OSM (oncostatin M) - Rat Genome Database

Name: OSM
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Advanced Search (OLGA)

Gene: OSM (oncostatin M) Homo sapiens

Analyze

Symbol:

OSM

Name:

oncostatin M

RGD ID:

69134

HGNC Page

HGNC:8506

Description:

Enables cytokine activity; growth factor activity; and oncostatin-M receptor binding activity. Involved in several processes, including oncostatin-M-mediated signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of tyrosine phosphorylation of STAT protein. Acts upstream of or within several processes, including positive regulation of MAPK cascade; positive regulation of protein phosphorylation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space.

Type:

protein-coding

RefSeq Status:

REVIEWED

Previously known as:

MGC20461; oncostatin-M

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Mus musculus (house mouse):	Osm (oncostatin M)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):	Osm (oncostatin M)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):	Osm (oncostatin M)	NCBI	Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):	OSM (oncostatin M)	NCBI	Ortholog
Canis lupus familiaris (dog):	OSM (oncostatin M)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Osm (oncostatin M)	NCBI	Ortholog
Sus scrofa (pig):	OSM (oncostatin M)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Chlorocebus sabaeus (green monkey):	OSM (oncostatin M)	NCBI	Ortholog
Heterocephalus glaber (naked mole-rat):	Osm (oncostatin M)	NCBI	Ortholog
Other homologs ²
Rattus norvegicus (Norway rat):	Mcph1 (microcephalin 1)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Osm (oncostatin M)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Rattus norvegicus (Norway rat):	Osm (oncostatin M)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	osm	Alliance	DIOPT (ZFIN)

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	30,262,829 - 30,266,851 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	30,262,829 - 30,266,851 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	30,658,818 - 30,662,840 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	28,988,818 - 28,992,840 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	28,983,374 - 28,987,394	NCBI
Celera	22	14,458,501 - 14,462,523 (-)	NCBI		Celera
Cytogenetic Map	22	q12.2	NCBI
HuRef	22	13,620,598 - 13,624,609 (-)	NCBI		HuRef
CHM1_1	22	30,617,955 - 30,621,966 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	30,726,147 - 30,730,169 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chloracne (EXP)

contact dermatitis (EXP)

COVID-19 (HEP)

Experimental Liver Cirrhosis (EXP)

juvenile rheumatoid arthritis (EXP)

Neoplasm Metastasis (EXP)

pancreatic ductal carcinoma (EXP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-pilocarpine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-estradiol (ISO)

17beta-estradiol 3-benzoate (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-acetamidofluorene (ISO)

2-amino-2-deoxy-D-glucopyranose (EXP)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxynon-2-enal (ISO)

4-nitroquinoline N-oxide (ISO)

acetamide (ISO)

acetylsalicylic acid (EXP)

acrolein (ISO)

aldehydo-D-glucosamine (EXP)

all-trans-retinoic acid (EXP)

alpha-amanitin (ISO)

amphetamine (ISO)

anthra[1,9-cd]pyrazol-6(2H)-one (EXP)

antimonite (EXP)

antirheumatic drug (EXP)

aristolochic acid A (EXP)

arsane (EXP)

arsenic atom (EXP)

arsenite(3-) (EXP)

baricitinib (EXP)

benzo[a]pyrene (EXP,ISO)

beta-D-glucosamine (EXP)

bicalutamide (EXP)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (ISO)

buta-1,3-diene (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

carboplatin (EXP)

ceric oxide (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

cobalt atom (EXP)

copper atom (ISO)

copper(0) (ISO)

corticosterone (ISO)

Cuprizon (ISO)

cyclophosphamide (ISO)

dextran sulfate (ISO)

Dibutyl phosphate (EXP)

diisopropyl fluorophosphate (ISO)

dioxygen (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (EXP)

erlotinib hydrochloride (EXP)

gemcitabine (EXP)

graphite (ISO)

hydroxyflutamide (EXP)

lead diacetate (ISO)

lipopolysaccharide (EXP)

lovastatin (EXP)

methylmercury chloride (EXP,ISO)

N,N-diethyl-m-toluamide (ISO)

N-ethylmaleimide (EXP)

nickel atom (EXP)

ochratoxin A (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

PF-956980 (EXP)

PhIP (EXP)

physostigmine (ISO)

Pyridostigmine bromide (ISO)

SB 203580 (EXP)

silicon dioxide (EXP,ISO)

silver atom (ISO)

silver(0) (ISO)

simvastatin (EXP)

sodium arsenite (EXP)

testosterone (ISO)

tetrachloromethane (ISO)

thioacetamide (ISO)

titanium dioxide (ISO)

tofacitinib (EXP,ISO)

toluene 2,4-diisocyanate (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP)

triptonide (ISO)

Tungsten carbide (EXP)

valproic acid (EXP,ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

behavioral response to pain (ISO)

immune response (IEA)

meiotic nuclear division (ISO)

negative regulation of cell population proliferation (TAS)

negative regulation of hormone secretion (IDA)

negative regulation of meiotic nuclear division (ISO)

oncostatin-M-mediated signaling pathway (IDA,IEA)

peripheral nervous system development (ISO)

positive regulation of acute inflammatory response (IC)

positive regulation of apoptotic signaling pathway (ISO)

positive regulation of cell division (IEA)

positive regulation of cell population proliferation (IDA)

positive regulation of inflammatory response (IDA)

positive regulation of interleukin-17 production (IDA)

positive regulation of MAPK cascade (IDA)

positive regulation of peptidyl-serine phosphorylation (IDA)

positive regulation of peptidyl-tyrosine phosphorylation (IDA)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IGI)

positive regulation of transcription by RNA polymerase II (IDA)

positive regulation of tyrosine phosphorylation of STAT protein (IDA)

regulation of cell communication (IEA)

regulation of hematopoietic stem cell differentiation (TAS)

regulation of signaling (IEA)

response to heat (ISO)

tyrosine phosphorylation of STAT protein (ISO)

Cellular Component

extracellular region (IEA,TAS)

extracellular space (IEA,TAS)

Molecular Function

cytokine activity (IBA,IDA,IEA,TAS)

growth factor activity (IDA)

oncostatin-M receptor binding (IEA,IPI,TAS)

protein binding (IPI)

signaling receptor binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

granulocyte-macrophage colony-stimulating factor signaling pathway (EXP)

interleukin-3 signaling pathway (EXP)

Jak-Stat signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	GOAs Human GO annotations	GOA_HUMAN data from the GO Consortium
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Heightened Innate Immune Responses in the Respiratory Tract of COVID-19 Patients.	Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.

