Epha3 (Eph receptor A3) - Rat Genome Database

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Gene: Epha3 (Eph receptor A3) Mus musculus
Analyze
Symbol: Epha3
Name: Eph receptor A3
RGD ID: 68567
MGI Page MGI
Description: Enables ephrin receptor activity and growth factor binding activity. Involved in several processes, including axonal fasciculation; ephrin receptor signaling pathway; and synaptic membrane adhesion. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus; negative regulation of neuron projection development; and regulation of cell migration. Is active in GABA-ergic synapse and presynapse. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human EPHA3 (EPH receptor A3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AW492086; Cek4; EK4; End; End3; EPH-like kinase 4; ephrin type-A receptor 3; ETK1; Hek; Hek4; Mek4; Tyr; Tyro4; tyrosine-protein kinase receptor ETK1; tyrosine-protein kinase TYRO4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391663,363,895 - 63,684,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1663,363,897 - 63,684,538 (-)EnsemblGRCm39 Ensembl
GRCm381663,543,532 - 63,864,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1663,543,534 - 63,864,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv371663,545,044 - 63,863,983 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361663,487,420 - 63,806,359 (-)NCBIMGSCv36mm8
Celera1663,844,890 - 64,154,791 (-)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1636.49NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-naphthylamine  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (ISO)
alpha-amanitin  (EXP)
ammonium chloride  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (EXP)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
cocaine  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
DDD  (ISO)
DDE  (ISO)
DDT  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (ISO)
dioxygen  (ISO)
diquat  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (ISO)
endrin  (ISO)
entinostat  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (ISO)
folic acid  (EXP)
formaldehyde  (ISO)
furan  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (EXP,ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nicotine  (ISO)
ozone  (ISO)
panobinostat  (ISO)
permethrin  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pioglitazone  (EXP)
ponatinib  (ISO)
potassium dichromate  (EXP)
progesterone  (ISO)
pyrethrins  (ISO)
rofecoxib  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (ISO)
sotorasib  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)
XL147  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon guidance  (IBA)
brain-derived neurotrophic factor receptor signaling pathway  (IEA)
cell migration  (IMP)
cellular response to follicle-stimulating hormone stimulus  (IDA)
cellular response to interleukin-1  (ISO)
cellular response to retinoic acid  (ISO)
chromatin remodeling  (IEA)
collagen-activated tyrosine kinase receptor signaling pathway  (IEA)
endocardial cushion development  (IMP)
ephrin receptor signaling pathway  (IBA,IDA,ISO)
epidermal growth factor receptor signaling pathway  (IEA)
fasciculation of motor neuron axon  (IMP)
fasciculation of sensory neuron axon  (IMP)
fever generation  (ISO)
fibroblast growth factor receptor signaling pathway  (IEA)
hepatocyte growth factor receptor signaling pathway  (IEA)
insulin receptor signaling pathway  (IEA)
insulin-like growth factor receptor signaling pathway  (IEA)
Kit signaling pathway  (IEA)
macrophage colony-stimulating factor signaling pathway  (IEA)
motor neuron axon guidance  (IMP)
negative regulation of endocytosis  (ISO)
negative regulation of neuron projection development  (IDA)
peptidyl-tyrosine phosphorylation  (ISO)
platelet-derived growth factor receptor-alpha signaling pathway  (IEA)
platelet-derived growth factor receptor-beta signaling pathway  (IEA)
positive regulation of neuron projection development  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
regulation of actin cytoskeleton organization  (ISO,ISS)
regulation of cell migration  (IGI)
regulation of epithelial to mesenchymal transition  (IMP)
regulation of focal adhesion assembly  (ISO,ISS)
regulation of microtubule cytoskeleton organization  (ISO,ISS)
response to lipopolysaccharide  (ISO)
synaptic membrane adhesion  (IDA,IMP)
vascular endothelial growth factor receptor-1 signaling pathway  (IEA)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Zic2 controls cerebellar development in cooperation with Zic1. Aruga J, etal., J Neurosci 2002 Jan 1;22(1):218-25.
