DUSP12 (dual specificity phosphatase 12)

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Gene: DUSP12 (dual specificity phosphatase 12) Pan paniscus

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Symbol:

DUSP12

Name:

dual specificity phosphatase 12

RGD ID:

11837796

Description:

ENCODES a protein that exhibits kinase binding (ortholog); phosphoprotein phosphatase activity (ortholog); INVOLVED IN dephosphorylation (ortholog); positive regulation of glucokinase activity (ortholog); protein dephosphorylation (ortholog); ASSOCIATED WITH autoimmune interstitial lung, joint, and kidney disease (ortholog); Charcot-Marie-Tooth disease type 1 (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

dual specificity protein phosphatase 12

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	88,029,384 - 88,037,407 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	87,697,674 - 87,706,594 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	137,161,774 - 137,169,503 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	140,959,867 - 140,968,821 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	140,959,867 - 140,968,821 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autoimmune interstitial lung, joint, and kidney disease (ISO)

Charcot-Marie-Tooth disease type 1 (ISO)

gastrointestinal stromal tumor (ISO)

parathyroid carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromatin remodeling (IEA)

dephosphorylation (ISO)

positive regulation of glucokinase activity (ISO)

protein dephosphorylation (ISO)

Cellular Component

cytoplasm (IEA)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

histone H2AXY142 phosphatase activity (IEA)

kinase binding (ISO)

non-membrane spanning protein tyrosine phosphatase activity (IEA)

phosphatase activity (IEA)

phosphoprotein phosphatase activity (IEA,ISO)

protein binding (ISO)

protein tyrosine phosphatase activity, metal-dependent (IEA)

protein tyrosine/serine/threonine phosphatase activity (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

DUSP12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	88,029,384 - 88,037,407 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	87,697,674 - 87,706,594 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	137,161,774 - 137,169,503 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	140,959,867 - 140,968,821 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	140,959,867 - 140,968,821 (+)	Ensembl	panpan1.1		panPan2

DUSP12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	161,749,786 - 161,757,238 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	161,749,758 - 161,757,238 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	161,719,576 - 161,727,028 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	159,986,205 - 159,993,576 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	158,451,238 - 158,458,609	NCBI
Celera	1	134,823,009 - 134,830,369 (+)	NCBI		Celera
Cytogenetic Map	1	q23.3	NCBI
HuRef	1	132,964,136 - 132,971,867 (+)	NCBI		HuRef
CHM1_1	1	163,141,376 - 163,148,736 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	161,094,105 - 161,101,566 (+)	NCBI		T2T-CHM13v2.0

Dusp12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	170,701,756 - 170,713,109 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	170,701,067 - 170,713,109 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	170,874,187 - 170,885,540 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	170,873,498 - 170,885,540 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	172,804,319 - 172,815,671 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	172,710,863 - 172,722,215 (-)	NCBI		MGSCv36	mm8
Celera	1	179,989,219 - 180,000,689 (+)	NCBI		Celera
Cytogenetic Map	1	H3	NCBI
cM Map	1	77.27	NCBI

Dusp12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	85,654,914 - 85,666,431 (-)	NCBI		GRCr8
mRatBN7.2	13	83,122,192 - 83,131,800 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	83,122,193 - 83,131,285 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	85,742,087 - 85,751,158 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	87,035,555 - 87,044,626 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	84,273,518 - 84,282,500 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	89,258,309 - 89,267,402 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	89,258,310 - 89,267,402 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	93,870,679 - 93,879,772 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	86,737,093 - 86,746,186 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	86,751,281 - 86,760,374 (-)	NCBI
Celera	13	82,775,073 - 82,784,182 (-)	NCBI		Celera
Cytogenetic Map	13	q24	NCBI

Dusp12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955462	14,556,094 - 14,565,840 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955462	14,555,919 - 14,565,046 (-)	NCBI	ChiLan1.0	ChiLan1.0

DUSP12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	20,912,543 - 20,921,137 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	20,912,546 - 20,921,125 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	20,964,899 - 20,973,061 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	20,995,914 - 21,004,157 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	20,995,394 - 21,004,163 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	20,967,831 - 20,975,985 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	21,320,983 - 21,328,971 (-)	NCBI		UNSW_CanFamBas_1.0

Dusp12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	7,636,761 - 7,643,999 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004937131	156,201 - 163,153 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004937131	156,175 - 163,392 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DUSP12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	88,809,565 - 88,818,411 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	88,811,565 - 88,818,513 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	96,827,001 - 96,834,199 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DUSP12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	2,316,668 - 2,319,972 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666038	1,353,582 - 1,363,032 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dusp12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624826	168,103 - 182,593 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624826	167,966 - 182,844 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003824556	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000043056 ⟹ ENSPPAP00000020264

