SLC6A8 (solute carrier family 6 member 8) - Rat Genome Database

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Gene: SLC6A8 (solute carrier family 6 member 8) Canis lupus familiaris
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Symbol: SLC6A8
Name: solute carrier family 6 member 8
RGD ID: 12270715
Description: ENCODES a protein that exhibits choline transmembrane transporter activity (ortholog); creatine transmembrane transporter activity (ortholog); creatine:sodium symporter activity (ortholog); INVOLVED IN creatine transmembrane transport (ortholog); embryonic brain development (ortholog); nitrogen compound transport (ortholog); PARTICIPATES IN creatine metabolic pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); autistic disorder (ortholog); creatine transporter deficiency (ortholog); FOUND IN glutamatergic synapse (ortholog); integral component of postsynaptic membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: sodium- and chloride-dependent creatine transporter 1; solute carrier family 6 (neurotransmitter transporter, creatine), member 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,505,117 - 121,511,674 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,505,141 - 121,510,347 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX106,832,742 - 106,841,046 (+)NCBI
ROS_Cfam_1.0X124,644,861 - 124,653,192 (+)NCBI
UMICH_Zoey_3.1X120,414,322 - 120,422,627 (+)NCBI
UNSW_CanFamBas_1.0X122,929,312 - 122,937,588 (+)NCBI
UU_Cfam_GSD_1.0X122,691,440 - 122,699,746 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
SLC6A8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X121,505,117 - 121,511,674 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX121,505,141 - 121,510,347 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX106,832,742 - 106,841,046 (+)NCBI
ROS_Cfam_1.0X124,644,861 - 124,653,192 (+)NCBI
UMICH_Zoey_3.1X120,414,322 - 120,422,627 (+)NCBI
UNSW_CanFamBas_1.0X122,929,312 - 122,937,588 (+)NCBI
UU_Cfam_GSD_1.0X122,691,440 - 122,699,746 (+)NCBI
SLC6A8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX153,687,926 - 153,696,588 (+)EnsemblGRCh38hg38GRCh38
GRCh38X153,687,926 - 153,696,593 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X152,953,381 - 152,962,048 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X152,606,586 - 152,615,234 (+)NCBINCBI36hg18NCBI36
Build 34X152,474,238 - 152,482,887NCBI
CeleraX153,187,436 - 153,195,732 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX141,612,842 - 141,619,133 (+)NCBIHuRef
CHM1_1X152,828,182 - 152,836,459 (+)NCBICHM1_1
Slc6a8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X72,716,739 - 72,726,108 (+)NCBIGRCm39mm39
GRCm39 EnsemblX72,716,756 - 72,726,108 (+)Ensembl
GRCm38X73,673,133 - 73,682,502 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX73,673,150 - 73,682,502 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X70,918,472 - 70,927,841 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X69,925,870 - 69,935,222 (+)NCBImm8
CeleraX64,926,949 - 64,936,317 (+)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX37.38NCBI
Slc6a8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X151,384,675 - 151,393,979 (+)NCBI
Rnor_6.0 EnsemblX157,129,987 - 157,139,291 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X157,129,987 - 157,139,321 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01152,879,305 - 152,888,640 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X159,570,789 - 159,580,093 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X159,645,625 - 159,654,519 (+)NCBI
Celera1136,495,566 - 136,504,870 (-)NCBICelera
Cytogenetic MapXq37NCBI
Slc6a8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955580419,696 - 426,727 (+)NCBIChiLan1.0ChiLan1.0
LOC100975352
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,126,415 - 153,132,917 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,126,415 - 153,133,189 (+)Ensemblpanpan1.1panPan2
Slc6a8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X118,833,463 - 118,840,527 (+)NCBI
SpeTri2.0NW_004936809571,234 - 578,298 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC6A8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX124,294,856 - 124,453,249 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X124,435,282 - 124,452,182 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X142,008,693 - 142,016,715 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC6A8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X128,116,490 - 128,124,899 (+)NCBI
ChlSab1.1 EnsemblX128,116,944 - 128,124,918 (+)Ensembl
Slc6a8
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624946389,806 - 396,653 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 6 5 6 6 6 6 6
Low 16 6 1 6 6 6 4
Below cutoff 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000030544   ⟹   ENSCAFP00000028381
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX121,505,141 - 121,510,347 (+)Ensembl
RefSeq Acc Id: XM_005641994   ⟹   XP_005642051
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X121,505,117 - 121,511,674 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038451229   ⟹   XP_038307157
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0X124,644,861 - 124,653,192 (+)NCBI
RefSeq Acc Id: XM_038464270   ⟹   XP_038320198
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_TashaX106,832,742 - 106,841,046 (+)NCBI
RefSeq Acc Id: XM_038524696   ⟹   XP_038380624
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1X120,414,322 - 120,422,627 (+)NCBI
RefSeq Acc Id: XM_038588661   ⟹   XP_038444589
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0X122,691,440 - 122,699,746 (+)NCBI
RefSeq Acc Id: XM_038653182   ⟹   XP_038509110
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0X122,929,312 - 122,937,588 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005642051   ⟸   XM_005641994
- Sequence:
RefSeq Acc Id: ENSCAFP00000028381   ⟸   ENSCAFT00000030544
RefSeq Acc Id: XP_038380624   ⟸   XM_038524696
RefSeq Acc Id: XP_038509110   ⟸   XM_038653182
RefSeq Acc Id: XP_038307157   ⟸   XM_038451229
RefSeq Acc Id: XP_038320198   ⟸   XM_038464270
RefSeq Acc Id: XP_038444589   ⟸   XM_038588661


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019243 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000028381 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000030544 UniProtKB/TrEMBL
InterPro Na/ntran_symport UniProtKB/TrEMBL
  Na/ntran_symport_creatine UniProtKB/TrEMBL
  SNS_sf UniProtKB/TrEMBL
NCBI Gene SLC6A8 ENTREZGENE
PANTHER PTHR11616 UniProtKB/TrEMBL
Pfam SNF UniProtKB/TrEMBL
PRINTS CRTTRANSPORT UniProtKB/TrEMBL
  NANEUSMPORT UniProtKB/TrEMBL
PROSITE NA_NEUROTRAN_SYMP_2 UniProtKB/TrEMBL
  NA_NEUROTRAN_SYMP_3 UniProtKB/TrEMBL
Superfamily-SCOP SSF161070 UniProtKB/TrEMBL
UniProt F1PZI9_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:54602 ENTREZGENE