PREB (prolactin regulatory element binding) - Rat Genome Database

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Gene: PREB (prolactin regulatory element binding) Chlorocebus sabaeus
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Symbol: PREB
Name: prolactin regulatory element binding
RGD ID: 18449314
Description: ENCODES a protein that exhibits GTPase binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN COPII vesicle coating (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH genetic disease (ortholog); Tatton-Brown-Rahman syndrome (ortholog); FOUND IN endoplasmic reticulum exit site (ortholog); endoplasmic reticulum membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: prolactin regulatory element-binding protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,485,178 - 80,489,081 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,485,252 - 80,488,438 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,650,124 - 31,654,028 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PREB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,485,178 - 80,489,081 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1480,485,252 - 80,488,438 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604531,650,124 - 31,654,028 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PREB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38227,130,756 - 27,134,636 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl227,130,756 - 27,134,666 (-)EnsemblGRCh38hg38GRCh38
GRCh37227,353,624 - 27,357,504 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,207,128 - 27,211,046 (-)NCBINCBI36Build 36hg18NCBI36
Build 34227,265,277 - 27,269,193NCBI
Celera227,199,929 - 27,203,847 (-)NCBICelera
Cytogenetic Map2p23.3NCBI
HuRef227,095,474 - 27,099,392 (-)NCBIHuRef
CHM1_1227,283,548 - 27,287,466 (-)NCBICHM1_1
T2T-CHM13v2.0227,172,401 - 27,176,281 (-)NCBIT2T-CHM13v2.0
Preb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,109,011 - 31,117,700 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl531,108,197 - 31,117,705 (-)EnsemblGRCm39 Ensembl
GRCm38530,951,667 - 30,960,356 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl530,950,853 - 30,960,361 (-)EnsemblGRCm38mm10GRCm38
MGSCv37531,254,040 - 31,262,734 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36531,231,629 - 31,236,816 (-)NCBIMGSCv36mm8
Celera528,431,460 - 28,439,754 (-)NCBICelera
Cytogenetic Map5B1NCBI
cM Map516.9NCBI
Preb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8631,138,757 - 31,142,544 (+)NCBIGRCr8
mRatBN7.2625,418,805 - 25,422,594 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl625,418,776 - 25,422,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx625,719,124 - 25,722,909 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0626,034,988 - 26,038,773 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0625,514,185 - 25,517,956 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0626,784,088 - 26,787,875 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,784,088 - 26,787,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,599,703 - 36,603,490 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,401,759 - 25,405,561 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1625,404,792 - 25,408,499 (+)NCBI
Celera624,909,529 - 24,913,316 (+)NCBICelera
Cytogenetic Map6q14NCBI
Preb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,098,124 - 9,101,408 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,097,579 - 9,101,361 (-)NCBIChiLan1.0ChiLan1.0
PREB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21299,380,869 - 99,384,810 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A99,384,837 - 99,388,771 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A27,129,731 - 27,133,645 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A27,218,957 - 27,222,876 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,218,957 - 27,222,876 (-)Ensemblpanpan1.1panPan2
PREB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11721,116,427 - 21,120,250 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1721,117,020 - 21,120,031 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1721,008,243 - 21,012,112 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01721,437,125 - 21,440,994 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1721,437,139 - 21,440,962 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11721,123,848 - 21,127,717 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01721,134,959 - 21,138,828 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01721,181,808 - 21,185,678 (-)NCBIUU_Cfam_GSD_1.0
Preb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629265,419,425 - 65,423,263 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364935,415,971 - 5,420,138 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364935,416,302 - 5,420,138 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,992,391 - 111,996,559 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,992,364 - 111,996,194 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23118,990,851 - 118,994,672 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Preb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247389,225,194 - 9,233,737 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247389,229,289 - 9,232,985 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 11 55
Low 9 5
Below cutoff

Sequence


RefSeq Acc Id: ENSCSAT00000007663   ⟹   ENSCSAP00000005836
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1480,485,252 - 80,488,438 (+)Ensembl
RefSeq Acc Id: XM_007971171   ⟹   XP_007969362
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11480,485,178 - 80,489,081 (+)NCBI
Vero_WHO_p1.0NW_02366604531,650,124 - 31,654,028 (-)NCBI
Sequence:
RefSeq Acc Id: XM_007971172   ⟹   XP_007969363
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11480,485,243 - 80,489,074 (+)NCBI
Vero_WHO_p1.0NW_02366604531,650,124 - 31,654,026 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007969362 (Get FASTA)   NCBI Sequence Viewer  
  XP_007969363 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000005836
  ENSCSAP00000005836.1
RefSeq Acc Id: XP_007969362   ⟸   XM_007971171
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RB47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_007969363   ⟸   XM_007971172
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RB47 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000005836   ⟸   ENSCSAT00000007663


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000009608 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000007663.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro Quinoprotein_ADH-like_supfam UniProtKB/TrEMBL
  Sec12-like UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
NCBI Gene PREB ENTREZGENE
PANTHER PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN UniProtKB/TrEMBL
  PTHR23284 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
PROSITE WD_REPEATS_2 UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50998 UniProtKB/TrEMBL
UniProt A0A0D9RB47 ENTREZGENE, UniProtKB/TrEMBL