Prkacb (protein kinase cAMP-activated catalytic subunit beta) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Prkacb (protein kinase cAMP-activated catalytic subunit beta) Heterocephalus glaber
Analyze
Symbol: Prkacb
Name: protein kinase cAMP-activated catalytic subunit beta
RGD ID: 18903602
Description: ENCODES a protein that exhibits cAMP-dependent protein kinase activity (ortholog); magnesium ion binding (ortholog); ubiquitin protein ligase binding (ortholog); INVOLVED IN negative regulation of meiotic cell cycle (ortholog); negative regulation of smoothened signaling pathway (ortholog); negative regulation of TORC1 signaling (ortholog); PARTICIPATES IN adenosine signaling pathway; dopamine signaling pathway; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH adrenal cortical adenoma (ortholog); biliary tract benign neoplasm (ortholog); brain ischemia (ortholog); FOUND IN cAMP-dependent protein kinase complex (ortholog); centrosome (ortholog); ciliary base (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cAMP-dependent protein kinase catalytic subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474213,242,593 - 13,357,986 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474213,243,248 - 13,357,873 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:21993625   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Prkacb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474213,242,593 - 13,357,986 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474213,243,248 - 13,357,873 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
PRKACB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38184,078,079 - 84,238,498 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl184,078,062 - 84,238,498 (+)EnsemblGRCh38hg38GRCh38
GRCh37184,543,762 - 84,704,181 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36184,316,333 - 84,476,769 (+)NCBINCBI36Build 36hg18NCBI36
Celera182,787,965 - 82,948,395 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef182,654,090 - 82,814,484 (+)NCBIHuRef
CHM1_1184,658,575 - 84,819,019 (+)NCBICHM1_1
T2T-CHM13v2.0183,918,534 - 84,078,964 (+)NCBIT2T-CHM13v2.0
Prkacb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393146,435,334 - 146,518,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3146,435,329 - 146,518,745 (-)EnsemblGRCm39 Ensembl
GRCm383146,729,579 - 146,812,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3146,729,574 - 146,812,990 (-)EnsemblGRCm38mm10GRCm38
MGSCv373146,392,543 - 146,475,910 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363146,666,965 - 146,750,316 (-)NCBIMGSCv36mm8
Celera3153,182,525 - 153,265,941 (-)NCBICelera
Cytogenetic Map3H2NCBI
cM Map372.28NCBI
Prkacb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82238,297,140 - 238,389,317 (-)NCBIGRCr8
mRatBN7.22235,636,878 - 235,726,928 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2235,636,885 - 235,726,198 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2243,435,379 - 243,522,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02241,326,025 - 241,413,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02236,193,035 - 236,280,486 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02252,602,197 - 252,691,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,605,307 - 252,691,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02271,129,418 - 271,218,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,949,303 - 245,035,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2227,617,114 - 227,701,913 (-)NCBICelera
Cytogenetic Map2q44NCBI
Prkacb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554239,629,378 - 9,747,820 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554239,630,308 - 9,747,820 (-)NCBIChiLan1.0ChiLan1.0
PRKACB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21142,704,501 - 142,865,759 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11141,858,945 - 142,019,573 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01116,625,640 - 116,786,396 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1185,574,094 - 85,647,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl185,487,681 - 85,644,253 (+)Ensemblpanpan1.1panPan2
PRKACB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1663,615,445 - 63,729,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl663,618,323 - 63,730,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha666,263,759 - 66,377,569 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0664,155,572 - 64,269,668 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl664,155,572 - 64,269,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1663,683,378 - 63,796,798 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0663,652,236 - 63,766,014 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0664,158,621 - 64,272,439 (-)NCBIUU_Cfam_GSD_1.0
