QKI (QKI, KH domain containing RNA binding) - Rat Genome Database

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Advanced Search (OLGA)
Gene: QKI (QKI, KH domain containing RNA binding) Chlorocebus sabaeus
Analyze
Symbol: QKI
Name: QKI, KH domain containing RNA binding
RGD ID: 18449114
Description: ENCODES a protein that exhibits miRNA binding (ortholog); transcription coactivator activity (ortholog); INVOLVED IN 3'-UTR-mediated mRNA destabilization (ortholog); axon ensheathment (ortholog); long-chain fatty acid biosynthetic process (ortholog); PARTICIPATES IN spliceosome pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); cervical cancer (ortholog); demyelinating disease (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic stress granule (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: KH domain-containing RNA-binding protein QKI
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1137,200,826 - 7,364,268 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366604062,921,663 - 63,087,940 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11391,045,167 - 91,206,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1391,045,209 - 91,208,471 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
3'-UTR-mediated mRNA destabilization  (ISO)
axon ensheathment  (ISO)
intracellular mRNA localization  (IEA)
long-chain fatty acid biosynthetic process  (ISO)
microglia differentiation  (IEA)
mRNA processing  (IEA,ISO)
mRNA stabilization  (IEA,ISO)
mRNA transport  (IEA)
muscle cell differentiation  (ISO)
myelination  (ISO)
myofibroblast contraction  (IEA)
negative regulation of 3'-UTR-mediated mRNA stabilization  (IEA)
negative regulation of angiogenesis  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of macrophage differentiation  (ISO)
negative regulation of miRNA catabolic process  (ISO)
negative regulation of translation  (IEA)
negative regulation of type I interferon production  (ISO)
positive regulation of 3'-UTR-mediated mRNA stabilization  (ISO)
positive regulation of cholesterol biosynthetic process  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of myelination  (ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of oligodendrocyte differentiation  (IEA,ISO)
regulation of astrocyte differentiation  (IEA)
regulation of cell development  (IEA)
regulation of epithelial to mesenchymal transition  (IEA)
regulation of macrophage differentiation  (IEA)
regulation of mRNA splicing, via spliceosome  (IEA)
regulation of multicellular organismal development  (IEA)
spermatid development  (ISO)
spliceosome-depend formation of circular RNA  (IEA)
vascular associated smooth muscle cell differentiation  (IEA)
vasculogenesis  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
QKI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1137,200,826 - 7,364,268 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366604062,921,663 - 63,087,940 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.11391,045,167 - 91,206,190 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1391,045,209 - 91,208,471 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
QKI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386163,414,718 - 163,578,592 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6163,414,000 - 163,578,827 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh376163,835,750 - 163,999,624 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366163,755,665 - 163,914,886 (+)NCBIBuild 36Build 36hg18NCBI36
Celera6164,606,149 - 164,729,418 (+)NCBICelera
Cytogenetic Map6q26NCBI
HuRef6161,290,590 - 161,453,987 (+)NCBIHuRef
CHM1_16164,097,893 - 164,261,842 (+)NCBICHM1_1
T2T-CHM13v2.06164,779,884 - 164,943,697 (+)NCBIT2T-CHM13v2.0
Qki
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391710,425,480 - 10,538,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1710,411,459 - 10,539,275 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381710,206,471 - 10,319,361 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1710,202,601 - 10,319,854 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv371710,399,336 - 10,512,226 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361710,053,536 - 10,163,211 (-)NCBIMGSCv36mm8
Celera1710,252,038 - 10,337,960 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map177.75NCBI
Qki
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8152,935,357 - 53,047,338 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl152,935,382 - 53,047,337 (+)EnsemblGRCr8
mRatBN7.2150,387,716 - 50,501,568 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl150,387,698 - 50,498,831 (+)EnsemblmRatBN7.2
Dahl_SR_JrHsd152,628,123 - 52,740,085 (+)NCBI
Lyon_Normotensive151,972,186 - 52,084,111 (+)NCBI
Lyon_Hypertensive153,141,119 - 53,253,077 (+)NCBI
F344_StmMcwi151,358,678 - 51,470,602 (+)NCBI
Rnor_6.0150,983,647 - 51,050,692 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl150,828,134 - 51,052,340 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.0152,104,976 - 52,207,885 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4144,922,562 - 45,025,572 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera146,204,164 - 46,271,210 (+)NCBICelera
Cytogenetic Map1q11NCBI
Qki
