OSM (oncostatin M) - Rat Genome Database

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Pathways
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Gene: OSM (oncostatin M) Chlorocebus sabaeus
Analyze
Symbol: OSM
Name: oncostatin M
RGD ID: 18763050
Description: ENCODES a protein that exhibits growth factor activity (ortholog); INVOLVED IN behavioral response to pain (ortholog); meiotic nuclear division (ortholog); negative regulation of hormone secretion (ortholog); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-3 signaling pathway; ASSOCIATED WITH Chloracne (ortholog); contact dermatitis (ortholog); COVID-19 (ortholog); FOUND IN extracellular region (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: oncostatin-M
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,142,652 - 13,147,548 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,144,442 - 13,147,494 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,998,919 - 113,002,927 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
OSM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11913,142,652 - 13,147,548 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1913,144,442 - 13,147,494 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045112,998,919 - 113,002,927 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
OSM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382230,262,829 - 30,266,851 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2230,262,829 - 30,266,851 (-)EnsemblGRCh38hg38GRCh38
GRCh372230,658,818 - 30,662,840 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362228,988,818 - 28,992,840 (-)NCBINCBI36Build 36hg18NCBI36
Build 342228,983,374 - 28,987,394NCBI
Celera2214,458,501 - 14,462,523 (-)NCBICelera
Cytogenetic Map22q12.2NCBI
HuRef2213,620,598 - 13,624,609 (-)NCBIHuRef
CHM1_12230,617,955 - 30,621,966 (-)NCBICHM1_1
T2T-CHM13v2.02230,726,147 - 30,730,169 (-)NCBIT2T-CHM13v2.0
Osm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39114,186,831 - 4,191,027 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl114,186,420 - 4,191,026 (+)EnsemblGRCm39 Ensembl
GRCm38114,236,785 - 4,241,026 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl114,236,420 - 4,241,026 (+)EnsemblGRCm38mm10GRCm38
MGSCv37114,136,788 - 4,141,029 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36114,136,423 - 4,141,029 (+)NCBIMGSCv36mm8
Celera114,735,950 - 4,740,191 (+)NCBICelera
Cytogenetic Map11A1NCBI
cM Map112.94NCBI
Osm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81483,327,202 - 83,332,073 (+)NCBIGRCr8
mRatBN7.21479,103,638 - 79,108,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1479,104,344 - 79,108,313 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1483,545,045 - 83,547,887 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01484,785,121 - 84,787,963 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01481,231,091 - 81,233,943 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01484,457,487 - 84,469,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1484,465,515 - 84,470,409 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01485,139,161 - 85,151,646 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41484,857,232 - 84,860,082 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1478,014,541 - 78,017,610 (+)NCBICelera
Cytogenetic Map14q21NCBI
Osm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554554,511,769 - 4,514,633 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554554,510,711 - 4,515,282 (-)NCBIChiLan1.0ChiLan1.0
OSM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22340,229,981 - 40,234,801 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12242,928,587 - 42,932,631 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02211,298,965 - 11,303,009 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12229,101,084 - 29,105,104 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2229,101,085 - 29,105,081 (-)Ensemblpanpan1.1panPan2
OSM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12623,421,787 - 23,439,332 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2623,421,787 - 23,426,036 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2623,292,978 - 23,297,000 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02623,805,727 - 23,809,749 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2623,805,727 - 23,809,632 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12623,507,438 - 23,511,460 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02623,770,285 - 23,774,307 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02623,830,630 - 23,834,652 (-)NCBIUU_Cfam_GSD_1.0
Osm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118116,339,969 - 116,342,209 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936904390,089 - 394,195 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1447,242,774 - 47,246,838 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11447,242,767 - 47,246,836 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21450,281,695 - 50,298,845 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Osm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247476,580,717 - 6,584,695 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium
Low 6 20 2
Below cutoff 28 36

Sequence


Reference Sequences
RefSeq Acc Id: ENSCSAT00000007577   ⟹   ENSCSAP00000005754
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1913,144,442 - 13,147,494 (-)Ensembl
RefSeq Acc Id: XM_007975382   ⟹   XP_007973573
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11913,142,652 - 13,147,510 (-)NCBI
Vero_WHO_p1.0NW_023666045113,000,369 - 113,002,927 (+)NCBI
Sequence:
RefSeq Acc Id: XM_007975383   ⟹   XP_007973574
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11913,143,488 - 13,147,548 (-)NCBI
Vero_WHO_p1.0NW_023666045112,998,919 - 113,002,927 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007973573 (Get FASTA)   NCBI Sequence Viewer  
  XP_007973574 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005754.1
Reference Protein Sequences
RefSeq Acc Id: XP_007973573   ⟸   XM_007975382
- Peptide Label: isoform X1
RefSeq Acc Id: XP_007973574   ⟸   XM_007975383
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RAW5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000005754   ⟸   ENSCSAT00000007577


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009500 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007577.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Leukemia_IF/oncostatin UniProtKB/TrEMBL
  Leukemia_IF/oncostatin_CS UniProtKB/TrEMBL
  OSM UniProtKB/TrEMBL
NCBI Gene OSM ENTREZGENE
PANTHER ONCOSTATIN-M UniProtKB/TrEMBL
  PTHR14261 UniProtKB/TrEMBL
Pfam LIF_OSM UniProtKB/TrEMBL
PROSITE LIF_OSM UniProtKB/TrEMBL
  PROKAR_LIPOPROTEIN UniProtKB/TrEMBL
SMART LIF_OSM UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A0D9RAW5 ENTREZGENE, UniProtKB/TrEMBL