Prkacb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505894,841,492 - 94,952,128 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366081,353,897 - 1,464,636 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366081,353,905 - 1,464,636 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKACB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6129,520,376 - 129,635,733 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16129,520,397 - 129,636,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26119,719,887 - 119,778,443 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKACB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12049,109,774 - 49,273,200 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2049,108,425 - 49,178,806 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603368,486,789 - 68,652,007 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSHGLT00000016208   ⟹   ENSHGLP00000016039
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474213,242,593 - 13,357,986 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000016209   ⟹   ENSHGLP00000016040
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474213,242,593 - 13,313,412 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000016210   ⟹   ENSHGLP00000016041
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474213,242,593 - 13,296,057 (-)Ensembl
Ensembl Acc Id: ENSHGLT00000016211   ⟹   ENSHGLP00000016042
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla_female_1.0 EnsemblNW_00462474213,242,593 - 13,294,804 (-)Ensembl
RefSeq Acc Id: XM_004841376   ⟹   XP_004841433
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474213,243,248 - 13,313,229 (-)NCBI
RefSeq Acc Id: XM_004841377   ⟹   XP_004841434
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474213,243,248 - 13,357,873 (-)NCBI
RefSeq Acc Id: XM_004841378   ⟹   XP_004841435
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474213,243,248 - 13,295,054 (-)NCBI
RefSeq Acc Id: XM_004841379   ⟹   XP_004841436
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474213,243,248 - 13,283,064 (-)NCBI
RefSeq Acc Id: XM_013070922   ⟹   XP_012926376
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474213,243,248 - 13,295,601 (-)NCBI
RefSeq Acc Id: XM_013070923   ⟹   XP_012926377
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474213,243,248 - 13,295,055 (-)NCBI
RefSeq Acc Id: XM_021255462   ⟹   XP_021111121
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474213,243,248 - 13,295,600 (-)NCBI
RefSeq Acc Id: XM_021255463   ⟹   XP_021111122
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474213,243,248 - 13,295,599 (-)NCBI
RefSeq Acc Id: XM_021255464   ⟹   XP_021111123
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_00462474213,243,248 - 13,295,054 (-)NCBI
RefSeq Acc Id: XP_004841434   ⟸   XM_004841377
- Peptide Label: isoform X4
- UniProtKB: A0AAX6P0Y6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004841433   ⟸   XM_004841376
- Peptide Label: isoform X1
- UniProtKB: G5C931 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012926376   ⟸   XM_013070922
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QUV4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111121   ⟸   XM_021255462
- Peptide Label: isoform X5
- UniProtKB: A0AAX6SNF2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111122   ⟸   XM_021255463
- Peptide Label: isoform X8
- UniProtKB: A0AAX6SQ43 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_012926377   ⟸   XM_013070923
- Peptide Label: isoform X3
- UniProtKB: A0A0P6JYL6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021111123   ⟸   XM_021255464
- Peptide Label: isoform X9
- UniProtKB: A0AAX6SR63 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004841435   ⟸   XM_004841378
- Peptide Label: isoform X6
- UniProtKB: A0AAX6P1J7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004841436   ⟸   XM_004841379
- Peptide Label: isoform X7
- UniProtKB: A0AAX6P1D1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSHGLP00000016041   ⟸   ENSHGLT00000016210
Ensembl Acc Id: ENSHGLP00000016039   ⟸   ENSHGLT00000016208
Ensembl Acc Id: ENSHGLP00000016042   ⟸   ENSHGLT00000016211
Ensembl Acc Id: ENSHGLP00000016040   ⟸   ENSHGLT00000016209


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000011472 Ensembl, ENTREZGENE
Ensembl Transcript ENSHGLT00000016208 ENTREZGENE
  ENSHGLT00000016209 ENTREZGENE
  ENSHGLT00000016210 ENTREZGENE
  ENSHGLT00000016211 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STKc_PKA UniProtKB/TrEMBL
KEGG Report hgl:101721558 UniProtKB/TrEMBL
NCBI Gene Prkacb ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE UniProtKB/TrEMBL
  CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6JYL6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6P0Y6 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6P1D1 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6P1J7 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QUV4 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SNF2 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SQ43 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SR63 ENTREZGENE, UniProtKB/TrEMBL
  G5C931 ENTREZGENE, UniProtKB/TrEMBL