Gad1 (glutamate decarboxylase 1) - Rat Genome Database

Name: Gad1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Gad1 (glutamate decarboxylase 1) Heterocephalus glaber

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Symbol:

Gad1

Name:

glutamate decarboxylase 1

RGD ID:

18901898

Description:

ENCODES a protein that exhibits glutamate binding (ortholog); glutamate decarboxylase activity (ortholog); identical protein binding (ortholog); INVOLVED IN cellular response to hypoxia (ortholog); cellular response to serotonin (ortholog); gamma-aminobutyric acid biosynthetic process (ortholog); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; beta-alanine metabolic pathway; Canavan disease pathway; ASSOCIATED WITH alcohol dependence (ortholog); amphetamine abuse (ortholog); anxiety disorder (ortholog); FOUND IN axon (ortholog); axon terminus (ortholog); cell cortex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

glutamate decarboxylase 1 isoform GAD67

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	8,308,759 - 8,347,686 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	8,308,759 - 8,345,929 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol dependence (ISO)

amphetamine abuse (ISO)

anxiety disorder (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

bipolar disorder (ISO)

cocaine dependence (ISO)

Cocaine-Related Disorders (ISO)

colorectal cancer (ISO)

developmental and epileptic encephalopathy 89 (ISO)

diabetes mellitus (ISO)

drug psychosis (ISO)

Drug Resistant Epilepsy (ISO)

Drug-Induced Dyskinesia (ISO)

early-onset vitamin B6-dependent epilepsy 4 (ISO)

epilepsy (ISO)

genetic disease (ISO)

Hearing Loss, Noise-Induced (ISO)

hereditary spastic paraplegia (ISO)

heroin dependence (ISO)

Hyperalgesia (ISO)

hyperprolactinemia (ISO)

hypertension (ISO)

major depressive disorder (ISO)

morphine dependence (ISO)

Neurodevelopmental Disorder with Progressive Spasticity and Brain White Matter Abnormalities (ISO)

pyridoxine-dependent epilepsy (ISO)

schizophrenia (ISO)

spastic quadriplegic cerebral palsy (ISO)

split hand-foot malformation 5 (ISO)

transient cerebral ischemia (ISO)

West syndrome (ISO)

withdrawal disorder (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

carboxylic acid metabolic process (IEA)

cellular response to hypoxia (ISO)

cellular response to serotonin (ISO)

gamma-aminobutyric acid biosynthetic process (IEA,ISO)

glutamate catabolic process (ISO)

locomotory exploration behavior (ISO)

positive regulation of locomotion involved in locomotory behavior (ISO)

response to auditory stimulus (ISO)

response to caloric restriction (ISO)

response to cocaine (ISO)

response to ethanol (ISO)

response to isolation stress (ISO)

response to methamphetamine hydrochloride (ISO)

response to morphine (ISO)

response to progesterone (ISO)

response to toxic substance (ISO)

response to xenobiotic stimulus (ISO)

social behavior (ISO)

Cellular Component

axon (ISO)

axon terminus (ISO)

cell cortex (ISO)

cytoplasm (IEA)

GABA-ergic synapse (ISO)

inhibitory synapse (ISO)

neuron projection terminus (ISO)

neuronal cell body (ISO)

perinuclear region of cytoplasm (ISO)

presynapse (ISO)

presynaptic active zone (IEA)

synapse (ISO)

Molecular Function

carboxy-lyase activity (IEA)

glutamate binding (ISO)

glutamate decarboxylase activity (IEA,ISO)

identical protein binding (ISO)

protein binding (ISO)

protein-containing complex binding (ISO)

pyridoxal phosphate binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

2-hydroxyglutaric aciduria pathway (ISO)

beta-alanine metabolic pathway (ISO)

Canavan disease pathway (ISO)

carnosinemia pathway (ISO)

GABA aminotransferase deficiency pathway (ISO)

glutamic acid/glutamate metabolic pathway (ISO)

homocarnosinosis pathway (ISO)

succinic semialdehyde dehydrogenase deficiency pathway (ISO)

taurine and hypotaurine metabolic pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gad1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624787	8,308,759 - 8,347,686 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624787	8,308,759 - 8,345,929 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

GAD1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	170,813,210 - 170,861,151 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	170,813,213 - 170,861,151 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	171,673,397 - 171,717,661 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	171,381,446 - 171,425,907 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	2	171,498,706 - 171,524,775	NCBI
Celera	2	165,289,914 - 165,334,327 (+)	NCBI		Celera
Cytogenetic Map	2	q31.1	NCBI
HuRef	2	163,562,349 - 163,606,375 (+)	NCBI		HuRef
CHM1_1	2	171,679,435 - 171,723,884 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	2	171,290,353 - 171,338,262 (+)	NCBI		T2T-CHM13v2.0

