Gch1 (GTP cyclohydrolase 1) - Rat Genome Database

Name: Gch1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Gch1 (GTP cyclohydrolase 1) Heterocephalus glaber

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Symbol:

Gch1

Name:

GTP cyclohydrolase 1

RGD ID:

18935181

Description:

ENCODES a protein that exhibits calcium ion binding (ortholog); GTP binding (ortholog); GTP cyclohydrolase I activity (ortholog); INVOLVED IN dihydrobiopterin metabolic process (ortholog); dopamine biosynthetic process (ortholog); negative regulation of blood pressure (ortholog); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); BH4-deficient hyperphenylalaninemia B (ortholog); FOUND IN cytoplasmic vesicle (ortholog); cytosol (ortholog); intracellular protein-containing complex (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GCH1 (GTP cyclohydrolase 1)	NCBI	Ortholog
Mus musculus (house mouse):	Gch1 (GTP cyclohydrolase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Gch1 (GTP cyclohydrolase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gch1 (GTP cyclohydrolase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GCH1 (GTP cyclohydrolase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GCH1 (GTP cyclohydrolase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gch1 (GTP cyclohydrolase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GCH1 (GTP cyclohydrolase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GCH1 (GTP cyclohydrolase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	14,459,303 - 14,500,429 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	14,459,164 - 14,502,485 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Acute Coronary Syndrome (ISO)

BH4-deficient hyperphenylalaninemia A (ISO)

BH4-deficient hyperphenylalaninemia B (ISO)

bipolar disorder (ISO)

cerebral infarction (ISO)

congestive heart failure (ISO)

COVID-19 (ISO)

diabetic angiopathy (ISO)

dilated cardiomyopathy (ISO)

DOPA-responsive dystonia (ISO)

Drug-Induced Dyskinesia (ISO)

dystonia (ISO)

Endotoxemia (ISO)

endotoxin shock (ISO)

epilepsy (ISO)

Experimental Diabetes Mellitus (ISO)

Gait Ataxia (ISO)

genetic disease (ISO)

hereditary spastic paraplegia 11 (ISO)

hypertension (ISO)

Hypokinesia (ISO)

intellectual disability (ISO)

intestinal disease (ISO)

Intestinal Ischemia (ISO)

liver cirrhosis (ISO)

Metabolic Syndrome (ISO)

middle cerebral artery infarction (ISO)

Muscle Rigidity (ISO)

Muscle Weakness (ISO)

Musculoskeletal Pain (ISO)

myocardial infarction (ISO)

Myocardial Ischemia (ISO)

Neuralgia (ISO)

Pain (ISO)

Parkinsonism (ISO)

peripheral artery disease (ISO)

phenylketonuria (ISO)

portal hypertension (ISO)

primary biliary cholangitis (ISO)

pulmonary fibrosis (ISO)

sciatic neuropathy (ISO)

Segawa Syndrome, Autosomal Recessive (ISO)

Sepsis (ISO)

sickle cell anemia (ISO)

sleep disorder (ISO)

syndromic microphthalmia 6 (ISO)

transient cerebral ischemia (ISO)

type 2 diabetes mellitus (ISO)

Visceral Pain (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dihydrobiopterin metabolic process (ISO)

dopamine biosynthetic process (ISO)

negative regulation of blood pressure (ISO)

negative regulation of cardiac muscle cell apoptotic process (ISO)

negative regulation of cellular senescence (ISO)

neuromuscular process controlling posture (ISO)

positive regulation of heart rate (ISO)

positive regulation of neuron apoptotic process (ISO)

positive regulation of nitric-oxide synthase activity (ISO)

positive regulation of telomere maintenance via telomerase (ISO)

protein-containing complex assembly (ISO)

pteridine-containing compound biosynthetic process (ISO)

regulation of blood pressure (ISO)

regulation of lung blood pressure (ISO)

regulation of removal of superoxide radicals (ISO)

response to lipopolysaccharide (ISO)

response to pain (ISO)

response to tumor necrosis factor (ISO)

response to type II interferon (ISO)

tetrahydrobiopterin biosynthetic process (IEA)

tetrahydrofolate biosynthetic process (IEA)

vasodilation (ISO)

Cellular Component

cytoplasm (IEA)

cytoplasmic vesicle (ISO)

cytosol (ISO)

intracellular protein-containing complex (ISO)

mitochondrion (ISO)

nuclear membrane (ISO)

nucleoplasm (ISO)

nucleus (IEA,ISO)

protein-containing complex (ISO)

Molecular Function

calcium ion binding (ISO)

GTP binding (IEA,ISO)

GTP cyclohydrolase I activity (IEA,ISO)

GTP-dependent protein binding (ISO)

GTPase activity (ISO)

hydrolase activity (IEA)

identical protein binding (ISO)

mitogen-activated protein kinase binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

protein-containing complex binding (ISO)

zinc ion binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

dopa responsive dystonia pathway (ISO)

Segawa syndrome pathway (ISO)

References

Additional References at PubMed

PMID:21993625	PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gch1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624731	14,459,303 - 14,500,429 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624731	14,459,164 - 14,502,485 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

GCH1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	54,842,017 - 54,902,826 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	54,842,008 - 54,902,826 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	55,308,735 - 55,369,544 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	54,378,473 - 54,439,292 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	54,378,484 - 54,439,279	NCBI
Celera	14	35,358,210 - 35,419,030 (-)	NCBI		Celera
Cytogenetic Map	14	q22.2	NCBI
HuRef	14	35,471,338 - 35,532,109 (-)	NCBI		HuRef
CHM1_1	14	55,247,346 - 55,308,167 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	49,047,244 - 49,108,020 (-)	NCBI		T2T-CHM13v2.0

