Slc6a8 (solute carrier family 6 member 8) - Rat Genome Database

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Gene: Slc6a8 (solute carrier family 6 member 8) Heterocephalus glaber
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Symbol: Slc6a8
Name: solute carrier family 6 member 8
RGD ID: 18900168
Description: ENCODES a protein that exhibits choline transmembrane transporter activity (ortholog); creatine transmembrane transporter activity (ortholog); creatine:sodium symporter activity (ortholog); INVOLVED IN creatine transmembrane transport (ortholog); embryonic brain development (ortholog); protein catabolic process (ortholog); PARTICIPATES IN creatine metabolic pathway; ASSOCIATED WITH anxiety disorder (ortholog); autistic disorder (ortholog); cardiomyopathy (ortholog); FOUND IN glutamatergic synapse (ortholog); postsynaptic membrane (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter, creatine), member 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946389,806 - 396,653 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slc6a8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946389,806 - 396,653 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
SLC6A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X153,687,926 - 153,696,593 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX153,687,914 - 153,696,591 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37X152,953,381 - 152,962,048 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,606,586 - 152,615,234 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34X152,474,238 - 152,482,887NCBI
CeleraX153,187,436 - 153,195,732 (+)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX141,612,842 - 141,619,133 (+)NCBIHuRef
CHM1_1X152,828,182 - 152,836,459 (+)NCBICHM1_1
T2T-CHM13v2.0X151,961,591 - 151,970,260 (+)NCBIT2T-CHM13v2.0
Slc6a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,716,739 - 72,726,108 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX72,716,728 - 72,726,108 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38X73,673,133 - 73,682,502 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,673,150 - 73,682,502 (+)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37X70,918,472 - 70,927,841 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X69,925,870 - 69,935,222 (+)NCBIMGSCv36mm8
CeleraX64,926,949 - 64,936,317 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.38NCBI
Slc6a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X156,536,017 - 156,545,321 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX156,536,017 - 156,545,321 (+)EnsemblGRCr8
mRatBN7.2X151,384,675 - 151,393,979 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX151,384,675 - 151,393,979 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX153,525,847 - 153,535,151 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X157,089,078 - 157,098,382 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X154,760,908 - 154,770,212 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X157,129,987 - 157,139,321 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX157,129,987 - 157,139,291 (-)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01152,879,305 - 152,888,640 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X159,570,789 - 159,580,093 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1136,495,566 - 136,504,870 (-)NCBICelera
RGSC_v3.1X159,645,625 - 159,654,519 (+)NCBI
Cytogenetic MapXq37NCBI
Slc6a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955580418,935 - 428,522 (+)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_004955580419,696 - 426,727 (+)NCBIChiLan1.0ChiLan1.0
SLC6A8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X153,728,332 - 153,737,003 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X153,731,936 - 153,740,609 (+)NCBINHGRI_mPanPan1
SLC6A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,505,117 - 121,511,674 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,505,141 - 121,510,347 (+)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_TashaX106,832,742 - 106,841,046 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0X124,644,861 - 124,653,192 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX124,644,885 - 124,668,051 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X120,414,322 - 120,422,627 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X122,929,312 - 122,937,588 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X122,691,440 - 122,699,746 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc6a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap1X1,948,646 - 1,957,868 (-)NCBImIctTri1.hap1
HiC_Itri_2X118,833,463 - 118,840,527 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936809569,918 - 580,449 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936809571,234 - 578,298 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,294,856 - 124,452,182 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.1X124,435,282 - 124,452,182 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,008,693 - 142,016,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1X2,204,907 - 2,213,493 (-)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_02366606565,978,641 - 65,987,221 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1X128,116,490 - 128,124,899 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX128,116,944 - 128,124,918 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Slc6a8
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1X128,911,959 - 128,921,276 (-)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_004874941   ⟹   XP_004874998
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946389,808 - 396,653 (+)NCBI
RefSeq Acc Id: XM_004874942   ⟹   XP_004874999
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946389,834 - 396,653 (+)NCBI
RefSeq Acc Id: XM_021252294   ⟹   XP_021107953
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946389,806 - 396,653 (+)NCBI
RefSeq Acc Id: XM_021252295   ⟹   XP_021107954
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_004624946389,835 - 396,653 (+)NCBI
Protein Sequences
Protein RefSeqs XP_004874998 (Get FASTA)   NCBI Sequence Viewer  
  XP_004874999 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107953 (Get FASTA)   NCBI Sequence Viewer  
  XP_021107954 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000000335
RefSeq Acc Id: XP_021107953   ⟸   XM_021252294
- Peptide Label: isoform X1
- UniProtKB: A0AAX6SJA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004874998   ⟸   XM_004874941
- Peptide Label: isoform X2
- UniProtKB: A0AAX6QJB0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_004874999   ⟸   XM_004874942
- Peptide Label: isoform X3
- UniProtKB: A0AAX6QGK3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021107954   ⟸   XM_021252295
- Peptide Label: isoform X4
- UniProtKB: A0AAX6SHB3 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000000318 ENTREZGENE
Ensembl Transcript ENSHGLT00000000369 ENTREZGENE
InterPro Na/ntran_symport UniProtKB/TrEMBL
  Na/ntran_symport_creatine UniProtKB/TrEMBL
  SNS_sf UniProtKB/TrEMBL
KEGG Report hgl:101718720 UniProtKB/TrEMBL
NCBI Gene Slc6a8 ENTREZGENE
PANTHER SODIUM- AND CHLORIDE-DEPENDENT CREATINE TRANSPORTER 1 UniProtKB/TrEMBL
  SODIUM/CHLORIDE DEPENDENT TRANSPORTER UniProtKB/TrEMBL
Pfam SNF UniProtKB/TrEMBL
PRINTS CRTTRANSPORT UniProtKB/TrEMBL
  NANEUSMPORT UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_1 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_2 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/TrEMBL
Superfamily-SCOP SNF-like UniProtKB/TrEMBL
UniProt A0AAX6QGK3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6QJB0 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SHB3 ENTREZGENE, UniProtKB/TrEMBL
  A0AAX6SJA9 ENTREZGENE, UniProtKB/TrEMBL