RGD Reference Report - Regulation of mRNA expression involved in Ras and PKA signal pathways during rat hypoglossal nerve regeneration. - Rat Genome Database

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Regulation of mRNA expression involved in Ras and PKA signal pathways during rat hypoglossal nerve regeneration.

Authors: Kiryu, S  Morita, N  Ohno, K  Maeno, H  Kiyama, H 
Citation: Kiryu S, etal., Brain Res Mol Brain Res. 1995 Mar;29(1):147-56.
RGD ID: 7327191
Pubmed: (View Article at PubMed) PMID:7769990

Using in situ hybridization histochemistry and immunohistochemistry, the present study examines the cooperative regulation of transcription of molecules involved in the Ras-signal and the cAMP dependent protein kinase (PKA) pathways during peripheral nerve regeneration in rats. Injury to hypoglossal motor neurons resulted in an increase in extracellular regulated kinase (ERK, or MAP kinase) and ERK kinase (MEK, or MAP kinase kinase) mRNAs, but in a decrease in the expression of the catalytic subunits of PKA (C alpha and C beta) mRNAs. These results show the importance of the Ras-signal pathway in the nerve regeneration process and extend recent observation which suggested a cross-talk between the Ras and PKA pathways in vitro. The down-regulation of PKA may facilitate the activation of the Ras pathway which is located downstream of the growth factor receptor. The present study may suggest a possibility of regulatory talk between these two major signal transduction pathways.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Prkaca  (protein kinase cAMP-activated catalytic subunit alpha)
Prkacb  (protein kinase cAMP-activated catalytic subunit beta)

Genes (Mus musculus)
Prkaca  (protein kinase, cAMP dependent, catalytic, alpha)
Prkacb  (protein kinase, cAMP dependent, catalytic, beta)

Genes (Homo sapiens)
PRKACA  (protein kinase cAMP-activated catalytic subunit alpha)
PRKACB  (protein kinase cAMP-activated catalytic subunit beta)


Additional Information