Gnpat (glyceronephosphate O-acyltransferase)

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Gene: Gnpat (glyceronephosphate O-acyltransferase) Rattus norvegicus

Analyze

Symbol:

Gnpat

Name:

glyceronephosphate O-acyltransferase

RGD ID:

620179

Description:

Predicted to enable glycerone-phosphate O-acyltransferase activity. Involved in several processes, including response to fatty acid; response to nutrient; and response to starvation. Located in peroxisomal membrane. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata type 2. Orthologous to human GNPAT (glyceronephosphate O-acyltransferase); PARTICIPATES IN plasmalogen biosynthetic pathway; plasmalogen metabolic pathway; glycerophospholipid metabolic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2-methoxyethanol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

acyl-CoA:dihydroxyacetonephosphate acyltransferase; acyl-CoA:dihydroxyacetonephosphateacyltransferase; DAP-AT; DHAP-AT; dihydroxyacetone phosphate acyltransferase; glycerone-phosphate O-acyltransferase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GNPAT (glyceronephosphate O-acyltransferase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Gnpat (glyceronephosphate O-acyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gnpat (glyceronephosphate O-acyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GNPAT (glyceronephosphate O-acyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GNPAT (glyceronephosphate O-acyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gnpat (glyceronephosphate O-acyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GNPAT (glyceronephosphate O-acyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GNPAT (glyceronephosphate O-acyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gnpat (glyceronephosphate O-acyltransferase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ADAMDEC1 (ADAM like decysin 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GNPAT (glyceronephosphate O-acyltransferase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gnpat (glyceronephosphate O-acyltransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gnpat (glyceronephosphate O-acyltransferase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	acl-7	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Dhap-at	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gnpat2	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gnpat	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	52,822,326 - 52,848,872 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	52,822,319 - 52,852,361 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	59,607,051 - 59,633,624 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	19	60,458,103 - 60,484,680 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	19	62,533,511 - 62,560,087 (+)	NCBI	Rnor_WKY
Rnor_6.0	19	57,614,813 - 57,640,524 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	57,614,628 - 57,640,726 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	68,328,052 - 68,353,763 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	55,033,777 - 55,059,491 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	55,038,657 - 55,064,372 (+)	NCBI
Celera	19	52,189,653 - 52,215,396 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Actin-Accumulation Myopathy (ISO)

congenital disorder of glycosylation type IIq (ISO)

disease of mental health (ISS)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

neurooculocardiogenitourinary syndrome (ISO)

parathyroid carcinoma (ISO)

prostate cancer (ISO)

rhizomelic chondrodysplasia punctata (ISO)

rhizomelic chondrodysplasia punctata type 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4-dinitrotoluene (EXP)

2-methoxyethanol (EXP)

3,4-methylenedioxymethamphetamine (ISO)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

arsenite(3-) (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

copper(II) sulfate (ISO)

cortisol (ISO)

cyclosporin A (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

ethanol (EXP)

finasteride (EXP)

folic acid (ISO)

hydralazine (ISO)

isotretinoin (ISO)

ivermectin (ISO)

lead(0) (ISO)

lead(2+) (ISO)

lithium chloride (ISO)

menadione (ISO)

methapyrilene (EXP,ISO)

mifepristone (ISO)

monosodium L-glutamate (ISO)

ozone (ISO)

paracetamol (ISO)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

sodium arsenite (ISO)

Soman (EXP)

temozolomide (ISO)

triptonide (ISO)

trovafloxacin (ISO)

valproic acid (EXP,ISO)

zinc atom (EXP)

zinc(0) (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cerebellum morphogenesis (ISO)

ether lipid biosynthetic process (IBA,IEA,ISO)

fatty acid metabolic process (IBA)

glycerophospholipid metabolic process (IEA)

membrane organization (ISO)

myelination (ISO)

paranodal junction assembly (ISO)

response to fatty acid (IEP)

response to nutrient (IEP)

response to starvation (IEP)

response to xenobiotic stimulus (IEP)

synapse assembly (ISO)

Cellular Component

mitochondrial membrane (IBA)

peroxisomal membrane (IBA,IDA,IEA,TAS)

peroxisome (IDA,ISO)