Additional References at PubMed

PMID:1536831	PMID:1542793	PMID:1542794	PMID:1717982	PMID:2026606	PMID:2325640	PMID:2779549	PMID:3540948	PMID:7508917	PMID:7867561	PMID:8406444	PMID:8422753
PMID:8999038	PMID:9847074	PMID:9920829	PMID:10556323	PMID:10591208	PMID:10997905	PMID:11711546	PMID:11777927	PMID:11811789	PMID:11818668	PMID:11839742	PMID:11936950
PMID:12061840	PMID:12061841	PMID:12090757	PMID:12138373	PMID:12218157	PMID:12391243	PMID:12477932	PMID:12531804	PMID:12640208	PMID:12692260	PMID:12707269	PMID:15146412
PMID:15461802	PMID:15489334	PMID:15712220	PMID:15809742	PMID:15831292	PMID:15837947	PMID:15863389	PMID:16051226	PMID:16369169	PMID:16713283	PMID:16802343	PMID:17009243
PMID:17028186	PMID:17081797	PMID:17372020	PMID:17471233	PMID:17604327	PMID:17761945	PMID:17881458	PMID:17979974	PMID:18028996	PMID:18187666	PMID:18317962	PMID:18398932
PMID:18499891	PMID:18564531	PMID:18637848	PMID:18772145	PMID:18981157	PMID:19019853	PMID:19086053	PMID:19148539	PMID:19158240	PMID:19158344	PMID:19342253	PMID:19565514
PMID:19652200	PMID:19913121	PMID:19916861	PMID:20088942	PMID:20101226	PMID:20149034	PMID:20189410	PMID:20237496	PMID:20408777	PMID:20626292	PMID:20628086	PMID:20650266
PMID:20661773	PMID:21196532	PMID:21376322	PMID:21399633	PMID:21399864	PMID:21457934	PMID:21481226	PMID:21775705	PMID:21832049	PMID:21873635	PMID:21900206	PMID:21912637
PMID:21965736	PMID:21975934	PMID:22051730	PMID:22056139	PMID:22082156	PMID:22267310	PMID:22267707	PMID:22829597	PMID:22931588	PMID:22982441	PMID:23128233	PMID:23313749
PMID:23584474	PMID:23621172	PMID:23735324	PMID:23867565	PMID:24297795	PMID:24381786	PMID:24418171	PMID:24600984	PMID:24710357	PMID:25241761	PMID:25252914	PMID:25735629
PMID:25804939	PMID:25840724	PMID:25845347	PMID:25849622	PMID:25954856	PMID:26186194	PMID:26198770	PMID:26304992	PMID:26311783	PMID:26355153	PMID:26399567	PMID:27107012
PMID:27211553	PMID:27349249	PMID:27486982	PMID:27676154	PMID:27892764	PMID:27993536	PMID:28053127	PMID:28106823	PMID:28288136	PMID:28368383	PMID:28471981	PMID:28514442
PMID:28560754	PMID:28729401	PMID:28972028	PMID:29269396	PMID:29511087	PMID:29526757	PMID:29898744	PMID:30091322	PMID:30142324	PMID:30373773	PMID:30670533	PMID:30930146
PMID:31461490	PMID:31753913	PMID:31861914	PMID:31930328	PMID:32325460	PMID:32359099	PMID:32652496	PMID:32678942	PMID:32690652	PMID:32703406	PMID:33216732	PMID:33624092
PMID:33923774	PMID:33961781	PMID:33990221	PMID:34011405	PMID:34037532	PMID:34102284	PMID:34117193	PMID:34301760	PMID:34534575	PMID:34547509	PMID:34674925	PMID:34921158
PMID:34933172	PMID:35020406	PMID:35064579	PMID:35163735	PMID:36054964	PMID:36623776	PMID:36856919	PMID:37047067	PMID:37247926	PMID:37476931	PMID:38035099	PMID:38151020
PMID:38953214

Genomics

Comparative Map Data

OSM
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	30,262,829 - 30,266,851 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	30,262,829 - 30,266,851 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	30,658,818 - 30,662,840 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	28,988,818 - 28,992,840 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	28,983,374 - 28,987,394	NCBI
Celera	22	14,458,501 - 14,462,523 (-)	NCBI		Celera
Cytogenetic Map	22	q12.2	NCBI
HuRef	22	13,620,598 - 13,624,609 (-)	NCBI		HuRef
CHM1_1	22	30,617,955 - 30,621,966 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	30,726,147 - 30,730,169 (-)	NCBI		T2T-CHM13v2.0

Osm
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	4,186,831 - 4,191,027 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	4,186,420 - 4,191,026 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	4,236,785 - 4,241,026 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	4,236,420 - 4,241,026 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	4,136,788 - 4,141,029 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	4,136,423 - 4,141,029 (+)	NCBI		MGSCv36	mm8
Celera	11	4,735,950 - 4,740,191 (+)	NCBI		Celera
Cytogenetic Map	11	A1	NCBI
cM Map	11	2.94	NCBI

