Mir488 (microRNA 488) - Rat Genome Database

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Gene: Mir488 (microRNA 488) Rattus norvegicus
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Symbol: Mir488
Name: microRNA 488
RGD ID: 2325487
Description: Predicted to enable mRNA base-pairing translational repressor activity. Predicted to be involved in negative regulation of gene expression and negative regulation of inflammatory response. Orthologous to human MIR488 (microRNA 488); INTERACTS WITH 2,5-hexanedione; endosulfan; furan.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: rno-mir-488
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81373,216,541 - 73,216,619 (+)NCBIGRCr8
mRatBN7.21370,683,064 - 70,683,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1370,683,064 - 70,683,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1373,260,030 - 73,260,108 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01374,560,257 - 74,560,335 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01371,819,607 - 71,819,685 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01376,198,593 - 76,198,671 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1376,198,593 - 76,198,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01381,112,954 - 81,113,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1370,496,620 - 70,496,698 (+)NCBICelera
Cytogenetic Map13q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir488Ratovarian cancer disease_progressionISOMIR488 (Homo sapiens)151356992mRNA:decreased expression:ovary (human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir488RatCocaine-Related Disorders  ISOMIR488 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20643829

1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir488Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOMIR488 (Homo sapiens)6480464[Tetrachlorodibenzodioxin co-treated with 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide] results in decreased expression of MIR488 mRNACTDPMID:29704546
Mir488Rat2,5-hexanedione increases expressionEXP 64804642 and 5-hexanedione results in increased expression of MIR488 mRNACTDPMID:31760062
Mir488Ratcadmium atom multiple interactionsISOMir488 (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIR488 mRNACTDPMID:28892167
Mir488Ratcadmium dichloride multiple interactionsISOMir488 (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MIR488 mRNACTDPMID:28892167
Mir488Ratcocaine multiple interactionsISOMir488 (Mus musculus)6480464AGO2 protein affects the reaction [Cocaine results in increased expression of MIR488 mRNA]CTDPMID:20643829
Mir488Ratcocaine increases expressionISOMir488 (Mus musculus)6480464Cocaine results in increased expression of MIR488 mRNACTDPMID:20643829
Mir488Ratendosulfan affects expressionEXP 6480464Endosulfan affects the expression of MIR488 mRNACTDPMID:31464424
Mir488Ratfuran decreases expressionEXP 6480464furan results in decreased expression of MIR488 mRNACTDPMID:20562052
Mir488Ratlead diacetate decreases expressionISOMir488 (Mus musculus)6480464lead acetate results in decreased expression of MIR488 mRNACTDPMID:36183778
Mir488Ratnitrofen increases expressionEXP 6480464nitrofen results in increased expression of MIR488 mRNACTDPMID:26720608
Mir488Ratp-cresol increases expressionISOMir488 (Mus musculus)64804644-cresol results in increased expression of MIR488 mRNACTDPMID:32105654
Mir488Ratpaclitaxel increases expressionISOMIR488 (Homo sapiens)6480464Paclitaxel results in increased expression of MIR488CTDPMID:35134991
Mir488Ratphenol increases expressionISOMir488 (Mus musculus)6480464Phenol results in increased expression of MIR488 mRNACTDPMID:32105654
Mir488Rattaurocholic acid increases expressionISOMIR488 (Homo sapiens)6480464Taurocholic Acid results in increased expression of MIR488 mRNACTDPMID:28851649
Mir488Rattributyl phosphate decreases expressionISOMir488 (Mus musculus)6480464tributyl phosphate results in decreased expression of MIR488 mRNACTDPMID:32105654
Mir488Ratzinc atom decreases expressionEXP 6480464Zinc deficiency results in decreased expression of MIR488 mRNACTDPMID:22689922
Mir488Ratzinc(0) decreases expressionEXP 6480464Zinc deficiency results in decreased expression of MIR488 mRNACTDPMID:22689922

1 to 17 of 17 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Mir488RatmRNA base-pairing translational repressor activity enablesISOMIR488 (Homo sapiens)1624291 PMID:28915828RGDPMID:28915828


