P2RX4 (purinergic receptor P2X 4) - Rat Genome Database

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Gene: P2RX4 (purinergic receptor P2X 4) Chlorocebus sabaeus
Analyze
Symbol: P2RX4
Name: purinergic receptor P2X 4
RGD ID: 18722764
Description: ENCODES a protein that exhibits ATP binding (ortholog); ATP-gated ion channel activity (ortholog); copper ion binding (ortholog); INVOLVED IN behavioral response to pain (ortholog); calcium ion transport (ortholog); cellular response to ATP (ortholog); ASSOCIATED WITH congestive heart failure (ortholog); COVID-19 (ortholog); epilepsy (ortholog); FOUND IN apical part of cell (ortholog); axon (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: P2X purinoceptor 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111116,585,276 - 116,609,401 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11116,585,586 - 116,609,511 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037128,472,594 - 128,496,813 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic signaling pathway  (IEA)
behavioral response to pain  (ISO)
calcium ion transmembrane transport  (IEA)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cellular response to ATP  (IEA,ISO)
cellular response to zinc ion  (ISO)
clathrin-dependent endocytosis  (ISO)
excitatory postsynaptic potential  (IEA,ISO)
inorganic cation transmembrane transport  (ISO)
membrane depolarization  (IEA)
monoatomic cation transmembrane transport  (IEA)
monoatomic ion transmembrane transport  (IEA)
negative regulation of cardiac muscle hypertrophy  (IEA)
neuronal action potential  (ISO)
nitric oxide biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (IEA)
positive regulation of calcium ion transport into cytosol  (IEA)
positive regulation of calcium-mediated signaling  (IEA)
positive regulation of endothelial cell chemotaxis  (IEA)
positive regulation of microglial cell migration  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
purinergic nucleotide receptor signaling pathway  (IEA)
regulation of blood pressure  (IEA)
regulation of cardiac muscle contraction  (IEA)
regulation of chemotaxis  (ISO)
regulation of response to drug  (ISO)
regulation of ruffle assembly  (ISO)
regulation of sodium ion transport  (ISO)
relaxation of cardiac muscle  (IEA)
response to ATP  (IEA)
response to axon injury  (ISO)
response to fluid shear stress  (IEA)
response to ischemia  (ISO)
sensory perception of pain  (ISO)
sensory perception of touch  (ISO)
signal transduction  (IEA)
vasodilation  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
P2RX4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111116,585,276 - 116,609,401 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11116,585,586 - 116,609,511 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037128,472,594 - 128,496,813 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2RX4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812121,210,129 - 121,234,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12121,210,065 - 121,234,106 (+)EnsemblGRCh38hg38GRCh38
GRCh3712121,647,932 - 121,671,909 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,132,047 - 120,156,292 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412120,110,383 - 120,134,627NCBI
Celera12121,285,420 - 121,309,664 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12118,657,246 - 118,681,512 (+)NCBIHuRef
CHM1_112121,616,508 - 121,640,746 (+)NCBICHM1_1
T2T-CHM13v2.012121,200,899 - 121,224,872 (+)NCBIT2T-CHM13v2.0
P2rx4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395122,845,581 - 122,867,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,845,607 - 122,867,801 (+)EnsemblGRCm39 Ensembl
GRCm385122,707,518 - 122,729,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,707,544 - 122,729,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv375123,157,566 - 123,179,053 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365122,968,240 - 122,989,661 (+)NCBIMGSCv36mm8
Celera5119,785,375 - 119,806,787 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.53NCBI
P2rx4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81239,505,438 - 39,523,349 (-)NCBIGRCr8
mRatBN7.21233,844,609 - 33,862,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,844,396 - 33,862,253 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,022,338 - 35,040,001 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,633,773 - 35,651,436 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,686,065 - 34,703,728 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,308,022 - 39,325,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,308,025 - 39,325,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,196,777 - 41,214,428 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,943,900 - 34,961,551 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,807,290 - 34,824,939 (-)NCBI
Celera1235,521,444 - 35,539,095 (-)NCBICelera
Cytogenetic Map12q16NCBI
P2rx4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554827,031,874 - 7,039,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554827,031,874 - 7,039,026 (-)NCBIChiLan1.0ChiLan1.0
P2RX4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210129,294,836 - 129,319,045 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112129,291,253 - 129,315,419 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,807,961 - 118,832,267 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112122,178,668 - 122,202,959 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12122,178,672 - 122,202,959 (+)Ensemblpanpan1.1panPan2
P2RX4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1267,897,528 - 7,914,279 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl267,898,015 - 7,914,234 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,062,300 - 8,079,042 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,155,694 - 8,172,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,155,705 - 8,172,399 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,115,630 - 8,132,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,174,205 - 8,190,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,130,559 - 8,147,306 (-)NCBIUU_Cfam_GSD_1.0
P2rx4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118156,402,015 - 156,417,147 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365583,059,886 - 3,077,451 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365583,062,279 - 3,077,493 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RX4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1431,368,303 - 31,387,905 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11431,368,542 - 31,387,960 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,232,162 - 33,251,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2rx4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474721,783,381 - 21,796,260 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474721,783,445 - 21,796,501 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000000234   ⟹   ENSCSAP00000015819
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl11116,585,586 - 116,609,511 (+)Ensembl
RefSeq Acc Id: XM_008004978   ⟹   XP_008003169
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111116,585,284 - 116,609,401 (+)NCBI
Vero_WHO_p1.0NW_023666037128,472,594 - 128,496,549 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008004979   ⟹   XP_008003170
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111116,585,276 - 116,609,401 (+)NCBI
Vero_WHO_p1.0NW_023666037128,472,594 - 128,496,813 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008004980   ⟹   XP_008003171
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.111116,585,500 - 116,609,401 (+)NCBI
Vero_WHO_p1.0NW_023666037128,472,594 - 128,496,813 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_008003169 (Get FASTA)   NCBI Sequence Viewer  
  XP_008003170 (Get FASTA)   NCBI Sequence Viewer  
  XP_008003171 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000015819
  ENSCSAP00000015819.1
RefSeq Acc Id: XP_008003170   ⟸   XM_008004979
- Peptide Label: isoform X1
- UniProtKB: A0A0D9S4N0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008003169   ⟸   XM_008004978
- Peptide Label: isoform X3
RefSeq Acc Id: XP_008003171   ⟸   XM_008004980
- Peptide Label: isoform X2
- UniProtKB: A0A0D9S4N0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000015819   ⟸   ENSCSAT00000000234


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000002217 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000000234.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.490.10 UniProtKB/TrEMBL
  atp-gated p2x4 ion channel UniProtKB/TrEMBL
InterPro P2X4_purnocptor UniProtKB/TrEMBL
  P2X_extracellular_dom_sf UniProtKB/TrEMBL
  P2X_purnocptor UniProtKB/TrEMBL
  P2X_RECEPTOR_CS UniProtKB/TrEMBL
NCBI Gene P2RX4 ENTREZGENE
PANTHER P2X PURINOCEPTOR UniProtKB/TrEMBL
  P2X PURINOCEPTOR 4 UniProtKB/TrEMBL
Pfam P2X_receptor UniProtKB/TrEMBL
PIRSF P2X_purinoceptor UniProtKB/TrEMBL
PRINTS P2X4RECEPTOR UniProtKB/TrEMBL
  P2XRECEPTOR UniProtKB/TrEMBL
PROSITE P2X_RECEPTOR UniProtKB/TrEMBL
UniProt A0A0D9S4N0 ENTREZGENE, UniProtKB/TrEMBL