PRKACB (protein kinase cAMP-activated catalytic subunit beta) - Rat Genome Database

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Gene: PRKACB (protein kinase cAMP-activated catalytic subunit beta) Pan paniscus
Analyze
Symbol: PRKACB
Name: protein kinase cAMP-activated catalytic subunit beta
RGD ID: 11795935
Description: ENCODES a protein that exhibits cAMP-dependent protein kinase activity (ortholog); INVOLVED IN negative regulation of meiotic cell cycle (ortholog); negative regulation of smoothened signaling pathway (ortholog); neural tube closure (ortholog); PARTICIPATES IN adenosine signaling pathway; dopamine signaling pathway; dopamine signaling pathway via D1 family of receptors; ASSOCIATED WITH adrenal cortical adenoma (ortholog); biliary tract benign neoplasm (ortholog); brain ischemia (ortholog); FOUND IN cAMP-dependent protein kinase complex (ortholog); perinuclear region of cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cAMP-dependent protein kinase catalytic subunit beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21142,704,501 - 142,865,759 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11141,858,945 - 142,019,573 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01116,625,640 - 116,786,396 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1185,574,094 - 85,647,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl185,487,681 - 85,644,253 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PRKACB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21142,704,501 - 142,865,759 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11141,858,945 - 142,019,573 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01116,625,640 - 116,786,396 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1185,574,094 - 85,647,446 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl185,487,681 - 85,644,253 (+)Ensemblpanpan1.1panPan2
PRKACB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38184,078,079 - 84,238,498 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl184,078,062 - 84,238,498 (+)EnsemblGRCh38hg38GRCh38
GRCh37184,543,762 - 84,704,181 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36184,316,333 - 84,476,769 (+)NCBINCBI36Build 36hg18NCBI36
Celera182,787,965 - 82,948,395 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef182,654,090 - 82,814,484 (+)NCBIHuRef
CHM1_1184,658,575 - 84,819,019 (+)NCBICHM1_1
T2T-CHM13v2.0183,918,534 - 84,078,964 (+)NCBIT2T-CHM13v2.0
Prkacb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393146,435,334 - 146,518,691 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3146,435,329 - 146,518,745 (-)EnsemblGRCm39 Ensembl
GRCm383146,729,579 - 146,812,946 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3146,729,574 - 146,812,990 (-)EnsemblGRCm38mm10GRCm38
MGSCv373146,392,543 - 146,475,910 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363146,666,965 - 146,750,316 (-)NCBIMGSCv36mm8
Celera3153,182,525 - 153,265,941 (-)NCBICelera
Cytogenetic Map3H2NCBI
cM Map372.28NCBI
Prkacb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82238,297,140 - 238,389,317 (-)NCBIGRCr8
mRatBN7.22235,636,878 - 235,726,928 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2235,636,885 - 235,726,198 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2243,435,379 - 243,522,815 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02241,326,025 - 241,413,467 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02236,193,035 - 236,280,486 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02252,602,197 - 252,691,886 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,605,307 - 252,691,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02271,129,418 - 271,218,985 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,949,303 - 245,035,266 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2227,617,114 - 227,701,913 (-)NCBICelera
Cytogenetic Map2q44NCBI
Prkacb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554239,629,378 - 9,747,820 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554239,630,308 - 9,747,820 (-)NCBIChiLan1.0ChiLan1.0
PRKACB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1663,615,445 - 63,729,386 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl663,618,323 - 63,730,146 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha666,263,759 - 66,377,569 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0664,155,572 - 64,269,668 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl664,155,572 - 64,269,867 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1663,683,378 - 63,796,798 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0663,652,236 - 63,766,014 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0664,158,621 - 64,272,439 (-)NCBIUU_Cfam_GSD_1.0
Prkacb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505894,841,492 - 94,952,128 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366081,353,897 - 1,464,636 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366081,353,905 - 1,464,636 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKACB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6129,520,376 - 129,635,733 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16129,520,397 - 129,636,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26119,719,887 - 119,778,443 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKACB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12049,109,774 - 49,273,200 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2049,108,425 - 49,178,806 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603368,486,789 - 68,652,007 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkacb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474213,242,593 - 13,357,986 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474213,243,248 - 13,357,873 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_014345898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034933959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034933965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034933971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034933981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034933989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034933996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034933999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034934003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034934006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034934013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034934019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034934024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034934034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063600154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000040365   ⟹   ENSPPAP00000017656