2. Inhibition of VEGF-dependent multistage carcinogenesis by soluble EphA receptors. Cheng N, etal., Neoplasia. 2003 Sep-Oct;5(5):445-56.
3. Upregulation of EphA3 receptor after spinal cord injury. Irizarry-Ramirez M, etal., J Neurotrauma. 2005 Aug;22(8):929-35.
4. Expression of Eph receptors and their ligands, ephrins, during lipopolysaccharide fever in rats. Ivanov AI, etal., Physiol Genomics. 2005 Apr 14;21(2):152-60. Epub 2005 Jan 25.
5. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
6. MGDs mouse GO annotations MGD data from the GO Consortium
7. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
8. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
9. Mouse MP Annotation Import Pipeline RGD automated import pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1281307   PMID:1657122   PMID:2025425   PMID:7522971   PMID:8108111   PMID:8552593   PMID:8812059   PMID:8889548   PMID:9267020   PMID:9883724   PMID:10349636   PMID:10495276  
PMID:10559410   PMID:10929715   PMID:11042159   PMID:11076861   PMID:11114734   PMID:11217851   PMID:11222144   PMID:11403717   PMID:11439183   PMID:11493561   PMID:11748150   PMID:11793228  
PMID:12124402   PMID:12217323   PMID:12477932   PMID:12528186   PMID:12684176   PMID:12895420   PMID:12971893   PMID:14585969   PMID:14681479   PMID:15142957   PMID:15145949   PMID:15254900  
PMID:15258590   PMID:15517401   PMID:15778706   PMID:15788771   PMID:15820684   PMID:15892098   PMID:15944189   PMID:15996548   PMID:16079153   PMID:16107646   PMID:16141072   PMID:16141073  
PMID:16185771   PMID:16380715   PMID:16446123   PMID:16491080   PMID:16547242   PMID:16602821   PMID:16774998   PMID:16829211   PMID:16910173   PMID:17039519   PMID:17046737   PMID:17145500  
PMID:17698011   PMID:18287559   PMID:18403711   PMID:19168674   PMID:19247962   PMID:19505147   PMID:19542359   PMID:19576892   PMID:19769959   PMID:19914184   PMID:20112066   PMID:20436479  
PMID:20473036   PMID:20576928   PMID:20655977   PMID:21135139   PMID:21150899   PMID:21267068   PMID:21465626   PMID:21791286   PMID:21862448   PMID:21873635   PMID:21966449   PMID:22103416  
PMID:22171039   PMID:22275477   PMID:22465667   PMID:22568954   PMID:22627288   PMID:22811059   PMID:23242526   PMID:23615279   PMID:23749471   PMID:23892084   PMID:24038871   PMID:24117969  
PMID:24427155   PMID:24723342   PMID:24728844   PMID:24803655   PMID:24952961   PMID:25073978   PMID:25367067   PMID:25480914   PMID:25713296   PMID:25859222   PMID:26238476   PMID:26297811  
PMID:26644518   PMID:26830346   PMID:26874185   PMID:26941654   PMID:27046536   PMID:27518902   PMID:27568519   PMID:27803162   PMID:27889898   PMID:28169277   PMID:28197551   PMID:28378742  
PMID:28538179   PMID:28558017   PMID:29878134   PMID:31001083   PMID:31262977   PMID:31351040   PMID:31577226   PMID:31597102   PMID:32553152   PMID:32857879   PMID:33554859   PMID:34321999  
PMID:34732824   PMID:35974052   PMID:36028553   PMID:36369193   PMID:36529279   PMID:36734036   PMID:37869988   PMID:38086370   PMID:38355793  


Genomics

Comparative Map Data
Epha3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391663,363,895 - 63,684,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1663,363,897 - 63,684,538 (-)EnsemblGRCm39 Ensembl
GRCm381663,543,532 - 63,864,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1663,543,534 - 63,864,175 (-)EnsemblGRCm38mm10GRCm38
MGSCv371663,545,044 - 63,863,983 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361663,487,420 - 63,806,359 (-)NCBIMGSCv36mm8
Celera1663,844,890 - 64,154,791 (-)NCBICelera
Cytogenetic Map16C1.3NCBI
cM Map1636.49NCBI
EPHA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38389,107,621 - 89,482,134 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl389,107,621 - 89,482,134 (+)EnsemblGRCh38hg38GRCh38
GRCh37389,156,771 - 89,531,284 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36389,239,364 - 89,613,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 34389,239,501 - 89,532,185NCBI
Celera389,910,744 - 90,285,017 (+)NCBICelera
Cytogenetic Map3p11.1NCBI
HuRef389,169,906 - 89,544,877 (+)NCBIHuRef
CHM1_1389,109,505 - 89,484,203 (+)NCBICHM1_1
