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Gene: Slc5a5 (solute carrier family 5 (sodium iodide symporter), member 5) Mus musculus
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Symbol: Slc5a5
Name: solute carrier family 5 (sodium iodide symporter), member 5
Description: Exhibits sodium:iodide symporter activity. Predicted to be involved in iodide transport and sodium ion transport. Predicted to localize to the nucleus and plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism. Is expressed in axial skeleton tail region; stomach; and thyroid gland. Orthologous to human SLC5A5 (solute carrier family 5 member 5); PARTICIPATES IN thyroid hormone biosynthetic pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na(+)/I(-)-symporter; NIS; sodium-iodide symporter; sodium/iodide cotransporter; solute carrier family 5 member 5
Orthologs:
Homo sapiens (human) : SLC5A5 (solute carrier family 5 member 5)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Slc5a5 (solute carrier family 5 member 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc5a5 (solute carrier family 5 member 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC5A5 (solute carrier family 5 member 5)
Canis lupus familiaris (dog) : SLC5A5 (solute carrier family 5 member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc5a5 (solute carrier family 5 member 5)
Sus scrofa (pig) : SLC5A5 (solute carrier family 5 member 5)
Chlorocebus sabaeus (African green monkey) : SLC5A5 (solute carrier family 5 member 5)
Heterocephalus glaber (naked mole-rat) : Slc5a5 (solute carrier family 5 member 5)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl870,882,889 - 70,892,757 (-)EnsemblGRCm38mm10GRCm38
GRCm38870,882,885 - 70,892,785 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37873,406,788 - 73,416,656 (-)NCBIGRCm37mm9NCBIm37
MGSCv36873,812,491 - 73,821,713 (-)NCBImm8
Celera873,444,192 - 73,454,060 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Slc5a5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 731752
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.