Molecular Function

catalytic activity (ISO)

glycerone-phosphate O-acyltransferase activity (IBA,IEA,ISO,TAS)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

glycerophospholipid metabolic pathway (IEA)

plasmalogen biosynthetic pathway (ISO)

plasmalogen metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment.	Bates EJ and Saggerson ED, Biochem J. 1979 Sep 15;182(3):751-62.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.	Kikuchi M, etal., J Biol Chem. 2004 Jan 2;279(1):421-8. Epub 2003 Oct 15.
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	Acyl-CoA:dihydroxyacetonephosphate acyltransferase: cloning of the human cDNA and resolution of the molecular basis in rhizomelic chondrodysplasia punctata type 2.	Ofman R, etal., Hum Mol Genet 1998 May;7(5):847-53.
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	Online Mendelian Inheritance in Man, OMIM (TM).	Online Mendelian Inheritance in Man, OMIM (TM).
10.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
11.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
12.	Peroxisomes and ether lipid biosynthesis in rat testis and epididymis.	Reisse S, etal., Biol Reprod 2001 Jun;64(6):1689-94.
13.	GOA pipeline	RGD automated data pipeline
14.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
16.	Studies of dihydroxyacetone phosphate acyltransferase in rat small intestine. Subcellular localization and effect of partially hydrogenated fish oil and clofibrate.	Ruyter B, etal., Biochem J. 1992 Mar 1;282 ( Pt 2):565-70.
17.	Effect of 3- and 4-thia-substituted fatty acids on glycerolipid metabolism and mitochondrial beta-oxidation in rat liver.	Skorve J, etal., Biochem Pharmacol. 1990 Nov 1;40(9):2005-12.
18.	Ether lipid biosynthesis: isolation and molecular characterization of human dihydroxyacetonephosphate acyltransferase.	Thai TP, etal., FEBS Lett 1997 Dec 29;420(2-3):205-11.
19.	Impaired membrane traffic in defective ether lipid biosynthesis.	Thai TP, etal., Hum Mol Genet 2001 Jan 15;10(2):127-36.

Additional References at PubMed

PMID:8186247	PMID:10456321	PMID:11792727	PMID:12477932	PMID:12874108	PMID:15687349	PMID:19270340	PMID:19946888	PMID:20178365	PMID:21525035

Genomics

Comparative Map Data

Gnpat
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	52,822,326 - 52,848,872 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	52,822,319 - 52,852,361 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	19	59,607,051 - 59,633,624 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	19	60,458,103 - 60,484,680 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	19	62,533,511 - 62,560,087 (+)	NCBI	Rnor_WKY
Rnor_6.0	19	57,614,813 - 57,640,524 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	57,614,628 - 57,640,726 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	68,328,052 - 68,353,763 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	55,033,777 - 55,059,491 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	19	55,038,657 - 55,064,372 (+)	NCBI
Celera	19	52,189,653 - 52,215,396 (+)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

GNPAT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	231,241,212 - 231,277,973 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	1	231,241,207 - 231,277,973 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	231,376,958 - 231,413,719 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	229,443,605 - 229,480,156 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	227,683,716 - 227,720,270	NCBI
Celera	1	204,641,787 - 204,678,590 (+)	NCBI		Celera
Cytogenetic Map	1	q42.2	NCBI
HuRef	1	201,860,306 - 201,897,106 (+)	NCBI		HuRef
CHM1_1	1	232,650,570 - 232,687,371 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	230,624,475 - 230,661,237 (+)	NCBI		T2T-CHM13v2.0

Gnpat
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	125,589,772 - 125,616,796 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	125,589,772 - 125,616,796 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	124,863,033 - 124,890,057 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	124,863,033 - 124,890,057 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	127,386,933 - 127,413,957 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	127,749,177 - 127,776,147 (+)	NCBI		MGSCv36	mm8
Celera	8	129,171,508 - 129,198,742 (+)	NCBI		Celera
Cytogenetic Map	8	E2	NCBI
cM Map	8	72.81	NCBI

Gnpat
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955492	7,489,080 - 7,519,590 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955492	7,489,080 - 7,519,590 (-)	NCBI	ChiLan1.0	ChiLan1.0

GNPAT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	1	18,120,797 - 18,157,389 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	206,794,245 - 206,830,840 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	211,819,259 - 211,855,974 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	211,819,259 - 211,855,885 (+)	Ensembl	panpan1.1		panPan2