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl185,487,681 - 85,644,253 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000040369   ⟹   ENSPPAP00000017660
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl185,487,681 - 85,613,834 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000040390   ⟹   ENSPPAP00000017680
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl185,553,814 - 85,644,253 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000040406   ⟹   ENSPPAP00000017695
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl185,585,838 - 85,612,200 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000040413   ⟹   ENSPPAP00000017702
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl185,587,274 - 85,644,253 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000040416   ⟹   ENSPPAP00000017705
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl185,591,088 - 85,644,253 (+)Ensembl
RefSeq Acc Id: XM_034933959   ⟹   XP_034789850
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21142,704,501 - 142,798,731 (-)NCBI
NHGRI_mPanPan11141,858,945 - 141,953,095 (-)NCBI
Mhudiblu_PPA_v01116,692,222 - 116,786,396 (+)NCBI
RefSeq Acc Id: XM_034933971   ⟹   XP_034789862
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21142,704,501 - 142,865,109 (-)NCBI
NHGRI_mPanPan11141,858,945 - 142,019,475 (-)NCBI
Mhudiblu_PPA_v01116,625,802 - 116,786,396 (+)NCBI
RefSeq Acc Id: XM_034933989   ⟹   XP_034789880
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21142,704,501 - 142,778,678 (-)NCBI
NHGRI_mPanPan11141,858,945 - 141,933,089 (-)NCBI
Mhudiblu_PPA_v01116,712,108 - 116,786,396 (+)NCBI
RefSeq Acc Id: XM_034933996   ⟹   XP_034789887
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21142,704,501 - 142,778,290 (-)NCBI
NHGRI_mPanPan11141,858,945 - 141,932,705 (-)NCBI
Mhudiblu_PPA_v01116,712,607 - 116,786,396 (+)NCBI
RefSeq Acc Id: XM_034933999   ⟹   XP_034789890
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21142,704,501 - 142,865,759 (-)NCBI
NHGRI_mPanPan11141,858,945 - 142,019,573 (-)NCBI
Mhudiblu_PPA_v01116,625,640 - 116,786,396 (+)NCBI
RefSeq Acc Id: XM_034934019   ⟹   XP_034789910
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21142,704,501 - 142,778,291 (-)NCBI
NHGRI_mPanPan11141,858,945 - 141,932,705 (-)NCBI
Mhudiblu_PPA_v01116,712,607 - 116,786,396 (+)NCBI
RefSeq Acc Id: XM_034934024   ⟹   XP_034789915
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21142,704,501 - 142,778,687 (-)NCBI
NHGRI_mPanPan11141,858,945 - 141,933,095 (-)NCBI
Mhudiblu_PPA_v01116,712,108 - 116,786,396 (+)NCBI
RefSeq Acc Id: XM_034934034   ⟹   XP_034789925
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21142,704,501 - 142,778,325 (-)NCBI
NHGRI_mPanPan11141,858,945 - 141,932,740 (-)NCBI
Mhudiblu_PPA_v01116,712,608 - 116,786,396 (+)NCBI
RefSeq Acc Id: XM_063600154   ⟹   XP_063456224
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21142,704,501 - 142,778,674 (-)NCBI
RefSeq Acc Id: XP_034789890   ⟸   XM_034933999
- Peptide Label: isoform X5
- UniProtKB: A0A2R9AJW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034789862   ⟸   XM_034933971
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AJW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034789850   ⟸   XM_034933959
- Peptide Label: isoform X1
- UniProtKB: A0A2R9APM3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034789880   ⟸   XM_034933989
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AJW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034789915   ⟸   XM_034934024
- Peptide Label: isoform X8
- UniProtKB: A0A2R9AJW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034789887   ⟸   XM_034933996
- Peptide Label: isoform X4
- UniProtKB: A0A2R9AJW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034789910   ⟸   XM_034934019
- Peptide Label: isoform X7
- UniProtKB: A0A2R9AJW1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034789925   ⟸   XM_034934034
- Peptide Label: isoform X9
- UniProtKB: A0A2R9AJW1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000017656   ⟸   ENSPPAT00000040365
Ensembl Acc Id: ENSPPAP00000017660   ⟸   ENSPPAT00000040369
Ensembl Acc Id: ENSPPAP00000017680   ⟸   ENSPPAT00000040390
Ensembl Acc Id: ENSPPAP00000017695   ⟸   ENSPPAT00000040406
Ensembl Acc Id: ENSPPAP00000017702   ⟸   ENSPPAT00000040413
Ensembl Acc Id: ENSPPAP00000017705   ⟸   ENSPPAT00000040416
RefSeq Acc Id: XP_063456224   ⟸   XM_063600154
- Peptide Label: isoform X6
- UniProtKB: A0A2R9AJW1 (UniProtKB/TrEMBL)
Protein Domains
AGC-kinase C-terminal   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031832 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000040365.1 UniProtKB/TrEMBL
  ENSPPAT00000040369.1 UniProtKB/TrEMBL
  ENSPPAT00000040390.1 UniProtKB/TrEMBL
  ENSPPAT00000040406.1 UniProtKB/TrEMBL
  ENSPPAT00000040413.1 UniProtKB/TrEMBL
  ENSPPAT00000040416.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STKc_PKA UniProtKB/TrEMBL
NCBI Gene PRKACB ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE UniProtKB/TrEMBL
  CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT BETA UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9AJW1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AK04_PANPA UniProtKB/TrEMBL
  A0A2R9APK3_PANPA UniProtKB/TrEMBL
  A0A2R9APM3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9APN7_PANPA UniProtKB/TrEMBL
  A0A2R9APP7_PANPA UniProtKB/TrEMBL