Osm
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	83,327,202 - 83,332,073 (+)	NCBI		GRCr8
mRatBN7.2	14	79,103,638 - 79,108,500 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	79,104,344 - 79,108,313 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	83,545,045 - 83,547,887 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	84,785,121 - 84,787,963 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	81,231,091 - 81,233,943 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	84,457,487 - 84,469,426 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	84,465,515 - 84,470,409 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	85,139,161 - 85,151,646 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	14	84,857,232 - 84,860,082 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	14	78,014,541 - 78,017,610 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

Osm
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955455	4,511,769 - 4,514,633 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955455	4,510,711 - 4,515,282 (-)	NCBI	ChiLan1.0	ChiLan1.0

OSM
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	40,229,981 - 40,234,801 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	42,928,587 - 42,932,631 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	11,298,965 - 11,303,009 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	29,101,084 - 29,105,104 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	29,101,085 - 29,105,081 (-)	Ensembl	panpan1.1		panPan2

OSM
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	23,421,787 - 23,439,332 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	23,421,787 - 23,426,036 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	23,292,978 - 23,297,000 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	23,805,727 - 23,809,749 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	23,805,727 - 23,809,632 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	23,507,438 - 23,511,460 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	23,770,285 - 23,774,307 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	23,830,630 - 23,834,652 (-)	NCBI		UU_Cfam_GSD_1.0