GNPAT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	8,155,186 - 8,190,403 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	8,155,191 - 8,190,229 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	8,147,533 - 8,182,713 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	8,180,644 - 8,215,844 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	8,180,644 - 8,215,139 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	8,184,206 - 8,219,358 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	8,306,165 - 8,341,341 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	8,534,802 - 8,569,933 (-)	NCBI		UU_Cfam_GSD_1.0

Gnpat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	43,248,868 - 43,276,893 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936484	19,410,956 - 19,434,929 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936484	19,414,094 - 19,434,929 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GNPAT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	59,203,090 - 59,241,247 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	59,203,519 - 59,240,303 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	63,872,123 - 63,904,272 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GNPAT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	68,518,643 - 68,553,055 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	68,518,300 - 68,553,767 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	70,426,054 - 70,460,430 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gnpat
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624775	18,410,755 - 18,439,246 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624775	18,410,514 - 18,443,169 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gnpat
80 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	303
Count of miRNA genes:	191
Interacting mature miRNAs:	212
Transcripts:	ENSRNOT00000026617
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	19	33838214	55283146	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	33838214	55283146	Rat
5135224	Leukc1	Leukocyte quantity QTL 1			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	19	44340214	55283277	Rat
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	49976481	53225766	Rat

Markers in Region

RH129086

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	52,848,909 - 52,849,075 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	57,641,205 - 57,641,370	NCBI	Rnor6.0
Rnor_5.0	19	68,354,444 - 68,354,609	UniSTS	Rnor5.0
RGSC_v3.4	19	55,060,172 - 55,060,337	UniSTS	RGSC3.4
Celera	19	52,216,077 - 52,216,242	UniSTS
RH 3.4 Map	19	725.7	UniSTS
Cytogenetic Map	19	q12	UniSTS

BE116945

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	52,850,678 - 52,850,828 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	57,642,974 - 57,643,123	NCBI	Rnor6.0
Rnor_5.0	19	68,356,213 - 68,356,362	UniSTS	Rnor5.0
RGSC_v3.4	19	55,061,941 - 55,062,090	UniSTS	RGSC3.4
Celera	19	52,217,846 - 52,217,995	UniSTS
RH 3.4 Map	19	720.9	UniSTS
Cytogenetic Map	19	q12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	49	33	19	33	8	11	74	35	41	11	8
Low			8	8		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053410	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC105521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF218826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098825	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474054	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ217065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ223620	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000314	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000026617 ⟹ ENSRNOP00000026617

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	52,822,319 - 52,852,361 (+)	Ensembl
Rnor_6.0 Ensembl	19	57,614,628 - 57,640,726 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000096315 ⟹ ENSRNOP00000077229

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	52,826,730 - 52,848,473 (+)	Ensembl

RefSeq Acc Id:

NM_053410 ⟹ NP_445862

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	52,822,326 - 52,848,867 (+)	NCBI
Rnor_6.0	19	57,614,813 - 57,640,524 (+)	NCBI
Rnor_5.0	19	68,328,052 - 68,353,763 (+)	NCBI
RGSC_v3.4	19	55,033,777 - 55,059,491 (+)	RGD
Celera	19	52,189,653 - 52,215,396 (+)	NCBI

Sequence:

