Mir488 (microRNA 488) - Rat Genome Database

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Gene: Mir488 (microRNA 488) Rattus norvegicus
Analyze
Symbol: Mir488
Name: microRNA 488
RGD ID: 2325487
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in negative regulation of gene expression and negative regulation of inflammatory response. Orthologous to human MIR488 (microRNA 488); INTERACTS WITH 2,5-hexanedione; endosulfan; furan.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-488
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81373,216,541 - 73,216,619 (+)NCBIGRCr8
mRatBN7.21370,683,064 - 70,683,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1370,683,064 - 70,683,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1373,260,030 - 73,260,108 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01374,560,257 - 74,560,335 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01371,819,607 - 71,819,685 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01376,198,593 - 76,198,671 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1376,198,593 - 76,198,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01381,112,954 - 81,113,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1370,496,620 - 70,496,698 (+)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MicroRNA-488 inhibits ovarian cancer cell metastasis through regulating CCNG1 and p53 expression. Guo JY, etal., Eur Rev Med Pharmacol Sci. 2020 Mar;24(6):2902-2910. doi: 10.26355/eurrev_202003_20654.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16381832   PMID:17604727   PMID:20403161   PMID:34102644   PMID:35795990   PMID:37874190   PMID:37961023  


Genomics

Comparative Map Data
Mir488
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81373,216,541 - 73,216,619 (+)NCBIGRCr8
mRatBN7.21370,683,064 - 70,683,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1370,683,064 - 70,683,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1373,260,030 - 73,260,108 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01374,560,257 - 74,560,335 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01371,819,607 - 71,819,685 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01376,198,593 - 76,198,671 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1376,198,593 - 76,198,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01381,112,954 - 81,113,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1370,496,620 - 70,496,698 (+)NCBICelera
Cytogenetic Map13q22NCBI
MIR488
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381177,029,363 - 177,029,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1177,029,363 - 177,029,445 (-)EnsemblGRCh38hg38GRCh38
GRCh371176,998,499 - 176,998,581 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,265,121 - 175,265,203 (-)NCBINCBI36Build 36hg18NCBI36
Celera1150,108,504 - 150,108,586 (-)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1148,224,993 - 148,225,075 (-)NCBIHuRef
CHM1_11178,422,539 - 178,422,621 (-)NCBICHM1_1
T2T-CHM13v2.01176,384,002 - 176,384,084 (-)NCBIT2T-CHM13v2.0
Mir488
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391158,333,195 - 158,333,303 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1158,333,195 - 158,333,303 (+)EnsemblGRCm39 Ensembl
GRCm381158,505,625 - 158,505,733 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1158,505,625 - 158,505,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,435,756 - 160,435,864 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1160,900,459 - 160,900,567 (+)NCBICelera
Cytogenetic Map1H1NCBI
cM Map168.46NCBI
MIR488
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1722,597,953 - 22,598,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl722,597,953 - 22,598,035 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha722,122,143 - 22,122,225 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0722,344,624 - 22,344,706 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl722,344,624 - 22,344,706 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1722,250,245 - 22,250,327 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0722,350,320 - 22,350,402 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0722,493,251 - 22,493,333 (+)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:10276
Count of gene targets:5999
Count of transcripts:6399
Interacting mature miRNAs:rno-miR-488-3p, rno-miR-488-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133975454484754544Rat
2303028Bp329Blood pressure QTL 329arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)135849787273485113Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133453521879535218Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)133843340883433408Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)135949252277046890Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133228447177284471Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
12879477Bp401Blood pressure QTL 401arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133726209282262092Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133741558482415584Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat


Expression

RNA-SEQ Expression

circulatory system
ectoderm
mesenchyme
mesoderm
nervous system
reproductive system
1 9 1 1 9 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_032299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000054388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1370,683,064 - 70,683,142 (+)Ensembl
Rnor_6.0 Ensembl1376,198,593 - 76,198,671 (+)Ensembl
RefSeq Acc Id: NR_032299
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81373,216,541 - 73,216,619 (+)NCBI
mRatBN7.21370,683,064 - 70,683,142 (+)NCBI
Rnor_6.01376,198,593 - 76,198,671 (+)NCBI
Rnor_5.01381,112,954 - 81,113,032 (+)NCBI
Celera1370,496,620 - 70,496,698 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325487 AgrOrtholog
BioCyc Gene G2FUF-17777 BioCyc
Ensembl Genes ENSRNOG00000036265 Ensembl
miRBase MI0006168 ENTREZGENE
NCBI Gene 100314120 ENTREZGENE
PhenoGen Mir488 PhenoGen
RatGTEx ENSRNOG00000036265 RatGTEx
RNAcentral URS00002A36ED RNACentral
  URS00002D77C3 RNACentral
  URS000075EE58 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir488  microRNA 488  Mir488  microRNA mir-488  Name updated 61478 APPROVED
2010-06-02 Mir488  microRNA mir-488      Symbol and Name status set to provisional 70820 PROVISIONAL