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543917,925,229 - 18,079,727 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_00495543917,925,205 - 18,079,727 (-)NCBIChiLan1.0ChiLan1.0
QKI
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25183,597,079 - 183,756,086 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16181,498,349 - 181,657,357 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06161,361,413 - 161,523,414 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16166,398,884 - 166,517,389 (+)NCBIPanPan1.1PanPan1.1panPan2
QKI
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1151,800,294 - 51,956,891 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl151,800,309 - 51,952,714 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha152,642,145 - 52,797,414 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0151,975,526 - 52,138,964 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl151,977,027 - 52,136,022 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1151,867,832 - 52,023,107 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0151,727,887 - 51,883,146 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0152,356,356 - 52,511,535 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Qki
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap184,926,329 - 5,059,900 (-)NCBImIctTri1.hap1
HiC_Itri_2NW_024404946146,649,733 - 146,750,270 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648913,901,754 - 13,999,983 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648913,901,066 - 14,000,652 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QKI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14,735,514 - 4,883,392 (-)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.114,732,575 - 4,883,386 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.216,380,698 - 6,486,326 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Qki
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462478515,738,231 - 15,845,051 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
HetGla_female_1.0 EnsemblNW_00462478515,739,187 - 15,845,024 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
Naked mole-rat maternal Ensembl180,979,031 - 81,132,918 (-)Ensembl
Qki
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12189,028,049 - 189,136,838 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in QKI
2567 total Variants

Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000010348   ⟹   ENSCSAP00000008443
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1391,045,209 - 91,208,471 (+)Ensembl
RefSeq Acc Id: XM_038001187   ⟹   XP_037857115
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap1137,200,826 - 7,364,266 (-)NCBI
Vero_WHO_p1.0NW_02366604062,921,663 - 63,087,940 (+)NCBI
RefSeq Acc Id: XM_038001188   ⟹   XP_037857116
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap1137,200,826 - 7,364,268 (-)NCBI
Vero_WHO_p1.0NW_02366604062,921,683 - 63,087,940 (+)NCBI
RefSeq Acc Id: XM_038001189   ⟹   XP_037857117
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap1137,208,600 - 7,364,266 (-)NCBI
Vero_WHO_p1.0NW_02366604062,921,663 - 63,085,396 (+)NCBI
RefSeq Acc Id: XM_038001190   ⟹   XP_037857118
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap1137,208,600 - 7,363,804 (-)NCBI
Vero_WHO_p1.0NW_02366604062,921,683 - 63,077,153 (+)NCBI
RefSeq Acc Id: XM_073022288   ⟹   XP_072878389
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap1137,200,826 - 7,363,804 (-)NCBI
RefSeq Acc Id: XM_073022289   ⟹   XP_072878390
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap1137,207,158 - 7,364,265 (-)NCBI
RefSeq Acc Id: XR_005241348
Type: NON-CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
mChlSab1.0.hap1137,200,826 - 7,364,265 (-)NCBI
Vero_WHO_p1.0NW_02366604062,921,663 - 63,087,627 (+)NCBI
Ensembl Acc Id: ENSCSAP00000008443   ⟸   ENSCSAT00000010348
RefSeq Acc Id: XP_037857115   ⟸   XM_038001187
- Peptide Label: isoform X1
- UniProtKB: A0A0D9RIK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037857117   ⟸   XM_038001189
- Peptide Label: isoform X4
- UniProtKB: A0A0D9RIK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037857116   ⟸   XM_038001188
- Peptide Label: isoform X3
- UniProtKB: A0A0D9RIK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_037857118   ⟸   XM_038001190
- Peptide Label: isoform X6
- UniProtKB: A0A0D9RIK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_072878389   ⟸   XM_073022288
- Peptide Label: isoform X2
- UniProtKB: A0A0D9RIK4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_072878390   ⟸   XM_073022289
- Peptide Label: isoform X5
- UniProtKB: A0A0D9RIK4 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000012257 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000010348.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.4010 UniProtKB/TrEMBL
  3.30.1370.10 UniProtKB/TrEMBL
InterPro BBP-like UniProtKB/TrEMBL
  KH_1_KHDC4/BBP-like UniProtKB/TrEMBL
  KH_dom UniProtKB/TrEMBL
  KH_dom_type_1_sf UniProtKB/TrEMBL
  Quaking_NLS UniProtKB/TrEMBL
  STAR_dimer UniProtKB/TrEMBL
NCBI Gene QKI ENTREZGENE
PANTHER PROTEIN QUAKING UniProtKB/TrEMBL
  PTHR11208 UniProtKB/TrEMBL
Pfam KH-I_KHDC4-BBP UniProtKB/TrEMBL
  Quaking_NLS UniProtKB/TrEMBL
  STAR_dimer UniProtKB/TrEMBL
SMART SM00322 UniProtKB/TrEMBL
Superfamily-SCOP SSF54791 UniProtKB/TrEMBL
UniProt A0A0D9RIK4 ENTREZGENE, UniProtKB/TrEMBL