show sequence

ATTTCTGGATCCAAAATGGACGTTCCTAGCTCCTCCAGCTCCCGATTCTCGGTCGGCTCTGCCA
GCCCTAGCAGTGTGCTCCTCTATGCGAAAGACCTCAAAAAGTGGGATGAGTTTGAAGACCTGTT
GGAGGAGAGGAGACAGGTCAGTGATTTCAAATTTGCAATGAAGTGCTACACACCACCCTTGTAT
AGAGGAATTACTCCCTGCAAGCCAAGTGATATCAAGTCCATCGTTCTCAATTCTGAAGAGATTA
ACTATGTCATTAAGCAGCTTTCCAGGGAGTCCCTGACGGGTGTGGATGTGCTCAGAGAAGAGGC
CAATGAGATCCTGGAGGAAATGAGTCACAAACTGCGTATAGGAGCCATTCGGTTCTTTGCCTTT
GTTCTGAGCAAAGTTTTTAAACAGATCTTCTCAAAGGTGTGTGTGAATGAAGAAGGCATTCAAA
AGCTACAACGAGCGATCCAGGAGCACCCCGTGATCCTGCTGCCCAGCCACCGGAGCTACATCGA
CTTCCTCATGCTGTCCTTTGTCCTCTACAACTATGACCTGCCCGTGCCGGTGATCGCAGCAGGG
ATGGACTTCCTGGGAATGCGAGTGGTGAGCGAGCTGCTCAGGATGTCTGGGGCCTTCTTCATGC
GACGTACTTTTGGAGGAAATAAGCTCTACTGGGCCGTATTCTCGGAATACGTGAAGACCATGCT
ACGGAGTGGTTATGCTCCTGTTGAATTTTTCCTCGAAGGGACAAGGAGTCGAGCTGCCAAGACC
TTGACTCCTAAATTCGGTCTCCTGAATATTGTGATGGAACCATTTTTTAAAAGAGAAGTTTTTG
ATACCTACTTTGTCCCAATTAGCATCAGTTATGATAAAATATTGGAAGAAAGTCTTTATGCGTA
TGAGCTCCTAGGAATCCCTAAGCCAAAGGAATCCACTACCGGACTGTTGAAAGCTAGACGGATT
CTCTCTGAGAACTTTGGAAGTATCCATGTGTACTTTGGAGACCCTGTGTCACTGCGCTCTCTAG
CTGCAGGGCGGCTCAGTCGGAACACGTATAACTTGGTGCCAAGGTGCATCCCTCAGAAGCAGCC
TGAGGATGTGCAAGCCTTTGTCACTGAAGTTGCCTATAAGATGCAGCTTTTGCAAATTGAAAAC
CTGGCTCTGAGCCCATGGCTTCTGGTAGTTGCCATTCTGCTTCAGAACCAGCTGTGCATGGACT
TCGATGCCCTGGTGGAAAAGACTCTGTGGCTGAAGGGCTTAACGCAGGTGTTTGGAGGGTTCCT
GCTTTGGCCTGATAACAAACTTCCTGAGGAAGTGGTCCAGTCGAGCATCCTCCTGCACTCTAAC
CTGGCCACCCTTGTCAAAGACCAGGTGGTTCTGAAAGTGGACTCTGAAAGCTCACAGATGGTCA
ACGGGCTTGTGCCCCAACACATTGCCTTCCTCATGTGCTCGGCGTACAGGAACCAGCTGCTCAA
CGTGTTTGCCCGTCCTTCCCTAGTAGCTGTGGCTTTGCACATGACTCCTGGGCTCAGGAAAGAG
GATGTCTTCAGTTGCTTTTCCTTCCTCCGCAACGTGTTTTCAGATGAGTTCATCTTCCTTCCAG
GAAACACACTCAGGGACTTTGAGGAAGGCTGTTACTTGCTGTGTAAAACTGAGGTTATGCAGAT
GACTGGGAAGGACATCATCCTCACAGACAAAGGGAATGCTGTATTACAGTTCCTCACAGGACTC
TTTAAACCTTTTGTGGAATCGTATCAGATACTTTCCAAATGCCTCTTGCATGAAGAGGACTACT
TCAGTGAGAAGGAGTACTTGGTCACAGCCAGGAAGTTCACCCGCCAGCTTCTGGATCAAGATGC
CTCTCAGTGTTACGACGCGCTGTCCTCTGAACTTCAGAAGAATGCCTTAGCAGCCTTCGTGAGA
CTCGGGGTGGTAGAAAAGAATAAGGTAGACAGTAAATATGTGTATTATGTCAACGGGCCTGCCA
CAAGCAAGTTAGAAGAAATGCTCGGATGTAAGAAGCCAATAGGAAAACCAGCCACTGCAAAACT
TTAAAAGCTTAGAAATC

hide sequence

RefSeq Acc Id:

XM_039098042 ⟹ XP_038953970

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	52,829,883 - 52,848,867 (+)	NCBI

RefSeq Acc Id:

