Gch1 (GTP cyclohydrolase 1) - Rat Genome Database

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Gene: Gch1 (GTP cyclohydrolase 1) Ictidomys tridecemlineatus
Analyze
Symbol: Gch1
Name: GTP cyclohydrolase 1
RGD ID: 12645688
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); GTP binding (ortholog); GTP cyclohydrolase I activity (ortholog); INVOLVED IN dihydrobiopterin metabolic process (ortholog); dopamine biosynthetic process (ortholog); negative regulation of blood pressure (ortholog); PARTICIPATES IN dopa responsive dystonia pathway; Segawa syndrome pathway; ASSOCIATED WITH Acute Coronary Syndrome (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); BH4-deficient hyperphenylalaninemia B (ortholog); FOUND IN cytoplasmic vesicle (ortholog); cytosol (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864074,457,811 - 74,501,265 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936697232,048 - 275,420 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gch1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864074,457,811 - 74,501,265 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936697232,048 - 275,420 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381454,842,017 - 54,902,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1454,842,008 - 54,902,826 (-)EnsemblGRCh38hg38GRCh38
GRCh371455,308,735 - 55,369,544 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361454,378,473 - 54,439,292 (-)NCBINCBI36Build 36hg18NCBI36
Build 341454,378,484 - 54,439,279NCBI
Celera1435,358,210 - 35,419,030 (-)NCBICelera
Cytogenetic Map14q22.2NCBI
HuRef1435,471,338 - 35,532,109 (-)NCBIHuRef
CHM1_11455,247,346 - 55,308,167 (-)NCBICHM1_1
T2T-CHM13v2.01449,047,244 - 49,108,020 (-)NCBIT2T-CHM13v2.0
Gch1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391447,391,352 - 47,426,870 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1447,391,352 - 47,426,870 (-)EnsemblGRCm39 Ensembl
GRCm381447,153,895 - 47,189,413 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1447,153,895 - 47,189,413 (-)EnsemblGRCm38mm10GRCm38
MGSCv371447,773,570 - 47,809,077 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361446,075,772 - 46,111,279 (-)NCBIMGSCv36mm8
Celera1443,334,771 - 43,370,387 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1424.6NCBI
Gch1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81522,884,006 - 22,917,412 (-)NCBIGRCr8
mRatBN7.21520,404,267 - 20,437,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1520,402,527 - 20,437,698 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1523,184,907 - 23,218,319 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01524,142,871 - 24,176,283 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01522,394,011 - 22,427,378 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01523,935,011 - 23,968,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1523,934,585 - 23,969,011 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01527,876,253 - 27,910,213 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41523,023,996 - 23,139,794 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11523,039,695 - 23,155,494 (-)NCBI
Celera1520,799,206 - 20,832,598 (-)NCBICelera
Cytogenetic Map15p14NCBI
Gch1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,624,468 - 8,668,614 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,624,225 - 8,670,436 (+)NCBIChiLan1.0ChiLan1.0
GCH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21555,932,208 - 56,026,639 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11455,179,865 - 55,240,594 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01435,428,676 - 35,489,359 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11453,706,723 - 53,767,393 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1453,706,723 - 53,767,393 (-)Ensemblpanpan1.1panPan2
GCH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1830,733,422 - 30,784,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl830,732,608 - 30,784,156 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha830,501,844 - 30,552,428 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0830,989,520 - 31,040,202 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl830,967,731 - 31,040,294 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1830,593,993 - 30,644,489 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0830,669,980 - 30,720,620 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0831,035,484 - 31,086,113 (-)NCBIUU_Cfam_GSD_1.0
GCH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1184,199,679 - 184,257,315 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11184,201,232 - 184,264,060 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21204,648,349 - 204,712,905 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GCH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12432,029,997 - 32,079,656 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2432,027,648 - 32,079,490 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605320,264,246 - 20,316,487 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gch1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,459,303 - 14,500,429 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,459,164 - 14,502,485 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005337955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010003700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: XM_005337955   ⟹   XP_005338012
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864074,457,811 - 74,501,265 (+)NCBI
SpeTri2.0NW_004936697232,048 - 275,420 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005338012 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000023176.2
GenBank Protein KAG3261404 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005338012   ⟸   XM_005337955
- UniProtKB: I3NFM9 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
GTP cyclohydrolase I


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000020010 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000026242.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.286.10 UniProtKB/TrEMBL
  3.30.1130.10 UniProtKB/TrEMBL
InterPro GTP-CH-I_C/QueF UniProtKB/TrEMBL
  GTP-CH-I_N UniProtKB/TrEMBL
  GTP_CycHdrlase_I UniProtKB/TrEMBL
  GTP_CycHdrlase_I_CS UniProtKB/TrEMBL
  GTP_CycHdrlase_I_dom UniProtKB/TrEMBL
NCBI Gene Gch1 ENTREZGENE
PANTHER GTP CYCLOHYDROLASE 1 UniProtKB/TrEMBL
  PTHR11109 UniProtKB/TrEMBL
Pfam GTP_cyclohydroI UniProtKB/TrEMBL
PROSITE GTP_CYCLOHYDROL_1_1 UniProtKB/TrEMBL
  GTP_CYCLOHYDROL_1_2 UniProtKB/TrEMBL
Superfamily-SCOP Tetrahydrobiopterin biosynthesis enzymes-like UniProtKB/TrEMBL
UniProt I3NFM9 ENTREZGENE, UniProtKB/TrEMBL