PREB (prolactin regulatory element binding) - Rat Genome Database

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Gene: PREB (prolactin regulatory element binding) Pan paniscus
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Symbol: PREB
Name: prolactin regulatory element binding
RGD ID: 12043186
Description: ENCODES a protein that exhibits RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN COPII vesicle coating (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH Tatton-Brown-Rahman syndrome (ortholog); FOUND IN endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,380,869 - 99,384,810 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,384,837 - 99,388,771 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,129,731 - 27,133,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,218,957 - 27,222,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,218,957 - 27,222,876 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PREBBonoboTatton-Brown-Rahman syndrome  ISORGD:13526758554872ClinVar Annotator: match by term: Tatton-Brown-Rahman overgrowth syndromeClinVarPMID:28492532


Biological Process
1 to 10 of 10 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PREBBonoboCOPII vesicle coating involved_inISORGD:619299068941PMID:11422940UniProtPMID:11422940|REF_RGD_ID:11344947
PREBBonoboendoplasmic reticulum to Golgi vesicle-mediated transport involved_inIEAUniRule:UR001628761150520179 UniProtGO_REF:0000104
PREBBonoboendoplasmic reticulum to Golgi vesicle-mediated transport involved_inIEAUniProtKB:Q9HCU5|ensembl:ENSP00000260643150520179 EnsemblGO_REF:0000107
PREBBonoboendoplasmic reticulum to Golgi vesicle-mediated transport involved_inIEAPANTHER:PTN000590375|PANTHER:PTN000590378150520179 TreeGrafterGO_REF:0000118
PREBBonobopositive regulation of transcription by RNA polymerase II  ISORGD:619299068941 RGDPMID:10194769|REF_RGD_ID:61705
PREBBonoboprotein transport involved_inIEAUniProtKB-KW:KW-0653150520179 UniProtGO_REF:0000043
PREBBonoboregulation of COPII vesicle coating involved_inIEAUniRule:UR001628761150520179 UniProtGO_REF:0000104
PREBBonoboregulation of COPII vesicle coating involved_inIEAUniProtKB:Q9HCU5|ensembl:ENSP00000260643150520179 EnsemblGO_REF:0000107
PREBBonoboregulation of COPII vesicle coating involved_inIEAPANTHER:PTN000590375|PANTHER:PTN000590378150520179 TreeGrafterGO_REF:0000118
PREBBonobovesicle-mediated transport involved_inIEAUniProtKB-KW:KW-0931150520179 UniProtGO_REF:0000043
1 to 10 of 10 rows

Cellular Component
1 to 9 of 9 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PREBBonoboendoplasmic reticulum located_inIEAUniProtKB-KW:KW-0256150520179 UniProtGO_REF:0000043
PREBBonoboendoplasmic reticulum exit site is_active_inIEAUniProtKB:Q9HCU5|ensembl:ENSP00000260643150520179 EnsemblGO_REF:0000107
PREBBonoboendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-0097150520179 UniProtGO_REF:0000044
PREBBonoboendoplasmic reticulum membrane located_inIEAUniRule:UR001628761150520179 UniProtGO_REF:0000104
PREBBonoboendoplasmic reticulum membrane located_inIEAPANTHER:PTN000590375|PANTHER:PTN000590378150520179 TreeGrafterGO_REF:0000118
PREBBonoboendoplasmic reticulum membrane is_active_inISORGD:619299068941PMID:11422940UniProtPMID:11422940|REF_RGD_ID:11344947
PREBBonobomembrane located_inIEAUniProtKB-KW:KW-0472150520179 UniProtGO_REF:0000043
PREBBonobonucleus located_inIEAUniProtKB:Q9HCU5|ensembl:ENSP00000260643150520179 EnsemblGO_REF:0000107
PREBBonobonucleus located_inIEAUniProtKB-SubCell:SL-0191150520179 UniProtGO_REF:0000044
1 to 9 of 9 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PREBBonoboGTPase binding enablesIEAUniProtKB:Q9WUQ2|ensembl:ENSMUSP00000074387150520179 EnsemblGO_REF:0000107
PREBBonoboguanyl-nucleotide exchange factor activity enablesIEAInterPro:IPR045260150520179 InterProGO_REF:0000002
PREBBonoboguanyl-nucleotide exchange factor activity enablesIEAUniProtKB:Q9HCU5|UniProtKB:Q9WUQ2|ensembl:ENSMUSP00000074387|ensembl:ENSP00000260643150520179 EnsemblGO_REF:0000107
PREBBonoboprotein binding enablesISOUniProtKB:Q96PC5-79068941 PMID:25202031, PMID:27170179UniProtPMID:25202031|PMID:27170179
PREBBonoboRNA polymerase II cis-regulatory region sequence-specific DNA binding  ISORGD:619299068941 RGDPMID:10194769|REF_RGD_ID:61705