#
Reference Title
Reference Citation
1. MicroRNA-488 inhibits ovarian cancer cell metastasis through regulating CCNG1 and p53 expression. Guo JY, etal., Eur Rev Med Pharmacol Sci. 2020 Mar;24(6):2902-2910. doi: 10.26355/eurrev_202003_20654.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:16381832   PMID:17604727   PMID:20403161   PMID:34102644   PMID:35795990   PMID:37874190   PMID:37961023  



Mir488
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81373,216,541 - 73,216,619 (+)NCBIGRCr8
mRatBN7.21370,683,064 - 70,683,142 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1370,683,064 - 70,683,142 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1373,260,030 - 73,260,108 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01374,560,257 - 74,560,335 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01371,819,607 - 71,819,685 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01376,198,593 - 76,198,671 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1376,198,593 - 76,198,671 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01381,112,954 - 81,113,032 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1370,496,620 - 70,496,698 (+)NCBICelera
Cytogenetic Map13q22NCBI
MIR488
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381177,029,363 - 177,029,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1177,029,363 - 177,029,445 (-)EnsemblGRCh38hg38GRCh38
GRCh371176,998,499 - 176,998,581 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361175,265,121 - 175,265,203 (-)NCBINCBI36Build 36hg18NCBI36
Celera1150,108,504 - 150,108,586 (-)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1148,224,993 - 148,225,075 (-)NCBIHuRef
CHM1_11178,422,539 - 178,422,621 (-)NCBICHM1_1
T2T-CHM13v2.01176,384,002 - 176,384,084 (-)NCBIT2T-CHM13v2.0
Mir488
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391158,333,195 - 158,333,303 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1158,333,195 - 158,333,303 (+)EnsemblGRCm39 Ensembl
GRCm381158,505,625 - 158,505,733 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1158,505,625 - 158,505,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,435,756 - 160,435,864 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1160,900,459 - 160,900,567 (+)NCBICelera
Cytogenetic Map1H1NCBI
cM Map168.46NCBI
MIR488
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1722,597,953 - 22,598,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl722,597,953 - 22,598,035 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha722,122,143 - 22,122,225 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0722,344,624 - 22,344,706 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl722,344,624 - 22,344,706 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1722,250,245 - 22,250,327 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0722,350,320 - 22,350,402 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0722,493,251 - 22,493,333 (+)NCBIUU_Cfam_GSD_1.0

.

Predicted Targets
Summary Value
Count of predictions:10276
Count of gene targets:5999
Count of transcripts:6399
Interacting mature miRNAs:rno-miR-488-3p, rno-miR-488-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 33 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)136906051977046890Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
71119Thym2Thymus enlargement QTL 23.8thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)134619797684753113Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat

1 to 10 of 33 rows



circulatory system
ectoderm
mesenchyme
mesoderm
nervous system
reproductive system
1 9 1 1 9 1


RefSeq Transcripts NR_032299 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000054388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1370,683,064 - 70,683,142 (+)Ensembl
Rnor_6.0 Ensembl1376,198,593 - 76,198,671 (+)Ensembl
RefSeq Acc Id: NR_032299
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81373,216,541 - 73,216,619 (+)NCBI
mRatBN7.21370,683,064 - 70,683,142 (+)NCBI
Rnor_6.01376,198,593 - 76,198,671 (+)NCBI
Rnor_5.01381,112,954 - 81,113,032 (+)NCBI
Celera1370,496,620 - 70,496,698 (+)NCBI
Sequence:

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 10 of 10 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-17777 BioCyc
Ensembl Genes ENSRNOG00000036265 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000054388 ENTREZGENE
miRBase MI0006168 ENTREZGENE
NCBI Gene 100314120 ENTREZGENE
PhenoGen Mir488 PhenoGen
RatGTEx ENSRNOG00000036265 RatGTEx
RNAcentral URS00002A36ED RNACentral
  URS00002D77C3 RNACentral
  URS000075EE58 RNACentral
1 to 10 of 10 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-09 Mir488  microRNA 488  Mir488  microRNA mir-488  Name updated 61478 APPROVED
2010-06-02 Mir488  microRNA mir-488      Symbol and Name status set to provisional 70820 PROVISIONAL