XM_039098043 ⟹ XP_038953971

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	52,824,276 - 52,848,872 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_445862	(Get FASTA)	NCBI Sequence Viewer
	XP_038953970	(Get FASTA)	NCBI Sequence Viewer
	XP_038953971	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG17548	(Get FASTA)	NCBI Sequence Viewer
	EDL96743	(Get FASTA)	NCBI Sequence Viewer
	EDL96744	(Get FASTA)	NCBI Sequence Viewer
	EDL96745	(Get FASTA)	NCBI Sequence Viewer
	Q9ES71	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_445862 ⟸ NM_053410

- UniProtKB:

Q9ES71 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MDVPSSSSSRFSVGSASPSSVLLYAKDLKKWDEFEDLLEERRQVSDFKFAMKCYTPPLYRGITP
CKPSDIKSIVLNSEEINYVIKQLSRESLTGVDVLREEANEILEEMSHKLRIGAIRFFAFVLSKV
FKQIFSKVCVNEEGIQKLQRAIQEHPVILLPSHRSYIDFLMLSFVLYNYDLPVPVIAAGMDFLG
MRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRSGYAPVEFFLEGTRSRAAKTLTPKF
GLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYELLGIPKPKESTTGLLKARRILSENF
GSIHVYFGDPVSLRSLAAGRLSRNTYNLVPRCIPQKQPEDVQAFVTEVAYKMQLLQIENLALSP
WLLVVAILLQNQLCMDFDALVEKTLWLKGLTQVFGGFLLWPDNKLPEEVVQSSILLHSNLATLV
KDQVVLKVDSESSQMVNGLVPQHIAFLMCSAYRNQLLNVFARPSLVAVALHMTPGLRKEDVFSC
FSFLRNVFSDEFIFLPGNTLRDFEEGCYLLCKTEVMQMTGKDIILTDKGNAVLQFLTGLFKPFV
ESYQILSKCLLHEEDYFSEKEYLVTARKFTRQLLDQDASQCYDALSSELQKNALAAFVRLGVVE
KNKVDSKYVYYVNGPATSKLEEMLGCKKPIGKPATAKL

hide sequence

RefSeq Acc Id:

ENSRNOP00000026617 ⟸ ENSRNOT00000026617

RefSeq Acc Id:	XP_038953971 ⟸ XM_039098043
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038953970 ⟸ XM_039098042
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000077229 ⟸ ENSRNOT00000096315

Protein Domains

Phospholipid/glycerol acyltransferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9ES71-F1-model_v2	AlphaFold	Q9ES71	1-678	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701242

Promoter ID:

EPDNEW_R11765

Type:

multiple initiation site

Name:

Gnpat_1

Description:

glyceronephosphate O-acyltransferase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	57,614,642 - 57,614,702	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620179	AgrOrtholog
BioCyc Gene	G2FUF-5228	BioCyc
BioCyc Pathway	PWY-7411 [phosphatidate biosynthesis (yeast)]	BioCyc
	PWY-7782 [plasmalogen biosynthesis]	BioCyc
Ensembl Genes	ENSRNOG00000019205	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000026617	ENTREZGENE
	ENSRNOP00000026617.4	UniProtKB/Swiss-Prot
	ENSRNOP00000077229	ENTREZGENE
	ENSRNOP00000077229.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000026617	ENTREZGENE
	ENSRNOT00000026617.7	UniProtKB/Swiss-Prot
	ENSRNOT00000096315	ENTREZGENE
	ENSRNOT00000096315.1	UniProtKB/TrEMBL
InterPro	DHAPAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPAT/DHAPAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPAT/DHAPAT_LPLAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPAT_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Plipid/glycerol_acylTrfase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:84470	UniProtKB/Swiss-Prot
NCBI Gene	84470	ENTREZGENE
PANTHER	DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR12563	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Acyltransferase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPAT_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gnpat	PhenoGen
PIRSF	DHAPAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPAT_DHAPAT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	PlsC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Glycerol-3-phosphate (1)-acyltransferase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5YBP7_RAT	UniProtKB/TrEMBL
	GNPAT_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Gnpat	glyceronephosphate O-acyltransferase		acyl-CoA:dihydroxyacetonephosphate acyltransferase	Name updated	1299863	APPROVED
2002-08-07	Gnpat	acyl-CoA:dihydroxyacetonephosphate acyltransferase			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to peroxisomes

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)