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	140,959,867 - 140,968,821 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000043065 ⟹ ENSPPAP00000020273

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	140,961,205 - 140,962,495 (+)	Ensembl

RefSeq Acc Id:

XM_003824556 ⟹ XP_003824604

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	88,029,384 - 88,037,407 (-)	NCBI
NHGRI_mPanPan1	1	87,697,674 - 87,706,594 (-)	NCBI
Mhudiblu_PPA_v0	1	137,161,774 - 137,169,503 (+)	NCBI
PanPan1.1	1	140,959,867 - 140,968,821 (+)	NCBI

Sequence:

show sequence

GGTAAAGAAAGGCAGGTTTATTAGATAAAGTATGAAAATACATTGCAAGGGTGCAACAGGCAGG
TCAGCAAGAGAGAAGCTGACTGCTAGGAAACAAAGGCTTGCTGGGGATTTTGTAGAATGGTGCT
TATGTTGTGGGTGGAAGAGGGCTTTGTGCAGTACTAATAATGCCAGGGTTGCAGTGAACTAACT
TCCATTTTTCTATCAGCTGAGGGTCTGGTGATGGCTGGGCACAGGCAGATTGTGAGTTATTTGC
ACAGCAGGGCTATGTGTCCTGGACCACGAAGAAAGGCAGACTTATGGCTTGTCTGCTTTCTCCT
TTTGCTTCCCTTCGTCCAGCCAGCCTGACTCCTTTTCCCTAATTAGGACTCCACACGCAAGGGT
TTGTTCTGTTCCAGAATAGAGACAGGTCGATGTATCTATCTTTATACCAGTACTATAGCTGCTA
CTTCTTGACCAATTACAGCTTTAGTATCTCTCTCACCTGTCCTCCCTATACAAAAGATATATAA
AATATACTCACTGTACTGAGTATCTTCCTGCAGCATTCAGTCTGGAGCAAAGCCTGCTTCCTTC
AACCCTTTCCAAAATCCCCAAATAAAAGCCCAAAATCTGTATAGGATCTTCCTAACATCCTCGT
GCTGAGATGCCCTGAAATTCTCCATAACTCATGACTGAGTAATAAAACCAACTTGCTTAATTAA
AGTTGGTTTCTTGTAGTCCTGGCTGGAGGACATTGACTTACAAAAATATAGGATTAGTATCTTC
AAAATAAATAGACAGTAAACATCAACAAGGATTCACACCCCAATAATGAAATTGGGCAGAAAAA
GGAAAAATAATCATGAAATGCACAGTAAAGATGGCTCCATAATATTGAAAAAAATTTTACTTCA
AATGCATAAAATGATGCTTCTGATTCAGCTGGTGCGACCTTTATTTCACATTTGAGTTCAGCTG
CTCCTGATGTCTCTTTCCTGAAAATTTCAATACTAAGAGCTCGAGAAACCCTGTATTTGGGGAA
GCTTATCCTTTACCATCAACTTTGGGGGTAGGGGTCAGAGGGAACAAGGGTGGAAAGGCCGCGC
TGAATGGGGCCGAAGCTCCGCCCCTCAGCGATAAGTCCAGATTCCTGCGGCCGACGTGGTCCTC
CGAGGGAGCAGCAGAGCCGCCGAGGCTGGCGAGTCCCAGGGGAAGGATGTTCTAGCCGGAGTCT
ACTCGATGGTAGGGCAGGAAGCCGCCTTGTCTCTGGGCGCGGCCATGTTGGAGGCTCCGGGCCC
GAGTGATGGCTGCGAGCTCAGCAACCCCAGCGCCAGCAGAGTCAGCTGCGCCAGGCAGATGCTG
GAAGTGCAGCCAGGATTGTATTTCGGTGGGGCCGCGGCCGTCGCGGAGCCAGATCACCTGAGGG
AAGCGGGCATCACGGCCGTGCTAACAGTGGACTCGGAGGAGCCCAGCTTCAAGGCGGGGCCTGG
GGTCGAGGATCTATGGCGCCTCTTCGTGCCAGCGCTGGACAAACCCGAGACGGACCTACTCAGC
CATCTGGACCGGTGCGTGGCCTTCATCGGTCAGGCCCGCGCTGAGGGCCGTGCGGTGTTGGTGC
ACTGTCATGCAGGAGTCAGTCGAAGTGTGGCCATAATAACTGCTTTTCTCATGAAGACTGACCA
ACTTCCCTTTGAAAAAGCCTATGAAAAGCTCCAGATTCTCAAACCAGAGGCTAAGATGAATGAG
GGGTTTGAGTGGCAACTGAAATTATACCAGGCAATGGGATACGAAGTGGATACCTCTAGTGCAA
TTTATAAGCAATATCGTTTACAAAAGGTTACAGAGAAGTATCCAGAATTGCAGAATTTACCTCA
AGAACTCTTTGCTGTTGACCCAACTACCGTTTCACAAGGATTGAAAGATGAGGTTCTCTACAAG
TGTAGAAAGTGCAGGCGATCATTATTTCGAAGTTCTAGTATTCTGGATCACCGTGAAGGAAGTG
GACCTATAGCCTTTGCCCACAAGAGAATGACGCCATCTTCCATGCTTACCACAGGGAGGCAAGC
TCAATGTACATCTTATTTCATTGAACCTGTACAGTGGATGGAATCTGCTTTGTTGGGAGTGATG
GATGGACAGCTTCTTTGCCCAAAATGCAGTGCCAAGTTGGGTTCCTTCAACTGGTATGGTGAAC
AGTGCTCTTGTGGTAGGTGGATAACACCTGCTTTTCAAATACATAAGAATAGAGTGGATGAAAT
GAAAATATTGCCTGTTTTGGGATCACAAACAGGAAAAATATGAACATGATATTTTATAGCTTGG
GAAGAAACTTGCACATGATATGTGCTGCCTTTGCTTCTTATCATTCATGGCAGATTGTTTGTGC
TGTCAACATTTCATGTGAAATGGGAGAAGATAAAATCACTTGATGTAACCTGGAAACTATGCTT
TACATGGCAATCAAAGCCTTTTGATCATGTACATTTTATTTGATATTAAAATCTTTTATAACCA
GA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003824604	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000020264.1
	ENSPPAP00000020273.1