PMID:22301074   PMID:30032202  



PREB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,380,869 - 99,384,810 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,384,837 - 99,388,771 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,129,731 - 27,133,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,218,957 - 27,222,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,218,957 - 27,222,876 (-)Ensemblpanpan1.1panPan2
PREB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,130,756 - 27,134,636 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,130,756 - 27,134,666 (-)EnsemblGRCh38hg38GRCh38
GRCh37227,353,624 - 27,357,504 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,207,128 - 27,211,046 (-)NCBINCBI36Build 36hg18NCBI36
Build 34227,265,277 - 27,269,193NCBI
Celera227,199,929 - 27,203,847 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,095,474 - 27,099,392 (-)NCBIHuRef
CHM1_1227,283,548 - 27,287,466 (-)NCBICHM1_1
T2T-CHM13v2.0227,172,401 - 27,176,281 (-)NCBIT2T-CHM13v2.0
Preb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,109,011 - 31,117,700 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,108,197 - 31,117,705 (-)EnsemblGRCm39 Ensembl
GRCm38530,951,667 - 30,960,356 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,950,853 - 30,960,361 (-)EnsemblGRCm38mm10GRCm38
MGSCv37531,254,040 - 31,262,734 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,231,629 - 31,236,816 (-)NCBIMGSCv36mm8
Celera528,431,460 - 28,439,754 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.9NCBI
Preb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,138,757 - 31,142,544 (+)NCBIGRCr8
mRatBN7.2625,418,805 - 25,422,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,418,776 - 25,422,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,719,124 - 25,722,909 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,034,988 - 26,038,773 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,514,185 - 25,517,956 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,784,088 - 26,787,875 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,784,088 - 26,787,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,599,703 - 36,603,490 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,401,759 - 25,405,561 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,404,792 - 25,408,499 (+)NCBI
Celera624,909,529 - 24,913,316 (+)NCBICelera
Cytogenetic Map6q14NCBI
Preb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,098,124 - 9,101,408 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,097,579 - 9,101,361 (-)NCBIChiLan1.0ChiLan1.0
PREB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,116,427 - 21,120,250 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,117,020 - 21,120,031 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,008,243 - 21,012,112 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,437,125 - 21,440,994 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,437,139 - 21,440,962 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,123,848 - 21,127,717 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,134,959 - 21,138,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,181,808 - 21,185,678 (-)NCBIUU_Cfam_GSD_1.0
Preb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,419,425 - 65,423,263 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,415,971 - 5,420,138 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,416,302 - 5,420,138 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,992,391 - 111,996,559 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,992,364 - 111,996,194 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23118,990,851 - 118,994,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PREB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,485,178 - 80,489,081 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,485,252 - 80,488,438 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,650,124 - 31,654,028 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Preb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,225,194 - 9,233,737 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,229,289 - 9,232,985 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.






Ensembl Acc Id: ENSPPAT00000034026   ⟹   ENSPPAP00000011370
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A27,218,957 - 27,222,876 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000034043   ⟹   ENSPPAP00000011387
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A27,219,616 - 27,222,622 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000034044   ⟹   ENSPPAP00000011388
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A27,219,657 - 27,222,622 (-)Ensembl
RefSeq Acc Id: XM_003827082   ⟹   XP_003827130
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21299,380,869 - 99,384,810 (+)NCBI
NHGRI_mPanPan12A99,384,837 - 99,388,771 (+)NCBI
Mhudiblu_PPA_v02A27,129,731 - 27,133,638 (-)NCBI
PanPan1.12A27,218,957 - 27,222,876 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024927614   ⟹   XP_024783382
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21299,380,896 - 99,384,810 (+)NCBI
NHGRI_mPanPan12A99,384,864 - 99,388,771 (+)NCBI
Mhudiblu_PPA_v02A27,129,731 - 27,133,645 (-)NCBI
PanPan1.12A27,219,657 - 27,222,876 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034952820   ⟹   XP_034808711
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21299,380,901 - 99,384,810 (+)NCBI
NHGRI_mPanPan12A99,384,868 - 99,388,771 (+)NCBI
Mhudiblu_PPA_v02A27,129,731 - 27,133,645 (-)NCBI
RefSeq Acc Id: XM_034952821   ⟹   XP_034808712
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21299,380,897 - 99,384,810 (+)NCBI
NHGRI_mPanPan12A99,384,865 - 99,388,771 (+)NCBI
Mhudiblu_PPA_v02A27,129,731 - 27,133,645 (-)NCBI
Protein RefSeqs XP_003827130 (Get FASTA)   NCBI Sequence Viewer  
  XP_024783382 (Get FASTA)   NCBI Sequence Viewer  
  XP_034808711 (Get FASTA)   NCBI Sequence Viewer  
  XP_034808712 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000011370.1
  ENSPPAP00000011387.1
  ENSPPAP00000011388.1
RefSeq Acc Id: XP_003827130   ⟸   XM_003827082
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A6R4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024783382   ⟸   XM_024927614
- Peptide Label: isoform X3
- UniProtKB: A0A2R9A298 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034808712   ⟸   XM_034952821
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034808711   ⟸   XM_034952820
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A283 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000011370   ⟸   ENSPPAT00000034026



1 to 22 of 22 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSPPAG00000028893 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034026.1 UniProtKB/TrEMBL
  ENSPPAT00000034043.1 UniProtKB/TrEMBL
  ENSPPAT00000034044.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  Sec12-like UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100986958 UniProtKB/TrEMBL
NCBI Gene PREB ENTREZGENE
PANTHER PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN UniProtKB/TrEMBL
  PTHR23284 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
  SSF50998 UniProtKB/TrEMBL
UniProt A0A2R9A283 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A298 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A6R4 ENTREZGENE, UniProtKB/TrEMBL
1 to 22 of 22 rows