T2T-CHM13v2.0389,183,660 - 89,558,507 (+)NCBIT2T-CHM13v2.0
Epha3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81114,585,041 - 14,920,721 (-)NCBIGRCr8
mRatBN7.2111,138,485 - 1,474,102 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl111,140,985 - 1,473,900 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx119,737,055 - 10,069,925 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0112,530,362 - 2,863,260 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0111,635,123 - 1,968,001 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.011421,253 - 783,037 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl11421,135 - 782,954 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.011420,518 - 782,868 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.411696,185 - 1,033,287 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.111696,200 - 1,033,287 (-)NCBI
Celera111,134,161 - 1,466,533 (-)NCBICelera
Cytogenetic Map11p12NCBI
Epha3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554074,138,362 - 4,500,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554074,135,671 - 4,500,900 (-)NCBIChiLan1.0ChiLan1.0
EPHA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2289,283,121 - 89,651,438 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1389,287,895 - 89,656,226 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0389,261,166 - 89,629,010 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1391,369,233 - 91,737,300 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl391,369,239 - 91,739,056 (+)Ensemblpanpan1.1panPan2
EPHA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.133770,234 - 1,092,063 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl33769,423 - 1,115,986 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha33949,355 - 1,298,894 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.033810,080 - 1,159,494 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl33810,033 - 1,149,524 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.133779,847 - 1,129,604 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.033811,416 - 1,161,165 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0331,284,819 - 1,381,967 (+)NCBIUU_Cfam_GSD_1.0
Epha3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404971462,842 - 799,414 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936610462,853 - 799,364 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936610462,842 - 799,466 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13166,592,493 - 166,942,767 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113166,592,492 - 166,942,791 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213177,406,602 - 177,539,843 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.213177,670,369 - 177,810,115 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12287,480,220 - 87,840,628 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2287,480,126 - 87,838,512 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604178,860,955 - 79,218,698 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epha3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247895,534,121 - 5,922,861 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247895,534,011 - 5,925,592 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Epha3
11648 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:896
Count of miRNA genes:486
Interacting mature miRNAs:633
Transcripts:ENSMUST00000064405
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301138Pcd4ts3_mp-glycoprotein positive CD4 T cell subset 3 (mouse)Not determined164059392374594076Mouse
1301394Eae11_msusceptibility to experimental allergic encephalomyelitis 11 (mouse)Not determined165356189187562035Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
4141212Imraq3_mimmune response to AAV2 QTL 3 (mouse)Not determined164438335078383506Mouse
1558836Dice1b_mdetermination of interleukin 4 commitment 1b (mouse)Not determined164551100072274485Mouse
1558740Bpq9_mblood pressure QTL 9 (mouse)Not determined166332733697327472Mouse
1301719Remslp3_mrapid eye movement sleep 3 (mouse)Not determined164438335078383506Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164219781782331174Mouse
