DUSP12 (dual specificity phosphatase 12) - Rat Genome Database

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Gene: DUSP12 (dual specificity phosphatase 12) Homo sapiens
Analyze
Symbol: DUSP12
Name: dual specificity phosphatase 12
RGD ID: 731810
HGNC Page HGNC:3067
Description: Enables phosphatase activity and zinc ion binding activity. Involved in dephosphorylation. Located in cytoplasm and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dual specificity protein phosphatase 12; dual specificity tyrosine phosphatase YVH1; DUSP1; serine/threonine specific protein phosphatase; YVH1; YVH1 protein-tyrosine phosphatase ortholog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: DUSP12P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,749,786 - 161,757,238 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,749,758 - 161,757,238 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,719,576 - 161,727,028 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,986,205 - 159,993,576 (+)NCBINCBI36Build 36hg18NCBI36
Build 341158,451,238 - 158,458,609NCBI
Celera1134,823,009 - 134,830,369 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,964,136 - 132,971,867 (+)NCBIHuRef
CHM1_11163,141,376 - 163,148,736 (+)NCBICHM1_1
T2T-CHM13v2.01161,094,105 - 161,101,566 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA,IEA)
cytosol  (IEA)
nucleoplasm  (IDA)
nucleus  (IBA,IDA,IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8670865   PMID:10446167   PMID:12477932   PMID:15489334   PMID:16169070   PMID:16189514   PMID:16710414   PMID:16936214   PMID:18029348   PMID:18269685   PMID:18854154   PMID:18973475  
PMID:19087671   PMID:19567874   PMID:20103624   PMID:21211013   PMID:21516116   PMID:21521943   PMID:21556130   PMID:21832049   PMID:21873635   PMID:21900206   PMID:24531476   PMID:25416956  
PMID:26288249   PMID:26344197   PMID:27432908   PMID:27702885   PMID:27856639   PMID:28077445   PMID:28330616   PMID:28675297   PMID:28846114   PMID:30779967   PMID:31515488   PMID:32296183  
PMID:33961781   PMID:34079125   PMID:35831314   PMID:36215168   PMID:36370849   PMID:37827155  


Genomics

Comparative Map Data
DUSP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,749,786 - 161,757,238 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1161,749,758 - 161,757,238 (+)EnsemblGRCh38hg38GRCh38
GRCh371161,719,576 - 161,727,028 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361159,986,205 - 159,993,576 (+)NCBINCBI36Build 36hg18NCBI36
Build 341158,451,238 - 158,458,609NCBI
Celera1134,823,009 - 134,830,369 (+)NCBICelera
Cytogenetic Map1q23.3NCBI
HuRef1132,964,136 - 132,971,867 (+)NCBIHuRef
CHM1_11163,141,376 - 163,148,736 (+)NCBICHM1_1
T2T-CHM13v2.01161,094,105 - 161,101,566 (+)NCBIT2T-CHM13v2.0
Dusp12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391170,701,756 - 170,713,109 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1170,701,067 - 170,713,109 (-)EnsemblGRCm39 Ensembl
GRCm381170,874,187 - 170,885,540 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1170,873,498 - 170,885,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv371172,804,319 - 172,815,671 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361172,710,863 - 172,722,215 (-)NCBIMGSCv36mm8
Celera1179,989,219 - 180,000,689 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map177.27NCBI
Dusp12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81385,654,914 - 85,666,431 (-)NCBIGRCr8
mRatBN7.21383,122,192 - 83,131,800 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1383,122,193 - 83,131,285 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1385,742,087 - 85,751,158 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01387,035,555 - 87,044,626 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01384,273,518 - 84,282,500 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01389,258,309 - 89,267,402 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1389,258,310 - 89,267,402 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01393,870,679 - 93,879,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41386,737,093 - 86,746,186 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11386,751,281 - 86,760,374 (-)NCBI