Osm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	116,339,969 - 116,342,209 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936904	390,089 - 394,195 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OSM
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	47,242,774 - 47,246,838 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	47,242,767 - 47,246,836 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	50,281,695 - 50,298,845 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OSM
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	13,142,652 - 13,147,548 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	13,144,442 - 13,147,494 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	112,998,919 - 113,002,927 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Osm
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624747	6,580,717 - 6,584,695 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in OSM
37 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 22q11.21-12.3(chr22:18178957-31821193)x3	copy number gain	See cases [RCV000050768]	Chr22:18178957..31821193 [GRCh38] Chr22:18661724..32217179 [GRCh37] Chr22:17041724..30547179 [NCBI36] Chr22:22q11.21-12.3	pathogenic
GRCh38/hg38 22q12.1-12.3(chr22:26979579-33992220)x3	copy number gain	See cases [RCV000050553]	Chr22:26979579..33992220 [GRCh38] Chr22:27375542..34388209 [GRCh37] Chr22:25705542..32718209 [NCBI36] Chr22:22q12.1-12.3	pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:28278805-31742328)x1	copy number loss	See cases [RCV000052870]	Chr22:28278805..31742328 [GRCh38] Chr22:28674793..32138314 [GRCh37] Chr22:27004793..30468314 [NCBI36] Chr22:22q12.1-12.2	pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:28441035-30276511)x1	copy number loss	See cases [RCV000052871]	Chr22:28441035..30276511 [GRCh38] Chr22:28837023..30672500 [GRCh37] Chr22:27167023..29002500 [NCBI36] Chr22:22q12.1-12.2	pathogenic
NM_020530.4(OSM):c.214G>A (p.Glu72Lys)	single nucleotide variant	Malignant melanoma [RCV000063888]	Chr22:30264428 [GRCh38] Chr22:30660417 [GRCh37] Chr22:28990417 [NCBI36] Chr22:22q12.2	not provided
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3	copy number gain	See cases [RCV000133646]	Chr22:16916608..50739836 [GRCh38] Chr22:17397498..51178264 [GRCh37] Chr22:15777498..49525130 [NCBI36] Chr22:22q11.1-13.33	pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3	copy number gain	See cases [RCV000134730]	Chr22:16916743..50739785 [GRCh38] Chr22:17397633..51178213 [GRCh37] Chr22:15777633..49525079 [NCBI36] Chr22:22q11.1-13.33	pathogenic
GRCh38/hg38 22q11.23-12.3(chr22:23279231-36247369)x3	copy number gain	See cases [RCV000138172]	Chr22:23279231..36247369 [GRCh38] Chr22:23621418..36643415 [GRCh37] Chr22:21951418..34973361 [NCBI36] Chr22:22q11.23-12.3	pathogenic
GRCh38/hg38 22q11.21-12.3(chr22:20907226-37187347)x3	copy number gain	See cases [RCV000137926]	Chr22:20907226..37187347 [GRCh38] Chr22:21261514..37583387 [GRCh37] Chr22:19591514..35913333 [NCBI36] Chr22:22q11.21-12.3	pathogenic
GRCh38/hg38 22q12.1-12.2(chr22:26451042-31451926)x1	copy number loss	See cases [RCV000143415]	Chr22:26451042..31451926 [GRCh38] Chr22:26847008..31847912 [GRCh37] Chr22:25177008..30177912 [NCBI36] Chr22:22q12.1-12.2	pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3	copy number gain	See cases [RCV000240091]	Chr22:16054691..51237518 [GRCh37] Chr22:22q11.1-13.33	pathogenic
NM_020530.6(OSM):c.436C>T (p.Leu146Phe)	single nucleotide variant	not specified [RCV004304043]	Chr22:30264206 [GRCh38] Chr22:30660195 [GRCh37] Chr22:22q12.2	likely benign
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3	copy number gain	See cases [RCV000446956]	Chr22:16054691..51220902 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.1-12.2(chr22:29537064-30994320)x3	copy number gain	See cases [RCV000448504]	Chr22:29537064..30994320 [GRCh37] Chr22:22q12.1-12.2	uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3	copy number gain	See cases [RCV000448847]	Chr22:16054691..51237463 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.2(chr22:30323089-31092425)x3	copy number gain	See cases [RCV000448760]	Chr22:30323089..31092425 [GRCh37] Chr22:22q12.2	uncertain significance
GRCh37/hg19 22q12.1-12.3(chr22:28349854-33013062)x3	copy number gain	See cases [RCV000510523]	Chr22:28349854..33013062 [GRCh37] Chr22:22q12.1-12.3	likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)	copy number gain	See cases [RCV000510873]	Chr22:16888900..51197838 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q11.23-12.3(chr22:23637907-36614412)x3	copy number gain	See cases [RCV000511098]	Chr22:23637907..36614412 [GRCh37] Chr22:22q11.23-12.3	pathogenic
NM_020530.6(OSM):c.391G>A (p.Glu131Lys)	single nucleotide variant	not specified [RCV004300588]	Chr22:30264251 [GRCh38] Chr22:30660240 [GRCh37] Chr22:22q12.2	uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3	copy number gain	See cases [RCV000512333]	Chr22:16888900..51197838 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.2(chr22:29644625-31051719)x1	copy number loss	not provided [RCV000684497]	Chr22:29644625..31051719 [GRCh37] Chr22:22q12.2	pathogenic
GRCh37/hg19 22q11.22-12.3(chr22:22460754-35198232)x3	copy number gain	not provided [RCV000684530]	Chr22:22460754..35198232 [GRCh37] Chr22:22q11.22-12.3	pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3	copy number gain	not provided [RCV000741689]	Chr22:16054667..51243435 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3	copy number gain	not provided [RCV000741691]	Chr22:16114244..51195728 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3	copy number gain	not provided [RCV000741692]	Chr22:16114244..51211392 [GRCh37] Chr22:22q11.1-13.33	pathogenic
GRCh37/hg19 22q12.2-13.33(chr22:30654764-51197838)x3	copy number gain	not provided [RCV001007181]	Chr22:30654764..51197838 [GRCh37] Chr22:22q12.2-13.33	pathogenic
inv(22)(q12.2q12.2)	inversion	Anaplastic ependymoma [RCV000785873]	Chr22:29684716..31740655 [GRCh37] Chr22:22q12.2	likely pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3	copy number gain	not provided [RCV000846344]	Chr22:16888899..51197838 [GRCh37] Chr22:22q11.1-13.33	pathogenic
NM_020530.6(OSM):c.21G>T (p.Gln7His)	single nucleotide variant	not specified [RCV004326387]	Chr22:30266779 [GRCh38] Chr22:30662768 [GRCh37] Chr22:22q12.2	uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3	copy number gain	See cases [RCV001263056]	Chr22:16197005..51224252 [GRCh37] Chr22:22q11.1-13.33	pathogenic
NC_000022.10:g.(?_29083885)_(34046674_?)dup	duplication	not provided [RCV001979643]	Chr22:29083885..34046674 [GRCh37] Chr22:22q12.1-12.3	uncertain significance
GRCh37/hg19 22q12.2(chr22:30649178-31035087)x3	copy number gain	not provided [RCV002473620]	Chr22:30649178..31035087 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.334G>A (p.Asp112Asn)	single nucleotide variant	not specified [RCV004153190]	Chr22:30264308 [GRCh38] Chr22:30660297 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.235G>A (p.Gly79Arg)	single nucleotide variant	not specified [RCV004217186]	Chr22:30264407 [GRCh38] Chr22:30660396 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.691G>A (p.Gly231Arg)	single nucleotide variant	not specified [RCV004114116]	Chr22:30263951 [GRCh38] Chr22:30659940 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.72C>A (p.Ser24Arg)	single nucleotide variant	not specified [RCV004153227]	Chr22:30265107 [GRCh38] Chr22:30661096 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.619C>T (p.Arg207Trp)	single nucleotide variant	not specified [RCV004227882]	Chr22:30264023 [GRCh38] Chr22:30660012 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.485C>T (p.Thr162Met)	single nucleotide variant	not specified [RCV004201988]	Chr22:30264157 [GRCh38] Chr22:30660146 [GRCh37] Chr22:22q12.2	likely benign
NM_020530.6(OSM):c.380G>A (p.Gly127Glu)	single nucleotide variant	not specified [RCV004181681]	Chr22:30264262 [GRCh38] Chr22:30660251 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.74T>C (p.Met25Thr)	single nucleotide variant	not specified [RCV004132317]	Chr22:30265105 [GRCh38] Chr22:30661094 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.7G>A (p.Val3Ile)	single nucleotide variant	not specified [RCV004154510]	Chr22:30266793 [GRCh38] Chr22:30662782 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.514G>A (p.Ala172Thr)	single nucleotide variant	not specified [RCV004074911]	Chr22:30264128 [GRCh38] Chr22:30660117 [GRCh37] Chr22:22q12.2	likely benign
NM_020530.6(OSM):c.694G>A (p.Val232Met)	single nucleotide variant	not specified [RCV004194363]	Chr22:30263948 [GRCh38] Chr22:30659937 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.107G>A (p.Arg36His)	single nucleotide variant	not specified [RCV004122493]	Chr22:30265072 [GRCh38] Chr22:30661061 [GRCh37] Chr22:22q12.2	likely benign
NM_020530.6(OSM):c.422C>T (p.Pro141Leu)	single nucleotide variant	not specified [RCV004189639]	Chr22:30264220 [GRCh38] Chr22:30660209 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.256A>G (p.Thr86Ala)	single nucleotide variant	not specified [RCV004104586]	Chr22:30264386 [GRCh38] Chr22:30660375 [GRCh37] Chr22:22q12.2	likely benign
NM_020530.6(OSM):c.506G>T (p.Gly169Val)	single nucleotide variant	not specified [RCV004278905]	Chr22:30264136 [GRCh38] Chr22:30660125 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.359C>T (p.Ala120Val)	single nucleotide variant	not specified [RCV004353341]	Chr22:30264283 [GRCh38] Chr22:30660272 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.166C>G (p.Leu56Val)	single nucleotide variant	not specified [RCV004357562]	Chr22:30265013 [GRCh38] Chr22:30661002 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.736A>C (p.Thr246Pro)	single nucleotide variant	not specified [RCV004338305]	Chr22:30263906 [GRCh38] Chr22:30659895 [GRCh37] Chr22:22q12.2	likely benign
NM_020530.6(OSM):c.697C>T (p.Arg233Cys)	single nucleotide variant	not specified [RCV004336764]	Chr22:30263945 [GRCh38] Chr22:30659934 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.269T>C (p.Leu90Pro)	single nucleotide variant	not specified [RCV004354227]	Chr22:30264373 [GRCh38] Chr22:30660362 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.101A>T (p.Glu34Val)	single nucleotide variant	not specified [RCV004504526]	Chr22:30265078 [GRCh38] Chr22:30661067 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.509G>A (p.Arg170Gln)	single nucleotide variant	not specified [RCV004504533]	Chr22:30264133 [GRCh38] Chr22:30660122 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.214G>C (p.Glu72Gln)	single nucleotide variant	not specified [RCV004504528]	Chr22:30264428 [GRCh38] Chr22:30660417 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.422C>G (p.Pro141Arg)	single nucleotide variant	not specified [RCV004504530]	Chr22:30264220 [GRCh38] Chr22:30660209 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.85G>A (p.Gly29Ser)	single nucleotide variant	not specified [RCV004504535]	Chr22:30265094 [GRCh38] Chr22:30661083 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.104A>G (p.Tyr35Cys)	single nucleotide variant	not specified [RCV004504527]	Chr22:30265075 [GRCh38] Chr22:30661064 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.302C>A (p.Ala101Asp)	single nucleotide variant	not specified [RCV004504529]	Chr22:30264340 [GRCh38] Chr22:30660329 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.478T>G (p.Ser160Ala)	single nucleotide variant	not specified [RCV004504531]	Chr22:30264164 [GRCh38] Chr22:30660153 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.524C>A (p.Pro175Gln)	single nucleotide variant	not specified [RCV004504534]	Chr22:30264118 [GRCh38] Chr22:30660107 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.536C>G (p.Thr179Ser)	single nucleotide variant	not specified [RCV004661894]	Chr22:30264106 [GRCh38] Chr22:30660095 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.479C>T (p.Ser160Leu)	single nucleotide variant	not specified [RCV004648035]	Chr22:30264163 [GRCh38] Chr22:30660152 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.575G>A (p.Cys192Tyr)	single nucleotide variant	not specified [RCV004648036]	Chr22:30264067 [GRCh38] Chr22:30660056 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.493C>T (p.Pro165Ser)	single nucleotide variant	not specified [RCV004648037]	Chr22:30264149 [GRCh38] Chr22:30660138 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.559C>T (p.Arg187Cys)	single nucleotide variant	not specified [RCV004648034]	Chr22:30264083 [GRCh38] Chr22:30660072 [GRCh37] Chr22:22q12.2	uncertain significance
NM_020530.6(OSM):c.604A>G (p.Met202Val)	single nucleotide variant	not specified [RCV004343631]	Chr22:30264038 [GRCh38] Chr22:30660027 [GRCh37] Chr22:22q12.2	uncertain significance

