Ncf2 (neutrophil cytosolic factor 2) - Rat Genome Database

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Gene: Ncf2 (neutrophil cytosolic factor 2) Heterocephalus glaber
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Symbol: Ncf2
Name: neutrophil cytosolic factor 2
RGD ID: 18910000
Description: ENCODES a protein that exhibits small GTPase binding (ortholog); superoxide-generating NAD(P)H oxidase activity (ortholog); INVOLVED IN cellular response to hormone stimulus (ortholog); positive regulation of blood pressure (ortholog); positive regulation of neuron apoptotic process (ortholog); ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); Acute Otitis Media (ortholog); Alzheimer's disease (ortholog); FOUND IN acrosomal vesicle (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Neutrophil cytosol factor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,107,357 - 10,134,711 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481410,107,351 - 10,134,737 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ncf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481410,107,357 - 10,134,711 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481410,107,351 - 10,134,737 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
NCF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381183,555,562 - 183,601,849 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1183,554,461 - 183,590,905 (-)EnsemblGRCh38hg38GRCh38
GRCh371183,524,697 - 183,560,049 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361181,791,320 - 181,826,339 (-)NCBINCBI36Build 36hg18NCBI36
Build 341180,256,354 - 180,291,668NCBI
Celera1156,635,747 - 156,671,088 (-)NCBICelera
Cytogenetic Map1q25.3NCBI
HuRef1154,760,563 - 154,795,907 (-)NCBIHuRef
CHM1_11184,947,718 - 184,983,070 (-)NCBICHM1_1
T2T-CHM13v2.01182,914,853 - 182,961,131 (-)NCBIT2T-CHM13v2.0
Ncf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,675,904 - 152,712,743 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,675,945 - 152,712,742 (+)EnsemblGRCm39 Ensembl
GRCm381152,800,153 - 152,836,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,800,194 - 152,836,991 (+)EnsemblGRCm38mm10GRCm38
MGSCv371154,655,020 - 154,684,120 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,570,108 - 154,599,208 (+)NCBIMGSCv36mm8
Celera1155,229,233 - 155,258,077 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map165.05NCBI
Ncf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81367,505,492 - 67,536,015 (+)NCBIGRCr8
mRatBN7.21364,955,622 - 64,986,144 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1364,955,503 - 64,986,277 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1367,557,295 - 67,587,614 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01368,844,234 - 68,874,605 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01366,095,157 - 66,125,664 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01370,226,441 - 70,259,019 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1370,226,647 - 70,257,576 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01375,197,561 - 75,229,600 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41367,806,516 - 67,834,105 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11367,797,870 - 67,848,218 (+)NCBI
Celera1364,862,007 - 64,890,467 (+)NCBICelera
Cytogenetic Map13q21NCBI
Ncf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540622,355,724 - 22,384,864 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540622,355,717 - 22,384,746 (-)NCBIChiLan1.0ChiLan1.0
NCF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2166,126,780 - 66,162,128 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1165,809,948 - 65,845,260 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01159,085,923 - 159,121,259 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11163,243,636 - 163,280,547 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1163,243,636 - 163,278,420 (-)Ensemblpanpan1.1panPan2
NCF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1716,914,629 - 16,946,370 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl716,904,031 - 16,945,372 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha716,500,692 - 16,530,126 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0716,646,647 - 16,676,710 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl716,643,324 - 16,676,880 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1716,555,169 - 16,584,783 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0716,664,590 - 16,693,979 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0716,795,528 - 16,824,986 (-)NCBIUU_Cfam_GSD_1.0
Ncf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934488,454,048 - 88,478,994 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364816,301,012 - 6,324,787 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364816,300,894 - 6,325,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NCF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9124,776,534 - 124,812,923 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19124,776,516 - 124,813,358 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29137,106,514 - 137,143,201 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NCF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12545,770,370 - 45,807,064 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2545,770,641 - 45,806,515 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605546,986,801 - 47,023,905 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000026506   ⟹   ENSHGLP00000026271
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462481410,107,357 - 10,134,711 (+)Ensembl
RefSeq Acc Id: XM_004862808   ⟹   XP_004862865
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462481410,107,351 - 10,134,737 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004862865 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EHB04057 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000026271
GenBank Protein JAO00475 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_004862865   ⟸   XM_004862808
- UniProtKB: G5B446 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000026271   ⟸   ENSHGLT00000026506


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000018696 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000026506 ENTREZGENE
Gene3D-CATH 1.25.40.10 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro NCF2_NOXA1 UniProtKB/TrEMBL
  P67-PHOX UniProtKB/TrEMBL
  p67phox_SH3_1 UniProtKB/TrEMBL
  PB1-like UniProtKB/TrEMBL
  PB1_dom UniProtKB/TrEMBL
  PB1_P67 UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/TrEMBL
  TPR_repeat UniProtKB/TrEMBL
KEGG Report hgl:101716459 UniProtKB/TrEMBL
NCBI Gene Ncf2 ENTREZGENE
PANTHER NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2 UniProtKB/TrEMBL
  PTHR15175:SF3 UniProtKB/TrEMBL
Pfam PB1 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
  TPR_8 UniProtKB/TrEMBL
PRINTS P67PHOX UniProtKB/TrEMBL
  SH3DOMAIN UniProtKB/TrEMBL
PROSITE PB1 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
SMART PB1 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TPR UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/TrEMBL
  SSF48452 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt G5B446 ENTREZGENE, UniProtKB/TrEMBL