Celera1382,775,073 - 82,784,182 (-)NCBICelera
Cytogenetic Map13q24NCBI
Dusp12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546214,556,094 - 14,565,840 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546214,555,919 - 14,565,046 (-)NCBIChiLan1.0ChiLan1.0
DUSP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2188,029,384 - 88,037,407 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1187,697,674 - 87,706,594 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01137,161,774 - 137,169,503 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11140,959,867 - 140,968,821 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1140,959,867 - 140,968,821 (+)Ensemblpanpan1.1panPan2
DUSP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13820,912,543 - 20,921,137 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3820,912,546 - 20,921,125 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3820,964,899 - 20,973,061 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03820,995,914 - 21,004,157 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3820,995,394 - 21,004,163 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13820,967,831 - 20,975,985 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03821,320,983 - 21,328,971 (-)NCBIUNSW_CanFamBas_1.0
Dusp12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050587,636,761 - 7,643,999 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004937131156,201 - 163,153 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004937131156,175 - 163,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DUSP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl488,809,565 - 88,818,411 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1488,811,565 - 88,818,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2496,827,001 - 96,834,199 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DUSP12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1202,316,668 - 2,319,972 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660381,353,582 - 1,363,032 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dusp12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624826168,103 - 182,593 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624826167,966 - 182,844 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in DUSP12
25 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q23.2-24.1(chr1:159479887-166895086)x1 copy number loss See cases [RCV000051172] Chr1:159479887..166895086 [GRCh38]
Chr1:159449677..166864323 [GRCh37]
Chr1:157716301..165130947 [NCBI36]
Chr1:1q23.2-24.1		 pathogenic
GRCh38/hg38 1q23.1-25.1(chr1:157747246-176021247)x3 copy number gain See cases [RCV000051854] Chr1:157747246..176021247 [GRCh38]
Chr1:157717036..175990383 [GRCh37]
Chr1:155983660..174257006 [NCBI36]
Chr1:1q23.1-25.1		 pathogenic
GRCh38/hg38 1q23.3-24.2(chr1:160789732-168617494)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053913]|See cases [RCV000053913] Chr1:160789732..168617494 [GRCh38]
Chr1:160759522..168586732 [GRCh37]
Chr1:159026146..166853356 [NCBI36]
Chr1:1q23.3-24.2		 pathogenic
GRCh38/hg38 1q23.3-25.1(chr1:161740907-173965154)x1 copy number loss See cases [RCV000053914] Chr1:161740907..173965154 [GRCh38]
Chr1:161710697..173934292 [GRCh37]
Chr1:159977321..172200915 [NCBI36]
Chr1:1q23.3-25.1		 pathogenic
GRCh38/hg38 1q21.2-25.2(chr1:149854269-180267197)x3 copy number gain See cases [RCV000143515] Chr1:149854269..180267197 [GRCh38]
Chr1:149825831..180236332 [GRCh37]
Chr1:148092455..178502955 [NCBI36]
Chr1:1q21.2-25.2		 pathogenic
GRCh37/hg19 1q23.2-25.1(chr1:160369890-175796325) copy number loss not provided [RCV000767779] Chr1:160369890..175796325 [GRCh37]