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1240
Count of miRNA genes:	682
Interacting mature miRNAs:	784
Transcripts:	ENST00000215781, ENST00000403389, ENST00000403463
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCh38)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581529	BP71_H	Blood pressure QTL 71 (human)	2	0.001	Blood pressure	pulse pressure	22	11094966	37094966	Human
406986835	GWAS635811_H	suicidal ideation QTL GWAS635811 (human)		0.000004	suicidal ideation		22	30263577	30263578	Human
406988673	GWAS637649_H	reticulocyte measurement QTL GWAS637649 (human)		2e-10	reticulocyte morphology trait (VT:0002424)	red blood cell measurement (CMO:0001356)	22	30264528	30264529	Human
406994438	GWAS643414_H	reticulocyte count QTL GWAS643414 (human)		9e-13	reticulocyte count	total reticulocyte count (CMO:0003020)	22	30264528	30264529	Human
407184848	GWAS833824_H	leukocyte count QTL GWAS833824 (human)		3e-08	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	22	30266774	30266775	Human
2289428	BW313_H	Body weight QTL 313 (human)	2.09	0.0015	Body weight	BMI	22	11344284	37344284	Human
407243824	GWAS892800_H	body height QTL GWAS892800 (human)		5e-14	body height (VT:0001253)	body height (CMO:0000106)	22	30263577	30263578	Human
406998824	GWAS647800_H	reticulocyte measurement QTL GWAS647800 (human)		6e-12	reticulocyte morphology trait (VT:0002424)	red blood cell measurement (CMO:0001356)	22	30264528	30264529	Human

Markers in Region

GDB:194718

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	30,659,854 - 30,660,307	UniSTS	GRCh37
Build 36	22	28,989,854 - 28,990,307	RGD	NCBI36
Celera	22	14,459,537 - 14,459,990	RGD
Cytogenetic Map	22	q12.2	UniSTS
HuRef	22	13,621,634 - 13,622,087	UniSTS

GDB:194719

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	30,660,016 - 30,660,840	UniSTS	GRCh37
Build 36	22	28,990,016 - 28,990,840	RGD	NCBI36
Celera	22	14,459,699 - 14,460,523	RGD
Cytogenetic Map	22	q12.2	UniSTS
HuRef	22	13,621,796 - 13,622,620	UniSTS

GDB:452636

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	30,659,212 - 30,659,419	UniSTS	GRCh37
Build 36	22	28,989,212 - 28,989,419	RGD	NCBI36
Celera	22	14,458,895 - 14,459,102	RGD
Cytogenetic Map	22	q12.2	UniSTS
HuRef	22	13,620,992 - 13,621,199	UniSTS

