RGD Reference Report - Alternative splicing: a pivotal step between eukaryotic transcription and translation. - Rat Genome Database

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Alternative splicing: a pivotal step between eukaryotic transcription and translation.

Authors: Kornblihtt, AR  Schor, IE  Allo, M  Dujardin, G  Petrillo, E  Munoz, MJ 
Citation: Kornblihtt AR, etal., Nat Rev Mol Cell Biol. 2013 Mar;14(3):153-65. doi: 10.1038/nrm3525. Epub 2013 Feb 6.
RGD ID: 9686381
Pubmed: PMID:23385723   (View Abstract at PubMed)
DOI: DOI:10.1038/nrm3525   (Journal Full-text)

Alternative splicing was discovered simultaneously with splicing over three decades ago. Since then, an enormous body of evidence has demonstrated the prevalence of alternative splicing in multicellular eukaryotes, its key roles in determining tissue- and species-specific differentiation patterns, the multiple post- and co-transcriptional regulatory mechanisms that control it, and its causal role in hereditary disease and cancer. The emerging evidence places alternative splicing in a central position in the flow of eukaryotic genetic information, between transcription and translation, in that it can respond not only to various signalling pathways that target the splicing machinery but also to transcription factors and chromatin structure.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Objects Annotated

Genes (Rattus norvegicus)
Ptbp1  (polypyrimidine tract binding protein 1)
Tial1  (Tia1 cytotoxic granule-associated RNA binding protein-like 1)

Genes (Mus musculus)
Ptbp1  (polypyrimidine tract binding protein 1)
Qki  (quaking, KH domain containing RNA binding)
Tial1  (Tia1 cytotoxic granule-associated RNA binding protein-like 1)

Genes (Homo sapiens)
PTBP1  (polypyrimidine tract binding protein 1)
QKI  (QKI, KH domain containing RNA binding)
TIAL1  (TIA1 cytotoxic granule associated RNA binding protein like 1)


Additional Information