Chr1:1q23.2-25.1		 pathogenic
GRCh37/hg19 1q23.3-25.3(chr1:161676893-184071723)x1 copy number loss See cases [RCV000447098] Chr1:161676893..184071723 [GRCh37]
Chr1:1q23.3-25.3		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q23.3(chr1:161469309-162517412)x3 copy number gain not provided [RCV000684667] Chr1:161469309..162517412 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.3(chr1:161726804-161867948)x1 copy number loss not provided [RCV000684668] Chr1:161726804..161867948 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q23.2-25.2(chr1:159815642-177026983)x1 copy number loss not provided [RCV000736717] Chr1:159815642..177026983 [GRCh37]
Chr1:1q23.2-25.2		 pathogenic
GRCh37/hg19 1q23.3(chr1:160744174-162583871)x3 copy number gain not provided [RCV000849025] Chr1:160744174..162583871 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.1-24.2(chr1:157321299-167391423)x1 copy number loss not provided [RCV000848773] Chr1:157321299..167391423 [GRCh37]
Chr1:1q23.1-24.2		 pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
GRCh37/hg19 1q23.2-24.1(chr1:160417296-166197042) copy number loss not specified [RCV002053658] Chr1:160417296..166197042 [GRCh37]
Chr1:1q23.2-24.1		 pathogenic
NC_000001.10:g.(?_158581054)_(162750036_?)dup duplication Autoimmune interstitial lung disease-arthritis syndrome [RCV001918952]|not provided [RCV001918953] Chr1:158581054..162750036 [GRCh37]
Chr1:1q23.1-23.3		 uncertain significance|no classifications from unflagged records
NC_000001.10:g.(?_161645027)_(161772082_?)dup duplication not provided [RCV001883368] Chr1:161645027..161772082 [GRCh37]
Chr1:1q23.3		 uncertain significance
NC_000001.10:g.(?_161279609)_(161751809_?)dup duplication Charcot-Marie-Tooth disease, type I [RCV003111375] Chr1:161279609..161751809 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.500C>T (p.Ala167Val) single nucleotide variant not specified [RCV004213149] Chr1:161751907 [GRCh38]
Chr1:161721697 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.559G>C (p.Val187Leu) single nucleotide variant not specified [RCV004206460] Chr1:161751966 [GRCh38]
Chr1:161721756 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.230G>A (p.Arg77His) single nucleotide variant not specified [RCV004200368] Chr1:161750031 [GRCh38]
Chr1:161719821 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.917A>G (p.Gln306Arg) single nucleotide variant not specified [RCV004182850] Chr1:161756841 [GRCh38]
Chr1:161726631 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.743A>C (p.His248Pro) single nucleotide variant not specified [RCV004113202] Chr1:161753143 [GRCh38]
Chr1:161722933 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.302T>C (p.Ile101Thr) single nucleotide variant not specified [RCV004174147] Chr1:161750103 [GRCh38]
Chr1:161719893 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.940A>G (p.Thr314Ala) single nucleotide variant not specified [RCV004183576] Chr1:161756864 [GRCh38]
Chr1:161726654 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.865C>T (p.Leu289Phe) single nucleotide variant not specified [RCV004141075] Chr1:161756789 [GRCh38]
Chr1:161726579 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.187G>A (p.Glu63Lys) single nucleotide variant not specified [RCV004178379] Chr1:161749988 [GRCh38]
Chr1:161719778 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.25G>A (p.Asp9Asn) single nucleotide variant not specified [RCV004112756] Chr1:161749826 [GRCh38]
Chr1:161719616 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.184G>A (p.Glu62Lys) single nucleotide variant not specified [RCV004220493] Chr1:161749985 [GRCh38]
Chr1:161719775 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.826A>G (p.Met276Val) single nucleotide variant not specified [RCV004292241] Chr1:161753226 [GRCh38]