4141113Tgq28_mtriglyceride QTL 28 (mouse)Not determined6298664696986646Mouse
1301364Lith14_mlithogenic gene 14 (mouse)Not determined165566184689661961Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16381786464620363Mouse
1300928Etia_methanol induced activation (mouse)Not determined166331390797314016Mouse
4142187Arrd3_mage-related retinal degeneration 3 (mouse)Not determined3252290965466552Mouse
11522747Eae41_mexperimental allergic encephalomyelitis susceptibility 41 (mouse)164039913478015472Mouse
14928310Manh80_mmandible shape 80 (mouse)164821984182219841Mouse
1301125Sluc27_msusceptibility to lung cancer 27 (mouse)Not determined166160864495608764Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16654297965466552Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163732036284696888Mouse
1301070Cypr1_mcytokine production 1 (mouse)Not determined163231279566312933Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16331786464620363Mouse
4142112Skts-fp3_mskin tumor susceptibility in FVB and PWK 3 (mouse)Not determined164005388172924385Mouse

Markers in Region
AW492086  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381663,603,529 - 63,603,622UniSTSGRCm38
MGSCv371663,603,355 - 63,603,448UniSTSGRCm37
Celera1663,902,969 - 63,903,062UniSTS
Cytogenetic Map16C1.3UniSTS
Whitehead/MRC_RH16704.16UniSTS
Epha3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371663,566,410 - 63,566,476UniSTSGRCm37
MGSCv371663,863,882 - 63,863,945UniSTSGRCm37
MGSCv371663,545,830 - 63,545,975UniSTSGRCm37
Celera1663,845,676 - 63,845,821UniSTS
Celera1663,866,112 - 63,866,178UniSTS
Celera1664,154,690 - 64,154,753UniSTS
Cytogenetic Map16C1.3UniSTS
cM Map16 UniSTS
M68513  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381663,545,997 - 63,546,131UniSTSGRCm38
MGSCv371663,545,823 - 63,545,957UniSTSGRCm37
Celera1663,845,669 - 63,845,803UniSTS
Cytogenetic Map16C1.3UniSTS
Whitehead/MRC_RH16706.12UniSTS
UniSTS:224333  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381663,610,631 - 63,610,786UniSTSGRCm38
MGSCv371663,610,457 - 63,610,612UniSTSGRCm37
Celera1663,910,067 - 63,910,222UniSTS
Cytogenetic Map16C1.3UniSTS
Epha3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C1.3UniSTS
Epha3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C1.3UniSTS
Epha3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381663,566,584 - 63,566,650UniSTSGRCm38
MGSCv371663,566,410 - 63,566,476UniSTSGRCm37
Celera1663,866,112 - 63,866,178UniSTS
Cytogenetic Map16C1.3UniSTS
Epha3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map16C1.3UniSTS
Epha3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381663,864,056 - 63,864,119UniSTSGRCm38
MGSCv371663,863,882 - 63,863,945UniSTSGRCm37
Celera1664,154,690 - 64,154,753UniSTS
Cytogenetic Map16C1.3UniSTS
Epha3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381663,546,004 - 63,546,149UniSTSGRCm38
MGSCv371663,545,830 - 63,545,975UniSTSGRCm37
Celera1663,845,676 - 63,845,821UniSTS
Cytogenetic Map16C1.3UniSTS
cM Map16 UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001362452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010140 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC154568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC155275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK044936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK045219 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK084921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK089119 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK132335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW491216 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC053479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC060164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC145349 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M68513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M68515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000064405   ⟹   ENSMUSP00000066554
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1663,363,897 - 63,684,521 (-)Ensembl
GRCm38.p6 Ensembl1663,543,534 - 63,864,158 (-)Ensembl
