C_3 UniProtKB/TrEMBL
  MAM_2 UniProtKB/TrEMBL
SMART CUB UniProtKB/TrEMBL
  FA58C UniProtKB/TrEMBL
  MAM UniProtKB/TrEMBL
Superfamily-SCOP SSF49785 UniProtKB/TrEMBL
  SSF49854 UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A8C2VDY8 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 42 rows