STS-M27288

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	22	30,659,654 - 30,659,835	UniSTS	GRCh37
Build 36	22	28,989,654 - 28,989,835	RGD	NCBI36
Celera	22	14,459,337 - 14,459,518	RGD
Cytogenetic Map	22	q12.2	UniSTS
HuRef	22	13,621,434 - 13,621,615	UniSTS
GeneMap99-GB4 RH Map	22	88.23	UniSTS
NCBI RH Map	22	125.2	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	entire extraembryonic component	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system
1204	2337	2671	2237	4613	1694	2181	2	599	1920	439	2019	7007	6391	22	3618	811	1666	1476	164

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001319108	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_020530	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_047441387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_054325661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB451493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC004264	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF129855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH001516	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC011589	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BM562358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CD368803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471095	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR456534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR541703	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR981101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000215781 ⟹ ENSP00000215781

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	30,262,829 - 30,266,851 (-)	Ensembl

Ensembl Acc Id:

ENST00000403389 ⟹ ENSP00000383893

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	30,263,868 - 30,265,818 (-)	Ensembl

Ensembl Acc Id:

ENST00000403463 ⟹ ENSP00000384543

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	22	30,264,075 - 30,266,839 (-)	Ensembl

RefSeq Acc Id:

NM_001319108 ⟹ NP_001306037

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	30,262,829 - 30,266,240 (-)	NCBI
CHM1_1	22	30,617,954 - 30,620,943 (-)	NCBI
T2T-CHM13v2.0	22	30,726,147 - 30,729,558 (-)	NCBI

Sequence:

show sequence

GCAGACCAGAGTCCCCATGGTGAACGGAACAGGTCTCCCTCACGCCGCACACAGACCCAGATGC
ACAGCCACACAGAAACCCCAGTCCCACGTGCGCTGCCACAGGCACAGGCCCCTGCCAGAGCCCG
GCAGCAGATACCTGGGGAGGCGGCGAGGGTGCCGTGGGGTCGCTAAGCCTGGGTGCCTGGCCCC
TTGGCCCTCCCCAACAGCCAGTCTTCCCCAAAGGGCCGGATGGTTCTTAGGACGGGAACGATGG
TGTCACTGCCTTCCGGGCCATTGCGCCATAGGCCCCTTCCGACCACGTGGCTGCCGGTGCCCCG
TTGGGGGTGGTGGTGAGCGGTAACTGTACCCGCCCCCAACACCTTCTGACAGGCTCACAGCATC
CCTGGTGGGCCTGACAGAAGGAGCCACTTATGGAGAGAGGAGGGAGGCAAGAGAGGTCAGGGGA
GAGCCCTGGCCTTGTGTGACCTGAGTAGGACCTTCTCCTGAGACTTGGTTTACCTGTCAGGAAA
GTGGGGACATGGACTGGAAGGTCTTCCACATCTGTTCCAGGCTGCACCTCTGGTTGAAAAGGCA
GCCTCTCCTGGTTCTAGACAGAGCTGAGGACACAAGCTGCTCCCGGGCTGCCTGCCCTGAAGCC
CTCTCAGGCCCATCTACCTGGATGGCCAGAGCAGCTGACAAGGTCTGGTCCTTGCACTCCTGTT
TCCAAGCATGGCGAGCATGGCGGCTATAGGCAGCTGCTCGAAAGAGTACCGCGTGCTCCTTGGC
CAGCTCCAGAAGCAGACAGATCTCATGCAGGACACCAGCAGACTCCTGGACCCCTATATACGTA
TCCAAGGCCTGGATGTTCCTAAACTGAGAGAGCACTGCAGGGAGCGCCCCGGGGCCTTCCCCAG
TGAGGAGACCCTGAGGGGGCTGGGCAGGCGGGGCTTCCTGCAGACCCTCAATGCCACACTGGGC
TGCGTCCTGCACAGACTGGCCGACTTAGAGCAGCGCCTCCCCAAGGCCCAGGATTTGGAGAGGT
CTGGGCTGAACATCGAGGACTTGGAGAAGCTGCAGATGGCGAGGCCGAACATCCTCGGGCTCAG
GAACAACATCTACTGCATGGCCCAGCTGCTGGACAACTCAGACACGGCTGAGCCCACGAAGGCT
GGCCGGGGGGCCTCTCAGCCGCCCACCCCCACCCCTGCCTCGGATGCTTTTCAGCGCAAGCTGG
AGGGCTGCAGGTTCCTGCATGGCTACCATCGCTTCATGCACTCAGTGGGGCGGGTCTTCAGCAA
GTGGGGGGAGAGCCCGAACCGGAGCCGGAGACACAGCCCCCACCAGGCCCTGAGGAAGGGGGTG
CGCAGGACCAGACCCTCCAGGAAAGGCAAGAGACTCATGACCAGGGGACAGCTGCCCCGGTAGC
CTCGAGAGCACCCCTTGCCGGTGAAGGATGCGGCAGGTGCTCTGTGGATGAGAGGAACCATCGC
AGGATGACAGCTCCCGGGTCCCCAAACCTGTTCCCCTCTGCTACTAGCCACTGAGAAGTGCACT
TTAAGAGGTGGGAGCTGGGCAGACCCCTCTACCTCCTCCAGGCTGGGAGACAGAGTCAGGCTGT
TGCGCTCCCACCTCAGCCCCAAGTTCCCCAGGCCCAGTGGGGTGGCCGGGCGGGCCACGCGGGA
CCGACTTTCCATTGATTCAGGGGTCTGATGACACAGGCTGACTCATGGCCGGGCTGACTGCCCC
CCTGCCTTGCTCCCCGAGGCCTGCCGGTCCTTCCCTCTCATGACTTGCAGGGCCGTTGCCCCCA
GACTTCCTCCTTTCCGTGTTTCTGAAGGGGAGGTCACAGCCTGAGCTGGCCTCCTATGCCTCAT
CATGTCCCAAACCAGACACCTGGATGTCTGGGTGACCTCACTTTAGGCAGCTGTAACAGCGGCA
GGGTGTCCCAGGAGCCCTGATCCGGGGGTCCAGGGAATGGAGCTCAGGTCCCAGGCCAGCCCCG
AAGTCGCCACGTGGCCTGGGGCAGGTCACTTTACCTCTGTGGACCTGTTTTCTCTTTGTGAAGC
TAGGGAGTTAGAGGCTGTACAAGGCCCCCACTGCCTGTCGGTTGCTTGGATTCCCTGACGTAAG
GTGGATATTAAAAATCTGTAAATCAGGACAGGTGGTGCAAATGGCGCTGGGAGGTGTACACGGA
GGTCTCTGTAAAAGCAGACCCACCTCCCAGCGCCGGGAAGCCCGTCTTGGGTCCTCGCTGCTGG
CTGCTCCCCCTGGTGGTGGATCCTGGAATTTTCTCACGCAGGAGCCATTGCTCTCCTAGAGGGG
GTCTCAGAAACTGCGAGGCCAGTTCCTTGGAGGGACATGACTAATTTATCGATTTTTATCAATT
TTTATCAGTTTTATATTTATAAGCCTTATTTATGATGTATATTTAATGTTAATATTGTGCAAAC
TTATATTTAAAACTTGCCTGGTTTCTAAA