Gad1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	70,392,109 - 70,432,358 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	70,383,416 - 70,432,358 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	70,561,303 - 70,602,014 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	70,553,072 - 70,602,014 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	70,400,221 - 70,440,069 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	70,363,052 - 70,402,853 (+)	NCBI		MGSCv36	mm8
Celera	2	72,228,088 - 72,268,083 (+)	NCBI		Celera
Cytogenetic Map	2	C2	NCBI
cM Map	2	41.63	NCBI

Gad1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	75,777,260 - 75,818,099 (+)	NCBI		GRCr8
mRatBN7.2	3	55,369,704 - 55,410,335 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	55,369,704 - 55,410,333 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	58,774,583 - 58,815,086 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	67,358,166 - 67,398,662 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	65,120,847 - 65,161,332 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	56,861,440 - 56,902,139 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	56,861,396 - 56,902,157 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	63,479,963 - 63,519,879 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	52,789,370 - 52,830,038 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	52,685,741 - 52,726,408 (+)	NCBI
Celera	3	54,926,942 - 54,967,478 (+)	NCBI		Celera
Cytogenetic Map	3	q22	NCBI

Gad1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955449	3,963,705 - 4,001,850 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955449	3,964,006 - 4,001,850 (-)	NCBI	ChiLan1.0	ChiLan1.0

GAD1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	13	73,489,127 - 73,533,319 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2B	73,504,103 - 73,548,292 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2B	58,100,623 - 58,145,045 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2B	175,558,538 - 175,602,951 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	175,558,538 - 175,602,944 (+)	Ensembl	panpan1.1		panPan2

GAD1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	36	15,351,289 - 15,391,701 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	36	15,349,683 - 15,391,824 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	36	15,364,114 - 15,403,437 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	36	15,474,678 - 15,516,842 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	36	15,474,925 - 15,516,838 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	36	15,565,032 - 15,604,314 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	36	15,552,796 - 15,592,193 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	36	15,664,544 - 15,703,870 (+)	NCBI		UU_Cfam_GSD_1.0

Gad1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405303	132,606,889 - 132,647,134 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936509	1,161,094 - 1,201,576 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936509	1,160,559 - 1,201,037 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GAD1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	76,991,928 - 77,034,812 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	76,991,863 - 77,034,819 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	86,375,113 - 86,419,237 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	15	q21-q22	NCBI

GAD1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	56,351,495 - 56,396,476 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	10	56,353,253 - 56,396,524 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	143,149,876 - 143,195,107 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_004857648	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AHKG01062720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GEBF01001132	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSHGLT00000009838 ⟹ ENSHGLP00000009730

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla_female_1.0 Ensembl	NW_004624787	8,308,759 - 8,347,686 (+)	Ensembl

RefSeq Acc Id:

XM_004857648 ⟹ XP_004857705

Type:

CODING

Position:

Naked Mole-Rat Assembly	Chr	Position (strand)	Source
HetGla 1.0	NW_004624787	8,308,759 - 8,345,929 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_004857705	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSHGLP00000009730
	ENSHGLP00100025207
GenBank Protein	JAO02501	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_004857705 ⟸ XM_004857648
- UniProtKB:	A0A0P6JY11 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSHGLP00000009730 ⟸ ENSHGLT00000009838

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSHGLG00000006981	Ensembl, ENTREZGENE
	ENSHGLG00100018493	UniProtKB/TrEMBL
Ensembl Transcript	ENSHGLT00000009838	ENTREZGENE
	ENSHGLT00100025464	UniProtKB/TrEMBL
Gene3D-CATH	3.40.640.10	UniProtKB/TrEMBL
	3.90.1150.170	UniProtKB/TrEMBL
InterPro	PyrdxlP-dep_de-COase	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase	UniProtKB/TrEMBL
	PyrdxlP-dep_Trfase_major	UniProtKB/TrEMBL
	Pyridoxal-P_BS	UniProtKB/TrEMBL
KEGG Report	hgl:101725846	UniProtKB/TrEMBL
NCBI Gene	Gad1	ENTREZGENE
PANTHER	GLUTAMATE DECARBOXYLASE 1	UniProtKB/TrEMBL
	GLUTAMATE DECARBOXYLASE-RELATED	UniProtKB/TrEMBL
Pfam	Pyridoxal_deC	UniProtKB/TrEMBL
PROSITE	DDC_GAD_HDC_YDC	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53383	UniProtKB/TrEMBL
UniProt	A0A0P6JY11	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

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Imported Annotations - SMPDB