SLC5A5 (solute carrier family 5 member 5) - Rat Genome Database

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Gene: SLC5A5 (solute carrier family 5 member 5) Sus scrofa
Analyze
Symbol: SLC5A5
Name: solute carrier family 5 member 5
RGD ID: 14114255
Description: ENCODES a protein that exhibits iodide transmembrane transporter activity (ortholog); sodium:iodide symporter activity (ortholog); symporter activity (ortholog); INVOLVED IN iodide transport (ortholog); sodium ion transport (ortholog); PARTICIPATES IN thyroid hormone biosynthetic pathway; ASSOCIATED WITH amenorrhea (ortholog); Breast Neoplasms (ortholog); cholangiocarcinoma (ortholog); FOUND IN plasma membrane (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl; clofibrate
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: NIS; sodium iodide symporter; sodium/iodide cotransporter; solute carrier family 5 (sodium iodide symporter), member 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,869,154 - 59,885,265 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,869,157 - 59,885,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,438,591 - 59,454,519 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:12586784   PMID:21461567   PMID:23969277   PMID:27108928  


Genomics

Comparative Map Data
SLC5A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,869,154 - 59,885,265 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,869,157 - 59,885,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2259,438,591 - 59,454,519 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC5A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,871,945 - 17,895,174 (+)EnsemblGRCh38hg38GRCh38
GRCh381917,871,394 - 17,895,175 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,982,754 - 18,005,983 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,843,782 - 17,865,897 (+)NCBINCBI36hg18NCBI36
Build 341917,843,781 - 17,865,897NCBI
Celera1917,884,497 - 17,907,699 (+)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,548,153 - 17,571,202 (+)NCBIHuRef
CHM1_11917,982,521 - 18,005,714 (+)NCBICHM1_1
Slc5a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,335,529 - 71,345,429 (-)NCBIGRCm39mm39
GRCm39 Ensembl871,335,533 - 71,345,401 (-)Ensembl
GRCm38870,882,885 - 70,892,785 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,882,889 - 70,892,757 (-)EnsemblGRCm38mm10GRCm38
MGSCv37873,406,788 - 73,416,656 (-)NCBIGRCm37mm9NCBIm37
MGSCv36873,812,491 - 73,821,713 (-)NCBImm8
Celera873,444,192 - 73,454,060 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
Slc5a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21618,546,709 - 18,556,698 (+)NCBI
Rnor_6.0 Ensembl1620,297,414 - 20,307,400 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01620,297,414 - 20,307,401 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01620,154,958 - 20,164,945 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,046,200 - 19,056,281 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,046,197 - 19,056,301 (+)NCBI
Celera1618,739,349 - 18,749,322 (+)NCBICelera
Cytogenetic Map16p14NCBI
Slc5a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555243,372,539 - 3,380,758 (-)NCBIChiLan1.0ChiLan1.0
SLC5A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11918,327,410 - 18,344,480 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,327,410 - 18,344,480 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01917,352,635 - 17,377,130 (+)NCBIMhudiblu_PPA_v0panPan3
SLC5A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,017,939 - 45,030,598 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,018,119 - 45,030,209 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,930,090 - 44,942,416 (-)NCBI
ROS_Cfam_1.02045,502,644 - 45,514,972 (-)NCBI
UMICH_Zoey_3.12044,739,503 - 44,751,827 (-)NCBI
UNSW_CanFamBas_1.02045,149,996 - 45,162,311 (-)NCBI
UU_Cfam_GSD_1.02045,425,947 - 45,438,272 (-)NCBI
Slc5a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,623,144 - 203,639,908 (-)NCBI
SpeTri2.0NW_0049365963,176,009 - 3,188,637 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC5A5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,346,361 - 16,367,833 (+)NCBI
Slc5a5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,401,812 - 1,410,471 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system hemolymphoid system nervous system respiratory system
High
Medium
Low 1 1 6 1
Below cutoff 1 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000015176   ⟹   ENSSSCP00000014770
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl259,869,154 - 59,885,265 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000043936   ⟹   ENSSSCP00000043693
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl259,869,154 - 59,885,265 (-)Ensembl
RefSeq Acc Id: NM_214410   ⟹   NP_999575
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1259,869,157 - 59,885,086 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_999575 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAC17810 (Get FASTA)   NCBI Sequence Viewer  
  CAC17816 (Get FASTA)   NCBI Sequence Viewer  
  CAC81949 (Get FASTA)   NCBI Sequence Viewer  
  CAD32248 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_999575   ⟸   NM_214410
- UniProtKB: Q9GJX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000014770   ⟸   ENSSSCT00000015176
RefSeq Acc Id: ENSSSCP00000043693   ⟸   ENSSSCT00000043936


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000013890 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000014770 UniProtKB/TrEMBL
  ENSSSCP00000043693 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000015176 UniProtKB/TrEMBL
  ENSSSCT00000043936 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.20.1730.10 UniProtKB/TrEMBL
InterPro Na/Glc_symporter_sf UniProtKB/TrEMBL
  Na/solute_symporter UniProtKB/TrEMBL
  Na/solute_symporter_CS UniProtKB/TrEMBL
  SLC5A5 UniProtKB/TrEMBL
KEGG Report ssc:399542 UniProtKB/TrEMBL
NCBI Gene SLC5A5 ENTREZGENE
Pfam SSF UniProtKB/TrEMBL
PROSITE NA_SOLUT_SYMP_1 UniProtKB/TrEMBL
  NA_SOLUT_SYMP_3 UniProtKB/TrEMBL
TIGRFAMs sss UniProtKB/TrEMBL
UniProt A0A287AIH3_PIG UniProtKB/TrEMBL
  F6Q402_PIG UniProtKB/TrEMBL
  Q9GJX7 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:93145 ENTREZGENE