Ensembl Acc Id: ENSMUST00000231270   ⟹   ENSMUSP00000156331
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1663,593,564 - 63,684,499 (-)Ensembl
GRCm38.p6 Ensembl1663,773,201 - 63,864,136 (-)Ensembl
Ensembl Acc Id: ENSMUST00000232049   ⟹   ENSMUSP00000155946
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1663,366,468 - 63,684,443 (-)Ensembl
GRCm38.p6 Ensembl1663,546,105 - 63,864,080 (-)Ensembl
Ensembl Acc Id: ENSMUST00000232370
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1663,662,281 - 63,684,538 (-)Ensembl
GRCm38.p6 Ensembl1663,841,918 - 63,864,175 (-)Ensembl
Ensembl Acc Id: ENSMUST00000232461   ⟹   ENSMUSP00000155890
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1663,431,386 - 63,683,776 (-)Ensembl
GRCm38.p6 Ensembl1663,611,023 - 63,863,413 (-)Ensembl
Ensembl Acc Id: ENSMUST00000232654   ⟹   ENSMUSP00000155997
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1663,430,675 - 63,684,520 (-)Ensembl
GRCm38.p6 Ensembl1663,610,312 - 63,864,157 (-)Ensembl
RefSeq Acc Id: NM_001362452   ⟹   NP_001349381
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391663,363,895 - 63,684,538 (-)NCBI
GRCm381663,543,532 - 63,864,175 (-)NCBI
Sequence:
RefSeq Acc Id: NM_010140   ⟹   NP_034270
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391663,363,895 - 63,684,538 (-)NCBI
GRCm381663,543,532 - 63,864,175 (-)NCBI
MGSCv371663,545,044 - 63,863,983 (-)RGD
Celera1663,844,890 - 64,154,791 (-)RGD
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_034270   ⟸   NM_010140
- Peptide Label: isoform 1 precursor
- UniProtKB: Q8BRB1 (UniProtKB/TrEMBL),   Q8C3U1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001349381   ⟸   NM_001362452
- Peptide Label: isoform 2 precursor
- UniProtKB: B7ZNN5 (UniProtKB/TrEMBL),   Q8C3U1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSMUSP00000156331   ⟸   ENSMUST00000231270
Ensembl Acc Id: ENSMUSP00000155890   ⟸   ENSMUST00000232461
Ensembl Acc Id: ENSMUSP00000155946   ⟸   ENSMUST00000232049
Ensembl Acc Id: ENSMUSP00000155997   ⟸   ENSMUST00000232654
Ensembl Acc Id: ENSMUSP00000066554   ⟸   ENSMUST00000064405
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29319-F1-model_v2 AlphaFold P29319 1-983 view protein structure

Promoters
RGD ID:6827023
Promoter ID:MM_KWN:21372
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   MEF_B6
Transcripts:ENSMUST00000064405,   UC007ZPZ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361663,863,686 - 63,864,186 (-)MPROMDB
RGD ID:13674214
Promoter ID:EPDNEW_M21256
Type:initiation region
Name:Epha3_1
Description:Mus musculus Eph receptor A3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381663,864,175 - 63,864,235EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:99612 AgrOrtholog
Ensembl Genes ENSMUSG00000052504 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000064405 ENTREZGENE
  ENSMUST00000064405.8 UniProtKB/TrEMBL
  ENSMUST00000231270.2 UniProtKB/TrEMBL
  ENSMUST00000232049 ENTREZGENE
  ENSMUST00000232049.2 UniProtKB/TrEMBL
  ENSMUST00000232461.2 UniProtKB/TrEMBL
  ENSMUST00000232654.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EphA3_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rcpt_TKs UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Growth_fac_rcpt_cys_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:99612 ENTREZGENE
NCBI Gene 13837 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPHRIN TYPE-A RECEPTOR 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Epha3 PhenoGen
PIRSF TyrPK_ephrin_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FNTYPEIII UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYRKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EGF_2 UniProtKB/Swiss-Prot
  EPH_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EPH_lbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57184 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A338P6A7_MOUSE UniProtKB/TrEMBL
  A0A338P7J9_MOUSE UniProtKB/TrEMBL
  B7ZNN5 ENTREZGENE, UniProtKB/TrEMBL
  EPHA3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BRB1 ENTREZGENE, UniProtKB/TrEMBL
  Q8C3U1 ENTREZGENE, UniProtKB/TrEMBL
  Q8C9K6_MOUSE UniProtKB/TrEMBL