RefSeq Acc Id:

XP_003824604 ⟸ XM_003824556

- UniProtKB:

A0A2R9AYW8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVGQEAALSLGAAMLEAPGPSDGCELSNPSASRVSCARQMLEVQPGLYFGGAAAVAEPDHLREA
GITAVLTVDSEEPSFKAGPGVEDLWRLFVPALDKPETDLLSHLDRCVAFIGQARAEGRAVLVHC
HAGVSRSVAIITAFLMKTDQLPFEKAYEKLQILKPEAKMNEGFEWQLKLYQAMGYEVDTSSAIY
KQYRLQKVTEKYPELQNLPQELFAVDPTTVSQGLKDEVLYKCRKCRRSLFRSSSILDHREGSGP
IAFAHKRMTPSSMLTTGRQAQCTSYFIEPVQWMESALLGVMDGQLLCPKCSAKLGSFNWYGEQC
SCGRWITPAFQIHKNRVDEMKILPVLGSQTGKI

hide sequence

Ensembl Acc Id:

ENSPPAP00000020264 ⟸ ENSPPAT00000043056

Ensembl Acc Id:

ENSPPAP00000020273 ⟸ ENSPPAT00000043065

Protein Domains

C2H2-type Tyrosine specific protein phosphatases Tyrosine-protein phosphatase

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000033359	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000043056.1	UniProtKB/TrEMBL
	ENSPPAT00000043065.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.190.10	UniProtKB/TrEMBL
InterPro	Dual-sp_phosphatase_cat-dom	UniProtKB/TrEMBL
	DUSP12	UniProtKB/TrEMBL
	Prot-tyrosine_phosphatase-like	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_dom	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL_dom	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
NCBI Gene	DUSP12	ENTREZGENE
PANTHER	DUAL SPECIFICITY PROTEIN PHOSPHATASE 12	UniProtKB/TrEMBL
	DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER	UniProtKB/TrEMBL
Pfam	DSPc	UniProtKB/TrEMBL
PIRSF	DUSP12	UniProtKB/TrEMBL
PROSITE	TYR_PHOSPHATASE_2	UniProtKB/TrEMBL
	TYR_PHOSPHATASE_DUAL	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
SMART	DSPc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52799	UniProtKB/TrEMBL
UniProt	A0A2R9ASV2_PANPA	UniProtKB/TrEMBL
	A0A2R9AYW8	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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