Preb (prolactin regulatory element binding) - Rat Genome Database

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Gene: Preb (prolactin regulatory element binding) Heterocephalus glaber
Analyze
Symbol: Preb
Name: prolactin regulatory element binding
RGD ID: 18930563
Description: ENCODES a protein that exhibits GTPase binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN COPII vesicle coating (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Tatton-Brown-Rahman syndrome (ortholog); FOUND IN endoplasmic reticulum exit site (ortholog); endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Prolactin regulatory element-binding protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,225,194 - 9,233,737 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,229,289 - 9,232,985 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PrebNaked Mole-RatTatton-Brown-Rahman syndrome  ISORGD:13526758554872ClinVar Annotator: match by term: Tatton-Brown-Rahman overgrowth syndromeClinVarPMID:28492532


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PrebNaked Mole-RatCOPII vesicle coating involved_inISORGD:619299068941PMID:11422940UniProtPMID:11422940|REF_RGD_ID:11344947
PrebNaked Mole-Ratendoplasmic reticulum to Golgi vesicle-mediated transport involved_inIEAUniRule:UR001628761150520179 UniProtGO_REF:0000104
PrebNaked Mole-Ratendoplasmic reticulum to Golgi vesicle-mediated transport involved_inIEAPANTHER:PTN000590373150520179 TreeGrafterGO_REF:0000118
PrebNaked Mole-Ratpositive regulation of transcription by RNA polymerase II  ISORGD:619299068941 RGDPMID:10194769|REF_RGD_ID:61705
PrebNaked Mole-Ratprotein transport involved_inIEAUniProtKB-KW:KW-0653150520179 UniProtGO_REF:0000043
PrebNaked Mole-Ratregulation of COPII vesicle coating involved_inIEAPANTHER:PTN000590373150520179 TreeGrafterGO_REF:0000118
PrebNaked Mole-Ratregulation of COPII vesicle coating involved_inIEAUniRule:UR001628761150520179 UniProtGO_REF:0000104
PrebNaked Mole-Ratvesicle-mediated transport involved_inIEAUniProtKB-KW:KW-0931150520179 UniProtGO_REF:0000043

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PrebNaked Mole-Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
PrebNaked Mole-Ratendoplasmic reticulum exit site is_active_inISORGD:13526759068941 PMID:25202031, PMID:27170179, PMID:28442536UniProtPMID:25202031|PMID:27170179|PMID:28442536
PrebNaked Mole-Ratendoplasmic reticulum membrane located_inIEAUniRule:UR001628761150520179 UniProtGO_REF:0000104
PrebNaked Mole-Ratendoplasmic reticulum membrane located_inIEAPANTHER:PTN000590373150520179 TreeGrafterGO_REF:0000118
PrebNaked Mole-Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-0097150520179 UniProtGO_REF:0000044
PrebNaked Mole-Ratendoplasmic reticulum membrane is_active_inISORGD:619299068941PMID:11422940UniProtPMID:11422940|REF_RGD_ID:11344947
PrebNaked Mole-Ratmembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
PrebNaked Mole-Ratnucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PrebNaked Mole-RatGTPase binding enablesISOUniProtKB:Q9CQC99068941 PMID:11422940UniProtPMID:11422940
PrebNaked Mole-Ratguanyl-nucleotide exchange factor activity enablesIEAInterPro:IPR045260150520179 InterProGO_REF:0000002
PrebNaked Mole-Ratprotein binding enablesISOUniProtKB:Q96PC5-79068941 PMID:25202031, PMID:27170179UniProtPMID:25202031|PMID:27170179
PrebNaked Mole-RatRNA polymerase II cis-regulatory region sequence-specific DNA binding  ISORGD:619299068941 RGDPMID:10194769|REF_RGD_ID:61705

