Qki (QKI, KH domain containing RNA binding) - Rat Genome Database

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Gene: Qki (QKI, KH domain containing RNA binding) Heterocephalus glaber
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Symbol: Qki
Name: QKI, KH domain containing RNA binding
RGD ID: 18913739
Description: ENCODES a protein that exhibits internal N(7)-methylguanine-containing RNA reader activity (ortholog); miRNA binding (ortholog); mRNA 3'-UTR binding (ortholog); INVOLVED IN axon ensheathment (ortholog); intracellular mRNA localization (ortholog); long-chain fatty acid biosynthetic process (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH demyelinating disease (ortholog); Experimental Autoimmune Encephalomyelitis (ortholog); high grade glioma (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Protein quaking; protein quaking isoform HQK-7B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478515,739,187 - 15,845,024 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478515,738,231 - 15,845,051 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
axon ensheathment  (ISO)
cell differentiation  (IEA)
intracellular mRNA localization  (ISO)
long-chain fatty acid biosynthetic process  (ISO)
microglia differentiation  (ISO)
mRNA processing  (IEA,ISO)
mRNA stabilization  (ISO)
mRNA transport  (IEA)
myelination  (ISO)
myofibroblast contraction  (ISO)
negative regulation of 3'-UTR-mediated mRNA stabilization  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cold-induced thermogenesis  (ISO)
negative regulation of macrophage differentiation  (ISO)
negative regulation of miRNA catabolic process  (ISO)
negative regulation of translation  (ISO)
negative regulation of type I interferon production  (ISO)
positive regulation of 3'-UTR-mediated mRNA stabilization  (ISO)
positive regulation of cholesterol biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of myelination  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of oligodendrocyte differentiation  (ISO)
regulation of astrocyte differentiation  (ISO)
regulation of epithelial to mesenchymal transition  (ISO)
regulation of macrophage differentiation  (ISO)
regulation of mRNA metabolic process  (IEA)
regulation of mRNA splicing, via spliceosome  (IEA)
regulation of translation  (IEA)
RNA splicing  (IEA)
spermatid development  (ISO)
spliceosome-depend formation of circular RNA  (ISO)
vascular associated smooth muscle cell differentiation  (ISO)
vasculogenesis  (ISO)

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic stress granule  (ISO)
cytosol  (ISO)
nucleus  (IEA,ISO)
synapse  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:21993625   PMID:30032202  


Genomics

Comparative Map Data
Qki
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478515,739,187 - 15,845,024 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478515,738,231 - 15,845,051 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
QKI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386163,414,718 - 163,578,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6163,414,000 - 163,578,592 (+)EnsemblGRCh38hg38GRCh38
GRCh376163,835,750 - 163,999,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366163,755,665 - 163,914,886 (+)NCBINCBI36Build 36hg18NCBI36
Celera6164,606,149 - 164,729,418 (+)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6161,290,590 - 161,453,987 (+)NCBIHuRef
CHM1_16164,097,893 - 164,261,842 (+)NCBICHM1_1
T2T-CHM13v2.06164,779,884 - 164,943,697 (+)NCBIT2T-CHM13v2.0
Qki
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391710,425,480 - 10,538,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1710,421,530 - 10,538,783 (-)EnsemblGRCm39 Ensembl
GRCm381710,206,471 - 10,319,361 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1710,202,601 - 10,319,854 (-)EnsemblGRCm38mm10GRCm38
MGSCv371710,399,336 - 10,512,226 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361710,053,536 - 10,163,211 (-)NCBIMGSCv36mm8
Celera1710,252,038 - 10,337,960 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map177.75NCBI
Qki
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,935,357 - 53,047,338 (+)NCBIGRCr8
mRatBN7.2150,387,716 - 50,501,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl150,387,698 - 50,498,831 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0150,983,647 - 51,050,692 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl150,828,134 - 51,052,340 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0152,104,976 - 52,207,885 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4144,922,562 - 45,025,572 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera146,204,164 - 46,271,210 (+)NCBICelera
Cytogenetic Map1q11NCBI
Qki
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543917,925,229 - 18,079,727 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543917,925,205 - 18,079,727 (-)NCBIChiLan1.0ChiLan1.0
QKI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25183,597,079 - 183,756,086 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16181,498,349 - 181,657,357 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06161,361,413 - 161,523,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16166,398,884 - 166,517,389 (+)NCBIpanpan1.1PanPan1.1panPan2
QKI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1151,800,294 - 51,956,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl151,800,309 - 51,952,714 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha152,642,145 - 52,797,414 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0151,975,526 - 52,138,964 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl151,977,027 - 52,136,022 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1151,867,832 - 52,023,107 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0151,727,887 - 51,883,146 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,356,356 - 52,511,535 (+)NCBIUU_Cfam_GSD_1.0
Qki
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946146,649,733 - 146,750,270 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648913,901,754 - 13,999,983 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648913,901,066 - 14,000,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QKI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14,735,514 - 4,883,392 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114,732,575 - 4,883,386 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.216,380,698 - 6,486,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
QKI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11391,045,167 - 91,206,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1391,045,209 - 91,208,471 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604062,921,663 - 63,087,940 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000004251   ⟹   ENSHGLP00000004193
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478515,739,187 - 15,845,024 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000004252   ⟹   ENSHGLP00000004194
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462478515,745,235 - 15,845,024 (-)Ensembl
RefSeq Acc Id: XM_021237995   ⟹   XP_021093654
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478515,738,231 - 15,845,051 (-)NCBI
RefSeq Acc Id: XM_021237996   ⟹   XP_021093655
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478515,739,740 - 15,845,051 (-)NCBI
RefSeq Acc Id: XR_002386860
Type: NON-CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462478515,738,231 - 15,845,051 (-)NCBI
Protein Sequences
Protein RefSeqs XP_021093654 (Get FASTA)   NCBI Sequence Viewer  
  XP_021093655 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB05040 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000004193
  ENSHGLP00000004194
  ENSHGLP00000033436
  ENSHGLP00100056192
GenBank Protein JAN96926 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021093654   ⟸   XM_021237995
- Peptide Label: isoform X1
- UniProtKB: G5B6X9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021093655   ⟸   XM_021237996
- Peptide Label: isoform X2
- UniProtKB: G5B6X9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000004194   ⟸   ENSHGLT00000004252
Ensembl Acc Id: ENSHGLP00000004193   ⟸   ENSHGLT00000004251


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000003074 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSHGLG00100000339 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000004251 ENTREZGENE
  ENSHGLT00000004252 ENTREZGENE
  ENSHGLT00000061890 UniProtKB/TrEMBL
  ENSHGLT00100059801 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.4010 UniProtKB/TrEMBL
  3.30.1370.10 UniProtKB/TrEMBL
InterPro BBP-like UniProtKB/TrEMBL
  KH_dom UniProtKB/TrEMBL
  KH_dom_type_1 UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/TrEMBL
  Quaking_NLS UniProtKB/TrEMBL
  STAR_dimer UniProtKB/TrEMBL
NCBI Gene Qki ENTREZGENE
PANTHER PROTEIN QUAKING UniProtKB/TrEMBL
  PTHR11208 UniProtKB/TrEMBL
Pfam KH_1 UniProtKB/TrEMBL
  Quaking_NLS UniProtKB/TrEMBL
  STAR_dimer UniProtKB/TrEMBL
SMART SM00322 UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/TrEMBL
UniProt A0A0P6IYV0_HETGA UniProtKB/TrEMBL
  G5B6X9 ENTREZGENE, UniProtKB/TrEMBL