Chr1:161723016 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.74G>A (p.Gly25Glu) single nucleotide variant not specified [RCV004272196] Chr1:161749875 [GRCh38]
Chr1:161719665 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.865C>A (p.Leu289Ile) single nucleotide variant not specified [RCV004252291] Chr1:161756789 [GRCh38]
Chr1:161726579 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.552A>C (p.Leu184Phe) single nucleotide variant not specified [RCV004347149] Chr1:161751959 [GRCh38]
Chr1:161721749 [GRCh37]
Chr1:1q23.3		 uncertain significance
GRCh37/hg19 1q23.1-23.3(chr1:158001058-162858285)x1 copy number loss not provided [RCV003483944] Chr1:158001058..162858285 [GRCh37]
Chr1:1q23.1-23.3		 likely pathogenic
NM_007240.3(DUSP12):c.259G>A (p.Glu87Lys) single nucleotide variant not specified [RCV004379655] Chr1:161750060 [GRCh38]
Chr1:161719850 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.574C>G (p.Pro192Ala) single nucleotide variant not specified [RCV004379657] Chr1:161751981 [GRCh38]
Chr1:161721771 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.746A>G (p.Lys249Arg) single nucleotide variant not specified [RCV004379660] Chr1:161753146 [GRCh38]
Chr1:161722936 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.65G>C (p.Ser22Thr) single nucleotide variant not specified [RCV004379658] Chr1:161749866 [GRCh38]
Chr1:161719656 [GRCh37]
Chr1:1q23.3		 likely benign
NM_007240.3(DUSP12):c.713G>A (p.Arg238His) single nucleotide variant not specified [RCV004379659] Chr1:161753113 [GRCh38]
Chr1:161722903 [GRCh37]
Chr1:1q23.3		 likely benign
NM_007240.3(DUSP12):c.395A>C (p.Lys132Thr) single nucleotide variant not specified [RCV004379656] Chr1:161751718 [GRCh38]
Chr1:161721508 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.754A>G (p.Thr252Ala) single nucleotide variant not specified [RCV004620136] Chr1:161753154 [GRCh38]
Chr1:161722944 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.191C>T (p.Pro64Leu) single nucleotide variant not specified [RCV004620137] Chr1:161749992 [GRCh38]
Chr1:161719782 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.331G>C (p.Val111Leu) single nucleotide variant not specified [RCV004620138] Chr1:161750132 [GRCh38]
Chr1:161719922 [GRCh37]
Chr1:1q23.3		 uncertain significance
NM_007240.3(DUSP12):c.544T>C (p.Tyr182His) single nucleotide variant not specified [RCV004620139] Chr1:161751951 [GRCh38]
Chr1:161721741 [GRCh37]
Chr1:1q23.3		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:658
Count of miRNA genes:436
Interacting mature miRNAs:465
Transcripts:ENST00000367943, ENST00000463365, ENST00000464004, ENST00000484291, ENST00000490591
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357381BW57_HBody weight QTL 57 (human)10.0001Body weightfat free mass after exercise training1140630236166630236Human
597071340GWAS1167414_Hserum IgG measurement QTL GWAS1167414 (human)3e-13serum IgG measurementserum immunoglobulin G level (CMO:0002102)1161751561161751562Human

Markers in Region
SGC30714  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371072,318,553 - 72,318,688UniSTSGRCh37
GRCh371161,718,367 - 161,718,502UniSTSGRCh37
Build 361159,984,991 - 159,985,126RGDNCBI36
Celera1065,600,314 - 65,600,449UniSTS
Celera1134,821,795 - 134,821,930RGD
Cytogenetic Map1q21-q22UniSTS
Cytogenetic Map10q22.1UniSTS
HuRef1066,312,079 - 66,312,214UniSTS
HuRef1132,962,922 - 132,963,057UniSTS
GeneMap99-GB4 RH Map1592.58UniSTS
Whitehead-RH Map1733.6UniSTS
RH69474  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371161,726,625 - 161,726,884UniSTSGRCh37
Build 361159,993,249 - 159,993,508RGDNCBI36
Celera1134,830,042 - 134,830,301RGD
Cytogenetic Map1q21-q22UniSTS
HuRef1132,971,540 - 132,971,799UniSTS
GeneMap99-GB4 RH Map1576.02UniSTS
DUSP12_2953  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371161,726,545 - 161,727,092UniSTSGRCh37
Build 361159,993,169 - 159,993,716RGDNCBI36
Celera1134,829,962 - 134,830,509RGD
HuRef1132,971,460 - 132,972,007UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 174 1