Gch1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	47,391,352 - 47,426,870 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	47,391,352 - 47,426,870 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	47,153,895 - 47,189,413 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	47,153,895 - 47,189,413 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	47,773,570 - 47,809,077 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	46,075,772 - 46,111,279 (-)	NCBI		MGSCv36	mm8
Celera	14	43,334,771 - 43,370,387 (-)	NCBI		Celera
Cytogenetic Map	14	C1	NCBI
cM Map	14	24.6	NCBI

Gch1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	22,884,006 - 22,917,412 (-)	NCBI		GRCr8
mRatBN7.2	15	20,404,267 - 20,437,727 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	20,402,527 - 20,437,698 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	23,184,907 - 23,218,319 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	24,142,871 - 24,176,283 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	22,394,011 - 22,427,378 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	23,935,011 - 23,968,971 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	23,934,585 - 23,969,011 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	27,876,253 - 27,910,213 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	23,023,996 - 23,139,794 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	23,039,695 - 23,155,494 (-)	NCBI
Celera	15	20,799,206 - 20,832,598 (-)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

Gch1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955409	8,624,468 - 8,668,614 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955409	8,624,225 - 8,670,436 (+)	NCBI	ChiLan1.0	ChiLan1.0

GCH1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	55,932,208 - 56,026,639 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	55,179,865 - 55,240,594 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	35,428,676 - 35,489,359 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	53,706,723 - 53,767,393 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	53,706,723 - 53,767,393 (-)	Ensembl	panpan1.1		panPan2

GCH1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	30,733,422 - 30,784,067 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	30,732,608 - 30,784,156 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	30,501,844 - 30,552,428 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	30,989,520 - 31,040,202 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	30,967,731 - 31,040,294 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	30,593,993 - 30,644,489 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	30,669,980 - 30,720,620 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	31,035,484 - 31,086,113 (-)	NCBI		UU_Cfam_GSD_1.0

Gch1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	74,457,811 - 74,501,265 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936697	232,048 - 275,420 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GCH1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	184,199,679 - 184,257,315 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	184,201,232 - 184,264,060 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	204,648,349 - 204,712,905 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GCH1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	32,029,997 - 32,079,656 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	32,027,648 - 32,079,490 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	20,264,246 - 20,316,487 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004835499	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_004835500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_013074646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_021261925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01003767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AHKG01003768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JH169915	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000016929 ⟹ ENSHGLP00000016758

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624731	14,459,303 - 14,500,429 (+)	Ensembl

RefSeq Acc Id:

XM_004835499 ⟹ XP_004835556

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624731	14,459,166 - 14,502,485 (+)	NCBI

RefSeq Acc Id:

XM_004835500 ⟹ XP_004835557

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624731	14,459,167 - 14,502,485 (+)	NCBI

RefSeq Acc Id:

XM_013074646 ⟹ XP_012930100

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624731	14,459,164 - 14,502,485 (+)	NCBI

RefSeq Acc Id:

XM_021261925 ⟹ XP_021117584

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624731	14,459,165 - 14,502,485 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_004835556	(Get FASTA)	NCBI Sequence Viewer
	XP_004835557	(Get FASTA)	NCBI Sequence Viewer
	XP_012930100	(Get FASTA)	NCBI Sequence Viewer
	XP_021117584	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EHB07940	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000016758
	ENSHGLP00000036637
	ENSHGLP00100032470

RefSeq Acc Id:	XP_012930100 ⟸ XM_013074646
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_021117584 ⟸ XM_021261925
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_004835556 ⟸ XM_004835499
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_004835557 ⟸ XM_004835500
- Peptide Label:	isoform X2
- UniProtKB:	G5BF79 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000016758 ⟸ ENSHGLT00000016929

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000011991	Ensembl, ENTREZGENE
	ENSHGLG00000040496	UniProtKB/TrEMBL
	ENSHGLG00100037665	UniProtKB/TrEMBL
Ensembl Transcript	ENSHGLT00000016929	ENTREZGENE
	ENSHGLT00000084282	UniProtKB/TrEMBL
	ENSHGLT00100064248	UniProtKB/TrEMBL
Gene3D-CATH	1.10.286.10	UniProtKB/TrEMBL
	3.30.1130.10	UniProtKB/TrEMBL
InterPro	GTP-CH-I_C/QueF	UniProtKB/TrEMBL
	GTP-CH-I_N	UniProtKB/TrEMBL
	GTP_CycHdrlase_I	UniProtKB/TrEMBL
	GTP_CycHdrlase_I_CS	UniProtKB/TrEMBL
	GTP_CycHdrlase_I_dom	UniProtKB/TrEMBL
NCBI Gene	Gch1	ENTREZGENE
PANTHER	GTP CYCLOHYDROLASE 1	UniProtKB/TrEMBL
	PTHR11109	UniProtKB/TrEMBL
Pfam	GTP_cyclohydroI	UniProtKB/TrEMBL
PROSITE	GTP_CYCLOHYDROL_1_1	UniProtKB/TrEMBL
	GTP_CYCLOHYDROL_1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Tetrahydrobiopterin biosynthesis enzymes-like	UniProtKB/TrEMBL
UniProt	G5BF79	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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