hide sequence

RefSeq Acc Id:

NM_020530 ⟹ NP_065391

RefSeq Status:

REVIEWED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	30,262,829 - 30,266,851 (-)	NCBI
GRCh37	22	30,658,817 - 30,662,829 (-)	NCBI
Build 36	22	28,988,818 - 28,992,840 (-)	NCBI Archive
HuRef	22	13,620,598 - 13,624,609 (-)	ENTREZGENE
CHM1_1	22	30,617,954 - 30,621,969 (-)	NCBI
T2T-CHM13v2.0	22	30,726,147 - 30,730,169 (-)	NCBI

Sequence:

show sequence

AGCCGAGAGGTGTCACCCCCAGCGGGCGCGGGCCGGAGCACGGGCACCCAGCATGGGGGTACTG
CTCACACAGAGGACGCTGCTCAGTCTGGTCCTTGCACTCCTGTTTCCAAGCATGGCGAGCATGG
CGGCTATAGGCAGCTGCTCGAAAGAGTACCGCGTGCTCCTTGGCCAGCTCCAGAAGCAGACAGA
TCTCATGCAGGACACCAGCAGACTCCTGGACCCCTATATACGTATCCAAGGCCTGGATGTTCCT
AAACTGAGAGAGCACTGCAGGGAGCGCCCCGGGGCCTTCCCCAGTGAGGAGACCCTGAGGGGGC
TGGGCAGGCGGGGCTTCCTGCAGACCCTCAATGCCACACTGGGCTGCGTCCTGCACAGACTGGC
CGACTTAGAGCAGCGCCTCCCCAAGGCCCAGGATTTGGAGAGGTCTGGGCTGAACATCGAGGAC
TTGGAGAAGCTGCAGATGGCGAGGCCGAACATCCTCGGGCTCAGGAACAACATCTACTGCATGG
CCCAGCTGCTGGACAACTCAGACACGGCTGAGCCCACGAAGGCTGGCCGGGGGGCCTCTCAGCC
GCCCACCCCCACCCCTGCCTCGGATGCTTTTCAGCGCAAGCTGGAGGGCTGCAGGTTCCTGCAT
GGCTACCATCGCTTCATGCACTCAGTGGGGCGGGTCTTCAGCAAGTGGGGGGAGAGCCCGAACC
GGAGCCGGAGACACAGCCCCCACCAGGCCCTGAGGAAGGGGGTGCGCAGGACCAGACCCTCCAG
GAAAGGCAAGAGACTCATGACCAGGGGACAGCTGCCCCGGTAGCCTCGAGAGCACCCCTTGCCG
GTGAAGGATGCGGCAGGTGCTCTGTGGATGAGAGGAACCATCGCAGGATGACAGCTCCCGGGTC
CCCAAACCTGTTCCCCTCTGCTACTAGCCACTGAGAAGTGCACTTTAAGAGGTGGGAGCTGGGC
AGACCCCTCTACCTCCTCCAGGCTGGGAGACAGAGTCAGGCTGTTGCGCTCCCACCTCAGCCCC
AAGTTCCCCAGGCCCAGTGGGGTGGCCGGGCGGGCCACGCGGGACCGACTTTCCATTGATTCAG
GGGTCTGATGACACAGGCTGACTCATGGCCGGGCTGACTGCCCCCCTGCCTTGCTCCCCGAGGC
CTGCCGGTCCTTCCCTCTCATGACTTGCAGGGCCGTTGCCCCCAGACTTCCTCCTTTCCGTGTT
TCTGAAGGGGAGGTCACAGCCTGAGCTGGCCTCCTATGCCTCATCATGTCCCAAACCAGACACC
TGGATGTCTGGGTGACCTCACTTTAGGCAGCTGTAACAGCGGCAGGGTGTCCCAGGAGCCCTGA
TCCGGGGGTCCAGGGAATGGAGCTCAGGTCCCAGGCCAGCCCCGAAGTCGCCACGTGGCCTGGG
GCAGGTCACTTTACCTCTGTGGACCTGTTTTCTCTTTGTGAAGCTAGGGAGTTAGAGGCTGTAC
AAGGCCCCCACTGCCTGTCGGTTGCTTGGATTCCCTGACGTAAGGTGGATATTAAAAATCTGTA
AATCAGGACAGGTGGTGCAAATGGCGCTGGGAGGTGTACACGGAGGTCTCTGTAAAAGCAGACC
CACCTCCCAGCGCCGGGAAGCCCGTCTTGGGTCCTCGCTGCTGGCTGCTCCCCCTGGTGGTGGA
TCCTGGAATTTTCTCACGCAGGAGCCATTGCTCTCCTAGAGGGGGTCTCAGAAACTGCGAGGCC
AGTTCCTTGGAGGGACATGACTAATTTATCGATTTTTATCAATTTTTATCAGTTTTATATTTAT
AAGCCTTATTTATGATGTATATTTAATGTTAATATTGTGCAAACTTATATTTAAAACTTGCCTG
GTTTCTAAA