Sequence


Ensembl Acc Id: ENST00000367943   ⟹   ENSP00000356920
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,749,786 - 161,757,238 (+)Ensembl
Ensembl Acc Id: ENST00000463365
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,752,399 - 161,753,406 (+)Ensembl
Ensembl Acc Id: ENST00000464004   ⟹   ENSP00000476912
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,749,780 - 161,753,105 (+)Ensembl
Ensembl Acc Id: ENST00000484291   ⟹   ENSP00000476528
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,749,758 - 161,757,238 (+)Ensembl
Ensembl Acc Id: ENST00000490591   ⟹   ENSP00000477122
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1161,749,805 - 161,751,781 (+)Ensembl
RefSeq Acc Id: NM_007240   ⟹   NP_009171
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,749,786 - 161,757,238 (+)NCBI
GRCh371161,719,558 - 161,726,952 (+)NCBI
Build 361159,986,205 - 159,993,576 (+)NCBI Archive
HuRef1132,964,136 - 132,971,867 (+)ENTREZGENE
CHM1_11163,141,353 - 163,148,738 (+)NCBI
T2T-CHM13v2.01161,094,105 - 161,101,566 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005244862   ⟹   XP_005244919
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,749,786 - 161,757,238 (+)NCBI
GRCh371161,719,558 - 161,726,952 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054334007   ⟹   XP_054189982
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01161,094,105 - 161,101,566 (+)NCBI
RefSeq Acc Id: NP_009171   ⟸   NM_007240
- UniProtKB: Q9UNI6 (UniProtKB/Swiss-Prot),   Q5VXA8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005244919   ⟸   XM_005244862
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSP00000476912   ⟸   ENST00000464004
Ensembl Acc Id: ENSP00000477122   ⟸   ENST00000490591
Ensembl Acc Id: ENSP00000476528   ⟸   ENST00000484291
Ensembl Acc Id: ENSP00000356920   ⟸   ENST00000367943
RefSeq Acc Id: XP_054189982   ⟸   XM_054334007
- Peptide Label: isoform X1
Protein Domains
Tyrosine-protein phosphatase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9UNI6-F1-model_v2 AlphaFold Q9UNI6 1-340 view protein structure

Promoters
RGD ID:6785080
Promoter ID:HG_KWN:5886
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000083588,   OTTHUMT00000083589,   OTTHUMT00000083590,   OTTHUMT00000083591,   UC001GBP.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361159,986,101 - 159,986,601 (+)MPROMDB
RGD ID:6857908
Promoter ID:EPDNEW_H2119
Type:initiation region
Name:DUSP12_1
Description:dual specificity phosphatase 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381161,749,804 - 161,749,864EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3067 AgrOrtholog
COSMIC DUSP12 COSMIC
Ensembl Genes ENSG00000081721 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000367943 ENTREZGENE
  ENST00000367943.5 UniProtKB/Swiss-Prot
  ENST00000464004.2 UniProtKB/TrEMBL
  ENST00000484291.5 UniProtKB/TrEMBL
  ENST00000490591.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000081721 GTEx
HGNC ID HGNC:3067 ENTREZGENE
Human Proteome Map DUSP12 Human Proteome Map
InterPro Dual-sp_phosphatase_cat-dom UniProtKB/Swiss-Prot
  DUSP12 UniProtKB/Swiss-Prot
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL_dom UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report hsa:11266 UniProtKB/Swiss-Prot
NCBI Gene 11266 ENTREZGENE
OMIM 604835 OMIM
PANTHER DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DSPc UniProtKB/Swiss-Prot
PharmGKB PA27522 PharmGKB
PIRSF DUSP12 UniProtKB/Swiss-Prot
PROSITE TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot
  TYR_PHOSPHATASE_DUAL UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
SMART DSPc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt DUS12_HUMAN UniProtKB/Swiss-Prot
  Q5VXA8 ENTREZGENE
  Q9UNI6 ENTREZGENE
  V9GY92_HUMAN UniProtKB/TrEMBL
  V9GYV5_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q5VXA8 UniProtKB/Swiss-Prot