PMID:21993625   PMID:22301074   PMID:30032202  



Preb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,225,194 - 9,233,737 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,229,289 - 9,232,985 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PREB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,130,756 - 27,134,636 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,130,756 - 27,134,666 (-)EnsemblGRCh38hg38GRCh38
GRCh37227,353,624 - 27,357,504 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,207,128 - 27,211,046 (-)NCBINCBI36Build 36hg18NCBI36
Build 34227,265,277 - 27,269,193NCBI
Celera227,199,929 - 27,203,847 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,095,474 - 27,099,392 (-)NCBIHuRef
CHM1_1227,283,548 - 27,287,466 (-)NCBICHM1_1
T2T-CHM13v2.0227,172,401 - 27,176,281 (-)NCBIT2T-CHM13v2.0
Preb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,109,011 - 31,117,700 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,108,197 - 31,117,705 (-)EnsemblGRCm39 Ensembl
GRCm38530,951,667 - 30,960,356 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,950,853 - 30,960,361 (-)EnsemblGRCm38mm10GRCm38
MGSCv37531,254,040 - 31,262,734 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,231,629 - 31,236,816 (-)NCBIMGSCv36mm8
Celera528,431,460 - 28,439,754 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.9NCBI
Preb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,138,757 - 31,142,544 (+)NCBIGRCr8
mRatBN7.2625,418,805 - 25,422,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,418,776 - 25,422,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,719,124 - 25,722,909 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,034,988 - 26,038,773 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,514,185 - 25,517,956 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,784,088 - 26,787,875 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,784,088 - 26,787,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,599,703 - 36,603,490 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,401,759 - 25,405,561 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,404,792 - 25,408,499 (+)NCBI
Celera624,909,529 - 24,913,316 (+)NCBICelera
Cytogenetic Map6q14NCBI
Preb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,098,124 - 9,101,408 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,097,579 - 9,101,361 (-)NCBIChiLan1.0ChiLan1.0
PREB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,380,869 - 99,384,810 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,384,837 - 99,388,771 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,129,731 - 27,133,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,218,957 - 27,222,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,218,957 - 27,222,876 (-)Ensemblpanpan1.1panPan2
PREB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,116,427 - 21,120,250 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,117,020 - 21,120,031 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,008,243 - 21,012,112 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,437,125 - 21,440,994 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,437,139 - 21,440,962 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,123,848 - 21,127,717 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,134,959 - 21,138,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,181,808 - 21,185,678 (-)NCBIUU_Cfam_GSD_1.0
Preb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,419,425 - 65,423,263 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,415,971 - 5,420,138 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,416,302 - 5,420,138 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,992,391 - 111,996,559 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,992,364 - 111,996,194 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23118,990,851 - 118,994,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PREB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,485,178 - 80,489,081 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,485,252 - 80,488,438 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,650,124 - 31,654,028 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.






Ensembl Acc Id: ENSHGLT00000010064   ⟹   ENSHGLP00000009954
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247389,225,194 - 9,233,737 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000010065   ⟹   ENSHGLP00000009955
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_0046247389,229,937 - 9,232,779 (-)Ensembl
RefSeq Acc Id: XM_004839172   ⟹   XP_004839229
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247389,229,289 - 9,232,985 (-)NCBI
RefSeq Acc Id: XM_004839173   ⟹   XP_004839230
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247389,229,289 - 9,232,983 (-)NCBI
RefSeq Acc Id: XM_021253610   ⟹   XP_021109269
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247389,229,937 - 9,232,985 (-)NCBI
Protein RefSeqs XP_004839229 (Get FASTA)   NCBI Sequence Viewer  
  XP_004839230 (Get FASTA)   NCBI Sequence Viewer  
  XP_021109269 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB14506 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000009954
  ENSHGLP00000009955
GenBank Protein JAO02584 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004839229   ⟸   XM_004839172
- Peptide Label: isoform X1
- UniProtKB: A0AAX6NXM1 (UniProtKB/TrEMBL),   G5BYZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004839230   ⟸   XM_004839173
- Peptide Label: isoform X2
- UniProtKB: A0AAX6NXX5 (UniProtKB/TrEMBL),   G5BYZ5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021109269   ⟸   XM_021253610
- Peptide Label: isoform X3
- UniProtKB: A0AAX6SKS3 (UniProtKB/TrEMBL),   G5BYZ5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000009954   ⟸   ENSHGLT00000010064
Ensembl Acc Id: ENSHGLP00000009955   ⟸   ENSHGLT00000010065



1 to 21 of 21 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSHGLG00000007142 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000010064 ENTREZGENE
  ENSHGLT00000010065 ENTREZGENE
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  Sec12-like UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene Preb ENTREZGENE
PANTHER PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN UniProtKB/TrEMBL
  PTHR23284 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50998 UniProtKB/TrEMBL
  WD40 repeat-like UniProtKB/TrEMBL
UniProt A0AAX6NXM1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6NXX5 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SKS3 ENTREZGENE, UniProtKB/TrEMBL
  G5BYZ5 ENTREZGENE, UniProtKB/TrEMBL
1 to 21 of 21 rows