hide sequence

RefSeq Acc Id:

XM_047441387 ⟹ XP_047297343

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	30,262,829 - 30,266,851 (-)	NCBI

RefSeq Acc Id:

XM_054325661 ⟹ XP_054181636

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
T2T-CHM13v2.0	22	30,726,147 - 30,730,077 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001306037	(Get FASTA)	NCBI Sequence Viewer
	NP_065391	(Get FASTA)	NCBI Sequence Viewer
	XP_047297343	(Get FASTA)	NCBI Sequence Viewer
	XP_054181636	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA36388	(Get FASTA)	NCBI Sequence Viewer
	AAC05173	(Get FASTA)	NCBI Sequence Viewer
	AAD31435	(Get FASTA)	NCBI Sequence Viewer
	AAH11589	(Get FASTA)	NCBI Sequence Viewer
	BAG70307	(Get FASTA)	NCBI Sequence Viewer
	CAG30420	(Get FASTA)	NCBI Sequence Viewer
	CAG46504	(Get FASTA)	NCBI Sequence Viewer
	EAW59864	(Get FASTA)	NCBI Sequence Viewer
	EAW59865	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000215781
	ENSP00000215781.2
	ENSP00000383893
	ENSP00000383893.1
	ENSP00000384543.1
GenBank Protein	P13725	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_065391 ⟸ NM_020530
- Peptide Label:	isoform 1 preproprotein
- UniProtKB:	Q6FHP8 (UniProtKB/Swiss-Prot), Q9UCP6 (UniProtKB/Swiss-Prot), P13725 (UniProtKB/Swiss-Prot), B5BUQ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQG LDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGL NIEDLEKLQMARPNILGLRNNIYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGC RFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR hide sequence

RefSeq Acc Id:	NP_001306037 ⟸ NM_001319108
- Peptide Label:	isoform 2
- UniProtKB:	B5MCX1 (UniProtKB/TrEMBL), B5BUQ7 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEE TLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNN IYCMAQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWG ESPNRSRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR hide sequence

Ensembl Acc Id:

ENSP00000215781 ⟸ ENST00000215781

Ensembl Acc Id:

ENSP00000384543 ⟸ ENST00000403463

Ensembl Acc Id:

ENSP00000383893 ⟸ ENST00000403389

RefSeq Acc Id:	XP_047297343 ⟸ XM_047441387
- Peptide Label:	isoform X1
- UniProtKB:	B5MCX1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_054181636 ⟸ XM_054325661
- Peptide Label:	isoform X1
- UniProtKB:	B5MCX1 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P13725-F1-model_v2	AlphaFold	P13725	1-252	view protein structure

Promoters

RGD ID:

6799857

Promoter ID:

HG_KWN:42293

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, Jurkat, K562, Lymphoblastoid, NB4

Transcripts:

ENST00000403389

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	22	28,991,341 - 28,992,737 (-)	MPROMDB

RGD ID:

6799860

Promoter ID:

HG_KWN:42294

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, Lymphoblastoid, NB4

Transcripts:

ENST00000403463, OTTHUMT00000320512

Position:

Human Assembly	Chr	Position (strand)	Source
Build 36	22	28,992,831 - 28,993,742 (-)	MPROMDB

RGD ID:

13603674

Promoter ID:

EPDNEW_H28021

Type:

initiation region

Name:

OSM_1

Description:

oncostatin M

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	22	30,266,851 - 30,266,911	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:8506	AgrOrtholog
COSMIC	OSM	COSMIC
Ensembl Genes	ENSG00000099985	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENST00000215781	ENTREZGENE
	ENST00000215781.3	UniProtKB/Swiss-Prot
	ENST00000403389	ENTREZGENE
	ENST00000403389.1	UniProtKB/TrEMBL
	ENST00000403463.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx	ENSG00000099985	GTEx
HGNC ID	HGNC:8506	ENTREZGENE
Human Proteome Map	OSM	Human Proteome Map
InterPro	4_helix_cytokine-like_core	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Leukemia_IF/oncostatin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Leukemia_IF/oncostatin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OSM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	hsa:5008	UniProtKB/Swiss-Prot
NCBI Gene	5008	ENTREZGENE
OMIM	165095	OMIM
PANTHER	ONCOSTATIN-M	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR14261	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	LIF_OSM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB	PA32836	PharmGKB
PROSITE	LIF_OSM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	LIF_OSM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47266	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	B5BUQ7	ENTREZGENE, UniProtKB/TrEMBL
	B5MC70_HUMAN	UniProtKB/TrEMBL
	B5MCX1	ENTREZGENE, UniProtKB/TrEMBL
	ONCM_HUMAN	UniProtKB/Swiss-Prot, ENTREZGENE
	Q6FHP8	ENTREZGENE
	Q9UCP6	ENTREZGENE
UniProt Secondary	Q6FHP8	UniProtKB/Swiss-Prot
	Q9UCP6	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)